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Manipulating Bloch surface waves in 2D: a platform concept-based flat lens

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Light(science & Applications) 2014年第1期3卷 370-376页

作者： Libo Yu Elsie Barakat Tristan sfez Lubos Hvozdara Joab Di Francesco Hans Peter herzig Optics&Phatonics Technology Laboratory(OPT) Ecole Polytechinique Federale de Lausanne(EPFL)CH-2000 NeuchatelSwitzerland

At the end of the 1970s,it was confirmed that dielectric multilayers can sustain Bloch surface waves(BsWs).However,BsWs were not widely studied until more *** advantage of their high-quality factor,sensing applications have focused on *** far,no work has been performed to manipulate and control the natural surface propagations in terms of defined functions with two-dimensional(2D)components,targeting the realization of a 2D *** this study,we demonstrate that 2D photonic components can be implemented by coating an in-plane shaped ultrathin(l/15)polymer layer on the dielectric *** presence of the polymer modifies the local effective refractive index,enabling direct manipulation of the *** locally shaping the geometries of the 2D components,the BsW can be deflected,diffracted,focused and coupled with 2D *** BsW manipulation in 2D,the dielectric multilayer can play a new role as a robust platform for 2D optics,which can pave the way for integration in photonic *** near-field measurements are used to study light propagation through micro-and nano-optical *** demonstrate that a lens-shaped polymer layer can be considered as a 2D component based on the agreement between near-field measurements and theoretical *** the focal shift and the resolution of a 2D BsW lens are measured for the first *** proposed platform enables the design of 2D all-optical integrated systems,which have numerous potential applications,including molecular sensing and photonic circuits.

关键词： Bloch surface wave 2D optics manipulation micro-and nano-optics nanophotonics platform

Inverse photonic design of functional elements that focus Bloch surface waves

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Light(science & Applications) 2018年第1期7卷 62-70页

作者： Yannick Augenstein Andreas Vetter Babak Vosoughi Lahijani Hans Peter herzig Carsten Rockstuhl Myun-sik Kim Institute of Theoretical solid state Physics Karlsruhe Institute of Technology76131 KarlsruheGermany Institute of Nanotechnology Karlsruhe Institute of Technology76344 Eggenstein-LeopoldshafenGermany sUss MicroOptics sA Rogues-Terres 61Hauterive 2068Switzerland Optics&Photonics Technology Laboratory Ecole Polytechnique Fédérale de Lausanne(EPFL)NeuchâtelSwitzerland

Bloch surface waves(BsWs)are sustained at the interface of a suitably designed one-dimensional(1D)dielectric photonic crystal and an ambient *** elements that control the propagation of BsWs are defined by a spatially structured device layer on top of the 1D photonic crystal that locally changes the effective index of the *** example of such an element is a focusing device that squeezes an incident BsW into a tiny ***,the ability to focus BsWs is limited since the index contrast achievable with the device layer is usually only on the order ofΔn≈0.1 for practical *** elements,e.g.,discs or triangles,which rely on a photonic nanojet to focus BsWs,operate insufficiently at such a low index *** solve this problem,we utilize an inverse photonic design strategy to attain functional elements that focus BsWs efficiently into spatial domains slightly smaller than half the *** examples of such functional elements are *** ability to focus BsWs is experimentally verified by measuring the field distributions with a scanning near-field optical *** focusing elements are promising ingredients for a future generation of integrated photonic devices that rely on BsWs,e.g.,to carry information,or lab-on-chip devices for specific sensing applications.

关键词： elements functional Bloch

Apoplastic barriers of Populus×canescens roots in reaction to different cultivation conditions and abiotic stress treatments

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stress Biology 2023年第1期3卷 269-282页

作者： Paul Grunhofer Ines Heimerich Lena herzig svenja Pohl Lukas schreiber Department of Ecophysiology Institute of Cellular and Molecular BotanyUniversity of BonnKirschallee 153115 BonnGermany

Populus is an important tree genus frequently cultivated for economical ***,the high sensitivity of poplars towards water deficit,drought,and salt accumulation significantly affects plant productivity and limits biomass *** cultivation and abiotic stress conditions have been described to significantly induce the formation of apoplastic barriers(Casparian bands and suberin lamellae)in roots of different monocotyledonous crop ***,this study aimed to investigate to which degree the roots of the dicotyledonous gray poplar(Populus×canescens)react to a set of selected cultivation conditions(hydroponics,aeroponics,or soil)and abiotic stress treatments(abscisic acid,oxygen deficiency)because a differing stress response could potentially help in explaining the observed higher stress *** apoplastic barriers of poplar roots cultivated in different environments were analyzed by means of histochemistry and gas chromatography and compared to the available literature on monocotyledonous crop ***,dicotyledonous poplar roots showed only a remarkably low induction or enhancement of apoplastic barriers in response to the different cultivation conditions and abiotic stress *** genetic optimization(e.g.,overexpression of biosynthesis key genes)of the apoplastic barrier development in poplar roots might result in more stress-tolerant cultivars in the future.

关键词： Hydroponics Aeroponics soil Abscisic acid(ABA) Oxygen deficiency Poplar root suberin

Ultra-thin Bloch-surface-wave-based reflector at telecommunication wavelength

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Photonics Research 2017年第5期5卷 494-499页

作者： R. DUBEY B. VOsOUGHI LAHIJANI M. HAYRINEN M. ROUssEY M. KUITTINEN H. P. herzig Optics & Photonics Technology Laboratory (OPT) ecole Polytechnique Federale de Lausanne (EPFL) rue de la Maladiere 71b Institute of Photonics University of Eastern Finland

We experimentally demonstrate the optical properties of gratings engraved in a single-mode waveguide fabricated on top of a dielectric multilayer platform. The structure can be approached as a reflector for Bloch-surface-wavebased two-dimensional optical systems. The gratings have been fabricated on a thin(～λ∕25) titanium dioxide layer with a thickness of a few tens of nanometers deposited on the top of a multilayer platform. The optical properties of the gratings have been characterized in the near field with the aid of multi-heterodyne scanning nearfield optical microscopy. We investigate the surface wave's interference pattern, produced by incident and reflected light in front of the gratings. The presented gratings behave as an efficient Bloch-surface–wave-basedreflector at telecommunication wavelength.

关键词： reflector Bloch waveguide multilayer behave grating Bragg dielectric titanium fabrication

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Magnetic spin–orbit interaction of light

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Light(science & Applications) 2018年第1期7卷 817-824页

作者： Mengjia Wang Hongyi Zhang Tatiana Kovalevich Roland salut Myun-sik Kim Miguel Angel suarez Maria-Pilar Bernal Hans-Peter herzig Huihui Lu Thierry Grosjean FEMTO-sT Institute UniversitéBourgogne Franche-ComtéUMR CNRS 617415B Av.des Montboucons25030 Besancon CedexFrance Optics and Photonics Technology Laboratory Ecole Polytechnique Fédérale de Lausanne(EPFL)Rue de la Maladière 71bNeuchâtel CH-2000Switzerland Department of Optoelectronic Engineering Guangdong Provincial Key Laboratory of Optical Fiber Sensing and CommunicationsJinan UniversityGuangzhou 510632China

We study the directional excitation of optical surface waves controlled by the magnetic field of *** theoretically predict that a spinning magnetic dipole develops a tunable unidirectional coupling of light to transverse electric(TE)polarized Bloch surface waves(BsWs).Experimentally,we show that the helicity of light projected onto a subwavelength groove milled into the top layer of a 1D photonic crystal(PC)controls the power distribution between two TE-polarized BsWs excited on both sides of the *** a phenomenon is shown to be solely mediated by the helicity of the magnetic optical field,thus revealing a magnetic spin-orbit interaction of ***,this magnetic optical effect is clearly observed via a near-field coupler governed by an electric dipole moment:it is of the same order of magnitude as the electric optical effects involved in the *** opens up new degrees of freedom for the manipulation of light and offers desirable and novel opportunities for the development of integrated optical functionalities.

关键词： light interaction dipole

Engagement of sialylated glycans with siglec receptors on suppressive myeloid cells inhibits anticancer immunity via CCL2

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Cellular & Molecular Immunology 2024年第5期21卷 495-509页

作者： Ronja Wieboldt Michael sandholzer Emanuele Carlini Chia-wei Lin Anastasiya Börsch Andreas Zingg Didier Lardinois Petra herzig Leyla Don Alfred Zippelius Heinz Läubli Natalia Rodrigues Mantuano Laboratory for Cancer Immunotherapy Department of BiomedicineUniversity Hospital and University of BaselBaselSwitzerland. Functional Genomics Center Zurich ETH ZurichZurichSwitzerland. Bioinformatics Core Facility Department of BiomedicineUniversity of Basel and Swiss Institute of BioinformaticsBaselSwitzerland. Department of Thoracic surgery University Hospital BaselBaselSwitzerland. Laboratory of Cancer Immunology Department of BiomedicineUniversity Hospital and University of BaselBaselSwitzerland. Division of Oncology University Hospital BaselBaselSwitzerland.

The overexpression of sialic acids on glycans,called hypersialylation,is a common alteration found in cancer *** glycans can enhance immune evasion by interacting with sialic acid-binding immunoglobulin-like lectin(siglec)receptors on tumorinfiltrating immune ***,we investigated the effect of sialylated glycans and their interaction with siglec receptors on myeloid-derived suppressor cells(MDsCs).We found that MDsCs derived from the blood of lung cancer patients and tumor-bearing mice strongly express inhibitory siglec receptors and are highly *** murine cancer models of emergency myelopoiesis,siglec-E knockout in myeloid cells resulted in prolonged survival and increased tumor infiltration of activated T *** suppressive myeloid cells by blocking siglec receptors or desialylation strongly reduced their suppressive *** further identified CCL2 as a mediator involved in T-cell suppression upon interaction between sialoglycans and siglec receptors on *** results demonstrated that sialylated glycans inhibit anticancer immunity by modulating CCL2 expression.

关键词： sialoglycans sialic acid-binding immunoglobulin-like lectin tumor microenvironment myeloid derived suppressor cells

Highlights and recent progress in micro-optics

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光机电信息 2003年第5期20卷 1-2页

作者： H. P. herzig M. T. Gale Institute of Microtechnology University of NeuchátelCSEM Zurich SwitzerlandSwitzerland

Micro-optics and diffractive optics have a long tradition in switzerland, in particular at the Institute of Microtechnology, University of Neuchátel (IMT-Uni NE) and at CsEM's Photonics Division in Zurich (formerly PsI / RCA Laboratories, Zurich). Driven by the pioneering work of these institutesand strongly supported by the swiss Priority Program OPTIQUE during 1993～1999, micro-optics has penetrated into swiss industry and has resulted in a number of start-up companies. Today, microoptical elements and design services are available from a multitude of swiss companies and facilities,including CsEM, Heptagon, Colibrys, suss Micro-Optics Neuchátel, and Leister Technologies.

关键词：微光学研究进展 MEMs CsEM

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角质化细胞生长因子及其受体在发生适应性改变回肠直肠窝黏膜中的表达

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 60-61页

作者： Otte J.-M. Boser s. Brunke G. K.-H. herzig 李宏宇 A. I. Virtanen-Institute for Molecular sciences University of Kuopio Neulaniementie 2 FIN-70211 Kuopio Finland

Objective: Total proctocolectomy with formation of an ileoanal pouch is a well-established surgical procedure for patients with ulcerative colitis (UC) or familiar adenomatous polyposis (FAP). The pouch mucosa undergoes adaptive changes, with inflammation of the ileal reservoir being the most common complication. The aetiology is unknown. The keratinocyte growth factor (KGF) has not only been shown to promote intestinal wound healing and re-epithelialization but also to have some immunomodulatory properties. This study was designed to investigate a putative involvement of KGF in observed histomorphological changes in the pouch mucosa. Material and methods. Multiple biopsies were obtained from age-matched and sex-matched patients. Biopsies were stained with H& E and scored for inflammation and morphological changes. mRNA expression levels of KGF and KGF-receptor (KGFR) were determined using competitive RT-PCR, protein expression and phosphorylation was analyzed byWestern blotting. KGF and KGFR were localized in tissue samples by immunohistochemistry. Results. Expression of KGF and KGFR was significantly increased in inflamed and adapting mucosa. Patterns of expression did not significantly differ in pouch mucosa from UC or FAP patients. Protein expression correlated with the mRNA results and KGFR was shown to be activated in adapting pouch mucosa. KGF was detected on subepithelial cells, mainly on fibroblasts, whereas expression of KGFR was restricted to epithelial cells. Conclusion. Expression of KGF and KGFR is significantly increased in the pouchmucosa, suggesting an involvement of this growth factor in tissue repair and adaptive changes. Topical application of KGF might alleviate the inflammatory and promote the adaptive process in the ileo-anal pouch mucosa.

关键词：角质化细胞直肠窝适应性改变生长因子溃疡性结肠炎组织形态学形态学改变免疫调节多发性腺癌

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一个可保持长期植入潜能的扩增脐带血造血干细胞体系的建立和临床前研究

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一个可保持长期植入潜能的扩增脐带血造血干细胞体系的建立和临床...