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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-man shao school of Mathematical sciences Shanghai Jiao Tong University school of Mathematics and statistics University of Melbourne Department of statistics and Data science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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Experimental investigation of fluidized-bed reactor performance for oxidative coupling of methane

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Journal of Natural Gas Chemistry 2012年第5期21卷 534-543页

作者： s.jašo s.sadjadi H.R.Godini U.simon s.Arndt O.Görke A.Berthold H.Arellano-Garcia H.schubert R.schomäcker G.Wozny Chair of Process Dynamics and Operation Berlin Institute of TechnologyStraβe des 17 Juni 135Sekr.KWT910623 BerlinGermany Institute for Material science and Technologies Berlin Institute of TechnologyHardenbergstr.4010623 BerlinGermany Institute for Technical Chemistry Berlin Institute of TechnologyStraβe des 17 Juni 12410623 BerlinGermany

Performance of the oxidative coupling of methane in fluidized-bed reactor was experimentally investigated using Mn-Na2WO4/siO2,La2O3/CaO and La2O3-srO/CaO *** catalysts were found to be stable,especially Mn-Na2WO4/siO2 *** effect of sodium content of this catalyst was analyzed and the challenge of catalyst agglomeration was addressed using proper catalyst composition of 2%Mn2.2%Na2WO4/*** other two catalysts,the effect of Lanthanum-strontium content was analyzed and 10%La2O 3-20%srO/CaO catalyst was found to provide higher ethylene yield than La2O3/CaO ***,the effect of operating parameters such as temperature and methane to oxygen ratio were also *** highest ethylene and ethane （C2） yield was achieved with the lowest methane to oxygen ratio around 2.40.5% selectivity to ethylene and ethane and 41% methane conversion were achieved over La2O3-srO/CaO catalyst while over Mn-Na2WO4 /siO2 catalyst,40% and 48% were recorded,***,the consecutive effects of nitrogen dilution,ethylene to ethane production ratio and other performance indicators on the down-stream process units were qualitatively discussed and Mn-Na2WO4/siO2 catalyst showed a better performance in the reactor and process scale analysis.

关键词： oxidative coupling of methane (OCM) fluidized-bed reactor catalyst stability

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Plant Communities and Factors Responsible for Vegetation Pattern in an Alpine Area of the Northwestern Himalaya

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Journal of Mountain science 2011年第6期8卷 817-826页

作者： man s.RANA s.s.s.manT Y.s.RAWAT Department of Plant science Government Degree College G.B.Pant Institute of Himalayan Environment & Development Department of Botany D.S.B.CampusKumaun University

The study intended to describe the alpine vegetation of a protected area of the northwestern Himalaya and identify the important environmental variables responsible for species *** placed random plots covering different habitats and altitude to record species composition and environmental *** was classified using hierarchical cluster analysis and vegetation-environment relationships were evaluated with Canonical Correspondence *** communities,each in alpine shrub and meadows were delineated and well justified in the ordination *** species for the different communities were *** species richness and diversity were found in community IV among shrub communities and community II among the *** environmental variables explained 61.5% variation in shrub vegetation and 59.8% variation in *** variables explained higher variability (～35%) than spatial variables (～21%) in both shrubs and ***,among the spatial variables and carbon/nitrogen ratio and nitrogen among the soil variables explained maximum *** 40% variations left *** and species diversity among the other variables had significant correlation with ordination *** showed that altitude and C/N ratio played a significant role in species *** sampling efforts and inclusion of other non-studied variables are also suggested for better understanding.

关键词： species diversity Indicator species Environmental variable Ordination Explainedvariation

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searching For(2+1)-dimensional nonlinear Boussinesq equation from(1+1)-dimensional nonlinear Boussinesq equation

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Communications in Theoretical Physics 2023年第7期75卷 58-61页

作者： man Jia s Y Lou school of Physical science and Technology Ningbo UniversityNingbo315211China

A novel(2+1)-dimensional nonlinear Boussinesq equation is derived from a(1+1)-dimensional Boussinesq equation in nonlinear schr?dinger type based on a deformation *** integrability of the obtained(2+1)-dimensional Boussinesq equation is guaranteed by its Lax pair obtained directly from the Lax pair of the(1+1)-dimensional Boussinesq *** of the effects of the deformation,the(2+1)-dimensional Boussinesq equation admits a special travelling wave solution with a shape that can be deformed to be asymmetric and/or multivalued.

关键词： (2+1)-dimensional Boussinesq equation deformation algorithm lax integrable an implicit travelling wave solution

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Extraction,Utilization Pattern and Prioritization of Fuel Resources for Conservation in manali Wildlife sanctuary,Northwestern Himalaya

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Journal of Mountain science 2012年第4期9卷 580-588页

作者： man s.RANA sakshi B.RANA s.s.s.manT Department of Plant sciences Government CollegeBanjar-Kullu175123Himachal PradeshIndia Department of Plant sciences Government CollegeKullu175101Himachal PradeshIndia G.B.Pant Institute of Himalayan Environment&Development Himachal UnitMohal-Kullu175126Himachal PradeshIndia

Fuelwood is the main source of the energy in mountainous ***,annual wood consumption is very *** on fuelwood resources,and their extraction and availability is very ***,present study was carried out to study the diversity of fuelwood species,annual collection,preference and availability of fuel species in the *** four species(25 trees and 9 shrubs) were extracted for fuel by the *** collection and species preference was highest for Picea smithiana,Cedrus deodara,Indigofera heterantha,Pinus wallchiana and sorbaria tomentosa,*** use index indicating use pressure was highest for ***,***,*** and Abies pindrow,*** native species,some non-native horticultural and agroforestry species such as Malus pumila,***,Celtis australis,*** also being used as *** species showed their availability in eight forest types whereas,population and regeneration status was ***,immediate actions are suggested to sustain current and future demand of *** afforestation of degraded,uncultivated and marginal lands through high quality and preferred fuel species might reduce pressure on wild and selective species.

关键词： Fuelwood Resource Use Index Communities Conservation

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Diversity,Distribution and Prioritization of Fodder species for Conservation in Kullu District,Northwestern Himalaya,India

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Journal of Mountain science 2007年第3期4卷 259-274页

作者： s. s. samant man singh manohar Lal shreekar Pant G.B.Pant Institute of Himalayan Environment & Development Himachal UnitMohal-Kullu175 126Himachal PradeshIndia

In the Indian Himalayan Region predominantly rural in character, livestock is one of the main sources of livelihood and integral part of the economy. Livestock mostly rely on fodder from wild. The diversity, distribution, utilization pattern, nativity, endemism, rarity, seasonality of availability, nutritive values, perceived economic values and pressure use index of livestock have not been studied. The present study attempts to enumerate 150 species of fodder representing trees (51 spp.), shrubs (54 spp.) and herbs (45 spp.). Poaceae (19 spp.) and Fabaceae (13 spp.) amongst families and salix (6 spp.), Ficus, Clematis, and Desmodium (5 spp., each) amongst genera are rich in species. Maximum species were found in the 1801 ~ 2600 m zone, and the remaining two zones showed relatively low diversity. Out of the 150 species, 109 are used in summer, 5 winter and 36 throughout year. During rainy season, mostly grasses are used as fodder. Only 83 species are native to the Himalayan region, one species, strobilanthus atropuroureus is endemic and 35 species are near endemic. The nutritive values of the fodder species were reviewed, and economic values and status of the species were also assessed. The pressure use index of the species was calculated on the basis of cumulative values of the utilization pattern, altitudinal distribution, availability, status, nativity and endemism. Amongst the species, Grewia oppositifoilia, Morus serrata, Indigofera heterantha, Quercus leucotrichphora, Ulmus villosa, U. wallichiana and Aesculus indica showed highest PUI indicating high preference and pressure. season wise prioritization of the species for different altitudinal zones has been done. Appropriate strategy and action plan have been suggested for the conservation and management of fodder species.

关键词： Diversity utilization native endemic nutritive and economic value pressure use index prioritization conservation Indian Himalayan Region

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Mechanical Behaviour of Composite Bioactive Bone Cements Consisting of Two Different Types of surface Treated Hydroxyapatite as Filler

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Journal of Wuhan University of Technology(Materials science) 2005年第B12期20卷 10-12页

作者： s Deb ja Roether Department of Biomaterials King's College London School of Dentistry at the Guy's King's & St Thomas Hospital Guy's Tower Guy's Hospital London Bridge London SE 1 9RT UK

Bioactive bone cements based on a paste-paste system for orthopaedic applications were developed consisting of hydroxyapatite （ HA ） filler panicles in a methacrylate matrix comprising urethane dimethacrylate （ UDMA ） and triethylene glycol dimethacrylate （ TEGDMA ）. To improve the interface between inorganic filler and organic matrix the HA panicles were subjected to two different surface treatment methods, using polyacrylic acid （PAA） and γ-methacryloxy propyl trimethoxy silane （γMPs）. The aim of the present study was to determine the influence of surface treatment and the inclusion of multifunctional methacrylates on the mechanical properties, namely 3-point flexural strength （Fs） and fracture toughness of the cements and the effect of ageing in simulated body fluid. Comparing the mechanical properties of the two cements, the γMPs- HA cement showed that the fracture toughness of the experimental bone cements were significantly greater （ p 〈 0.001） compared to that of the PMMA cement, whereas PAA-HA containing cement had strength vollues around 20% lower. Interestingly, PAA was found to be more effective in improving the interface as the PAA treated HA cement （ UTHAPPA ） maintained its strength on immersion in sBF, suggesting that PAA provided a coupling, which was less sensitive to moisture, a similar trend was also observed with the inclusion of the carboxyl containing multifunctional methacrylates.

关键词： bioactive bone cements coupling agents composites polyacrylic acid

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Relativistic atomic data for W XLVⅡ

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Chinese Physics B 2015年第5期24卷 305-312页

作者： sunny Aggarwal A.K.s.Jha Indu Khatri Narendra singh man Mohan Department of Physics and Astrophysics University of Delhi Department of Physics Shyamlal College University of Delhi

Energy levels, radiative rates, and lifetimes are calculated for all levels of 3s23p, 3s23d, 3s3p2, 3s3d2, 3s3p3d, 3p23d, 3s3d2, 3p3d2, 3p3, and 3d3 configurations of Al-like tungsten ion （W XLVII）. Multiconfigurational Dirac-Fock （MCDF） method is adopted for calculating energy levels and radiative rates. Oscillator strengths, radiative rates, and line strengths are reported for some E1 transitions from the ground level. Comparisons are made with the available data in the literature and good agreement has been found which confirms the reliability of our results.

关键词： atomic data multiconfigurational Dirac-Fock method transition probability

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Exogenous neural stem cell transplantation for cerebral ischemia

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Neural Regeneration Research 2019年第7期14卷 1129-1137页

作者： Ling-Yi Liao Benson Wui-man Lau Dalinda Isabel sánchez-Vidana Qiang Gao Department of Rehabilitation Medicine West China HospitalSichuan University Department of Rehabilitation sciences The Hong Kong Polytechnic University

Cerebral ischemic injury is the main manifestation of stroke,and its incidence in stroke patients is 70–80%.Although ischemic stroke can be treated with tissue-type plasminogen activator,its time window of effectiveness is ***,the incidence of paralysis,hypoesthesia,aphasia,dysphagia,and cognitive impairment caused by cerebral ischemia is *** tissue regeneration can promote the recovery of the aforementioned *** stem cells can participate in the reconstruction of the damaged nervous system and promote the recovery of nervous function during self-repair of damaged brain *** stem cell transplantation for ischemic stroke has been a hot topic for more than 10 *** review discusses the treatment of ischemic stroke with neural stem cells,as well as the mechanisms of their involvement in stroke treatment.

关键词： nerve regeneration stem cell therapy neural stem cells cell transplantation ischemic stroke cerebral ischemia neuroplasticity functional recovery neural regeneration

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