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Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation

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Wnt-induced deubiquitination FoxM1 ensures nucleus β-cateni...

Impact of lattice relaxations on phase transitions in a high-entropy alloy studied by machine-learning potentials

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Chen Y Li Y Xue j Gong A Yu G zhou A Lin K zhang s zhang N Gottardi Cj Huang s Department of Neurosurgery The University of Texas MD Anderson Cancer Center Cell Engineering Research Center and Department of Cell Biology Fourth Military Medical University Department of Medicine Northwestern University Feinberg School of Medicine Department of Neurosurgery The University of Texas MD Anderson Cancer CenterHoustonTXUSA Program in Cancer BiologyThe University of Texas Graduate School of Biomedical Sciences at Houston

A key step of Wnt signaling activation is the recruitment of β-catenin to the Wnt target-gene promoter in the nucleus, but its mechanisms are largely unknown. Here, we identified FoxM1 as a novel target of Wnt signaling, which is essential for β-catenin/TCF4 transactivation. GsK3 phosphorylates FoxM1 on serine 474 which induces FoxM1 ubiquitination mediated by FBXW7. Wnt signaling activation inhibits FoxM1 phosphorylation by GsK3-Axin complex and leads to interaction between FoxM1 and deubiquitinating enzyme UsP5, thereby deubiquitination and stabilization of FoxM1. FoxM1 accumulation in the nucleus promotes recruitment of β-catenin to Wnt target-gene promoter and activates the Wnt signaling pathway by protecting the β-catenin/TCF4 complex from ICAT inhibition. subsequently, the UsP5-FoxM1 axis abolishes the inhibitory effect of ICAT and is required for Wnt-mediated tumor cell proliferation. Therefore, Wnt-induced deubiquitination of FoxM1 represents a novel and critical mechanism for controlling canonical Wnt signaling and cell proliferation.

关键词： FoxM1 ICAT UsP5 Wnt/β-catenin signaling ubiquitination

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npj Computational Materials 2019年第1期5卷 670-676页

作者： Tatiana Kostiuchenko Fritz Körmann jörg Neugebauer Alexander shapeev skolkovo Institute of science and Technology Skolkovo Innovation CenterNobel St.3Moscow 143026Russia Computational Materials Design Max-Planck-Institut für Eisenforschung GmbH40237 DüsseldorfGermany Materials science and Engineering Delft University of Technology2628 CD DelftThe Netherlands

Recently,high-entropy alloys(HEAs)have attracted wide attention due to their extraordinary materials properties.A main challenge in identifying new HEAs is the lack of efficient approaches for exploring their huge compositional *** initio calculations have emerged as a powerful approach that complements ***,for multicomponent alloys existing approaches suffer from the chemical complexity *** this work we propose a method for studying HEAs *** approach is based on the application of machine-learning potentials based on ab initio data in combination with Monte Carlo *** high efficiency and performance of the approach are demonstrated on the prototype bcc NbMoTaW *** approach is employed to study phase stability,phase transitions,and chemical short-range *** importance of including local relaxation effects is revealed:they significantly stabilize single-phase formation of bcc NbMoTaW down to room ***,a so-far unknown mechanism that drives chemical order due to atomic relaxation at ambient temperatures is discovered.

关键词： alloy relaxation entropy

测定离子注入单晶损伤与应变的双晶(n^v,-n^v)排列方法

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journal of semiconductors 1990年第1期11卷 14-19页

作者：李润身 H.K.Wagenfeld j.s.Williams stephen Milkins Andrew stevenson 中国科学院上海冶金研究所 Royal Melbourune Institute of Technology Australia CsIRO.Division of Material science and Technology Australia

依据双晶摇摆曲线的形成原理,提出了一种高分辨率,高灵敏度的测定离子注入单晶损伤与应变的双晶(n^v,—n^v)排列方法。考虑到掠入射情形的色散效应,对掠射角的选择进行了讨论。对Ga注入si单晶样品的测定证实了(n^v—n^v)排列的优越性,... 详细信息

依据双晶摇摆曲线的形成原理,提出了一种高分辨率,高灵敏度的测定离子注入单晶损伤与应变的双晶(n^v,—n^v)排列方法。考虑到掠入射情形的色散效应,对掠射角的选择进行了讨论。对Ga注入si单晶样品的测定证实了(n^v—n^v)排列的优越性,摇摆曲线上得到了未曾见过的细微振荡。

关键词：离子注入单晶损伤硅双晶排列法

Reduction of bend scour with an air-bubble screen-morphology and flow patterns

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International journal of sediment Research 2013年第1期28卷 15-23页

作者： Violaine DUGU Koen BLANCKAERT Qiuwen CHEN Anton j.sCHLEIss Ecole Polytechnique Fédérale de Lausanne(EPFL) Laboratory of Hydraulic Constructions(LCH)Station 18CH-1015 LausanneSwitzerland state Key Laboratory of Urban and Regional EcologyResearch Center for Eco-Environmental SciencesChinese Academy of Sciences

The interplay between streamwise flow,curvature-induced secondary flow,sediment transport and bed morphology leads to the formation of a typical bar-pool bed morphology in open-channel *** associated scour at the outer bank and deposition at the inner bank may endanger the outer bank’s stability or reduce the navigable width of the *** preliminary laboratory experiments in a sharply curved flume with a fixed horizontal bed have shown that a bubble screen located near the outer bank can generate an additional secondary flow located between the outer bank and the curvature-induced secondary flow and with a sense of rotation opposite to the *** bubble-induced secondary flow redistributes velocities and bed shear *** reported study investigates the implications of a bubble screen on the flow and the morphology in configurations with mobile *** measurements show that the bubble-induced secondary flow shifts the curvature-induced secondary flow in inwards direction and reduces its *** bubble screen considerably reduces morphological *** bend scour is reduced by about 50%and occurs further away from the outer bank where it does not endanger the bank stability *** location of maximum scour coincides with the junction of the curvature-induced and bubble-induced secondary *** this same location,the maximum streamwise velocities and maximum vertical velocities impinging on the bed also occur,which indicates their importance with respect to the formation of bend *** bubble screen also substantially reduced deposition at the inner *** preliminary experiments show the potential of a bubble screen to influence and modify the bed morphology.

关键词： Bubble screen Erosion scour Morphodynamics Open-channel bend

Two advances on the photoelectric parallel measuring of spectrum

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Chinese science Bulletin 1997年第23期42卷 1965-1970页

作者： Lin, LZ Pu, XY zhang, j Wen, XM Liu, Qj Yunnan Univ Dept Phys Kunming 650091 Peoples R China

THE tendency of the technique of spectral measurement is now towards sensitivity, precision,quickness, time and spatial resolving spectrum. For the spectrophotometers, which acquirespectral data with the serious method, the measurement of spectral intensity for differentwavelengths is not simultaneous. It is difficult to quickly get a spectrum, because time must bespent on tuning the dispersive device, and it is also impossible to process time and spatial Te-solving spectrum. The problems mentioned above are the fatal disadvantages for further devel-oping the spectrophotometer equipped with monochromator. The best way to solve these prob-

关键词： photoelectric parallel measuring of spectrum system’ s resolving power simultaneous spectral width multilayer gratings polychromator.

Luminosities and energies of e^(+)e^(−) collision data taken between √s=4.61 GeV and 4.95 GeV at BEsⅢ

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Chinese Physics C 2022年第11期46卷 64-75页

作者： M.Ablikim M.N.Achasov P.Adlarson M.Albrecht R.Aliberti A.Amoroso M.R.An Q.An X.H.Bai Y.Bai O.Bakina R.Baldini Ferroli I.Balossino Y.Ban V.Batozskaya D.Becker K.Begzsuren N.Berger M.Bertani D.Bettoni F.Bianchi j.Bloms A.Bortone I.Boyko R.A.Briere A.Brueggemann H.Cai X.Cai A.Calcaterra G.F.Cao N.Cao s.A.Cetin j.F.Chang W.L.Chang G.Chelkov C.Chen G.Chen H.s.Chen M.L.Chen s.j.Chen T.Chen X.R.Chen X.T.Chen Y.B.Chen Z.j.Chen W.s.Cheng X.Chu G.Cibinetto F.Cossio j.j.Cui H.L.Dai j.P.Dai A.Dbeyssi R.Ede Boer D.Dedovich Z.Y.Deng A.Denig I.Denysenko M.Destefanis F.De Mori Y.Ding j.Dong L.Y.Dong M.Y.Dong X.Dong s.X.Du P.Egorov Y.L.Fan j.Fang s.s.Fang W.X.Fang Y.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.H.Feng K Fischer M.Fritsch C.Fritzsch C.D.Fu H.Gao Y.N.Gao Yang Gao s.Garbolino I.Garzia P.T.Ge C.Geng E.M.Gersabeck A Gilman K.Goetzen L.Gong W.X.Gong W.Gradl M.Greco M.H.Gu C.Y Guan A.Q.Guo L.B.Guo R.P.Guo Y.P.Guo A.Guskov T.T.Han W.Y.Han X.Q.Hao F.A.Harris K.K.He K.L.He F.H.Heinsius C.H.Heinz Y.K.Heng C.Herold M.Himmelreich T.Holtmann G.Y.Hou Y.R.Hou Z.L.Hou H.M.Hu j.F.Hu T.Hu Y.Hu G.s.Huang K.X.Huang L.Q.Huang L.Q.Huang X.T.Huang Y.P.Huang Z.Huang T.Hussain N Husken W.Imoehl M.Irshad j.jackson s.jaeger s.janchiv Q.ji Q.P.ji X.B.ji X.L.ji Y.Y.ji Z.K.jia H.B.jiang s.s.jiang X.s.jiang Y.jiang j.B.jiao Z.jiao s.jin Y.jin M.Q.jing T.johansson N.Kalantar-Nayestanaki X.s.Kang R.Kappert M.Kavatsyuk B.C.Ke I.K.Keshk A.Khoukaz P.Kiese R.Kiuchi R.Kliemt L.Koch O.B.Kolcu B.Kopf M.Kuemmel M.Kuessner A.Kupsc W.Kuhn j.j.Lane j.s.Lange P.Larin A.Lavania L.Lavezzi Z.H.Lei H.Leithoff M.Lellmann T.Lenz C.Li C.Li C.H.Li Cheng Li D.M.Li F.Li G.Li H.Li H.Li H.B.Li H.j.Li H.N.Li j.Q.Li j.s.Li j.W.Li Ke Li L.j Li L.K.Li Lei Li M.H.Li P.R.Li s.X.Li s.Y.Li T.Li W.D.Li W.G.Li X.H.Li X.L.Li Xiaoyu Li Z.Y.Li H.Liang H.Liang H.Liang Y.F.Liang Y.T.Liang G.R.Liao L.Z.Liao j.Libby A.Limphirat C.X.Lin D.X.Lin T.Lin B.j.Liu C.X.Liu D.Liu F.H.Liu Fang Liu Feng Liu G.M.Liu H.Liu H.M.Liu Huanhuan Liu Huihui Liu j.B.Liu j.L.Liu j.Y.Liu K.Liu K.Y.L Institute of High Energy Physics Beijing 100049China Beihang University Beijing 100191China Beijing Institute of Petrochemical Technology Beijing 102617China Bochum Ruhr-University D-44780 BochumGermany Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China China Center of Advanced science and Technology Beijing 100190China COMsATs University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000 LahorePakistan Fudan University Shanghai 200433China G.I.Budker Institute of Nuclear Physics sB RAs(BINP) Novosibirsk 630090Russia GsI Helmholtzcentre for Heavy Ion Research GmbH D-64291 DarmstadtGermany Guangxi Normal University Guilin 541004China Hangzhou Normal University Hangzhou 310036China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University of science and Technology Luoyang 471003China Henan University of Technology Zhengzhou 450001China Huangshan College Huangshan 245000China Hunan Normal University Changsha 410081China Hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly INFN Laboratori Nazionali di Frascati INFN Sezione di PerugiaI-06100PerugiaItaly INFN Laboratori Nazionali di Frascati University of PerugiaI-06100PerugiaItaly INFN sezione di Ferrara INFN Sezione di FerraraI-44122FerraraItaly INFN sezione di Ferrara University of FerraraI-44122FerraraItaly Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Ave.54BUlaanbaatar 13330Mongolia jilin University Changchun 130012China johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45D-55099 MainzGermany joint Institute for Nuclear Research 141980 DubnaMoscow regionRussia justus-Liebig-Universitaet Giessen II.Physikalisches InstitutHeinrich-Buff-Ring 16

From December 2019 to june 2021,the BEsⅢ experiment collected approximately 5.85 fb^(−1) of data at center-of-mass energies between 4.61 and 4.95 *** is the highest collision energy BEPCⅡ has reached to *** accumulated e^(+)e^(−) annihilation data samples are useful for studying charmonium(-like)states and charmed-hadron *** adopting a novel method of analyzing the production of A_(c)^(+)A_(c)^(-) pairs in e^(+)e^(−) annihilation,the center-of-mass energies are measured with a precision of 0.6 *** luminosities are measured with a precision of better than 1% by analyzing the events of large-angle Bhabha *** measurements provide important inputs to analyses based on these data samples.

关键词： luminosity center-of-mass energy BEsⅢdetector

Effect of Heat Input on the Microstructure and Properties of Dissimilar Weld joint Between Incoloy 28 and superaustenitic stainless steel

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Acta Metallurgica sinica(English Letters) 2014年第2期27卷 259-266页

作者： M.s.Abdel Rahman N.A.Abdel Raheem M.R.El Koussy Department of Metallurgy Faculty of EngineeringCairo University

Abstract This work focuses on studying the effect of welding heat input within the range from 1 to 5 kj/mm on the microstructure and the corresponding mechanical and corrosion properties of dissimilar joint between superaustenitic stainless steel （UNs s31254） and Incoloy 28 （UNs N08028）. The two materials were butt-welded with ER NiCrMo3. The metallurgical changes associated with welding of sAss and Incoloy 28 were studied using optical microscope, sEM, and EDX. The mechanical and corrosion properties were investigated using tensile test, Vickers hardness test, and pitting and crevice corrosion tests. The weld metal microstructure showed precipitates with needle-like shape at 3 and 5 kj/mm. Also, the microstructure showed unmixed zone （UMZ） at the fusion line of both sAss and Incoloy 28 sides at all the investigated heat inputs. The Mo microsegregation within UMZ at Incoloy 28 side increased as the heat input increased from 1 to 5 k j/ram but that in sAss increased with increasing heat input from 1 to 3 kj/mm and then decreased with increasing from 3 to 5 kj/mm. The ultimate tensile strengths for all specimens at all the investigated heat inputs are acceptable. The average hardness noticeably changed in weld metal as the heat input increased from 1 to 5 kj/mm. Other zones such as HAZ or UMZ did not demonstrate marked changes in the average hardness. The pitting and crevice corrosion rates of the weld joint were found significant at l and 3 kj/mm but insignificant at 5 kj/mm according to AsTM G48.

关键词： superaustenitic Incoloy 28 Welding Heat input Unmixed zone Microsegregation Corrosion

Temperature-induced hormesis in plants

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journal of Forestry Research 2019年第1期30卷 13-20页

作者： Evgenios Agathokleous Mitsutoshi Kitao Hisanori Harayama Edward j.Calabrese Hokkaido Research Center Forestry and Forest Products Research Institute (FFPRI) Forest Research and Management Organization Research Faculty of Agriculture Hokkaido University Department of Environmental Health sciences Morrill IN344 University of Massachusetts

Environmental change attracts particular attention by biologists concerned with the performance of biological systems under stress. To investigate these, dose–response relationships should be clarified. It was previously assumed that the fundamental nature of biological dose–responses follows a linear model, either with no threshold or with a threshold below which no effects are expected to occur in biological endpoints. However, substantial literature, including widespread documentation in plants, has revealed that hormesis commonly occurs. Hormesis is highly generalized and can be utilized as a quantitative measure of biological plasticity. Conditioning induced by adaptive responses also occurs in the framework of hormesis and is of particular importance to environmental change biology with regards to evolutionary *** paper presents additional evidence for hormetic dose responses induced by temperature in plants. The current understanding on hormesis provides a perspective for next generation environmental change research. Hormesis should have a central role in environmental change biology of vegetation.

关键词： Adaptive response Biological plasticity Dose response Hormesis stress biology

Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

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World journal of stem Cells 2021年第11期13卷 1696-1713页

作者： jelena Krstić slavko Mojsilović sonja s Mojsilović juan F santibanez Gottfried schatz Research Center Medical University of GrazGraz 8010Austria Group for Hematology and stem Cells Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11129Serbia Group for Immunology Institute for Medical ResearchNational Institute of Republic of SerbiaBelgrade 11129Serbia Group for Molecular Oncology Institute for Medical ResearchNational Institute of Republic of SerbiaUniversity of BelgradeBelgrade 11000Serbia Centro Integrativo de Biología y Química Aplicada Universidad Bernardo O’HigginsChile 8370993Chile

Bone regeneration is a tightly regulated process that ensures proper repair and functionality after *** delicate balance between bone formation and resorption is governed by cytokines and signaling molecules released during the inflammatory ***(IL)-17A,produced in the early phase of inflammation,influences the fate of *** to their inherent capacity to differentiate into osteoblasts,mesenchymal stem/stromal cells(MsCs)contribute to bone healing and *** review presents an overview of IL-17A signaling and the leading cellular and molecular mechanisms by which it regulates the osteogenic differentiation of *** main findings demonstrating IL-17A’s influence on osteoblastogenesis are *** this end,divergent information exists about the capacity of IL-17A to regulate MsCs’osteogenic fate,depending on the tissue context and target cell type,along with contradictory findings in the same cell ***,we summarize the data showing both the pro-osteogenic and anti-osteogenic roles of IL-17,which may help in the understanding of IL-17A function in bone repair and regeneration.

关键词： Interleukin-17 Mesenchymal stem cells Osteoblast Bone Osteogenesis Inflammation