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Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li steffen Tiedt eng H.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA Consortium International pour la Recherche Circadienne sur l’AVC(CIRCA) BostonUSA Institute for stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

Comparative Orotomy of the Archean superior, North China, and Phanerozoic Altaid Orogenic systems Architecture

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Acta Geologica sinica(english Edition) 2024年第S1期 33-35页

作者： T.M.KUsKY A.M.C.?eng?R Center for Global Tectonics School of Earth Sciences and State Key Laboratory for Geological Processes and Mineral Resources China University of Geosciences Eurasia Institute of Earth sciences Istanbul Technical University Department of Geology Faculty of Mines Istanbul Technical University

Geological maps encode vast amounts of data about rock types, ages, chemistry, orogenic architecture and deep-time history or different tectonic units, yet these are often difficult to extract because of the way different geologists portray their results at various scales. To understand orogenesis in 4D, it is essential to uniformly integrate map data, together with geophysical data and deep geochemical mapping(Wang et al., 2023).

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岭南猪肉卷章加工及其安全风险研究进展

肉类研究 2024年第4期38卷 70-76页

作者：徐青怡 PHUAH eng-Tong 董浩曾晓房白卫东李光辉仲恺农业工程学院轻工食品学院广东省岭南特色食品科技重点实验室农业农村部岭南特色食品绿色加工与智能制造重点实验室广东广州510225 文莱科技大学应用科学与数学学院文莱斯里巴加湾BE1410

猪肉卷章(肉卷)是我国岭南地区著名的传统美食,以猪后腿肉和腐皮为主要原料,制卷并经油炸制作而成。目前,猪肉卷章面临高饱和脂肪、高盐及热加工中伴随危害物产生等问题,具有引发心血管疾病、肥胖、糖尿病等风险。因此,低盐、低脂和营... 详细信息

猪肉卷章(肉卷)是我国岭南地区著名的传统美食,以猪后腿肉和腐皮为主要原料,制卷并经油炸制作而成。目前,猪肉卷章面临高饱和脂肪、高盐及热加工中伴随危害物产生等问题,具有引发心血管疾病、肥胖、糖尿病等风险。因此,低盐、低脂和营养健康是猪肉卷章的研究方向。本文围绕岭南特色卷章的研究现状及发展趋势进行综述,指出岭南特色卷章的加工方法及其潜在的食品安全风险,提出Pickering乳液替代脂肪、减盐策略及危害物预防控制的解决方案,并对其后续脂肪替代、营养健康和市场前景等方面进行展望,旨在为营养健康的新型卷章在食品工业中的应用提供理论依据。

关键词：猪肉卷章 Pickering乳液脂肪替代营养

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Randomly Generating Four Mixed Bell-Diagonal states with a Concurrences sum to Unity

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Chinese Physics Letters 2012年第1期29卷 24-27页

作者： s.P.Toh Hishamuddin Zainuddin Kim eng Foo Faculty of engineering The University of Nottingham Malaysia CampusJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Laboratory of Computational sciences and Mathematical Physics Institute for Mathematical ResearchUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Department of Physics Faculty of ScienceUniversiti Putra Malaysia43400 UPM SerdangSelangorMalaysia Faculty of health and Life sciences INTI International UniversityPersiaran Perdana BBNPutra Nilai71800 NilaiNegeri SembilanMalaysia

A two-qubit system in quantum information theory is the simplest bipartite quantum system and its concurrence for pure and mixed states is well *** a subset of two-qubit systems,Bell-diagonal states can be depicted by a very simple geometrical representation of a tetrahedron with sides of length 2√*** on this geometric representation,we propose a simple approach to randomly generate four mixed Bell decomposable states in which the sum of their concurrence is equal to one.

关键词： quantum concurrence representation

Fluids in abdominal surgery: what is the goal?

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hepatobiliary surgery and Nutrition 2018年第3期7卷 227-228页

作者： Oliver s. eng Division of surgical Oncology Department of SurgeryCity of Hope National Medical CenterDuarteCAUSA

In the early 2000s, the approach to perioperative fluid management in major abdominal surgery underwent a paradigm change in favor of restrictive, rather than standard or liberal, fluid regimens. The basis for this shift in philosophy was a result of randomized controlled trials such as one by Brandstrup et al., which demonstrated improved morbidity and outcomes with perioperative fluid restriction (1). With similar results reported across a variety of other prospective trials, the practice of perioperative fluid restriction garnered more support and acceptance (2,3).

关键词： fluid surgery s.

碱激发下粉煤灰-市政污泥固废基混凝土抗冻融性能

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工程科学与技术 2024年第3期56卷 277-286页

作者：贺盛夏鑫覃志笛于鹏广西大学土木建筑工程学院广西南宁530004 广西博世科环保科技股份有限公司广西南宁530007 广西大学广西防灾减灾与工程安全重点实验室广西南宁530004 广西大学工程防灾与结构安全教育部重点实验室广西南宁530004

为改善市政污泥对混凝土抗冻融性能的劣化效果,在氢氧化钠及水玻璃的复合激发下,用经生石灰改性后的市政污泥取代10%细骨料,粉煤灰分别取代10%、20%与30%水泥,制备了混凝土;分析不同冻融循环次数下,混凝土的表观现象、相对质量、相对动... 详细信息

为改善市政污泥对混凝土抗冻融性能的劣化效果,在氢氧化钠及水玻璃的复合激发下,用经生石灰改性后的市政污泥取代10%细骨料,粉煤灰分别取代10%、20%与30%水泥,制备了混凝土;分析不同冻融循环次数下,混凝土的表观现象、相对质量、相对动弹性模量、相对抗压强度及微观结构随粉煤灰掺量与碱当量的变化规律;分别以相对动弹性模量与相对抗压强度为损伤变量建立不同的冻融损伤模型。研究结果表明:随冻融循环次数增加,混凝土表观损伤愈发严重,内部孔隙增多,相对动弹性模量及相对抗压强度逐渐降低;与对照组相比,粉煤灰及碱激发剂的加入可以改善市政污泥对混凝土冻融耐久性的劣化效果,降低混凝土在冻融循环作用下的质量损失、动弹性模量损失及抗压强度损失;当粉煤灰掺量10%、碱当量4%时,粉煤灰会在碱激发剂及改性污泥中残余碱的联合作用下被较充分地激发,消纳改性污泥中的残余碱,减弱市政污泥对混凝土抗冻融性能的劣化效果,此时,混凝土水化程度最高,在冻融循环作用下的质量损失、动弹性模量损失及抗压强度损失最小,且服役寿命最长,约为16 a以上;相对动弹性模量与相对抗压强度相关性良好,分别以两者为损伤变量的冻融损伤模型与试验结果均吻合良好。

关键词：市政污泥固废资源化利用冻融循环微观结构冻融损伤模型

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The Hidden side of the story between the Placenta and Preeclampsia: Preliminary Results of a Prospective Cohort of Pregnant Women in Cameroon

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Open Journal of Obstetrics and Gynecology 2024年第4期14卷 610-620页

作者： Junie Annick Metogo Ntsama Ambroise Merci engounou seme Urielle Julie Tchuente sutchueng Wilfried Loic Tatsipie Christian Vagoda henry-Leonard Chatelin Mol Madye Ngo Dingom Felix Essiben Cyrille Claude Noa Ndoua Yann chris eng Odile Fernande Zeh Faculty of Medicine and Biomedical sciences University of Yaound&#233 I Yaound&#233 Cameroon Faculty of Medicine and Pharmaceutical sciences University of Dschang Dschang Cameroon

Introduction: Pre-eclampsia is a complication of pregnancy that generally occurs in the third trimester. It is associated with a maternal and foetal mortality rate of around 27%. In view of the grim picture painted by this condition for both mother and newborn, studies have been carried out into the early detection of patients at risk of developing pre-eclampsia. These make it possible to introduce pregnancy-specific monitoring and preventive strategies to reduce the incidence of the condition. Objective: To establish the link between placental ultrasound characteristics and the onset of pre-eclampsia. Methodology: A multicentre prospective cohort study was conducted in two hospitals in Yaoundé, namely the Yaoundé Gynaecological Obstetrics and Paediatrics Hospital and the Nkolndongo health and social Animation Centre, in the gynaecology and radiology departments over a period of 11 months, from October 2022 to August 2023. It included pregnant women who had undergone obstetric ultrasound between 12 and 18 weeks’ gestation. In addition to routine obstetric ultrasound, we performed obstetric Doppler measurements in these patients. The resistance index of the left and right uterine arteries, the umbilical artery and the placental volume were the characteristics sought. At the end of this examination, two groups were formed: cases (pathological Doppler group) and controls (normal Doppler group). Blood pressure and urine dipstick were taken at each antenatal visit until delivery, then during the immediate postpartum period and finally at 7 days, 21 days and 42 days after delivery. Results: sixty-seven (67) patients were included. Of these, 35 (47.8%) had pathological Dopplers. sixteen patients had arterial hypertension associated with proteinuria and were therefore labelled as pre-eclampsia (PE). This gives a prevalence of 23.9%. Fifteen (42.8%) of these patients belonged to the exposed group and one to the unexposed group. The mean IR of the pre-eclampsia patients was s

关键词： Pre-Eclampsia Doppler Ultrasound Placenta

Intelligent Exit-selection Behaviors during a Room Evacuation

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Chinese Physics Letters 2012年第1期29卷 291-294页

作者： Zarita Zainuddin Lim eng Aik school of Mathematical sciences Universiti Sains Malaysia11800 MindenPenangMalaysia Institut Matematik Kejuruteraan Universiti Malaysia Perlis02000 Kuala PerlisPerlisMalaysia

A modified version of the existing cellular automata (CA) model is proposed to simulate an evacuation procedure in a classroom with and without *** on the numerous literature on the implementation of CA in modeling evacuation motions,it is notable that most of the published studies do not take into account the pedestrian's ability to select the exit route in their *** resolve these issues,we develop a CA model incorporating a probabilistic neural network for determining the decision-making ability of the pedestrians,and simulate an exit-selection phenomenon in the *** exit-selection behavior is observed in our *** the simulation results,it is observed that occupants tend to select the exit closest to them when the density is low,but if the density is high they will go to an alternative exit so as to avoid a long *** reflects the fact that occupants may not fully utilize multiple exits during *** improvement in our proposed model is valuable for further study and for upgrading the safety aspects of building designs.

关键词： Exit utilize automata

Comparative orotomy of the Archean superior and Phanerozoic Altaid orogenic systems

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National science Review 2023年第2期10卷 20-48页

作者： Timothy M.Kusky A.M.Celal ?eng?r Center for Global Tectonics School of Earth Sciences and State Key Laboratory for Geological Processes and Mineral ResourcesChina University of Geosciences Badong National Observatory and Research station for Geohazards Ministry of Education China University of Geosciences Department of Geological engineering Middle East Technical University Eurasia Institute of Earth sciences Istanbul Technical University Department of Geology Faculty of Mines Istanbul Technical University

We compare and contrast the materials and mechanisms of continental crustal growth in the largest preserved regions of Phanerozoic and Archean juvenile additions to the crust,to test for similarities or differences in the formation of continents through *** accomplish this through a comparison of map patterns,lithological contents,and structural and metamorphic evolution of the Phanerozoic Altaid orogenic system of Asia,with the Archean superior Province of the North American Craton,using a method termed comparative *** orogenic systems consist of collages of curvilinear belts of eroded arcs,some older continental slivers,and vast tracts of former subduction/accretionary *** contain numerous shreds of portions of the ophiolite suite,slivers of island and continental arcs,and accreted oceanic plateau,all intruded by multiple magmatic suites during or between multiple deformation events,then sliced by large transcurrent fault systems and bent into large oroclinal *** make this comparison because the superior Province is a typical Archean craton that was later,in the P aleoproterozoic,incorporated into the larger North American Craton,and has occupied a central position in several super continents(*** and Nuna,which then formed the core of Columbia,Rodinia,Laurentia and Pangea) during its *** it is the largest single fragment of Archean continental cratonic lithosphere preserved on Earth,the superior Province is widely regarded as a testing ground for how Earth’s continental crust was ***,the Altaids encompass the largest region of crustal growth for the *** comparison with the Altaids is needed,as in recent years many myths about how the planet may have responded to higher heat production and flow in the Archean have emerged,because of trends in the science where regional geology is ignored in favor of numerical models,isotopic proxies for assumed models of chemical behavior for crust-for

关键词： Altaids superior province ophiolite subduction strike-slip