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Thoracic surgery in 2030

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中华胸部外科电子杂志 2021年第3期8卷 145-152页

作者： Joyce W.Y.Chan Rainbow W.h.Lau Aliss T.C.Chang Ivan C.h.siu Teddy h.Y.Wong Zheng Li Calvin s.h.ng Department of surgery Prince of Wales Hospitalthe Chinese University of Hong KongHong Kong SARChina

Introduction Thoracic surgery has evolved at an exponential pace since the first clinical lung resection in *** first pneumonectomy was performed in 1895,the first lobectomy in 1901,while double lumen endotracheal intubation for pulmonary resection did not occur until *** 1990s saw the development of game-changer video-assisted thoracoscopic surgeries(VATs),while the 2000s gave witness to the explosive boom of robotic *** Abraham Lincoln once said,“The best way to predict the future is to create it”,in this article we discuss the current cutting-edge technologies and attempt to predict the future of thoracic surgery in 10 years’time.

关键词： surgery lung clinical

初始不可切除IIIB期非小细胞肺癌免疫联合化疗后的根治性微创手术

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中国肺癌杂志 2022年第11期25卷 835-840页

作者： hongsheng DEng Jun LIU Xiuyu CAI Jiawei ChEN Gaetano ROCCO Rene' horsleben PETERsEN Alessandro BRUNELLI Calvin s.h.ng Thomas A.D'AMICO Wenhua LIAng Jianxing hE 雷杰 Department of Thoracic surgery and Oncology the First Affiliated Hospital of Guangzhou Medical University State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Health Department of General Internal Medicine Sun Yat-sen University Cancer Centre State Key Laboratory of Oncology in South China Collaborative Innovation Centre for Cancer Medicine Department of surgery Memorial Sloan Kettering Cancer Center Department of Cardiothoracic surgery University Hospital of CopenhagenRigshospitalet Department of Thoracic surgery St. James's University Hospital Division of Cardiothoracic surgery Department of Surgery Prince of Wales Hospital the Chinese University of Hong Kong Division of Thoracic surgery Department of Surgery Duke University Medical Center 空军军医大学第二附属医院胸腔外科

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NsCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NsCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生... 详细信息

背景新辅助免疫治疗在局部晚期非小细胞肺癌（non-small cell lung cancer, NsCLC）的应用仍存在争议。因此，本研究旨在报道通过免疫联合化疗将初始不可切除c IIIB期NsCLC患者转化为根治性微创手术的系列病例，评估手术效果和术后的生存获益。方法回顾性分析2018年5月-2020年8月期间接受程序性细胞死亡受体1(programmed cell death-1,PD-1)抑制剂联合含铂双药化疗的51例c IIIB期NsCLC患者。收集入组患者手术相关数据和肿瘤相关数据。结果31例患者最终接受手术治疗，其中23例（74.2%）患者行肺叶切除术，1例（3.2%）患者行全肺切除术，5例（16.1%）患者行袖状肺叶切除术，2例（6.5%）患者行双肺叶切除术。中位手术时间为205 min（范围100-520），平均失血量为185 m L（范围10-1100）。15例患者出现致密粘连或纤维化。术后平均住院时间为6 d（范围3-13）。无手术相关死亡，仅5例（16.1%）患者发生术后并发症（无3级以上并发症）。10例（32.3%）患者达到主要病理缓解，22/31例（71.0%）患者出现纵隔病变降期。中位随访15.4个月，31例手术患者的中位无进展生存期/无病生存期（progression-free survival/disease-free survival, PFs/DFs）相对于未进行手术的无缓解或缓解的患者（分别为27.5个月vs 4.7个月vs 16.7个月）更长。结论初始不可切除的IIIB期NsCLC接受免疫联合化疗治疗后行根治性手术相对安全，手术相关死亡率和并发症发病率较低，与未手术患者相比DFs/PFs更长。

关键词：免疫联合化疗新辅助治疗初始不可切除非小细胞肺癌手术切除

single-pilot operations in commercial flight:Effects on neural activity and visual behaviour under abnormalities and emergencies

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Chinese Journal of Aeronautics 2024年第8期37卷 277-292页

作者： Qinbiao LI Chun-hsien ChEN Kam K.h.ng Xin YUAN Cho Yin YIU human Factors and Ergonomics Laboratory Department of Aeronautical and Aviation EngineeringThe Hong Kong Polytechnic UniversityHong Kong Special Administrative Region 100872China school of Mechanical&Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

With cutting-edge technologies and considering airline human-resource-saving,a single pilot in commercial jets could be technically *** changes in captains’natural behaviours are initially required to comprehend the specific safe human performance envelope for safeguarding single-pilot flight,particularly in high-risk *** paper investigates how captains’performance transforms for fixing emergencies when operating from Dual-Pilot Operations(DPO)to single-Pilot Operations(sPO)through a physiological-based *** pilots flew an emergency-included flight with/without first officers’*** neural activities and scanning behaviours were recorded using a 32-channel Electroencephalogram(EEG)and glasses-based eye tracker,with the observation and post-experiment questionnaires to evaluate the flight operations and pilots’*** alone,there was a significantly increased cortical activity in h and b waves over the frontal,parietal,and temporal lobes during the more complicated emergencies,and pilots focused less on the primary flight display while spending significantly more time scanning the other *** physiological fluctuating patterns associated with risky operations in sPO were highlighted by cross-correlating multimodal *** experimental-based noteworthy insights may wish to inform commercial sPO measures to lessen the persistent physiological fluctuation,assisting airlines in creating sPO-oriented intelligent flight systems to give captains adequate support for assuring safer air transportation.

关键词： Aviation engineering single pilot operations Behaviour changes Eye tracker Electroencephalogram

Jetting-based bioprinting:process,dispense physics,and applications

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Bio-Design and Manufacturing 2024年第5期7卷 771-799页

作者： Wei Long ng Viktor shkolnikov singapore Centre for 3D Printing(sC3DP) School of Mechanical and Aerospace EngineeringNanyang Technological University(NTU)Singapore 639798Singapore hP Inc. Palo AltoCA 94304USA

Jetting-based bioprinting facilitates contactless drop-on-demand deposition of subnanoliter droplets at well-defined positions to control the spatial arrangement of cells,growth factors,drugs,and biomaterials in a highly automated layer-by-layer fabrication *** to its immense versatility,jetting-based bioprinting has been used for various applications,including tissue engineering and regenerative medicine,wound healing,and drug development.A lack of in-depth understanding exists in the processes that occur during jetting-based *** review paper will comprehensively discuss the physical considerations for bioinks and printing conditions used in jetting-based *** first present an overview of different jetting-based bioprinting techniques such as inkjet bioprinting,laser-induced forward transfer bioprinting,electrohydrodynamic jet bioprinting,acoustic bioprinting and microvalve ***,we provide an in-depth discussion of various considerations for bioink formulation relating to cell deposition,print chamber design,droplet formation and droplet ***,we highlight recent accomplishments in jetting-based *** present the advantages and challenges of each method,discuss considerations relating to cell viability and protein stability,and conclude by providing insights into future directions of jetting-based bioprinting.

关键词： 3D bioprinting Biofabrication Jetting-based Dispense physics Machine learning

Dysfunction of synaptic endocytic trafficking in Parkinson's disease

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Neural Regeneration Research 2024年第12期19卷 2649-2660页

作者： Xin Yi ng Mian Cao Programme in Neuroscience and Behavioural Disorders Duke-NUS Medical SchoolSingaporeSingapore Department of Physiology National University of SingaporeSingaporeSingapore

Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the *** precise reasons behind the specific degeneration of these dopamine neurons remain largely *** investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's ***,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis *** suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"***,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively *** models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical *** this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(sYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic ***,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,sAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease *** will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK

关键词： autophagy auxilin/PARK19 clathrin-mediated endocytosis dopamine neurons neurodegeneration nigrostriatal pathway Parkinson's disease synaptic vesicle recycling synaptojanin1/PARK20

动态增强MRI、扩散加权MRI以及18F-FDGPET/CT对口咽与下咽鳞状细胞癌病人化疗后生存率的预测

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国际医学放射学杂志 2017年第1期 107-108页

作者： s.h.ng C.T.Liao C.Y.Lin s.C.Chan Y.C.Lin T.C.Yen 柴超 Department of Medical Imaging and Radiological sciences Chang Gung Memorial Hospital Chang Gung University

摘要目的前瞻性评估治疗前动态增强MRI、扩散加权MRI与;F-FDG PET/CT对口咽与下咽鳞状细胞癌病人化疗后生存率的预测。方法组织学证实的患有口咽与下咽鳞状

关键词：扩散加权口咽 MRI 动态增强病人化疗鳞状细胞癌生存率 CT

stability and Generalization of hypergraph Collaborative Networks

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Machine Intelligence Research 2024年第1期21卷 184-196页

作者： Michael K.ng hanrui Wu Andy Yip Institute of Data science The University of Hong KongHong KongChina Department of Mathematics The University of Hong KongHong KongChina College of Information science and Technology Jinan UniversityGuangzhou 510006China

Graph neural networks have been shown to be very effective in utilizing pairwise relationships across ***,there have been several successful proposals to generalize graph neural networks to hypergraph neural networks to exploit more com-plex *** particular,the hypergraph collaborative networks yield superior results compared to other hypergraph neural net-works for various semi-supervised learning *** collaborative network can provide high quality vertex embeddings and hyperedge embeddings together by formulating them as a joint optimization problem and by using their consistency in reconstructing the given *** this paper,we aim to establish the algorithmic stability of the core layer of the collaborative network and provide generaliz--ation *** analysis sheds light on the design of hypergraph filters in collaborative networks,for instance,how the data and hypergraph filters should be scaled to achieve uniform stability of the learning *** experimental results on real-world datasets are presented to illustrate the theory.

关键词： hypergraphs vertices hyperedges collaborative networks graph convolutional neural networks(CNNs) stability generalization guarantees

The sUPER reporting guideline suggested for reporting of surgical technique

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hepatobiliary surgery and Nutrition 2023年第4期12卷 534-544,I0024-I0026页

作者： Kaiping Zhang Yanfang Ma Jinlin Wu Qianling shi Leandro Cardoso Barchi Marco scarci Rene horsleben Petersen Calvin s.h.ng steven hochwald Ryuichi Waseda Fabio Davoli Robert Fruscio Giovanni Battista Levi sandri Michel Gonzalez Benjamin Wei Guillaume Piessen Jianfei shen Xianzhuo Zhang Panpan Jiao Yulong he Nuria M.Novoa Benedetta Bedetti sebastien Gilbert Alan D.L.sihoe Alper Toker Alfonso Fiorelli Marcelo F.Jimenez Toni Lerut Aung Y.Oo Grace s.Li Xueqin Tang Yawen Lu hussein Elkhayat Tomaz stupnik Tanel Laisaar Firas Abu Akar Diego Gonzalez-Rivas Zhanhao su Bin Qiu stephen D.Wang Yaolong Chen shugeng Gao Editorial Office AME Publishing CompanyHong KongChina school of Chinese Medicine Hong Kong Baptist UniversityHong KongChina Department of Cardiovascular surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Evidence-based Medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina Lanzhou University Institute of health Data science LanzhouChina Digestive surgery Division Department of GastroenterologyUniversity of Sao Paulo School of MedicineSão PauloBrazil Department of Cardiothoracic surgery Imperial College Healthcare NHS TrustLondonUK Department of Cardiothoracic surgery University Hospital of CopenhagenRigshospitaletCopenhagenDenmark The Chinese University of hong Kong Prince of Wales HospitalShatinNew TerritoriesHong KongChina Department of surgical Oncology Roswell Park Cancer InstituteBuffaloNYUSA Department of General Thoracic Breast and Pediatric SurgeryFukuoka UniversityFukuokaJapan Department of Thoracic surgery AUSL RomagnaS.Maria delle Croci Teaching HospitalRavennaItaly Clinic of Obstetrics and Gynecology University of Milan-BicoccaSan Gerardo HospitalMonzaItaly Division of General surgery and Liver Transplantation S.Camillo HospitalRomeItaly service of Thoracic surgery Lausanne University Hospital(CHUV)LausanneSwitzerland Division of Cardiothoracic surgery Department of SurgeryUniversity of Alabama BirminghamBirminghamALUSA University of Lille CNRSInsermCHU LilleUMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to TherapiesLilleFrance Department of Cardiothoracic surgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhaiChina The First school of Clinical Medicine Lanzhou UniversityLanzhouChina Thoracic surgery service University Hospital of SalamancaBiomedical Institute of SalamancaSalamancaSpain Department of Thoracic surgery Helios Clinic Bonn/Rhein SiegBonnGermany Division of Thoracic surgery Department of SurgeryThe Ottawa

Background:Existing reporting guidelines pay insufficient attention to the detail and comprehensiveness reporting of surgical *** surgical techniqUe rePorting chEcklist and standaRds(sUPER)aims to address this gap by defining reporting standards for surgical *** sUPER guideline intends to apply to articles that encompass surgical technique in any study design,surgical discipline,and stage of surgical ***:Following the EQUATOR(Enhancing the QUAlity and Transparency Of health Research)Network approach,16 surgeons,journal editors,and methodologists reviewed existing reporting guidelines relating to surgical technique,reviewed papers from 15 top journals,and brainstormed to draft initial items for the *** initial items were revised through a three-round Delphi survey from 21 multidisciplinary Delphi panel experts from 13 countries and *** final sUPER items were formed after an online consensus meeting to resolve disagreements and a three-round wording refinement by all 16 sUPER working group members and five sUPER ***:The sUPER reporting guideline includes 22 items that are considered essential for good and informative surgical technique *** items are divided into six sections:background,rationale,and objectives(items 1 to 5);preoperative preparations and requirements(items 6 to 9);surgical technique details(items 10 to 15);postoperative considerations and tasks(items 16 to 19);summary and prospect(items 20 and 21);and other information(item 22).Conclusions:The sUPER reporting guideline has the potential to guide detailed,comprehensive,and transparent surgical technique reporting for *** may also assist journal editors,peer reviewers,systematic reviewers,and guideline developers in the evaluation of surgical technique papers and help practitioners to better understand and reproduce surgical technique.

关键词： surgical technique surgical innovation reporting guideline reporting checklist surgical techniqUe rePorting chEcklist and standaRds(sUPER)

Perspectives in human brain plasticity sparked by glioma invasion:from intraoperative(re)mappings to neural reconfigurations

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Neural Regeneration Research 2024年第5期19卷 947-948页

作者： sam ng hugues Duffau Guillaume herbet Department of Neurosurgery Gui de Chauliac HospitalMontpellier University Medical CenterMontpellierFrance Institute of Functional Genomics University of MontpellierCNRSINSERMMontpellierFrance Praxiling Laboratory UMR5267CNRSPaul Valéry-Montpellier 3 UniversityMontpellierFrance

Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative *** term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical ***,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.

关键词： plasticity figuration consequences