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Assessment on facile Diels-Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds

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Natural Products and Bioprospecting 2022年第1期12卷 137-157页

作者： Aluru Rammohan Albert F.Khasanov Dmitry s.Kopchuk Duvvuru Gunasekar Grigory V.Zyryanov Oleg N.Chupakhin Ural Federal University 19 Mira St.Ekaterinburg 620002Russian Federation Natural Products Division Department of ChemistrySri Venkateswara UniversityTirupati 517502India Ural Division of the Russian Academy of sciences I.Ya.Postovsky Institute of Organic Synthesis22 S.Kovalevskoy St.Ekaterinburg 620219Russian Federation

The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in *** this aspect,the Diels-Alder reaction(DAR)has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic ***,α-pyrone and terpeno-quinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance,(±)-crinine,(±)-joubertinamine,(±)-pancratistatin,(−)-cyclozonarone,and 8-ephipuupehedione,***,the current review summarizes the Diels-Alder reaction application ofα-pyrone and terpenoquinone to the construc-tive synthesis of various natural products over the past two decades(2001-2021).Equally,it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocy-clic molecules.

关键词： α-Pyrone Diels-Alder reaction(DAR) Marine natural compounds Terpenoquinone Total synthesis

两种口腔生物膜材料在牙种植引导骨再生中的应用及对骨厚度、植骨厚度的影响

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临床医学工程 2018年第8期25卷 989-990页

作者：徐强谢苗苗古丽米拉.木明兰馨叶钟泰深圳市宝安区人民医院口腔科广东深圳518000

目的比较两种口腔膜材料在牙种植引导骨再生中的临床效果及对骨厚度、植骨厚度的影响。方法回顾性分析2016年5月至2018年4月于我院口腔科进行牙种植的患者60例,根据使用口腔生物膜材料的不同分为对照组和观察组,对照组26例给予钛膜引导... 详细信息

目的比较两种口腔膜材料在牙种植引导骨再生中的临床效果及对骨厚度、植骨厚度的影响。方法回顾性分析2016年5月至2018年4月于我院口腔科进行牙种植的患者60例,根据使用口腔生物膜材料的不同分为对照组和观察组,对照组26例给予钛膜引导骨再生进行修复,观察组34例采用海奥口腔修复膜引导骨再生进行修复,观察和比较两组患者的临床效果。结果观察组患者的修复成功率为91.18%,显著高于对照组患者的69.23%,差异有统计学意义(P<0.05)。术后2周、1个月、3个月时,观察组患者的骨厚度、植骨厚度均显著大于对照组(P<0.05)。观察组的不良反应发生率显著低于对照组(P<0.05)。结论海奥口腔修复膜在引导骨再生进行牙缺损修复方面有良好的效果,可显著提高修复成功率,值得推广。

关键词：海奥口腔修复膜钛膜牙种植骨厚度植骨厚度

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喷砂预处理钛合金表面类金刚石薄膜的制备及性能研究

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北京生物医学工程 2017年第4期36卷 354-360,426页

作者：吾凡别克.巴合提米拉.巴合提董棣文阿依古丽.土尔地王富国新疆维吾尔自治区人民医院口腔科乌鲁木齐830000 新疆医科大学口腔医学院乌鲁木齐830000 中国科学院兰州化学物理研究所兰州730000

目的利用等离子体增强化学气相沉积(plasma enhanced chemical vapor deposition,PECVD)技术,在不同粗糙度医用钛合金表面制备类金刚石薄膜(diamond-like carbon film,DLC),并对类金刚石薄膜的膜-基结合力、电化学腐蚀行为及生物学行为... 详细信息

目的利用等离子体增强化学气相沉积(plasma enhanced chemical vapor deposition,PECVD)技术,在不同粗糙度医用钛合金表面制备类金刚石薄膜(diamond-like carbon film,DLC),并对类金刚石薄膜的膜-基结合力、电化学腐蚀行为及生物学行为进行研究,探索基底材料喷砂预处理对于表面制备的类金刚石薄膜是否是一种有效改性方法。方法通过不同粒度的Al2O3在一定条件下喷砂钛合金表面,制备出不同粗糙度表面的钛合金片,采用PECVD技术在其表面制备类金刚石薄膜。通过扫描电子显微镜、X-射线光电子能谱仪、拉曼光谱仪、接触角测量仪、表面性能测试仪和电化学方法检测各组样品的物理化学性能表征;利用MTT比色法、荧光染色法进行薄膜表面生物学行为的评价。结果将DLC沉积在喷砂预处理的钛合金表面,可以明显增强类金刚石的膜-基结合力,最高达到45N;耐腐蚀性研究中,表面沉积DLC的钛合金实验组腐蚀电位均正向大于未沉积DLC的钛合金组(Ps60实验组细胞增殖状况最佳,明显大于未喷砂s0组(P<0.05)。结论将钛合金基底喷砂预处理后沉积DLC,可以提高类金刚石薄膜的膜-基结合力、耐腐蚀性及生物相容性,是一种有效的医用钛合金表面改性方法,具有潜在的临床应用价值。

关键词：钛合金类金刚石薄膜喷砂粗糙度膜-基结合力耐腐蚀性增殖细胞相容性

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Prevalence and intensity of soil-transmitted helminth infections among school-age children in the Cagayan Valley, the Philippines

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Asian Pacific Journal of Tropical Medicine 2021年第3期14卷 113-121页

作者： Ryan V.Labana Vimar A.Romero Analette M.Guinto Alvin N.Caril Kimberly D.Untalan Alejandro Jose C.Reboa Khristine L.sandoval Kristel Joy s.Cada Gary Antonio C.Lirio Iris Rowena A.Bernardo Lanieleen Jerah Mae Arocha Julieta Z.Dungca Department of Biology College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines Graduate school Centro Escolar UniversityManilathe Philippines Center for Life sciences Research Institute of Science and Technology ResearchPolytechnic University of the PhilippinesSta.MesaManilathe Philippines Department of Nutrition and Dietetics College of SciencePolytechnic University of the PhilippinesSta.MesaManilathe Philippines school of science and Technology Centro Escolar UniversityManilathe Philippines

Objective:To identify the prevalence of soil-transmitted helminthiasis(sTH)among school-age children in the Cagayan Valley,the Philippines,assess their level of awareness on the disease,and determine predisposing factors of the ***:A total of 478 GradesⅢ-Ⅴschool-age children in Pamplona and sanchez-mira school Districts in the Cagayan Valley answered the questionnaire assessing their knowledge,attitude,and practices on sTH,subjected to anthropometric measurements,and provided faecal samples for parasitologic assessment(direct smear,Kato-Katz,and formol-ether concentration techniques).Results:The participants of the study,with 55.86%females,were 8 to 14 years *** nutritional status was assessed‘normal’(84.31%),‘severely wasted’(6.49%),‘wasted’(5.23%),‘overweight’(2.72%),and‘obese’(1.26%).The prevalence of infection with at least 1 sTH species was 25.99%in Pamplona and 19.40%in ***,the prevalence of heavy intensity was 7.11%for Ascaris lumbricoides and 1.67%for Trichuris *** hookworm infections had light *** majority of the school-age children had a low score in the KAP *** knowledge of sTH,‘stunted growth as a symptom of infection’was associated with a lower risk of Ascaris lumbricoides infection(OR 0.448;95%CI 0.212,0.945;P=0.035)while‘playing with soil as a mode of transmission’was associated with an increased risk of Ascaris lumbricoides infection(OR 2.067;95%CI 1.014,4.212;P=0.046).In attitude towards sTH,‘I think I have intestinal worm now’was associated with a higher risk of Ascaris lumbricoides infection(OR 1.681;95%CI 1.061,2.662;P=0.027).Conclusions:The prevalence rate of Ascaris lumbricoides among the school-age children in the Cagayan Valley shows the need to further intensify intervention in the area to meet the threshold set by the World Health *** identified predictors of infection,which concerns the school-age children’s knowledge and attitude toward sTH,can be used in augmenting

关键词： Intestinal worms War on worms Infectious disease Neglected tropical diseases

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mira轮胎试验场的继续开发及用途

合成橡胶工业 1988年第S1期 174-183页

作者： C.Ashley,B.J.Cheney,A.R.Williams,K.s.MacKellar,瞿光明 Managing Director Lotus Engineering(Formerly Director of mira). Manager Tyre Evalution sP Tyres (UK) Ltd. General Manager Truck Tyre Develop-ment sP Tyres (UK) Ltd. Head of Civil Engineering Design at mira.

本文讨论一项投资数百万英磅的英国本土“汽车工业研究协会”(mira)试验场的开发。计划分三个阶段开发,其中两个阶段业已完成。这些设施是一条操纵性和稳定性试验跑道,一组噪声和湿抓着性试验设施和一条高速湿操纵性试验跑道,其设计均... 详细信息

本文讨论一项投资数百万英磅的英国本土“汽车工业研究协会”(mira)试验场的开发。计划分三个阶段开发,其中两个阶段业已完成。这些设施是一条操纵性和稳定性试验跑道,一组噪声和湿抓着性试验设施和一条高速湿操纵性试验跑道,其设计均可供轮胎和车辆试验使用。一俟建成,mira试验场将成为车辆及其部件,特别是小轿车和载重汽车轮胎试验方面第一流的设施之一。

关键词：车辆试验跑道 mira 试验场载重汽车货车

The Use of Modern Digital Technologies in Engineering Education on the Example of the Online Course «Engineering Mechanics»

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教育研究前沿（中英文版） 2019年第4期9卷 264-267页

作者： s.A.Berestova Е.M.Romanovskaia N.D.Romanovskaia Ural Federal University Mira 19YekaterinburgRussia620002

The article discusses the use of modern digital technologies in engineering education on the example of the online course"Engineering mechanics".The course was the first online course of Ural Federal University,placed on the international *** course consists of original digital content:lecture notes,database of training tasks(simulators),test and homework,practical examples and demonstration video materials and other training *** main result of the work is a radical change in the content and form of presentation of traditional material on *** unity of a bright visual image,a strict mathematical model and rational solution of examples and problems is a new approach to achieving high learning outcomes for students.

关键词： Online Course Engineering Education Digital Technology

肾综合症出血热血清蛋白与肝肾功能及临床关系的研究

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泰山医学院学报 2001年第3期22卷 200-201页

作者：刘春水王振华侯可法刘慧芝彭建莱芜市人民医院山东莱芜271000

目的　了解肾综合症出血热 (HFRs)各期血清蛋白的变化特点及其与肝、肾功能的关系。方法　采用瑞士产COBAsmiraPLUsCC全血动生化分析仪及日本产MA 42 10尿液分析仪分别检测同时的空腹静脉血及晨尿。结果　 15 0例HFRs患者 2 17次检测血... 详细信息

目的　了解肾综合症出血热 (HFRs)各期血清蛋白的变化特点及其与肝、肾功能的关系。方法　采用瑞士产COBAsmiraPLUsCC全血动生化分析仪及日本产MA 42 10尿液分析仪分别检测同时的空腹静脉血及晨尿。结果　 15 0例HFRs患者 2 17次检测血清总蛋白 (T)平均为 6 3 5 1g/L ,白蛋白 (A)为 36 2 9g/L ,球蛋白 (G)为 2 7 2 2g/L ,A/G =1 33。其中A/G为 1 49～ 1 0者 137例 (6 3 3% ) ,A/G s患者有 75 5 8%存在着低白蛋白血症 ,并贯穿于各期 ,异常程度与病情轻重呈正相关 ,主要原因是肾脏损害 ,大量白蛋白从尿中丢失。

关键词：血清蛋白肾功能肾综合征出血热肝功能临床研究

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