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Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse Mboowa Gerald Kamgang Basile Caminade Cyril Duke Dawn C. Githeko Andrew Karanja Ogega Obed M. Elloué Nestor Engone sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nicaise T. Paupy Christophe Bockarie Moses otomo Patricks Voua Molecular and Cellular Biology Laboratory (LabMC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmacology and Improved Traditional Medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The African Center of Excellence in Bioinformatics and Data-Intensive sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Centers for Disease Control and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Centre for Research in Infectious Diseases P.O. Box Yaoundé Cameroon Earth system Physics Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Community Health support Program P.O. Box Kisumu Kenya The African Academy of sciences Nairobi Kenya Center for Phylosophical studies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UMRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic Diseases Control Program Ministry of Health Libreville Gabon MIVEGEC Univ. Montpellier CNRS IRD Montpellier France MERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana school of Community Health sciences Njala University Bo Sierra Leone

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.s. National Institutes of Health, and the Bill and Melinda Gates Foundation as well as initiatives such as the African Research Initiative for scientific Excellence and the Pan-African Mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

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Rescue case of low birth weight infant with acute hepatic failure

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World Journal of Gastroenterology 2017年第40期23卷 7337-7342页

作者： Noriki Okada Yukihiro sanada Taizen Urahashi Yoshiyuki Ihara Naoya Yamada Yuta Hirata Takumi Katano Kentaro Ushijima s.inya otomo shujiro Fujita Koichi Mizuta Department of Transplant surgery Jichi Medical University Department of Clinical Pharmacology Jichi Medical University Department of Pharmacy Jichi Medical University Department of Pediatrics Yokohama City University School of Medicine

We report a case involving a rescued low birth weight infant(LBWI) with acute liver failure. Case: The patient was 1594 g and 32^(3/7) gestational wk at birth. At the age of 11 d, she developed acute liver failure due to gestational alloimmune liver disease. Exchange transfusion and high-dose gamma globulin therapy were initiated, and body weight increased with enteral nutrition. Exchange transfusion was performed a total of 33 times prior to living donor liver transplantation(LDLT). Her liver dysfunction could not be treated by medications alone. At 55 d old and a body weight of 2946 g, she underwent LDLT using an s2 monosegment graft from her mother. Three years have passed with no reports of intellectual disability or liver dysfunction. LBWIs with acute liver failure may be rescued by LDLT after body weight has increased to over 2500 g.

关键词： Liver transplantation Acute liver failure Low birth weight infant Transplantable body weight Monosegment graft

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脂质微球:新的药物载体

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国外医学.药学分册 1986年第5期 268-270页

作者： Mizushim A shoji Y Yokozama K otomo s 陸明盛

脂质体是一种可在一定时间内、于病灶(靶)部位能释放所需浓度的药物而又不出现副作用或减少副作用的释药体系,但脂质体不够稳定且不易大量生产。而由乳磷脂乳化豆油制成的脂肪乳剂却十分稳定,室温下能保存二年,在临床上可广泛用作高营... 详细信息

脂质体是一种可在一定时间内、于病灶(靶)部位能释放所需浓度的药物而又不出现副作用或减少副作用的释药体系,但脂质体不够稳定且不易大量生产。而由乳磷脂乳化豆油制成的脂肪乳剂却十分稳定,室温下能保存二年,在临床上可广泛用作高营养输液,其用量高达500ml 亦无副作用。脂肪乳剂中平均直径为0.2μ的乳粒,称之为脂质微球(Lipid micro-spheres)。

关键词：脂质微球地塞米松毫微脂粒氟甲去氢氢化可的松 PGE 角叉菜胶

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日本“地域活性化”战略促进农村振兴的实践--以农家餐馆为例

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现代日本经济 2020年第3期39卷 28-40页

作者：覃梦妮贾磊大友和佳子广西财经学院经济与贸易学院广西南宁530001 上海市农业科学院农业科技信息研究所上海201403 JA共济综合研究所农业·农村·JA调查研究部日本东京102-0093

以释放农业农村多种功能为契机,日本制定并实施"地域活性化"战略,力图挽救不断衰落的农村。"地域活性化"是以地域资源为基础,发挥农户的主体作用和创造力,培育特色产业,最终实现农业农村功能价值多样化并满足社会多元需求。农家餐馆是"... 详细信息

以释放农业农村多种功能为契机,日本制定并实施"地域活性化"战略,力图挽救不断衰落的农村。"地域活性化"是以地域资源为基础,发挥农户的主体作用和创造力,培育特色产业,最终实现农业农村功能价值多样化并满足社会多元需求。农家餐馆是"地域活性化"的实施手段之一。通过案例分析可知,农家餐馆源于农户对农村发展困境解决之道的思考,以餐馆为媒介推动农业与加工业、服务业、信息产业有机融合,并在经营中融入地方特色元素,逐步使农村成为人气兴旺、经济活跃、生态良好之地,获得振兴农村的良好效果。

关键词：地域活性化农家餐馆价值挖掘乡村振兴日本

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遗传背景和性别对ALs2缺失同族鼠的整体表现型的影响

遗传背景和性别对ALS2缺失同族鼠的整体表现型的影响

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中华医学会第十三次全国神经病学学术会议

作者：潘雷 shinji hadano yasuhiro yoshii asako otomo ryota kunita kyoko suzuki-utsunomiya shigeru kakuta yasuo iwasaki yoichiro iwakura joh-E.Ikeda 东海大学医学院东邦大学大森医院东京大学医学研究所加拿大渥太华东欧太利欧儿童医院

目的检查在ALs2(Amyotrophic lateral scleros s 2)缺失的同族鼠中,遗传背景与性别对整体表现型的影响.方法我们用不同种系的小鼠包括C57BL/6,FVB/N构建了ALs2缺失小鼠,然后观察其表现型的不同.

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