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Analysis of hydro-mechanical processes in a ventilated tunnel in an argillaceous rock on the basis of different modelling approaches

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 1-17页

作者： B.Garitte A.Bond A.Millard C.Zhang C.Mcdermott s.nakama A.Gens Universidad Politécnica de Catalunya Quintessa WarringtonUK Commissariat à l'Energie Atomique Gif-sur-Yvette France Chinese Academy of sciences ECOssE University of Edinburgh Japan Atomic Energy Agency

In this paper, a modelling benchmark exercise from the DECOVALEX-2011 project is presented. The bench- mark is based on the performance and results of a laboratory drying test and of the ventilation experiment （VE） carried out in the Mont Terri Underground Rock Laboratory （URL）. Both tests involve Opalinus clay. The work aims at the identification, understanding and quantification of mechanisms taking place during the ventilation of a gallery in argillaceous host rocks on one hand and at investigating the capacity of different codes and individuals to reproduce these processes on the other hand. The 4-year in situ VE took place in a 1.3 m diameter unlined tunnel and included two resaturation-desaturation cycles. The test area was equipped with over one hundred sensors （including the global water mass balance of the system, relative humidity （RH）, water content, liquid pressure, relative displacement and concentration of some chemical species） to monitor the rock behaviour during ventilation. The laboratory drying experiment, carried out before the VE, was designed to mimic the in situ conditions. The work was organized in a progressive manner in terms of complexity of the computations to be performed, geared towards the full hydro-mechano-chemical （HMC） understanding of the VE, the final objective. The main results from the modelling work reported herein are that the response of the host rock to ventilation in argillaceous rocks is mainly governed by hydraulic processes （advective Darcy flow and non-advective vapour diffu- sion） and that the hydro-mechanical （TM） back coupling is weak. A ventilation experiment may thus be regarded as a large scale-long time pump test and it is used to determine the hydraulic conductivity of the rock mass.

关键词： Hydro-mechanical (HM) couplingNumerical modellingMont Terri Underground Rock Laboratory(URL)Ventilation experiment (VE)ArgilliteWater permeability

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Numerical modeling for the coupled thermo-mechanical processes and spalling phenomena in sp Pillar stability Experiment (APsE)

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 58-72页

作者： T.Koyama M.Chijimatsu H.shimizu s.nakama T.Fujita A.Kobayashi Y.Ohnishi Department of Urban Management Kyoto University Hazama Corporation Institute of Fluid science Tohoku University Japan Atomic Energy Agency (JAEA) Faculty of Environmental and Urban Engineering Kansai University Kyoto University

In this paper, the coupled thermo-mechanical （TM） processes in the AEspoe Pillar stability Experiment （APsE） carried out by the swedish Nuclear Fuel and Waste Management Company （sKB） were simulated using both continuum and discontinuum based numerical methods. Two-dimensional （2D） and three- dimensional （3D） finite element method （FEM） and 2D distinct element method （DEM） with particles were used. The main objective for the large scale in situ experiment is to investigate the yielding strength of crystalline rock and the formation of the excavation disturbed/damaged zone （EDZ） during excavation of two boreholes, pressurizing of one of the boreholes and heating. For the DEM simulations, the heat flow algorithm was newly introduced into the original code. The calculated stress, displacement and temperature distributions were compared with the ones obtained from in situ measurements and FEM simulations. A parametric study for initial microcracks was also performed to reproduce the spalling phenomena observed in the APsE.

关键词： Coupled thermo-mechanical (TM)processesAspoe Pillar stability Experiment (APsE)Excavation disturbed/damaged zone (EDZ)Finite element method (FEM)Distinct element method (DEM)

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Accounting for anisotropic effects in the prediction of the hydro-mechanical response of a ventilated tunnel in an argillaceous rock

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第2期5卷 97-109页

作者： Alain Millard Alex Bond s.igeo nakama Chengyuan Zhang Jean-Dominique Barnichon Benoit Garitte Commissariatà l'Energie Atomique et aux Energies Alternatives Gif-sur-Yvette France Quintessa Ltd. Chadwick House Birchwood Park Warrington Cheshire WA3 6AE UK Japan Atomic Energy Agency Tokai Japan Insititute of Rock and soil Mechanics Chinese Academy of Sciences Institute for Nuclear Radioprotection and safety Fontenay-aux-roses France Universidad Politécnica de Catalunya Barcelona Spain

In order to investigate the hydro-mechanical （HM） and chemical perturbations induced in an argillaceous formation by forced ventilation during the operational period of a nuclear waste repository, a specific experiment has been performed in a tunnel, at Mont Terri Underground Research Laboratory （URL） in switzerland. This experiment has been selected in the international project DECOVALEX for model vali- dation and the numerical simulation of this ventilation experiment （VE） is the object of the present paper. since the argillaceous rock exhibits anisotropic properties, particular attention is given to the evaluation of the effects of various anisotropic features on the predicted results. In situ measurements such as relative humidity （RH）, global water mass extracted, pore water pressure, water content, and relative displace- ments are compared to predictions using both isotropic and anisotropic parameters. Water permeability anisotropy is shown to be the most influencing parameter by far, whereas in situ stress anisotropy has an effect only during the excavation phase. The anisotropy for mechanical parameterization has also some influence, in particular through HM couplings. These HM couplings have the potential to be very significant in terms of providing confidence in describing the experimental observation, and should be considered for further investigation.

关键词： Hydro-mechanical (HM) coupling Numerical modelling Anisotropy Mont Terri Underground Research Laboratory (URL) Ventilation experiment (VE) Argillite

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Reactive and non-reactive transport modelling in partially water saturated argillaceous porous media around the ventilation experiment,Mont Terri

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Journal of Rock Mechanics and Geotechnical Engineering 2013年第1期5卷 44-57页

作者： Alexander Bond steven Benbow James Wilson Alain Millard s.igeo nakama Myles English Christopher McDermott Benoit Garitte Quintessa Ltd. Chadwick House Birchwood Park Warrington Cheshire WA3 6AE UK Commissariat à l'Energie Atomique Japan Atomic Energy Agency (JAEA) University of Edinburgh Universidad Politécnica de Catalunya

At Mont Terri Underground Research Laboratory （URL） switzerland, a specific experiment has been per- formed in a tunnel, in order to investigate the hydro-mechano-chemical （HMC） perturbations induced in the argillaceous formation by forced ventilation. This experiment has been selected in the international project DECOVALEX to be used for process model development and validation. The numerical simula- tion of the geochemical response to the ventilation experiment （VE） is the object of the present paper, focusing on the transport of chloride as a conservative species and sulphate as a reactive species. Uti- lising the validated hydro-mechanical （HM） results from earlier steps of the DECOVALEX task, reactive and non-reactive transport models, incorporating the current understanding of the geochemistry at the site, were successfully constructed for the whole experimental period. The associated parametric and process uncertainty analyses clearly demonstrate that the basic HM understanding must be sound. How- ever, to demonstrate this degree of robustness, the explicit inclusion of process representations of water desaturation, liquid vaporisation, species exclusion porosity, and redox processes, is required.

关键词： Reactive transportHydro-mechanical (HM) couplingNumerical modellingMont Terri Underground ResearchLaboratory (URL)Ventilation experiment (VE)ArgilliteChloridesulphate

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Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

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Neural Regeneration Research 2021年第4期16卷 780-786页

作者： Maria Eduarda Ziani Gutierrez Anne suély Pinto savall Edina da Luz Abreu Kelly Ayumi nakama Renata Bem Dos santos Marina Costa Monteiro Guedes Daiana silvaÁvila Cristiane Luchese sandra Elisa Haas Caroline Brandão Quines simone Pinton Postgraduation Program in Biochemistry Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Pharmaceutical science Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Biochemistry and Bioprospecting Federal University of Pelotas(UFPEL)Capão do LeãoRSBrazil

Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s ***,there is data suggesting that inflammation plays a role in its development and ***,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease *** purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in *** were prepared by the nanoprecipitation *** swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in *** the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in ***,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition ***,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 *** study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 *** study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(app

关键词： Alzheimer’s disease curcumin cyclooxygenase-2 lipid core nanocapsules meloxicam memory rats inflammation

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A case report:Bilateral atraumatic proximal tibiofibular joint osteoarthritis

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Case Reports in Clinical Medicine 2013年第4期2卷 267-271页

作者： Gilberto Yoshinobu nakama Guilherme C.Gracitelli Alberto de Castro Pochini Caio Augusto de souza Nery Mario Carneiro Filho Knee surgery and Arthroscopy Group Federal University of Sao PauloSao PauloBrazil Department of Orthopedics and Traumatology Federal University of Sao PauloSao PauloBrazil

Introduction: Proximal tibiofibular joint osteoarthritis is a rare disease most commonly occurring in the presence of either systemic inflammatory conditions or severe knee osteoarthritis. Case Presentation: The authors present a case report of isolated bilateral tibiofibular arthrosis in an otherwise healthy 28-year-old female patient. The patient presented with complaints of lateral knee pain. Radiographs and magnetic resonance imaging (MRI) revealed bilateral tibiofibular joint osteoarthritis. Trauma, repetitive use injury, and rheumatologic causes were excluded. The patient’s pain was initially managed conservatively, but she subsequently underwent tibiofibular arthrodesis for progressive pain symptoms. We review in this report the current literature on tibiofibular joint osteoarthritis and its treatment. Conclusion: Isolated tibiofibular joint osteoarthritis is a rare condition that may progress and requires surgical treatment to achieve optimal clinical outcomes.

关键词： Proximal Tibiofibular Joint Osteoarthritis Arthrodesis

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Genetic diseases conferring resistance to infectious diseases

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Genes & Diseases 2015年第3期2卷 247-254页

作者： Isabelle C.Withrock stephen J.Anderson Matthew A.Jefferson Garrett R.McCormack Gregory s.A.Mlynarczyk Aron nakama Jennifer K.Lange Carrie A.Berg sreemoyee Acharya Matthew L.stock Melissa s.Lind K.C.Luna Naveen C.Kondru sireesha Manne Bhavika B.Patel Bierlein Mde la Rosa Kuei-Pin Huang shaunik sharma Hilary Z.Hu sri Harsha Kanuri steve A.Carlson Department of Biomedical sciences Iowa State University College of Veterinary MedicineAmesIA 50011USA Department of Psychology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Kinesiology Iowa State University College of Liberal Arts and SciencesAmesIA 50011USA Department of Genetics Developmental and Cell BiologyIowa State University College of Liberal Arts and SciencesAmesIA 50011USA Neuroscience Interdepartmental Program Iowa State UniversityAmesIA 50011USA

This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious *** short,we explore a number of genetic conditions,which carry some benefits in adverse circumstances including exposure to infectious *** examples discussed are conditions known to result in resistance to a specific infectious disease,or have been proposed as being associated with resistance to various infectious *** infectious diseasedgenetic disorder pairings include malaria and hemoglobinopathies,cholera and cystic fibrosis,tuberculosis and Tay-sachs disease,mycotic abortions and phenylketonuria,infection by enveloped viruses and disorders of glycosylation,infection by filoviruses and NiemannePick C1 disease,as well as rabies and myasthenia *** also discuss two genetic conditions that lead to infectious disease hypersusceptibility,although we did not cover the large number of immunologic defects leading to infectious disease *** of the resistance-associated pairings(malaria/hemogloginopathies,cholera/cystic fibrosis,tuberculosis/Tay-sachs,and mycotic abortions/phenylketonuria)appear to be a result of selection pressures in geographic regions in which the specific infectious agent is *** other pairings do not appear to be based on selection pressure and instead may be ***,research investigating these relationships may lead to treatment options for the aforementioned diseases by exploiting established mechanisms between genetically affected cells and infectious *** may prove invaluable as a starting point for research in the case of diseases that currently have no reliably curative treatments,e.g.,HIV,rabies,and Ebola.

关键词： Disease Infectious Pathogen Polymorphism Resistance susceptibility

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梅兰芳赴日公演之时日本知识界的反应

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戏剧艺术 2015年第2期 53-63页

作者：仲万美子郭艳平平林宣和日本同志社女子大学武汉大学哲学学院不详

大正年间梅兰芳访日公演之所以取得成功,日本的"文化翻译者"借助于传媒的广泛传播起到了非常重要的作用。这些"文化翻译者"依托他们自身的学识素养,促进了异文化之间的理解与接受,一定程度上避免了普通日本观众对中国京剧产生的种种"误... 详细信息

大正年间梅兰芳访日公演之所以取得成功,日本的"文化翻译者"借助于传媒的广泛传播起到了非常重要的作用。这些"文化翻译者"依托他们自身的学识素养,促进了异文化之间的理解与接受,一定程度上避免了普通日本观众对中国京剧产生的种种"误解"。

关键词：梅兰芳京剧文化翻译者

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HIV和甲基苯丙胺滥用对大脑损伤的独立和联合影响

HIV和甲基苯丙胺滥用对大脑损伤的独立和联合影响

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第十届全国药物依赖性学术会议暨首届中美药物滥用和HIV/HCV共病专题研讨会

作者： J.Panee A.Yanagihara M.Ricardo-Dukelow Buchthal s H.nakama M.Berry T.Ernst Department of Cell & Molecular Biology John A.Burns School of Medicine Bekesy Lab Pacific Biosciences Research CenterUniversity of Hawaii at ManoaHonolulu Hawaii96821 Department of Medicine John A.Burns School of Medicine Department of Psychiatry John A.Burns School of Medicine

Oxidative stress may be involved in neuronal injury in HIV patients with or without history of methamphetamine (METH) *** glutathione (GsH),an antioxidant,were shown to be decreased in HIV,as well as in postmortem bra... 详细信息

关键词： HIV methamphetamine abuse brain injury

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