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Gaia Metaphor in Latour’s Ecological Thought

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Journal of Philosophy study 2023年第6期13卷 260-268页

作者： DING man LING Yi Dalian University of Technology DalianChina

Bruno Latour’s Actor-Network Theory(ANT)gained recognition for its distinctive features,namely its emphasis on acknowledging the agency of non-human actors and its strong focus on understanding the intricacies of networks and *** foundational aspects not only laid the groundwork for Latour’s subsequent exploration of ecological issues but also paved the way for the development of his influential notion of Gaia *** Gaia metaphor serves as a vital carrier for Latour’s ecological thinking,encompassing the core ideas of ANT while providing a significant framework for comprehending the complex dynamics of ecology we live *** contemplating the predicament of human existence and the pressing challenges of ecological crises,through the Gaia metaphor,Latour proposes that we should reject a purely global perspective,trace loops,and cultivate sensitivity within aesthetics as a means to perceive and engage with Gaia,promoting a more nuanced understanding of our interdependencies with the ***,the Gaia metaphor holds an indispensable position within Latour’s ecological thought,offering profound insights into the theoretical foundation and deeper implications of his ecological framework.

关键词： Gaia Actor-Network Theory Latour ecology

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

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World Journal of Gastroenterology 2015年第15期21卷 4644-4651页

作者： scott Bowden stephen Locarnini Ting-Tsung Chang You-Chen Chao Kwang-Hyub Han Robert G Gish Robert A de man Miao Yu Cyril Llamoso Hong Tang Victorian Infectious Diseases Reference Laboratory Division of Gastroenterology Department of Internal Medicine National Cheng Kung University Hospital Division of Gastroenterology Department of Internal Medicine Tri-Service General Hospital National Defense Medical Center Division of Gastroenterology Department of Internal Medicine Severance Hospital of Yonsei University Consultants LLC San Diego st Joseph’s Hospital and Medical Center Phoenix Hepatitis B Foundation Doylestown Department of Gastroenterology and Hepatology Room H375 Erasmus Medical Center Bristol-Myers squibb Research and Development 5 Research Pkwy Wallingford Center Bristol-Myers squibb Research and Development Princeton

AIM: To investigate the reduction in hepatitis B virus(HBV) covalently closed-circular DNA(ccc DNA) with entecavir(ETV) or lamivudine(LAM). METHODs: This analysis included patients who had participated in the randomized Phase Ⅲ study ETV-022 comparing ETV vs LAM in nucleos(t)ide-naive, HBe Agpositive patients. Patients received ETV(0.5 mg daily) or LAM(100 mg daily) for a minimum of 52 wk. Patients were eligible to participate in this sub-study if they had paired biopsies at baseline and week 48 with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA. The main objective was to compare changes in hepatic HBV ccc DNA and total hepatic HBV DNA at week 48 of ETV or LAM treatment, which was a secondary endpoint of study ETV-022. Additional post hoc analyses included linear regression analyses to assess associations of baseline levels and on-treatment changes of ccc DNA with other baseline factors [sex,age, serum HBV DNA, alanine aminotransferase(ALT), Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBV genotype], or ontreatment factors(changes from baseline at week 48 in serum HBV DNA, ALT, Knodell necroinflammatory score, Ishak fibrosis score, total hepatic HBV DNA, and HBe Ag loss at week 48).REsULTs: Overall, 305 patients(ETV = 159; LAM = 146) of ETV-022 had paired baseline and week 48 liver biopsies with evaluable measurements for hepatic HBV ccc DNA and total hepatic HBV DNA, and were included in this analysis. Baseline demographics and disease characteristics were comparable between the two arms. After 48 wk, ETV resulted in significantly greater reductions in hepatic HBV ccc DNA [-0.9 log10 copies/human genome equivalent(HGEq) vs-0.7 log10 copies/HGEq; P = 0.0033] and total hepatic DNA levels(-2.1 log10 copies/HGEq vs-1.6 log10 copies/HGEq; P stologic response rates at week 48 were also greater with ETV than with LAM. Baseline HBV ccc DNA levels were positivel

关键词： Hepatitis B virus Nucleos(t)ide analogtherapy Intrahepatic hepatitis B virus DNA Antiviralsuppression Virologic cure

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脑干卒中患者的认知障碍研究

国际神经病学神经外科学杂志 2017年第5期44卷 482-486页

作者：付秀娟肖哲曼卢祖能武汉大学人民医院神经内科湖北省武汉市430060

目的研究急性孤立性脑干卒中患者认知功能与正常对照之间的差异,探究脑干卒中对认知功能的影响及其主要受损的认知域。方法选取符合入组标准的、性别、年龄和受教育年限匹配的首次发病的急性孤立性脑干卒中患者29例和正常对照20例,分别... 详细信息

目的研究急性孤立性脑干卒中患者认知功能与正常对照之间的差异,探究脑干卒中对认知功能的影响及其主要受损的认知域。方法选取符合入组标准的、性别、年龄和受教育年限匹配的首次发病的急性孤立性脑干卒中患者29例和正常对照20例,分别进行艾登布鲁克斯认知检测(ACE-Ⅲ)、蒙特利尔认知评估量表(MoCA)、数字符号转换测验(sDMT)、韦氏数字广度测验(Ds)、连线测验(TMT)、stroop词色测验等量表评测及事件相关电位P300检测。结果脑干卒中患者MoCA量表和ACE-Ⅲ量表总体评分与对照组相比显著降低(P=0.012,P=0.004),其中受损的认知域主要为语言功能(P=0.024)及视空间功能(P=0.004)。sDMT、Ds、TMT和stroop等量表完成度欠佳,与对照组相比,均未见显著差异(P>0.05)。P300检测结果显示脑干卒中患者较对照组存在显著的波幅降低(P=0.022)及潜伏期延长(P=0.033)。ACE-Ⅲ与MoCA显著正相关(P<0.001),而与P300潜伏期显著负相关(P=0.006)。结论急性孤立性脑干卒中患者存在一定的认知功能障碍,受损的认知域主要为注意力、语言及视空间能力。

关键词：脑干梗死认知障碍 P300 认知量表 P300

Non-alkaloids with anti-nematode activity from stemona parviflora roots

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Non-alkaloids with anti-nematode activity from Stemona parvi...

中国化学会第十二届全国天然有机化学学术会议

作者： sheng-Zhuo Huang Fan-Dong Kong Qing-Yun Ma Li-man Zhou Qing-Yi Xie Hao-Fu Dai You-Xing Zhao Hainan Key Laboratory for Research and Development of Natural Products from Li Folk Medicine Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agriculture Sciences

Chinese medicine herbs have a long history in botanic *** stemona species [*** L.,s.(Blume) Mi quel,and s. Miquel.] from stemonaceae family are listed as pesticide in the Chinese Pharmacopoeia. In the present study,twelve new non-alkaloids including six phenanthrene derivatives [parviphenanthrines A-F(1-6)],two stilbene derivatives[parvistilbines A-B(7-8)],three esters [parviesters A-C(9-11)],and one sesquiterpenoid[parvidiol A(12)] were isolated from the roots of stemona *** 1 and 5 showed nematicidal activity against Meloidogyne incognita with IC value of 14 and 2 mM,respectively.

关键词： stemona parviflora non-alkaloids nematicidal activity

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离子束注入硅酸盐细菌诱变选育研究

华中农业大学学报 2006年第6期25卷 636-639页

作者：卢文轩蒋立科罗曼安徽农业大学生命科学学院暨南大学生物医学工程研究所广州510632

硅酸盐细菌能分解铝硅酸盐类矿物中的钾、磷、硅等元素,直接供植物生长利用。采用低能N离子束注入技术对硅酸盐细菌进行诱变,然后经有氮培养基初筛、缺钾培养基复筛,获得解钾能力强的硅酸盐细菌s-05突变株,扫描电镜观察菌株的形态。进... 详细信息

硅酸盐细菌能分解铝硅酸盐类矿物中的钾、磷、硅等元素,直接供植物生长利用。采用低能N离子束注入技术对硅酸盐细菌进行诱变,然后经有氮培养基初筛、缺钾培养基复筛,获得解钾能力强的硅酸盐细菌s-05突变株,扫描电镜观察菌株的形态。进行盆栽试验,研究s-05菌株对水稻根际土壤速效钾含量的影响。结果发现,发酵液50倍稀释处理组速效钾含量最高,比原菌株处理组(CK1)和空白对照组(CK2)分别提高55.79%和260.84%。

关键词：离子束注入硅酸盐细菌选育

Dissolution method for delapril and manidipine combination tablets based on an absorption profile of manidipine

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Journal of Pharmaceutical Analysis 2016年第1期6卷 49-55页

作者： Vitor Todeschini Maximiliano s.sangoi Gustavo K.Goelzer Jaison C.Machado Clesio s.Paim Bibiana V.Araujo Nadia M.Volpato Federal University of Rio de Janeiro Faculty of Pharmacy27930-560 MacaeR JBrazil Federal University of Rio Grande do sul Faculty of Pharmacy90610-000 Porto AlegreRSBrazil Federal University of Pampa Faculty of Pharmacy97500-009 UruguaianaRSBrazil

The present study describes the development and validation of a dissolution method for delapril （DEL） and manidipine （man） combination tablets, using a simulated absorption profile based on in vivo data for man. The suitable in vitro dissolution profile for this formulation was obtained using 900 mL of citrate buffer pH 3.2 at 37 ℃ ± 0.5 ℃ as dissolution medium and UsP apparatus 2 （paddle） at 75 rpm. All samples were analyzed by a liquid chromatography （LC） method. Under these conditions, a significant linear relationship between the absorbed （calculated by deconvolution approach） and dissolved fractions of man was obtained （R=0.997） and an in vivo-in vitro （IVIV） correlation for this particular formulation containing man can be established. Validation parameters for dissolution methodology such as the specificity, linearity, accuracy and precision were also evaluated according to the international guidelines, giving results within the acceptable range. Therefore, the proposed dissolution conditions can be applied for the simultaneous release analysis of DEL and man from the solid dosage form, contributing to the improvement of the quality control of pharmaceutics and minimizing the number of bioavailability studies.

关键词： Delapril Dissolution manidipine Validation in vivo-in vitro correlation

不同地理种群草间钻头蛛(Hylyphantes graminicola)对杀虫剂的敏感性及抗、感种群的相对适合度

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生态学报 2007年第12期27卷 5093-5097页

作者：冯涛彭宇刘凤想方满陈建湖北大学生命科学学院武汉430062

采用成蛛浸渍法测定了湖北武汉、湖北来凤、陕西渭南和山东菏泽4个草间钻头蛛地理种群对氰戊菊酯、溴氰菊酯、辛硫磷和甲胺磷4种杀虫剂的敏感性。结果表明:湖北武汉和山东菏泽草间钻头蛛种群对4种杀虫剂的抗药性都较小,处于敏感水平,陕... 详细信息

采用成蛛浸渍法测定了湖北武汉、湖北来凤、陕西渭南和山东菏泽4个草间钻头蛛地理种群对氰戊菊酯、溴氰菊酯、辛硫磷和甲胺磷4种杀虫剂的敏感性。结果表明:湖北武汉和山东菏泽草间钻头蛛种群对4种杀虫剂的抗药性都较小,处于敏感水平,陕西渭南、湖北来凤种群对甲胺磷和辛硫磷的抗性达到了中抗水平。4个种群对溴氰菊酯和氰戊菊酯均未产生抗药性,说明拟除虫菊酯类杀虫剂对草间钻头蛛的毒力要大于有机磷类杀虫剂。在测定了蜘蛛对不同杀虫剂敏感水平的基础上,以陕西渭南种群为抗性种群(R),湖北武汉种群为敏感种群(s),比较研究了这2个种群的生物学特性和相对适合度。结果表明两种群在发育历期和成活率上无显著差异。在繁殖力方面,R种群产卵率、产卵量和孵化率均明显下降。R种群的相对适合度为0.74,对有机磷产生抗性的草间钻头蛛种群存在繁殖不利性。

关键词：草间钻头蛛地理种群敏感性测定相对适合度

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皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌

临床皮肤科杂志 2019年第4期48卷 226-228页

作者：雷秋花沈宏满孝勇杭州市第三人民医院皮肤科浙江杭州310000

报告1例皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。患者男,46岁。因头皮疣状斑块46年,破溃出血2个月就诊。皮损组织病理学检查诊断为皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。皮脂腺痣有恶变的可能,建议临床密切随访,一旦出现短期... 详细信息

报告1例皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。患者男,46岁。因头皮疣状斑块46年,破溃出血2个月就诊。皮损组织病理学检查诊断为皮脂腺痣并发乳头状汗管囊腺瘤及基底细胞癌。皮脂腺痣有恶变的可能,建议临床密切随访,一旦出现短期内增大或破溃等表现建议立即手术切除并行组织病理学检查。

关键词：痣,皮脂腺汗管囊腺瘤,乳头状基底细胞癌

"Pipa Fairy Maiden" Zhang Hongyan

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Women of China 1995年第9期 28-28页

作者： HAN FUFANG man LIN

WHEN Zhang Hongyan plays the completely traditional Chinese musical instrument, the pipa, she is called a "pipa fairy maiden" by her audiences, "the pipa queen with outstanding talent and appearance" by the Hong Kong press and "a national flower of the Women Philharmonic Orchestra" in singapore. Having completed her master’s degree program at the folk music department of the Central Conservatory of Music. Zhang is continuing there as a teacher. On the unforgettable night of June 9, 1992, Zhang Hongyan presented her first solo concerto concert at the Beijing Concert Hall, in cooperation with the celebrated Central Philharmonic Orchestra based in Beijing and its famous conductor Hu Yongyan. This concert made her the first folk musical instrument player to present a special concerto concert in cooperation with a Western style orchestra. It is the result of many years of effort. Zhang was born in shengxian County, Zhejiang Province, famous as the home of Yue Opera. Her father is a musician with a Yue

关键词： Zhang Hongyan Pipa Fairy Maiden