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Effect of seed Bacterization on Plant Growth Response and Induction of Disease Resistance in chilli

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Agricultural sciences in china 2009年第8期8卷 963-971页

作者： Yasmeen siddiqui sariah meon Laboratory of Food crops and Floriculture Institute of Tropical AgricultureUniversiti Putra Malaysia (UPM)

This study aimed to examine the induction of disease resistance, and growth response in chilli plants elicited by plant growth promoting endophytic bacteria [Pseudomonas aeruginosa （UPMP3）, Burkholderia cepacia （UPMB3）, and serratia marcescens （UPMs3）]. seed bacterization with UPMP3 and UPMB3 significantly increased peroxidase （PO）, polyphenol oxidase （PPO）, and phenylalanine ammonia-lyase （PAL） activities. This increase corresponded to greater reduction in pre-and post-emergence damping-off caused by sclerotium rolfsii. UPMs3 alone or as mixture with UPMP3 and UPMB3 did not show any significant reduction in disease incidence. However, all the isolates tested did not inhibit the seed germination and seedling establishment in chilli.

关键词： endophytic bacteria induced resistance PO PPO PAL sclerotium rolfsii

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain cIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

classification of hypersurfaces with two distinct principal curvatures and closed Mbius form in s^(m+1)

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science china Mathematics 2012年第7期55卷 1463-1478页

作者： LINLiMiao GU0Zhen DepartmentofMathematics EastChinaNormalUniversityShanghai200241China DepartmentofMathematics YunnanNormalUniversityKunming650092China

Let x be an m-dimensional umbilic-free hypersurface in an （m＋1）-dimensional unit sphere sm＋l （m≥3）. In this paper, we classify and explicitly express the hypersurfaces with two distinct princi- pal curvatures and closed Msbius form, and then we characterize and classify conformally flat hypersurfaces of dimension larger than 3.

关键词： moebius geometry principal curvature conformally fiat Msbius form

serological surveillance for sARs-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R conde sofia L costa Regina c s sant’Anna Isa M F Antunes Mônica c carneiro Fabio s Ronzei Julia c scaffo Felipe R Pinheiro Lialyz s Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda s Hemerly Gisele c Alexandre Karla c de Paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de sáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(sARs-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for sARs-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-sARs-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](Ps who had been in contact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(Pse who had received the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(Psocial isolation(OR=0.59,95%cI:0.41-0.84)(Psho

关键词： serological surveillance sARs-coV-2 antibodies cOVID-19 serological rapid test Risk factors for cOVID-19

Induction of Tolerance to Fusarium Wilt and Defense-Related Mechanisms in the Plantlets of susceptible Berangan Banana Pre-Inoculated with Pseudomonas sp.(UPMP3) and Burkholderia sp.(UPMB3)

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Agricultural sciences in china 2010年第8期9卷 1140-1149页

作者： Elya Masya Mohd Fishal sariah meon Wong Mui Yun Laboratory of Food crops and Floriculture Institute of Tropical AgricultureUniversiti Putra Malaysia

This study is aimed at assessing the ability of two endophytic bacteria originally isolated from healthy oil palm roots, Pseudomonas sp. （UPMP3） and Burkholderia sp. （UPMB3） to induce resistance in susceptible Berangan banana against Fusarium oxysporum race 4 （FocR4）. Increased accumulation of resistance-related enzymes such as peroxidase （PO）, phenylalanine ammonia lyase （PAL）, lignithioglycolic acid （LTGA）, and pathogenesis-related （PR） proteins （ehitinase and β-1,3-glucanase） has been observed in plantlets treated with endophytic bacteria UPMP3 and UPMB3 singly or as mixture under glasshouse conditions. Pre-inoculation of banana plantlets with UPMP3 showed a significant reduction in Fusarium wilt incidence 72 d after challenged inoculation with FocR4. UPMB3 was less effective in suppressing Fusarium wilt compared to UPMP3, whereas, the mixture of both endophytes showed an intermediate effect. Based on these results, it is concluded that UPMP3 could be a promising biological control agent that can trigger resistance against Fusarium wilt in susceptible Berangan banana.

关键词： banana Pseudomonas sp. Burkholderia sp. induce resistance Fusarium wilt

Implementing symmetries of a Free Bose field via White Noise Operators

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Acta Mathematica sinica,English series 2003年第1期19卷 147-158页

作者： shunLongLU0 InstituteofAppliedMathematics AcademyofMathematicsandSystemSciencesChineseAcademyofSciencesBeijing1

Linear symmetries of a free Bose field are exploited in the framework of Hida's white noise functionals triple. General symplectic automorphisms on the single particle space are implemented by generalized operators. The intertwining operators are constructed in a physically intuitive way, characterized analytically in terms of symbols, and factorized into three fundamental parts according to Wick ordering procedure. In particular, the classical shale's theorem is rederived.

关键词： Free Bose field symplectic automorphisms symbols Gaussian Kernel operators

A New Approach to Nonlinear Partial Differential Equations

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communications in Nonlinear science and Numerical simulation 1997年第4期2卷 230-235页

作者： Jihuan HE (shanghai University,shanghai Institute of Applied Mathematics and Mechanics,shanghai 2 0 0 0 72 ,china) shanghai University Shanghai Institute of Applied Mathematics and Mechanics Shanghai 200072 China

In this paper,a novel method called variational iteration method is proposed to solve nonlinear partial differential equations without linearization or small *** this method,a correction functional is constructed by a general Lagrange multiplier,which can be identified via variational *** analytical solution can be obtained from its trial- function with possible unknown constants,which can be identified by imposing the boundary conditions,by successively iteration.

关键词： Nonlinear Problems Partial Differential Equations Variational Iteration Method Variational Theory

creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cs De Oliveira Luiz c Di stasi Ligia Y sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease