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starburst amacrine cells,involved in visual motion perception,lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients

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Translational Neurodegeneration 2023年第1期12卷 638-653页

作者： Xavier sánchez-sáez Isabel Ortuño-Lizarán Carla sánchez-Castillo Pedro Lax Nicolás Cuenca Department of Physiology Genetics and MicrobiologyUniversity of AlicanteSan Vicente del RaspeigSpain Alicante Institute for Health and Biomedi-cal Research(IsABIAL) AlicanteSpain Ramón Margalef Institute University of AlicanteSan Vicente del RaspeigSpain.

Background The main clinical symptoms characteristic of Parkinson’s disease(PD)are bradykinesia,tremor,and other motor ***,non-motor symptoms,such as visual disturbances,can be identified at early stages of the *** of these symptoms is the impairment of visual motion ***,we sought to determine if the starburst amacrine cells,which are the main cellular type involved in motion direction selectivity,are degenerated in PD and if the dopaminergic system is related to this *** Human eyes from control(n=10)and PD(n=9)donors were available for this *** immunohistochemistry and confocal microscopy,we quantified starburst amacrine cell density(choline acetyltransferase[ChAT]-positive cells)and the relationship between these cells and dopaminergic amacrine cells(tyrosine hydroxylase-positive cells and vesicular monoamine transporter-2-positive presynapses)in cross-sections and wholemount *** First,we found two different ChAT amacrine populations in the human retina that presented different ChAT immunoreactivity intensity and different expression of calcium-binding *** populations are affected in PD and their density is reduced compared to ***,we report,for the first time,synaptic contacts between dopaminergic amacrine cells and ChAT-positive cells in the human *** found that,in PD retinas,there is a reduction of the dopaminergic synaptic contacts into ChAT *** Taken together,this work indicates degeneration of starburst amacrine cells in PD related to dopaminergic degeneration and that dopaminergic amacrine cells could modulate the function of starburst amacrine *** motion perception circuitries are affected in PD,their assessment using visual tests could provide new insights into the diagnosis of PD.

关键词： Parkinson’s disease Retinal neurodegeneration Human retina ChAT amacrine cells Dopaminergic amacrine cells

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sYNTHEsEs AND CHARACTERIZATIONs OF OLIGO(AZOMETHINE ETHER)s DERIVED FROM 2,2'-[1,4-ENYleNEBIs(METHYleNEOXY)]DIBENZALDEHYDE AND 2,2'-[1,2-PHENYleNEBIs(METHYleNEOXY)]DIBENZALDEHYDE

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Chinese Journal of Polymer science 2012年第5期30卷 682-693页

作者： Ismet Kaya süleyman Culhaoglu Canakkale Onsekiz Mart University Faculty of Science and ArtsDepartment of ChemistryCanakkale 17020Turkey

The oligo（azomethine ether）s were synthesized via polycondensation of alkyl diamines with aromatic dialdehydes. Two series of dialdehydes, namely 2,2＇-[1,2-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-1,2-（PBMODB）] and 2,2＇- [1,4-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-I,4-（PBMODB）] were prepared from the condensation reactions of salicylaldehyde with o-xylenedibromide and p-xylenedibromide, respectively. The structures of dialdehydes and oligomers were determined by FT-IR, 1H-NMR and 13C-NMR. The thermal analyses of oligomers were conducted by DsC and TG/DTA techniques, respectively. size exclusion chromatography （sEC） technique was also used to determine molecular weights and molecular weight distributions of oligomers. Electrochemical properties of the synthesized products were investigated.

关键词： Polyazomethine Thermal analysis Dialdehyde Oligoazomethine.

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Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

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Neumann＇s method for boundary problems of thin elastic shells

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUsTADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The possibility of using Neumann＇s method to solve the boundary problems for thin elastic shells is studied. The variational statement of the static problems for the shells allows for a problem examination within the distribution space. The convergence of Neumann＇s method is proven for the shells with holes when the boundary of the domain is not completely fixed. The numerical implementation of Neumann＇s method normally requires significant time before any reliable results can be achieved. This paper suggests a way to improve the convergence of the process, and allows for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elastic shell theory Neumann's method variational principle Korn's inequality distribution embedding theorem Green tensor

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Fluid dynamics analysis and pyrolysis of brewer’s spent grain in a spouted bed reactor

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Particuology 2019年第1期17卷 199-207页

作者： Marcos A.s. Barrozo Lidja D.M.s. Borel Taísa s. Lira Carlos H. Ataíde school of Chemical Engineering Federal University of UberlandiaBrazil Department of Engineering and Technologies Federal University of Espirito SantoBrazil

Brewer’s spent grain (BsG) is a large-scale agroindustrial waste that could be more efficiently utilized. This waste is composed of lignocellulosic material and so may serve as a good source of biomass for thermochemical conversion. The present study investigated the fluid dynamics behavior of mixtures of sand and BsG in a spouted bed to assess the viability of the thermochemical conversion of this biomass via fast pyrolysis. Fluid dynamics analyses were performed while varying the mass fraction of BsG (6–80%) and the static bed height (6.6–13.4 cm). Empirical equations for predicting the minimum spouting conditions and the mixing index were obtained using a regression technique, and the selected fluid dynamics parameters were employed in the spouted bed pyrolysis. The bio-oil resulting from this process was rich in phenolic compounds, various nitrogenated compounds (representing precursors for pharmaceuticals) and long-chain hydrocarbons. The products obtained from the analytical and spouted bed pyrolysis processes were also compared.

关键词： Brewer’s spent grain Agroindustrial residue spouted bed Fast pyrolysis Particle mixing

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Maternal exposure to specific perfluoroalkyl substances is associated with increasing blood glucose in pregnant women

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Journal of Environmental sciences 2018年第7期30卷 1-2页

作者： Jagdeesh s.Uppal Qi Zheng X.Chris le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and Dentistry University of Alberta Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of Education Institute of Environment and HealthJianghan University

Imagine if a group of toxic substances that increase oxidative stress and disrupt glucose and lipid metabolism have been broadly used worldwide for applications such as repellent,food packaging,and non-stick frying pa... 详细信息

关键词： perfluoroalkyl and polyfluoroalkyl substances PFAs PFOs gestational diabetes mellitus blood glucose

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An improved and simple method for removal of arsenic from drinking water

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Journal of Environmental sciences 2019年第2期31卷 415-417页

作者： Jagdeesh s.Uppal Qi Zheng X.Chris le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of Alberta Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationInstitute of Environment and HealthJianghan University

Arsenic (As)is a naturally occurring *** toxicity of arsenic is dependent on the specific arsenic species,and the concentration and duration of exposure to the arsenic species (Moe et al.,2016).Chronic human exposure to high concentrations of inorganic arsenic species has been associated with cardiovascular disease,diabetes,neurological diseases,skin lesions,and various cancers (Naujokas et al.,2013).

关键词： Arsenic species Activated carbon Water treatment Morphology of nanostructures Iron and manganese nanomaterials

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Microbial methylation of mercury in the water-level fluctuation zone of the Three Gorges Reservoir,China

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Journal of Environmental sciences 2018年第6期30卷 218-220页

作者： Karen s.Hoy Wei Feng X.Chris le Department of Chemistry and Department of Laboratory Medicine and Pathology University of Alberta

Methylmercury （MeHg） is an organic form of the global pollutant mercury （Hg） which readily accumulates in fish tissue. A majority of Hg methylation is a result of microbial activity and the abundance of inorganic Hg within the water reservoirs （Eckley et al., 2017）. Compared to natural lakes and rivers, reservoirs have elevated Hg levels from the decompo- sition of recently flooded organic material which promote Hg release and enhance microbial methylation of Hg （Eckley et al., 2017）. Microorganisms containing the gene clusters hgcA and hgcB, such as sulfate reducing bacteria （sRB） and iron reducing bacteria （FeRB）.

关键词： Methyl mercury Microbial community 16s rRNA soil bacteria Floodplains and wetlands

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Ultra-flat twisted superlattices in 2D heterostructures

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npj Computational Materials 2020年第1期6卷 909-914页

作者： Márton szendrő Péter süle Gergely Dobrik levente Tapasztó Institute of Technical Physics and Materials science(MFA) Centre for Energy ResearchHungarian Academy of SciencesP.O.Box 49Budapest 1525Hungary

Moiré-superlattices are ubiquitous in 2D heterostructures,strongly influencing their electronic *** give rise to new Dirac cones and are also at the origin of the superconductivity observed in magic-angle bilayer *** modulation amplitude(corrugation)is an important yet largely unexplored parameter in defining the properties of 2D *** generally accepted view is that the corrugation monotonically decreases with increasing twist angle,while its effects on the electronic structure diminish as the layers become progressively decoupled.

关键词： properties cor twisted

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Arsenic biotransformation and an arsenite sadenosylmethionine methyltransferase in plankton

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Journal of Environmental sciences 2017年第11期29卷 118-121页

作者： Jagdeesh s.Uppal Qin shuai Zhuang Li X.Chris le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology Faculty of Medicine and DentistryUniversity of Alberta College of Material science and Chemistry China University of GeosciencesWuhan China

Arsenic（As）is a well-recognized toxicant and *** exposure to inorganic arsenic causes a range of human cancers（e.g.,skin,bladder,and lung）and increases the risk of developing diabetes,hypertension,and cardiovascular and neurological *** prevalence of arsenic species and the severity of their health effects continue to drive and demand for extensive research（Carlin et al.,2016）.

关键词： Arsenic speciation spirulina platensis Methyltransferase Arsenic detoxification Biomethylation enzymes Aquatic environment

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