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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

可疑卵巢癌病人行影像引导下穿刺:是一种安全有效的技术吗?

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国际医学放射学杂志 2009年第2期32卷 200-200页

作者： N.Griffin L.A.Grant s.j.freeman L.H.Berman E.sala H.Earl 孙志超 Department of Radiology Addenbrooke’s Hospital

对于疑为晚期卵巢癌的病人，行新辅助化疗前获得精确的组织学诊断非常重要。本研究旨在确定超声或CT引导下行经皮穿刺活检获得组织学诊断的准确性及并发症的发生率。2002--2007年共60例可疑卵巢癌病人行影像引导下经皮穿刺活检，过程中... 详细信息

对于疑为晚期卵巢癌的病人，行新辅助化疗前获得精确的组织学诊断非常重要。本研究旨在确定超声或CT引导下行经皮穿刺活检获得组织学诊断的准确性及并发症的发生率。2002--2007年共60例可疑卵巢癌病人行影像引导下经皮穿刺活检，过程中记录以下变量：穿刺组织、影像技术、穿刺者经验、穿刺针大小、穿刺次数、并发症及最后病理结果。

关键词：卵巢新生物超声 CT 穿刺

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

segmental colitis associated diverticulosis syndrome

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World journal of Gastroenterology 2016年第36期22卷 8067-8069页

作者： Hugh j freeman Department of Medicine(Gastroenterology) University of British Columbia

segmental colitis associated diverticulosis(sCAD) has become increasingly appreciated as a form of inflammatory disease of the colon. several features suggest that sCAD is a distinct disorder. sCAD tends to develop almost exclusively in older adults, predominately, but not exclusively, males. The inflammatory process occurs mainly in the sigmoid colon, and usually remains localized to this region of the colon alone. sCAD most often presents with rectal bleeding and subsequent endoscopic visualization reveals a well localized process with non-specific histopathologic inflammatory changes. Granulomas are not seen, and if present, may be helpful in definition of other disorders such as Crohn's disease of the colon, an entity often confused with sCAD. Bacteriologic and parasitic studies for an infectious agent are negative. Normal rectal mucosa(i.e., "rectal sparing") is present and can be confirmed with normal rectal biopsies. sCAD often resolves spontaneously without treatment, or completely after a limited course of therapy with only a 5-aminosalicylate. Recurrent episodes may occur, but most often, patients with this disorder have an entirely self-limited clinical course. Occasionally, treatment with other agents, including corticosteroids, or surgical resection has been required.

关键词： segmental colitis associated Diverticulosis syndrome Ulcerative colitis Diverticulitis segmental colitis Diverticulosis Inflammatory bowel disease

A chaotic neural network mimicking an olfactory system and its application on image recognition

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journal of Bionic Engineering 2004年第3期1卷 191-198页

作者： Walter j. freeman Department of Molecular & Cell Biology UCB LSA 142 Berkeley CA 94720-3200 USA

Based on the research of a biological olfactory system, a novel chaotic neural network model - K set model has been es- tablished. This chaotic neural network not only simulates the real brain activity of an olfactory system, but also presents a novel chaotic concept for signal processing and pattern recognition. The characteristics of the K set models are investigated and show that a KIII model can be used for image pattern classification.

关键词： olfactory system pattern recognition neural networks image classification

Triple metachronous colon cancer

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World journal of Gastroenterology 2013年第27期19卷 4443-4444页

作者： Hugh j freeman Department of Gastroenterology School of MedicineUniversity of British Columbia

A 72-year-old male with an early stage "node-negative" sigmoid colon cancer developed 2 separate "node-negative" early stage colon cancers during a subsequent colonoscopy surveillance regimen, the first in the descending colon 7 years later, and the second in the cecum almost 14 years after the first cancer was resected. After the initial symptomatic cancer, all subsequent neoplastic disease, including malignant cancers were completely asymptomatic. This entity, multiple primary cancers, likely reflected the use of a colonoscopic surveillance regimen.

关键词： Colorectal cancer surveillance colonoscopy Multiple primary cancer syndrome Metachronous colorectal cancer

Detecting stable phase structures in EEG signals to classify brain activity amplitude patterns

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journal of Zhejiang University-science A(Applied Physics & Engineering) 2009年第10期10卷 1483-1491页

作者： Yusely RUIZ Guang LI Walter j.freeman Eduardo GONZALEZ Department of Biomedical Engineering Zhejiang University Hangzhou 310027China National Lab of Industrial Control Technology Institute of Cyber-Systems and ControlZhejiang UniversityHangzhou 310027China Department of Molecular&Cell Biology 101 Donner University of California at BerkeleyCA 94720-3206USA

Obtaining an electrocorticograms(ECoG)signal requires an invasive procedure in which brain activity is recorded from the cortical *** contrast,obtaining electroencephalograms(EEG)recordings requires the non-invasive procedure of recording the brain activity from the scalp surface,which allows EEG recordings to be performed more easily on healthy *** this work,a technique previously used to study spatial-temporal patterns of brain activity on animal ECoG was adapted for use on *** main issues are centered on solving the problems introduced by the increment on the interelectrode distance and the procedure to detect stable *** results showed that spatial patterns of beta and gamma activity can also be extracted from the EEG signal by using stable frames as time markers for feature *** adapted technique makes it possible to take advantage of the cognitive and phenomenological awareness of a normal healthy subject.

关键词： Electroencephalograms(EEG) spatial-temporal pattem stable phase structure Frames

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant