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in situ direct reprogramming of astrocytes to neurons via polypyrimidine tract-binding protein 1 knockdown in a mouse model of ischemic stroke

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Neural Regeneration Research 2024年第10期19卷 2240-2248页

作者： Meng Yuan Yao Tang Tianwen huang Lining ke En huang key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Human Anatomy School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina s.ientific Research Center School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurology Fujian Medical University Union HospitalFuzhouFujian ProvinceChina Fujian key Laboratory of Vascular Aging Fujian Medical UniversityFuzhouFujian ProvinceChina

in situ direct reprogramming technology can directly convert endogenous glial cells.into functional neurons.in vivo for central nervous system repair. Polypyrimidine tract-binding protein 1(PTB) knockdown has been shown to reprogram astrocytes to functional neurons.in situ. in this study, we used AAV-PHP.e B-GFAP-sh PTB to knockdown PTB in a mouse model of ischemic stroke induced by endothelin-1, and inves.igated the effects of GFAP-sh PTB-mediated direct reprogramming to neurons. Our results showed that in the mouse model of ischemic stroke, PTB knockdown effectively reprogrammed GFAP-positive cells to neurons.in ischemic foci, restored neural tissue structure, reduced inflammatory response, and improved behavioral function. These findings validate the effectiveness of in situ trans.ifferentiation of astrocytes, and suggest that the approach may be a promising strategy for stroke treatment.

关键词： astrocyte in situ direct reprogramming ischemic stroke miR-30 based shRNA neuron polypyrimidine tract-binding protein 1 trans.ifferentiation

Base-controlled NHC-Ru-catalyzed transfer hydrogenation andα-methylation/transfer hydrogenation of ketones using methanol

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Chinese Chemical Letters 2024年第7期35卷 276-280页

作者： Ming huang Xiuju Cai Yan Liu Zhuofeng ke school of pharmacy School of clinical pharmacyGuangdong Pharmaceutical UniversityGuangzhou 510006China school of Materials s.ience&Engineering PCFM LabSchool of ChemistrySun Yat-sen UniversityGuangzhou 510275China school of Chemical Engineering and Light industry Guangdong University of TechnologyGuangzhou 510006China

Herein,we report the NHC-Ru catalyst system that realizes the chemo-selective transformation of ketones with *** simply changing the base,a broad range of structurally diverse ketones,could be selectively and efficiently converted to the correspondingβ-methylated secondary alcohols or secondary ***,this catalytic system was very effective for the synthesis of bio-related molecules and deuterated alcohols,as well as the three-component coupling between methyl ketones,primary alcohols,and *** reaction mechanism was further revealed by experiment and DFT mechanis.ic inves.igations.

关键词： Ru complexes Methanol ketones β-Methylated secondary alcohols Transfer hydrogenation

High-frequency magnetic properties of biphase Ce_(2)Fe_(17)N_(3)/α-Fe microflakes with easy-plane anisotropy

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Journal of Rare Earths 2024年第1期42卷 110-115,I0004页

作者： ke Wang Hang Zhang Yuandong huang Zhibiao Xu Fashen Li Tao Wang key Laboratory for Magnetism and Magnetic Materials of MOE Lanzhou UniversityLanzhou730000China key Laboratory of special Function Materials and structure Design Ministry of EducationLanzhou UniversityLanzhou730000China

soft magnetic composites(sMCs)are effective as magnetic powder cores.in an *** to high saturation magnetization,large magnetocrystalline anisotropy and high operating frequency of M(metal)-RE(rear earth)soft magnetic composites.it is pos.ible to miniaturize inductor cores by reducing total loss,especially eddy current loss and excess loss at high *** this article,the characteris.ics of Ce_(2)Fe_(17)N_(3)/α-Fe(CFN/F)loss per volume and effective permeability reaching a high frequency of 3 MHz are *** biphase CFN/F composite exhibits a high permeability of 16 at 70 MHz,which is two times greater than that of pure Ce_(2)Fe_(17)N_(3)(CFN)*** total loss.is as low as 545 mW/cm^(3)at 3 MHz and 6 *** direct current(DC)-bias properties have a percent of permeability exceeding 65% at H=7960 A/*** phenomenon indicates that our material has a higher working frequency and lower core loss than other materials;the biphase CFN/F structure is a promising and efficient approach for developing the miniaturized radio frequency(RF)inductor core.

关键词： High frequency soft magnetic composites Easy-plane anisotropy Permeability spectra Core loss Rare earths

Effects of the inlet particle spatial distribution on the performance of a gas-solid cyclone separator

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Particuology 2024年第2期85卷 133-145页

作者： Yuge Yao Manxia shang Xiwei ke Zhong huang Tuo Zhou Junfu Lyu key Laboratory for Thermal s.ience and Power Engineering of Ministry of Education Department of Energy and Power EngineeringTsinghua UniversityBeijing100084China

The present study was aimed at the inlet particle spatial distribution of a gas-solid separator with high solid loading and inves.igated its effects on cyclone performance and the inner flow *** flow fields of a cyclone with different rectangular particle flow areas on the inlet surface were numerically simulated using a four-way coupling *** simulated results.indicate that reducing the inlet particle flow area and lowing the inlet particle position can effectively reduce the scattered particles.inside the cyclone separator and enhance the separation *** gathering the particles to the centerline can also weaken the particle *** particles near the roof account for the s.irling particle ceiling *** inlet particle spatial distribution affects the pressure drop mainly by affecting the gas tangential velocity in the cylinder ***,compared to the hori-zontal particle distribution on the inlet surface,the vertical particle distribution has greater effects on cyclone performance.

关键词： Gas-solid cyclone inlet particle spatial distribution Four-way coupling separation efficiency scattered particle

in vivo 3-photon fluorescence microscopy of white matter in mouse brain excited at the 1700 nm window

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Journal of innovative Optical Health s.iences 2024年第5期17卷 81-87页

作者： Jie huang Jincheng Zhong shen Tong Yingxian Zhang Ping Qiu ke Wang key Laboratory of Optoelectronic Devices and systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060P.R.China school of Medical information and Engineering Xuzhou Medical UniversityXuzhou 221004P.R.China

White matter,a densely packed collection of myelinated axons,plays an essential part in neural *** high spatial resolution and deep penetration,multi-photon microscopy(MPM)is promising for white matter imaging in animal models.in *** third harmonic generation(THG)signal can be generated from white matter,but the bottom part of the white matter layer generates weak THG due to its high ***,we demonstrate an in vivo labeling and imaging technology,capable of visualizing the white matter layer in the mouse brain,combining°uorescence labeling with MitoTracker Red and three-photon°uorescence(3PF)microscopy excited at the 1700 nm window.3PF signals are several times higher than THG signals,resulting in deeper imaging of the white matter layer with the *** results.indicate that 3PF microscopy is a promising technology for white matter imaging in the deep brain in vivo.

关键词： Three-photon microscopy white matter myelin MitoTracker Red

A Novel Approach for Trajectory Tracking Control of an Under-Actuated Quad-Rotor UAV

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iEEE/CAA Journal of Automatica sinica 2024年第9期11卷 2030-2032页

作者： ke shao Kang huang shengchao Zhen Hao sun Rongrong Yu school of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072 school of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Dear Editor,This letter presents a novel Udwadia-Kalaba(U-K)approach for the trajectory tracking control of a quad-rotor unmanned aerial vehicle(UAV).Compared to conventional control approaches,the desired trajectorie... 详细信息

关键词： letter desired constraints

Aerodynamic/stealth design of s-duct inlet based on discrete adjoint method

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 725-746页

作者： Jun DENG ke ZHAO Lin ZHOU Wei ZHANG Bowen sHU Jiangtao huang Zhenghong GAO school of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Aerospace Technology Institute of China Aerodynamic Research and Development CenterMianyang 621000Sichuan ProvinceChina

it is a major challenge for the airframe-inlet design of modern combat aircrafts,as the flow and electromagnetic wave propagation in the inlet of stealth aircraft are very *** this study,an aerodynamic/stealth optimization design method for an s-duct inlet is *** upwind scheme is.introduced to the aerodynamic adjoint equation to resolve the shock wave and flow *** multilevel fast multipole algorithm(MLFMA)is utilized for the stealth adjoint equation.A dorsal s-duct inlet of flying wing layout is optimized to improve the aerodynamic and stealth *** the aerodynamic and stealth characteris.ics of the inlet are effectively ***,the optimization results are analyzed,and it shows that the main contradiction between aerodynamic characteris.ics and stealth characteris.ics.is the centerline and crosssectional *** s-duct is smoothed,and the cross-sectional area is.increased to improve the aerodynamic characteris.ics,while it is completely opposite for the stealth *** radar cross section(RCs.is reduced by phase cancelation for low frequency *** method is s.itable for the aerodynamic/stealth design of the aircraft airframe-inlet system.

关键词： s-duct inlet aerodynamic/stealth optimization design discrete adjoint upwind scheme multilevel fast multipole algorithm(MLFMA)

First wetland mapping at 10-m spatial resolution in south America using multi-source and multi-feature remote sensing data

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s.ience China Earth s.iences 2024年第10期67卷 3252-3269页

作者： Weiwei sUN Gang YANG Yuling huang Dehua MAO ke huang Lin ZHU Xiangchao MENG Tian FENG Chao CHEN Yong GE Department of Geography and spatial information Techniques Ningbo UniversityNingbo 315211China state key Laboratory of Resources and Environmental information system Institute of Geographic Sciences&Natural Resources ResearchChinese Academy of SciencesBeijing 100101China Natural Resources and Planning Bureau Shanghai Pudong New DistrictShanghai 200100China key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Faculty of Electrical Engineering and Computer s.ience Ningbo UniversityNingbo 315211China school of Geography s.ience and Geomatics Engineering Suzhou University of Science and TechnologySuzhou 215009China

Wetland degradation has been accelerating in recent years globally. Accurate information on the geographic distribution and categories of wetlands.is essential for their conservation and management. Des.ite being the world′s fourth largest continent, south America has limited research on wetland mapping, and there is currently no available map that provides comprehensive information on wetland distribution and categories.in the region. To address this.issue, we used sentinel-1, sentinel-2 and sRTM data, developed a sample collection method and a wetland mapping method with a collection of multi-source features such as optical features, polarization features and shape features for south American wetlands. We produced a 10-m resolution wetland map based on the Google Earth Engine(GEE) platform. Our Level-1 wetland cover map accurately captured six wetland sub-categories with an overall accuracy of 96.24% and a kappa coefficient of 0.8649, while our Level-2 water cover map included five sub-categories with an overall accuracy of 97.23% and a kappa coefficient of0.9368. The results show that the total area of exis.ing wetlands.in south America is approximately 1,737,000 km~2, which is6.8% of the total land area. Among the ten wetland categories, shallow sea had the largest area(960,527.4 km~2), while aquaculture ponds had the smallest area 1513.6 km~2. swamp had the second largest area(306,240.1 km~2). Brazil, Argentina,Venezuela, Bolivia, and Colombia were found to have the largest wetland areas, with Brazil and Colombia having the most diverse wetland categories. This product can serve as baseline data for subsequent monitoring, management, and conservation of south American wetlands.

关键词： Wetland mapping Google Earth Engine sentinel imagery south America

Microstructure Recrystallization and Mechanical Properties of a Cold-Rolled TiNbZrTaHf Refractory High-Entropy Alloy

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Acta Metallurgica sinica(English Letters) 2024年第4期37卷 633-647页

作者： Chuan Rong Jieren Yang Xiaoliang Zhao ke huang Ying Liu Xiaohong Wang Dongdong Zhu Ruirun Chen College of Materials s.ience and Engineering Sichuan UniversityChengdu610065China key Laboratory of Air-Driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou324000China school of Materials s.ience and Engineering Harbin Institute of TechnologyHarbin150001China

The equiatomic TiNbZrTaHf alloy was successfully rolled at room temperature with the reduction of ~ 85%. The microstructure and tensile properties were inves.igated after cold working and annealing. it was determined that the recrystallization temperature of the TiNbZrTaHf alloy between 850 and 900 ℃. Complete recrystallization and normal grain growth occurred, the high stability of single phase was maintained after annealing at 1000, 1200, and 1400 ℃. But the precipitated phase appeared after long term annealing, as seen after 500 h at 1000 ℃. After cold working, the tensile strength and the elongation of TiNbZrTaHf were 1137 MPa and 25.1%, respectively. The annealed alloy has a high tensile strength (σ_(b )= 863 MPa) and ductility (ε_(e )= 28.5%). Moreover, the oxidation of TiNbZrTaHf alloy at elevated temperatures has a significant impact on its mechanical properties. The poor oxidation resistance of TiNbZrTaHf can accelerate tensile failure by inducing fractures at grain boundaries.

关键词： Refractory high entropy alloy Cold rolling Recrystallization Oxidation resistance Mechanical properties