检索结果-南通市图书馆

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang Jun ke Feng Chen shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The second Department of intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resus.itation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,pos.ibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells.into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells.inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expres.ion of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resus.itation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Merging bound states.in the continuum in an open acous.ic resonator

在线全文

学校读者我要写书评

暂无评论

s.ience China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 124-131页

作者： Lujun huang Bin Jia Artem s.Pilipchuk sibo huang Chen shen Almas F.sadreev Yong Li Andrey E.Miroshnichenko school of Physics and Electronic s.iences East China Normal University ins.itute of Acous.ics Tongji University L.V.Kirensky ins.itute of Physics Department of Mechanical Engineering Rowan University school of Engineering and Technology University of New South Wales at Canberra

Bound states.in the continuum （BiCs） are perfectly localized resonances des.ite embedding in the continuum ***,an isolated BiC is very sensitive to the structure ***,we report merging acous.ic BiCs.in a single open resonator,robust against the structure *** find that both symmetry-protected BiC and Friedrich-Wintgen BiC are sustained in a single coupled waveguide-resonator *** varying the height and length of the resonator,these two BiCs move toward each other and merge into a single one at a critical *** to an individual BiC,the merged BiC is robust against fabrication error because its Q-factor is proportional to ΔL-4,whereΔL embodies the structure *** essence of this extraordinary phenomenon is perfectly explained by the two-and three-level approximations of the effective nonHermitian ***,we present direct experimental demonstrations of the moving and merging of BiCs.in a coupled 3D waveguide-resonator,which are evidenced by the vanis.ing of the linewidth of Fano resonance in the trans.is.ion *** results may find exciting applications.in designing high-quality acous.ic sources,sensors and filters.

关键词： acous.ic resonances bound state in the continuum high-Q resonances

Role of nutrition in diabetes mellitus and infections

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao huang Xin-Yue Li Ming-ke Wang Ji-shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

in this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates.immune *** deficiencies augment the risk of infection,but the relations.ip with diabetes.is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus infection Macronutrients Vitamins Minerals

A general stabilizing strategy based on vitamin C for n-type organic semiconductors

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

s.ience China Materials 2025年第01期 303-304页

作者： Hui huang College of Materials s.ience and Opto-Electronic Technology Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Organic semiconductors (OsCs), as an emerging next-generation semiconductor material, hold promising prospects.in fields such as flexible displays, electronic s.ins, smart healthcare,and the internet of Things, due to their excellent flexibility,solution processability, and tunable band structures [1,2]. These molecules are often clas.ified into n-type and p-type, depending on whether the prevalent charge carriers are electrons or holes[3].

关键词：

同方期刊数据库

Efficient white-light-emitting lead-free halide double perovs.ites enabling full-spectrum pc-WLEDs

在线全文

学校读者我要写书评

暂无评论

s.ience China Materials 2025年第1期 305-306页

作者： Xiaoyong huang College of Physics and Optoelectronics Taiyuan University of Technology

With the rapid development of solid-state lighting, an important goal of phosphor-converted white light-emitting diodes (pc-WLEDs) is to provide a healthy and comfortable fullspectrum artificial light source with a co...

关键词：

同方期刊数据库

Quickly obtaining densely dispersed coherent particles.in steel matrix and its related mechanical property

在线全文

学校读者我要写书评

暂无评论

international Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang school of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally clas.ified into the liquid-solid route and the solid-solid ***,the formation of DCN structures.in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compres.ion test work hardening

Neuropeptide cholecystokinin:a key neuromodulator for hippocampal functions

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1991-1992页

作者： Fengwen huang stephen Temitayo Bello Department of Neuros.ience City University of Hong KongKowloon TongHong Kong Special Administrative RegionChina Center for Regenerative Medicine and Health Hong Kong Institute of Science&InnovationChinese Academy of SciencesHong Kong Special Administrative RegionChina

spatial memory is crucial for survival within external surroundings and wild *** hippocampus,a critical hub for spatial learning and memory formation,has received extensive inves.igations on how neuromodulators shape its functions(Teixeira et al.,2018;Zhang et al.,2024).However,the landscape of neuromodulations.in the hippocampal system remains poorly understood because most studies focus on clas.ical monoamine neuromodulators,such as acetylcholine,serotonin,dopamine,and *** neuropeptides,comprising the most abundant neuromodulators.in the central nervous system,play a pivotal role in neural information proces.ing in the hippocampal ***(CCK),one of the most abundant neuropeptides,has been implicated in regulating various physiological and neurobiological statuses(Chen et al.,2019).CCK-A receptor(CCK-AR)and CCK-B receptors(CCK-BR)are two key receptors mediating the biological functions of CCK,both of which belong to class-A sevenfold transmembrane G protein-coupled receptors(Nis.imura et al.,2015).CCK-AR preferentially reacts to sulfated CCK,whereas CCK-BR binds both CCK and gastrin with similar affinities(Ding et al.,2022).The expres.ion patterns of CCK-AR and CCK-BR are dis.inct,implying that CCK has various functions.in target *** instance,CCK-AR is widely expressed in the Gi and brain subregions and is hence implicated in the control of diges.ive function and satiety ***,CCK-BR is abundantly and widely distributed in the central nervous system,which majorly regulates anxiety,learning,and memory(Ding et al.,2022).However,the roles of endogenous CCK and CCK receptors.in regulating hippocampal function at electrophysiological and behavioral levels have received less attention.

关键词： abundant functions modulator

The role of axon guidance molecules.in the pathogenesis of epilepsy

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan Hao huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progres.ion of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules.is associated with epilepsy susceptibility. in this review, we discuss the essential role of axon guidance molecules.in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plas.icity and brain tissue remodeling. Furthermore, we examine the relations.ip between axon guidance molecules and neuroinflammation, as well as the structural changes.in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations.in their expres.ion or function can disrupt neuronal connections, ultimately leading to epileptic s.izures. The remodeling of neural networks.is a significant characteris.ic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. inflammatory signals can regulate the expres.ion and function of axon guidance molecules, thus.influencing axonal growth, axon orientation, and synaptic plas.icity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves.into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plas.icity neurons synaptic remodeling

Glucocorticoid receptor signaling in the brain and its.involvement in cognitive function

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin su Taiqi huang Meiyu Zhang Yanyu Zhang Yan Zeng Xingxing Chen Brain s.ience and Advanced Technology ins.itute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids.in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes.including glutamate neurotrans.is.ion,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expres.ion and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expres.ion can improve cognitive function,while exces.ive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depres.ion,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate trans.is.ion hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplas.icity stress