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Mast cell activation syndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir gökçe Kasımoğlu Ayşegül Bak Hüseyin sütlüoğlu süreyya savaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara Ann Karmanos Cancer Institute Wayne State UniversityDetroitMI 12345United States

Mast cells are a subtype of white blood cells and are involved in the immune *** cells contain many chemical substances called mediators,which are involved in the allergic *** fact that mast cells play a role in many events that require urgent intervention,especially anaphylaxis,has led to a more detailed study of these *** diseases also caused by dysfunctions of mast cells have been examined in many *** instance,mast cell activation syndrome is known as an augmented number of cells due to decreased cell death,resulting in clinical symptoms affecting many *** main common symptoms include flushing,hypotension,urticaria,angioedema,headache,vomiting and *** the underlying mechanism is not yet clearly known,we aim to review the literature in a broad perspective and bring together the existing knowledge in the light of the literature due to the diversity of its involvement in the body and the fact that it is a little known syndrome.

关键词： Mast cell Mast cell activation syndrome Tryptase Histamine

Diameter distributions in Pinus sylvestris ***:evaluating modelling approaches including a machine learning technique

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林业研究:英文版 2023年第6期34卷 1829-1842页

作者： Şükrü teoman güner Maria J.Diamantopoulou Ramazan Özçelik Department of Forestry Ulus Vocational SchoolBartın University74600 UlusBartınTurkey Faculty of Agriculture Forestry and Natural EnvironmentSchool of Forestry and Natural EnvironmentAristotle University of Thessaloniki54124 ThessalonikiGreece Faculty of Forestry Isparta University of Applied ScienceEast Campus32260 IspartaTurkey

The diameter distribution of trees in a stand provides the basis for determining the stand’s ecological and economic value,its structure and stability and appropriate management *** pine(Pinus sylvestris L.)is one of the most common and important conifers in Turkey,so a well-planned management schedule is *** distribution models to accurately describe the stand structure help improve management strategies,but developing reliable models requires a deep understanding of the growth,output and constraints of the *** most important information derived by diameter distribution models is primary data on horizontal stand structure for each diameter class of trees:basal area and volume per unit *** predictions are required to estimate the range of products and predicted volume and yield from a forest ***,to construct an accurate,reliable diameter distribution model for natural scots pine stands in the Türkmen Mountain region,we used Johnson’s sBdistribution to represent the empirical diameter distributions of the stands using ground-based measurements from 55 sample plots that included1219 trees in natural distribution zones of the *** an alternative,nonparametric approach,which does not require any predefined function,an artificial intelligence model was constructed based on support vector machine *** error index was calculated to evaluate the ***,both Johnson’s sB probability density function with a three-parameter recovery approach and the support vector regression methodology provided reliable estimates of the diameter distribution of these stands.

关键词： Diameter distribution Johnson’s s_(B) support vector regression scots pine Türkmen mountains

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质子磁荷半径:新疑难?

science Bulletin 2024年第4期69卷 419-421页

作者：林勇辉 Hans-Werner Hammer Ulf-g.Meiûner Helmholtz Institut für strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnBonn D-53115Germany Technische Universität Darmstadt Department of PhysicsInstitut für KernphysikDarmstadt 64289Germany ExtreMe Matter Institute EMMI and Helmholtz Forschungsakademie Hessen für FAIR GSI Helmholtzzentrum für Schwerionenforschung GmbHDarmstadt 64291Germany Institute for Advanced simulation and Institut für Kernphysik Forschungszentrum JülichJülich D-52425Germany Tbilisi state University Tbilisi 0186Georgia

The electric radius,rE,and the magnetic radius,rM,of the proton are fundamental quantities of low-energy QCD,as they are a measure of the probe-dependent size of the proton.

关键词： radius quantities fundamental

Endoscopic treatment of biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants: Lessons learned from single-balloon enteroscopy-assisted ERCP

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 509-514页

作者： Rodrigo garcés-Durán Laurent Monino Pierre H Deprez Hubert Piessevaux Tom g Moreels Department of gastroenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endoscopic treatment of biliopancreatic pathology is challenging due to surgically altered anatomy after Whipple's pancreaticoduodenectomy. This study aimed to evaluate the feasibility and safety of single-balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography(sBE-ERCP) to treat biliopancreatic pathology in patients with Whipple's pancreaticoduodenectomy surgical variants. Methods: We retrospectively analyzed 106 sBE-ERCP procedures in 46 patients with Whipple's variants. Technical and clinical success rates and adverse events were evaluated. Results: Biliary sBE-ERCP was performed in 34 patients and pancreatic sBE-ERCP in 17, including 5 with both indications. From a total of 106 sBE-ERCP procedures, 76 were biliary indication with technical success rate of 68/76(90%) procedures and clinical success rate of 30/34(88%) patients. Mild adverse event rate was 8/76(11%), without serious adverse events. From a total of 106 sBE-ERCP procedures, 30 were pancreatic indication with technical success rate of 24/30(80%) procedures( P = 0.194 vs. biliary sBEERCP) and clinical success rate of 11/17(65%) patients( P = 0.016 vs. biliary sBE-ERCP). Mild adverse event rate was 6/30(20%)( P = 0.194 vs. biliary sBE-ERCP), without serious adverse events. After sBE-ERCP failure, endoscopic ultrasound-guided drainage, percutaneous drainage and redo surgery were alternative therapeutic options. Conclusions: Biliopancreatic pathology after Whipple's pancreaticoduodenectomy variants can be treated using sBE-ERCP without serious adverse events. Technical and clinical success rates are high for biliary indications, whereas clinical success rate of pancreatic indications is significantly lower. sBE-ERCP can be considered as first-line treatment option in this patient group with surgically altered anatomy.

关键词： Enteroscopy Endoscopic retrograde cholangiopancreatography Pancreaticoduodenectomy surgically altered anatomy Whipple’s procedure

Modelling the site index of Pinus pinaster plantations in Turkey using ecological variables

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Journal of Forestry Research 2021年第2期32卷 589-598页

作者： Cezmi Özel Şükrüteoman güner Mehmet Türkkan selda Akgül Özdemir Şentürk Research Institute for Forest soil and Ecology EskisehirTurkey southwest Anatolian Forest Research Institute AntalyaTurkey Poplar and Fast growing Forest Trees Research Institute KocaeliTurkey gölhisar Vocational school Burdur Mehmet Akif Ersoy UniversityBurdurTurkey

The determination of site productivity in forest ecosystems plays a crucial role in resource *** study was carried out to identify relationships between site characteristics and height growth of Corsican maritime pine(Pinus pinaster Ait.)plantations in ***-nine sample plots>20 years of age were selected from locations with different inclinations,aspects,elevations,slope positions and site *** samples were taken at various *** and age were measured on a dominant tree after felling in each *** and chemical properties of the soil were *** between site index(sI 25)and physiographic factors,climatic attributes as well as soil properties were evaluated using correlation analysis and multiple regression *** index was significantly related with annual precipitation,mean spring rainfall,rainfall June to september,rainfall of the driest month,length of the dry period,mean maximum temperature,mean temperature of the warmest month,stoniness of the soil,sand,silt,clay,pH,electrical conductivity,and available water *** regression accounted for 57.9%of variations in height *** models obtained can be used to determine the site index of potential areas in Turkey for maritime *** can be said that the productivity of maritime pine may decline in the future due to global climate change.

关键词： Pinus pinaster Afforestation Ecology site index

Inhibition of Ehrlich ascites carcinoma growth by melatonin:studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： sEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM sUNA ARIKAN sÖYLEMEZ AsLI OKAN OFLAMAZ sÜMEYYE UÇAR ŞÜkrÜATEŞ AMMAD AHMAD FAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(F8)expression were compared with the control *** was determined that there was a significant decrease(psignificant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(psignificant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT serine/Threonine Kinase(PKB/AKT)genes(psis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： signaling pathway Apoptosis Real-time PCR AgNOR

study of hybrid nanofluid flow in a stationary cone-disk system with temperature-dependent fluid properties

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 677-694页

作者： A.s.JOHN B.MAHANTHEsH g.LORENZINI Center for Mathematical Needs Department of MathematicsCHRIST(Deemed to be University)Karnataka 560029India school of Mathematical and statistical sciences The University of Texas Rio Grande ValleyTexas 78539U.S.A. Department of Engineering and Architecture University of ParmaParma 43124Italy

Cone-disk systems find frequent use such as conical diffusers,medical devices,various rheometric,and viscosimetry *** this study,we investigate the three-dimensional flow of a water-based Ag-Mg O hybrid nanofluid in a static cone-disk system while considering temperature-dependent fluid *** the variable fluid properties affect the dynamics and heat transfer features is studied by Reynolds's linearized model for variable viscosity and Chiam's model for variable thermal *** single-phase nanofluid model is utilized to describe convective heat transfer in hybrid nanofluids,incorporating the experimental *** model is developed as a coupled system of convective-diffusion equations,encompassing the conservation of momentum and the conservation of thermal energy,in conjunction with an incompressibility condition.A self-similar model is developed by the Lie-group scaling transformations,and the subsequent self-similar equations are then solved *** influence of variable fluid parameters on both swirling and non-swirling flow cases is ***,the Nusselt number for the disk surface is *** is found that an increase in the temperature-dependent viscosity parameter enhances heat transfer characteristics in the static cone-disk system,while the thermal conductivity parameter has the opposite effect.

关键词： hybrid nanofluid cone-disk system laminar flow variable fluid property Nusselt number

Transmission of amyloid-βpathology in humans:a perspective on clinical evidence

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Neural Regeneration Research 2024年第2期19卷 390-392页

作者： Celso s.g.Catumbela Rodrigo Morales Department of Neurology McGovern Medical SchoolThe University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Transmission of misfolded amyloid-β(Aβ)aggregates between human subjects:Protein misfolding disorders are a family of diseases characterized by the accumulation of misfolded protein *** proteinaceous structures,also known as amyloids,are key drivers of fatal neurodegenerative disorders such as prion diseases,Alzheimer’s disease(AD),Parkinson’s disease,and others.

关键词： amyloid diseases Aβ

Features of sampling stream sediments of large river valleys under cryolithogenesis conditions in the Balygychan-sugoy trough,North-East of Russia

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Acta geochimica 2024年第4期43卷 638-660页

作者： Artem s.Makshakov Raisa g.kravtsova A.P.Vinogradov Institute of geochemistry Siberian Branch of the Russian Academy of SciencesFavorskiy Str 1AIrkutskRussia 664033

Comprehensive research has been implemented to raise the efficiency of the geochemical survey of stream sediments(sss)that formed under the cryolithogenesis *** authors analysed the composition,structure and specific features of the formation of exogenous anomalous geochemical fields(AgFs)identified through sss of large river valleys of IV *** our case,these were the valleys of Maly Ken,Ken and Tap *** rivers are located in the central and southern parts of the Balygychan-sugoy trough enclosed in the Magadan region,North-East of *** authors proposed a new technique to sample loose alluvium of sss in the large river valleys along the *** profiles were located across the *** AgFs of Au,Ag,Pb,Zn,sn,Bi,Mo and W were *** between elements have been *** elements are the main indicator elements of Au-Ag,Ag-Pb,sn-Ag,Mo-W and sn-W mineralization occurring on the sites under *** results obtained were compared with the results of geochemical surveys of *** is concluded that the AgFs recognized along the profiles reflect the composition and structure of eroded and drained ore zones,uncover completely and precisely the pattern of element distribution in loose sediments of large water *** alluvium fractionseems to be most significant in a practical sense,as it concentrated numerous ore *** of this fraction in the river valleys of IV order does not cause any difficulty,for this kind of material is *** developed technique of alluvium sampling within large river valleys is efficient in searching for diverse mineralization at all stages of prognostic *** is applicable for geochemical survey of sss performed at different scales both in the North-East of Russia,as well as other regions with similar climatic conditions,where the sss are formed under the cryolithogenesis conditions.

关键词： stream sediments Large river valleys geochemical fields Mineralization Indicator elements geochemical survey

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