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世界核心医学期刊文摘(眼科学分册) 2006年第2期 61-61页

作者： Michaelides M Johnson s Bradshaw K. D.M. Hunt 白芳 Institute of Oph thalmology University College London 11- 43 Bath Street London EC1V 9EL Un ited Kingdom Dr.

Purpose: To perform a detailed clinical, psychophysical, and molecular assessment of members of 4 families with an unusual X-linked cone dysfunction syndrome associated with myopia. Participants: Affected and unaffected members of 4 British nonconsanguineous families. Methods: subjects underwent both detailed clinical examination and psychophysical testing. After informed consent was obtained, blood samples were taken for DNA extraction, and molecular genetic analysis was performed. The strategy for molecular analysis was to amplify the coding regions of the long and middle wavelength-sensitive cone opsin genes and the upstream locus control region by polymerase chain reaction and to examine these fragments for mutations by sequencing of DNA. Results: The phenotype was almost identical in all 4 families, consisting of moderate to high myopia, astigmatism, moderately reduced acuity, and normal fundi. electroretinography showed abnormal cone but normal rod responses. Psychophysical testing showed a selective impairment of long cones in combination with well-preserved middle cone and short cone function. There was no evidence to suggest that the phenotype was progressive. Molecular analysis of the X-linked opsin gene array in the 4 families indicated that affected males have inherited the same X-chromosome from their mother. In 2 families, a long/middle hybrid gene was detected. In a third family, the commonly described deleterious Cys203Arg amino acid substitution was identified in both the long and middle opsin genes. In the fourth family, the only abnormality was absence of a middle opsin exon 2; the cause of the protanopia in this family is uncertain. Conclusions: The Xlinked cone dysfunction syndrome associated with myopia and dichromacy described here has many similarities to Bornholm eye disease, a condition previously mapped to Xq28. Except for the Cys203Arg substitution in one family, no alterations in the opsin gene array were identified that could underlie t

关键词：视锥细胞红色盲近视屈光不正功能障碍综合征综合病症

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幽门螺杆菌在胰岛素抵抗中的效应

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世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 19-19页

作者： Aydemir s. Bayraktaroglu T. sert M. 赵天智 Zonguldak Karaelmas Universitesi Tip Fakültesi Ic. Hastaliklari ABD Gastroenteroloji BD 67800 Zonguldak TurkeyDr

Helicobacter pylori causes a lifelong infection in the stomach after exposure. H. pylori has been shown to be associated with peptic ulcer and gastric cancer development. Moreover, it is held responsible for some other nongastric diseases. Among them, coronary heart disease attracts much debate. Many studies have demonstrated a close relationship between insulin resistance and atherosclerosis. Chronic inflammation and alterations in counter-regulatory hormones are deemed responsible for the etiology of insulin resistance. We aimed to examine the effect of H. pylori on insulin resistance. sixty-three patients were enrolled in the study. Patients were divided into two groups according to H. pylori presence. HOMA-IR (homeostasis model assessment of insulin resistance) level was used to assess insülin resistance. Thirty-six patients were H. pylori positive and 27 were H. pylori negative. There was no difference between the two groups with regard to age, gender, or body mass index. HOMA-IR level was 1.73±.1.1inthe H. pylori-negative group, whereas it was 2.56 ±.1.54 in the H. pylori-positive group (P s study provides the first direct evidence for an association between chronic H. pylori infection and insulin resistance.

关键词：胰岛素抵抗消化性溃疡发病机制胃肠道疾病模式评估本项内稳态试验研究慢性炎症

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HBV感染与AFP相关性的研究

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实用医技杂志 2004年第11B期11卷 2359-2360页

作者：黄建宏欧兴义梁小兵黄琳林虹珠海市人民医院广东珠海519000

目的 :探讨乙肝各血清学模式中发生癌变的风险。方法 :应用 el IsA法对 5 6 0例 AFP介于 2 0 ng/ml～4 0 0 ng/m l的乙型肝炎患者及 5 3例有乙肝感染史的肝细胞癌患者 (AFP:4 2 0 ng/ml～ 10 92 ng/ml)进行了乙肝血清学指标测定。结果 ... 详细信息

目的 :探讨乙肝各血清学模式中发生癌变的风险。方法 :应用 el IsA法对 5 6 0例 AFP介于 2 0 ng/ml～4 0 0 ng/m l的乙型肝炎患者及 5 3例有乙肝感染史的肝细胞癌患者 (AFP:4 2 0 ng/ml～ 10 92 ng/ml)进行了乙肝血清学指标测定。结果 :乙肝血清学指标各模式间存在相当大的差异 ,5 6 0例乙肝患者中 M1[HBs Ag(+)、HBe Ag(+)、HBc Ag(+) ]模式占 2 4 .1% ,M2 [HBs Ag(+)、HBe Ab(+)、HBc Ab(+) ]模式占 4 6 .4 % ,M3[HBs Ab(+)、HBe Ab(+)、HBc Ab(+) ]模式占 7.0 % ,M4 [HBe Ab(+)、HBc Ab(+) ]模式占 2 2 .3% ;5 3例肝细胞癌患者中 M1[HBs Ag(+)、HBe Ag(+)、HBc Ab(+) ]模式占 2 2 .6 % ,M2 [HBs Ag(+)、HBe Ab (+)、HBc Ab(+) ]模式占 4 1.5 % ,M3[HBs Ab(+)、HBe Ab(+)、HBc Ab(+) ]模式占 9.4 % ,M4 [HBe Ab(+)、HBc Ab(+) ]模式占 2 6 .4 %。结论 :乙肝各种模式 AFP的增高有高度相关性。

关键词： AFP HBV 相关性

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Biological Corridors as a Connectivity Tool in the Region of the Great American Chaco:Identification of Biodiversity Hotspots in the Ecoregions of the Paraguayan Chaco

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Research in Ecology 2020年第1期2卷 27-36页

作者： María Fátima Mereles Gloria Céspedes JoséLuís Cartes Rosalía Goerzen JuanaDe Egea-elsam Laura Rodríguez Alberto Yanosky Laura Villalba Andrea Weiler Pier Cacciali Centro para el Desarrollo de la Investigación Científica(CEDIC) Asunción-Paraguay y Programa Nacional de Incentivo a Investigadores(PRONII-CONACYT) Asociación Etnobotánica Paraguaya(AEPY) San Lorenzo-Paraguay y Programa Nacional de Incentivo a Investigadores(PRONII-CONACYT) Asociación Guyra-Paraguay y Programa Nacional de Incentivo a Investigadores(PRONII-CONACYT) Cooperativa Fernheim FiladelfiaChaco Fundación Moisés Bertoni Universidad Nacional de Asunción Facultad de Ciencias Exactas y NaturalesDirección de Biología

This work presents the main biodiversity hotspots existing in the Paraguayan Chaco and is an update of the results obtained in the first Ecoregional Assessment of the Great American *** are the results of a series of workshops that included scientific and technical discussions carried out by local experts in zoology,botany,forestry,soil science,and hydrogeology applying a biodiversity vision of 25-30 years for the territory,after overlapping the maps of the first assessment with that of the advance of the changes of land use in the *** for detecting biodiversity hotspots were discussed,including:permanent and temporary watercourses,other bodies of water such as fresh and salty lagoons,reserve areas of different categories,as well as important bird areas(IBAs),RAMsAR areas and others,which must be connected in the future,combining the production areas with the conservation of biodiversity.

关键词： Conservation Fauna Flora Endemic species sustainable use

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低浓度HBsAg感染者乙肝5项标志物测定意义

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实用医技杂志 2002年第5期9卷 333-334页

作者：施根林何海明林国英武警江苏总队医院江苏扬州225003

目的 :观察低浓度 HBs Ag感染者乙肝 5项标志物的模式特征。方法 :采用 el IsA法测定了 38例 HBs Ag浓度在5μg/ L以下血清中乙肝病毒表面抗体 (抗 - HBs)、乙肝病毒核心抗体 (抗 - HBc)、乙肝病毒 e抗原及其抗体 (HBe Ag、抗 - HBe)。... 详细信息

目的 :观察低浓度 HBs Ag感染者乙肝 5项标志物的模式特征。方法 :采用 el IsA法测定了 38例 HBs Ag浓度在5μg/ L以下血清中乙肝病毒表面抗体 (抗 - HBs)、乙肝病毒核心抗体 (抗 - HBc)、乙肝病毒 e抗原及其抗体 (HBe Ag、抗 - HBe)。结果 :低浓度 HBs Ag感染者血清 5项 HBV标志有 8种表现模式 ,以“HBs Ag、抗 - HBc、抗 - HBe阳性 ,抗 - HBs、HBe Ag阴性”模式为主(6 5 .79% ) ,其次为“HBs Ag、抗 - HBc、HBe Ag阳性 ,抗 - HBs、抗 - HBe阴性”和“HBs Ag、抗 - HBc阳性 ,抗 - HBs、HBe Ag、抗 - HBe阴性”模式 (分别为 10 .5 3%和 7.89% ) ,HBs Ag和抗 - HBc同时阳性者 92 .11%。结论 :低浓度 HBs Ag感染者具有特殊的流行病学特点 ,提高 HBs Ag测定灵敏度具有重要意义。

关键词：乙型肝炎病毒乙型肝炎表面抗原浓度测定

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Open-Gate Undoped-AIGaN-GaN HEMT structure for pH sensing Application

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材料科学与工程（中英文版） 2010年第7期4卷 1-6页

作者： sharifabad Maneea Eizadi Zainal Abidin Mastura shafinaz Mustafa Farahiyah Hashim abdul Manaf abd Rahman shaharin Fadzli abdul Rahman abdul Rahim Qindeel Rabia Omar Nurul Afzan Material Innovations and Nanoelectronics Research Group Faculty of Electrical Engineering Universiti Teknologi Malaysia Skudai 81310 Johor Malaysia Department of Physics Faculty of Science Universiti Teknologi Malaysia Skudai 81310 Johor Malaysia Telekom Research and Development TM Innovation Centre Cyberjaya 63000 Malaysia

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氧化剂和抗氧化剂在组织水平上对泛发性白癜风的作用

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 30-30页

作者： Yildirim M. Baysal V. Inaloz H.s. 马慧群 suleyman Demirel Unive rsitesi Tip Fakultesi Dematoloji Anabilim Dali 32100 Isparta Turkey

Background. The role of oxidative stress has not been fully understood in the aetiopathogenesis of vitiligo in different studies. Aim. We aimed to investigat e the role of the oxidative stress in the pathogenesis of vitiligo. Methods. In this study, we examined levels of superoxide dismutase, glutathione peroxidase, malondialdehyde and nitric oxide in tissue of 25 patients with generalized vitil igo and 25 healthy controls. Results. Our results revealed that levels of supero xide dismutase, glutathione peroxidase and malondialdehyde in tissue were signif icantly increased in patientswith generalized vitiligo (P s no statistically significantly difference between two groups at tissue lev el of nitric oxide (P > 0.05). Conclusion. Our results demonstrate the presence of an imbalance in the oxidant-antioxidant system in vitiligo at tissue level and provide further support for a free radical-mediated damage as an initial p athogenic event in melanocyte degeneration in vitiligo.

关键词：泛发性组织水平一氧化氮水平丙二醛水平氧化应激黑色素细胞氧化-抗氧化超氧化歧化酶发病机制

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无线胶囊内窥镜在社区胃肠疾病检查中的应用

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世界核心医学期刊文摘（胃肠病学分册） 2005年第7期1卷 42-42页

作者： Napierkowski J.J. Maydonovitch C.L. Belle L.s. 樊菁 78 Mahealani Pl. Kailua HI 96734 United States Dr.

Goals: This study was performed to evaluate the use of wireless capsule endos copy in a community gastroenterology practice. Background: Experience with wirel ess capsule endoscopy at referral centers has been reported, but little has been reported about community gastroenterologists’ experience. study: A retrospect ive review of charts and wireless capsule endoscopies performed at a community h ospital was performed. Results: A total of 99 wireless capsule endoscopies were reviewed and complete data were available in 72 cases. Indications included susp ected obscure GI bleeding in 97% of cases; 55% of patients were taking anti - platelet or anti- coagulant medications; 71% of examinations were complete . Pathologic findings included angioectasias (36% ), gastritis/erosions (21% ) , bleeding (18% ), small bowel ulcers (16% ), duodenitis (7% ), and small bow el erosions (6% ). strictures, Crohn’ s disease, and tumors were each seen in 3% . There were no abnormal findings in 37% . One complication, nonnatural exc retion of the capsule, caused a transient bowel obstruction but passed without e ndoscopic intervention or surgery. Conclusions: In a community- based gastroent erology setting, wireless capsule endoscopy is a safe tool that shows abnormalit ies in a significant proportion of exams.

关键词：胶囊内窥镜胃肠疾病十二指肠炎小肠溃疡医生经验病理发现血管扩张克罗恩病抗凝药物

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Phase Ⅱ trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/CDKN2A

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signal Transduction and Targeted Therapy 2023年第11期8卷 5518-5527页

作者： Javier Martin-Broto Jeronimo Martinez-Garcia David sMoura Andres Redondo Antonio Gutierrez Antonio Lopez-Pousa Javier Martinez-Trufero Isabel sevilla Roberto Diaz-Beveridge Maria Pilar solis-Hernandez Amancio Carnero Marco Perez David Marcilla Jesus Garcia-Foncillas Pablo Romero Javier Fernandez-Jara Daniel Lopez-Lopez Ivan Arribas Nadia Hindi Health Research Institute-Fundación Jiménez Díaz University Hospital Universidad Autónoma de Madrid(IIS-FJDUAM)28040MadridSpain Medical Oncology Department Fundación Jimenez Diaz University Hospital28040MadridSpain General de Villalba University Hospital 28400MadridSpain Medical Oncology Department University Hospital Virgen de la Arrixaca30120MurciaSpain Department of Medical Oncology Hospital Universitario La Paz-IdiPAZP.Castellana26128046MadridSpain Hematology Department University Hospital Son Espases07120MallorcaSpain Medical Oncology Department Sant Pau Hospital08025BarcelonaSpain Medical Oncology Department University Hospital Miguel Servet50009ZaragozaSpain Investigación Clínica y Traslacional en Cáncer/Instituto de Investigaciones Biomédicas de Malaga(IBIMA)/Hospitales Universitarios Regional y Virgen de la Victoria de Malaga MalagaSpain Medical Oncology Department Hospital Universitari i Politècnic La Fe46026ValenciaSpain Medical Oncology Department Central University Hospital of Asturias33011OviedoSpain Instituto de Biomedicina de sevilla(IBis HUVRCSICUS)41013SevillaSpain Pathology Department Virgen del Rocio University Hospital41013SevillaSpain Radiology Department Fundación Jimenez Diaz University Hospital28040MadridSpain Computational Medicine Platform Fundación progreso y salud(FPS)Hospital Virgen del Rocío41013SevilleSpain Bioinformatics in Rare Diseases(BiER).Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER) FPSHospital Virgen del RocioSevillaSpain Universitat de València-ERI-CEs 46010ValenciaSpain

Cyclin-dependent kinases 4 and 6(CDK4/6)inhibitors demonstrated activity in terms of progression-free survival(PFs)in advanced dedifferentiated liposarcoma(DD-LPs),a sarcoma with CDK4 ***4 overexpression is by far more common than amplification in sarcomas and it might be a rational target for CDK *** investigators of this study found that CDK4 overexpression,while not of CDKN2A,was the most consistent predictive factor for palbociclib efficacy in *** adult-type soft-tissue sarcoma,excluding DD-LPs,or bone sarcoma patients,progressing after at least one systemic line,whose tumors overexpressed CDK4,but not CDKN2A at baseline biopsy,were accrued in this single-arm phase II trial(EudraCT number:2016-004039-19).With the main endpoint of a 6-month PFs rate,40%was considered promising in this *** was administered orally at 125 mg/day for 21 days in 28-day cycles.A total of 214 patients with 236 CDK4/CDKN2A determinations were assessed for prescreening,archival material(141),and screening,baseline biopsy(95).There were 28(29%)with favorable mRNA profiles from 95 screened patients at *** 23 enrolled patients,21 evaluable,the 6-month PFs rate was 29%(95%CI 9–48),and there were 6 patients out of 21 with a PFs longer than 6 *** median PFs and overall survival were 4.2(95%CI 3.6–4.8)and 12(95%CI 8.7–15.4)months,*** research showed a significant correlation between CDK4 mRNA and protein *** was active in a variety of sarcoma subtypes,selected by CDK4/CDKN2A,and deserves further investigation in the sarcoma context.

关键词： CDKN2A sarcoma CDK4

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围体外循环期红细胞膜表面补体C3b受体和血清磷脂酶A2等变化的临床意义

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山西医药杂志 2001年第5期30卷 379-381页

作者：张鸿毅王代全郭志宏陈瑞程燕生山西省儿童医院胸心外科 030013 山西省儿童医院麻醉科 030013

目的　观察先天性心脏病患儿围体外循环期血清 RBC- CR1 和 s PL A2 的动态变化及其意义。方法　随机选择 2 0例患儿按 7个时点 ,用 el IsA等方法测 RBC- CR1 表达量的吸光度 ( A)值 ,s PL A2 和 GsH - Px酶活性及 RBC- GsH含量。结果　... 详细信息

目的　观察先天性心脏病患儿围体外循环期血清 RBC- CR1 和 s PL A2 的动态变化及其意义。方法　随机选择 2 0例患儿按 7个时点 ,用 el IsA等方法测 RBC- CR1 表达量的吸光度 ( A)值 ,s PL A2 和 GsH - Px酶活性及 RBC- GsH含量。结果　 RBC- CR1 表达量在各检测时点均显著下降 ;从升主动脉阻断前 5 m in至术后 2 4 hs PL A2 显著上升 ;从开放升主动脉后 5 m in至术后 2 4 h GsH- Px显著下降 ,而 RBC- GsH含量各时点值与术前相比无统计学意义。 RBC- CR1 的 A值与 s PL A2 呈负相关 ,RBC- CR的 A值与 GsH - Px呈显著正相关。

关键词：体外循环 C3b受体磷脂酶A2 谷胱甘肽过氧化物酶红细胞谷胱甘肽

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