检索结果-南通市图书馆

Association of cannabinoid receptor CB2 gene with alcoholism and development of alcohol preference.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of cannabinoid receptor CB2 gene with alcoholism...

Characteristics of Magneto-Dielectric-Barrier Discharge Trench Reactors for Oxidation and Reduction of Gaseous Pollutants

第十五届国际药理学大会

作者： H.Ishiguro s.iwasaki L.Teasenfitz s.Higuchi E.Onaivi T.Ari nami Institute of Basic Medical sciences University of Tsukuba Japan Institute of Basic Medical sciences University of Tsukuba Japan William Paterson University Wayne NJ USA Kurihama National Hospital Japan William Paterson University Wayne NJ USA Institute of Basic Medical sciences University of Tsukuba Japan

＜正＞ We tested the hypothesis that genetic variants of CB2 gene might be associated with alcoholism in human population and this was probed using the non - synonymous polymorphisms. R63Q and H316Y in the CB2 gene in Japanese alcoholic subjects. In mice CB2 gene expression was determined in brain regions after a cute administration of ethanol. and development of alcohol preference. Ethanol consumption in mice subjected to chronic mild stress and the effect of chronic daily administration with CB2 agonist JWH015 on ethanol consumption in stressed and control animals were measured. High incidence of the Q63R but not the H316Y polymorphism was found in Japanese alcoholics. Mice that developed alcohol preference had reduced CB2 gene expression and chronic treatment with JWH015 enhanced alcohol consumption in stressed but not in control mice. CB2 cannabinoid receptors are involved with the effects of alcohol along with epigenet ic factors, such as stressors, and may be targeted with CB2 ligands in alcoholism.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Characteristics of Magneto-Dielectric-Barrier Discharge Tren...

亚太绿色氧化还原技术国际研讨会

作者： D.Brocilo s.iwasaki Y.Takagi J.W.Hoard C.Ayrault K.Urashima G.D.Harvel H.Ehara T.Ito McMaster Institute of Applied Radiation McMaster University Hamilton Canada McMaster Institute of Applied Radiation McMaster University Hamilton Canada Department of Electrical Musashi Institute of Technology Japan Currently Horiba Kyoto Japan McMaster Institute of Applied Radiation McMaster University Hamilton Canada Department of Electrical Musashi Institute of Technology Japan Chemical Engineering Department Ford Motor Company Research Laboratory USA McMaster Institute of Applied Radiation McMaster University Hamilton Canada McMaster Institute of Applied Radiation McMaster University Hamilton Canada McMaster Institute of Applied Radiation McMaster University Hamilton Canada Department of Electrical Musashi Institute of Technology Japan Department of Electrical Musashi Institute of Technology Japan

The discharge characteristics of a magneto-trench-barrier-discharge (MTBD) reactor for oxidation and reduction of gaseous pollutants was studied. Four different magnetic field distribution inside the

关键词： diesel engine exhaust nitrogen oxide non-thermal plasma barrier discharge magnetic field

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

解析法预测汽车转向系的冲击特性

专用汽车 1989年第2期 34-38页

作者： Y.Kobayashi A.Nobata s.iwasaki K.sawazaki 杨义彪

汽车在正面碰撞时,转向装置是一种伤害不系安全带的驾驶员的典型部件。因此,许多国家都有极为相似的技术条件,用来指导冲击试验的方法和转向装置的规格设计。由于在进行这些试验时,总要损坏一些零件,因此,提高转向装置的安全性能就需要... 详细信息

汽车在正面碰撞时,转向装置是一种伤害不系安全带的驾驶员的典型部件。因此,许多国家都有极为相似的技术条件,用来指导冲击试验的方法和转向装置的规格设计。由于在进行这些试验时,总要损坏一些零件,因此,提高转向装置的安全性能就需要许多试验零件和大量的人力;另一个问题就是难以在设计的早期阶段预测对试验人体模块的冲击载荷。在努力解决这些问题的过程中,我们试制并验证了可拆式钢球转向柱,以分析转向装置的工作情况和影响最大冲击载荷的因素,利用获得的结果,再根据吸能部件的特性,提出了模拟冲击试验法。这种方法考虑到垂直于转向柱轴线的作用力,也考虑到确保解决前束的需要。该法预测最大冲击载荷及其发生的时间的误差在百分之几以内,同时能定量地研究转向系的每个部件对冲击现象的作用。

关键词：冲击载荷冲击特性汽车转向吸能转向柱正面碰撞可拆式冲击试验转向装置柱轴线

维普期刊数据库

A new electric field mill array with each of the mill’s rotor controlled precisely by a GPs module:Equipment and initial results

在线全文

学校读者我要写书评

暂无评论

Earth and Planetary Physics 2024年第2期8卷 423-435页

作者： Kozo Yamashita Hironobu Fujisaka DaoHong Wang Hiroyuki iwasaki Kazuo Yamamoto Koichiro Michimoto Masashi Hayakawa Department of Production systems Engineering and sciences Komatsu UniversityNu 1-3 Shicho-machiKomatsuIshikawa 923-8511Japan Fujisaka Technology Office 1058-5 Yoshizawa-choOhta-shiGunma 373-0019Japan Department of Electrical Electronic and Computer EngineeringGifu University1-1 YanagidoGifu CityGifu 501-1193Japan Cooperative Faculty of Education Gunma University4-2-Aramaki-machiMaebashiGunma 371-8510Japan Department of Electrical and Electronic Engineering Chubu University1200 Matsumoto-choKasugaiAichi 487-8501Japan Independent Researcher Kosenba Town 2-44-11-406Kawagoe CitySaitama350-0036Japan Advanced Wireless&Communications Research Center The University of Electro-Communications1-5-1 ChofugaokaChofuTokyo 182-8585Japan

We have newly designed an electrostatic sensor,called an electric field mill(EFM),to simplify the estimation of the charge position and charge amount transferred by lightning *** is necessary for this remote estimation of the transferred charge to measure electric field changes caused by charge loss at the time of a lightning strike at multiple *** multiple-station measurement of electric field changes,not only speed but also phase for exposure and shielding of the sensing plates inside each EFM of the array should be synchronized to maintain the sensitivities of the deployed ***,there is no such EFM with specified speed and phase control performance of the rotary ***,we developed a new EFM in which the rotary mechanism was controlled consistently to within 3%error by a GPs *** EFMs had been distributed in the Hokuriku area of Japan during the winter season of 2022-2023 for a test *** we describe the design and a simple calibration method for our new EFM *** analysis method based on the assumption of a simple monopole charge structure is also *** validation,locations of assumed point charges were compared with three-dimensional lightning mapping data estimated by radio observations in the MF-HF *** results indicated the validity to estimate transferred charge amounts and positions of winter cloud-to-ground lightning discharges with our new EFM array.

关键词： lightning electrostatic field electric field mill electric field change

维普期刊数据库

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2024年第3期32卷 463-476页

作者： Hur sUN MAsANORI KAWANO TATsUYA iwasaki ICHRO ITONAGA YUTA KUBOTA HROsHI TsUMURA KAZUHRO TANAKA Department of Orthopaedic surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(Os)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of Os and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined Os cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of Os cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the Os cell line,the expression of TCF7L1 decreased,the proliferation of Os cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/s transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of Os xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in Os cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI sUN MAsANORI KAWANO TATsUYA iwasaki ICHIRO ITONAGA YUTA KUBOTA HIROsHI TsUMURA KAZUHIRO TANAKA Department of Orthopaedic surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence sensitizer Rare earths

First evidence for chiral wobbling of triaxial nuclei

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handiness”)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the same binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are insensitive to the geometry are also the *** different geometry is the reason why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the same ***,the geometrical differences between the two species may have other *** two species of the carvon molecule shown in Fig.1 taste quite differently.

关键词： turns Chiral mirror

维普期刊数据库

Tribological behavior of lubricant-impregnated porous polyimide

在线全文

学校读者我要写书评

暂无评论

Friction 2024年第4期12卷 711-725页

作者： Jinbang LI Ningning ZHOU Janet s.s.WONG school of Mechanical Engineering and Mechanics Ningbo UniversityNingbo 315211China Beijing Key Laboratory of Long-life Technology of Precise Rotation and Transmission Mechanisms Beijing Institute of Control EngineeringBeijing 100029China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Porous materials impregnated with lubricants can be used in conditions where limited lubricant is *** this work,three porous polyimides(PPI)with different densities were ***(PAO)impregnated PPI(iPPI)discs were rubbed against steel and sapphire *** operando observations of the iPPI-sapphire contacts show that oil is released under an applied load,forming a meniscus around *** at the outlet is created at high sliding *** amount of released oil increases with increasing PPI *** moduli,E*,estimated based on the actual contact size show that trapped oil in iPPIs contributes to load *** higher speeds,tribological rehydration of the contact occurs in low density iPPI,with that E*rises with *** high density PPIs,high speeds give a constantly high E*which is limited by the viscoelastic properties of the PPI network and possibly the rate of oil *** of iPPI-steel contacts is governed by the mechanical properties of the PPI,the flow of the lubricant,and the roughness of the PPI *** low-and medium-density(highly porous,high roughness)PPIs,large amount of oil is released,and lubrication is mainly via lubricant restricted in the contact in the pores and possibly tribological *** high density(low porosity)PPI,with lower roughness,hydrodynamic lubrication is achieved which gives the lowest *** results show that polymeric porous materials for effective lubrication require the optimization of its surface roughness,stiffness,oil flow,and oil retentions.

关键词： polyimide porous material friction mechanism polymer limited lubrication