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Multiple metastases to the small bowel from large cell bronchial carcinomas

World Journal of Gastroenterology 2005年第9期11卷 1399-1402页

作者： Davor Tomas Mario Ledinsky Mladen Belicza Bozo kru(s|ˇ)lin Ljudevit Jurak University Department of Pathology University Department of surgery

AIM: Metastases from lung cancer to gastrointestinal tract are not rare at postmortem studies but the development of clinically significant symptoms from the gastrointestinal metastases is very unusual. METHODs: Formalin-fixed, paraffin-embedded tissues were cut into 5 urn thick sections and routinely stained with hematoxylin and eosin. some slides were also stained with Alcian-PAs. Antibodies used were primary antibodies to pancytokeratin, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, vimentin, smooth muscle actin and CD-117. REsULTs: We observed three patients who presented with multiple metastases from large cell bronchial carcinoma to small intestine. Two of them had abdominal symptoms (sudden onset of abdominal pain, constipation and vomiting) and in one case the tumor was incidentally found during autopsy. Microscopically, all tumors showed a same histological pattern and consisted almost exclusively of strands and sheets of poorly cohesive, polymorphic giant cells with scanty, delicate stromas. Few smaller polygonal anaplastic cells dispersed between polymorphic giant cells, were also observed. Immunohistochemistry showed positive staining of the tumor cells with cytokeratin and vimentin. Microscopically and immunohistochemically all metastases had a similar pattern to primary anaplastic carcinoma of the small intestine. CONCLUsION: In patients with small intestine tumors showing anaplastic features, especially with multiple tumors, metastases from large cell bronchial carcinoma should be first excluded, because it seems that they are more common than expected.

关键词： small intestine tumors Bronchial carcinomas Large cell carcinoma Tumor metastases

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Is there an association between Helicobacter pylori in the inlet patch and globus sensation?

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World Journal of Gastroenterology 2010年第1期16卷 42-47页

作者： Hakan Alagozlu Zahide simsek selahattin Unal Mehmet Cindoruk s.kru dumlu Ayse Dursun Division of Gastroenterology Department of Internal MedicineFaculty of MedicineGazi University Hospital Department of Pathology Faculty of MedicineGazi University Hospital

AIM:To determine the association between Helicobacter pylori(***)and globus sensation(Gs)in the patients with cervical inlet patch. METHODs:sixty-eight patients with esophageal inlet patches were identified from 6760 consecutive patients undergoing upper gastrointestinal endoscopy *** these 68 patients with cervical inlet patches, symptoms of globus sensation(lump in the throat), hoarseness,sore throat,frequent clearing of the throat,cough,dysphagia,odynophagia of at least 3 mo duration was questioned prior to endoscopy. REsULTs:Cervical heterotopic gastric mucosa(CHGM) was found in 68 of 6760 *** endoscopic prevalence of CHGM was determined to be 1%.*** was identified in 16(23.5%)of 68 patients with inlet patch.53 patients were classified as CHGMⅡ.This group included 48 patients with globus sensation,4 patients with chronic cough and 1 patient with *** the patients who were ***(+)in cervical inlet patches had globus ***:Often patients with CHGM have a long history of troublesome throat *** speculate that disturbances in globus sensation are like non-ulcer dyspepsia.

关键词： Barrett’s esophagus Cervical heterotopic gastric mucosa Globus sensation Helicobacter pylori Inlet patch

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