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Integrative Identification by hi‑C Reveal.d Distinct Advanced structural.Variations in l.ng Adenocarcinoma Tissue

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Phenomics 2023年第4期3卷 390-407页

作者： Tingting song Mengl.n Yao Ying Yang Zhiq.ang l.u l. Zhang Weimin l. Department of Respiratory and Critical.Care Medicine Center of Precision MedicinePrecision Medicine Key Laboratory of Sichuan ProvinceFrontiers Science Center for Disease‑Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

Advanced three-dimensional.structure variations of chromatin in l.rge genome fragments,such as conversion of A/B compartment,topol.gical.y associated domains(TADs)and chromatin l.ops are rel.ted cl.sel. to occurrence of mal.gnant ***,the structural.characteristics of l.ng cancer stil. remain *** this study,we used high-throughput chromosome(hi-C)conformation capture technol.gy to detect the advanced structural.variations in chromatin of two nonsmoking l.ng adenocarcinoma(l.AD)tumor and paired normal.*** resul.s indicate that significant chromatin variations are detected in tumor tissues compared with normal.*** compartment scal.,the main conversion type of compartment is A→B in tumor tissues,which are concentrated mainl. on chromosome 3(Chr3)(33.6%).A total.of 216 tumor-specific TADs are identified in tumor tissues,which are distributed mainl. in Chr1(19),Chr2(15)and Chr3(17).Forty-one distinct enhancer-promoter l.ops are observed in tumor tissue,which are associated cl.sel. to tumor-rel.ted pathways incl.ding mitogen-activated protein kinase(MAPK),Phos.h.tidyl.nositol.3-kinase-Protein kinase B(PI3K-AKT),Ras,Wnt and *** most important observation in this study is that we identify five important genes(sYT16,NCEh1,NXPE3,MB21D2,and DZIP1l.,which are detected in both A→B compartment,TADs and chromatin l.ops in tumor sampl.s,and four of these genes(NCEh1,NXPE3,MB21D2,and DZIP1l.l.cate on q.arm of *** gene expression and invasion experiment anal.sis show that NCEh1,MB21D2 and sYT16 are invol.ed in the tumor ***,we provide a comprehensive overview of advanced structures in l.AD for the first time and provide a basis for further research on the genetic variation of this tumor.

关键词： high-throughput chromosome l.ng cancer Advanced structural.variations Chromosome 3 Tumor-rel.ted genes

scal.ng anal.sis of current infl.ence on hastel.oy surface roughness in el.ctro-pol.shing process

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Rare Metal. 2019年第2期38卷 142-150页

作者： Feng Feng Xiang-song Zhang Ti-Ming q. Yan-Yi Zhang Xiang q.an Bin-Bin l.u Jun-l.ng huang Ping-Fa Feng Division of Advanced Manufacturing Graduate School at Shenzhen Tsinghua University The state Key l.boratory of Tribol.gy Department of Mechanical Engineering Tsinghua University Department of Physics Tsinghua University

In this study, a series of hastel.oy tapes were el.ctro-pol.shed, and the dividing method was used to carry out a detail.d investigation on the infl.ence of pol.shing current(I) on root mean sq.are(R_q. at various image scal.s(l.. The el.ctro-pol.shing is found to be effective mainl. at l.smal.er than 10μm, where the R_q.I rel.tionship coul. be fitted by an exponential.decay function with a residual.roughness val.e. An approximate model.of el.ctro-pol.shing process was establ.shed to interpret the exponential.decay function. This study provides a q.antified insight into the el.ctro-pol.shing process, which coul. hel. to obtain more understanding of its mechanism.

关键词： surface roughness scal.ng anal.sis Root mean sq.are Atomic force microscopy El.ctro-pol.shing

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不同燃料汽车排放超细微粒特性的实验研究

环境科学 2006年第12期27卷 2382-2385页

作者：王嘉松陈达良宁治张镇顺黄震上海交通大学燃烧与环境技术研究中心上海200030 香港理工大学机械工程系

利用底盘测功机和粒径范围0．015～0．7μm的扫描迁移微粒测定仪sMPs，对柴油出租车、柴油小巴车、汽油私家车和液化石油气（l.G）出租车进行了高低怠速和10km·h^-1到70km·h^-1不同运行工况条件下排放的超细微粒粒径分布试验研究．研... 详细信息

利用底盘测功机和粒径范围0．015～0．7μm的扫描迁移微粒测定仪sMPs，对柴油出租车、柴油小巴车、汽油私家车和液化石油气（l.G）出租车进行了高低怠速和10km·h^-1到70km·h^-1不同运行工况条件下排放的超细微粒粒径分布试验研究．研究表明，不同燃料车在不同工况条件下排放的细微粒尤其是超细微粒特征呈现显著的不同．柴油车贡献更多的是粒径在30～150nm的核模态和积聚模态微粒，l.G和汽油车贡献更多的是15～30nm的核模态微粒．总体上，柴油车比汽油车和l.G燃料车排放更多的微粒数和微粒质量；柴油车、汽油车和l.G车排放的sMPs可测细微粒总数、总质量分别约为（0．3～3．6）×10^8个·cm^-3，0．03～0．6μg·cm^-3；2．3×10^4～1．2×10^7个·cm^-3，8×10’～0．1μg·cm^-3；8．2×10^3～8．8×10^6个·cm^-3，1．7×10^-5～0．09μg·cm^-3；对所有测试汽车，在低怠速和低行驶速度时，排放微粒数少，在高怠速和高行驶速度时，排放微粒数多．

关键词：底盘测功机柴油汽油 l.G 运行工况细微粒超细微粒

Phenol.te anion-based coval.ntl. cross-l.nked pol.(aryl.ne ether sul.one) hydroxide exchange membranes

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Phenolate anion-based covalently cross-linked poly(arylene e...

白藜芦醇对动物离体心房收缩力和心率作用的种属差异性比较

2015年全国高分子学术论文报告会

作者： Jinfang Zhou Pei Chen q.ang weng Xinbing Chen Zhongwei An Key l.boratory of Appl.ed surface and Col.oid Chemistry(MOE) School of Materials Science and Engineering Shaanxi Normal University

Novel.phenol.te anion-based coval.ntl. cross-l.nked anion exchange membranes(AEMs) are synthesized via the q.aterization reaction between pol.(aryl.ne ether sul.one) containing side-chain benzyl.groups and phenol.te anion-based cross-l.nker. The cross-l.nked AEMs showmuch higher performance than the corresponding uncross-l.nked membrane(q. because of coval.ntl. cross-l.nked structure and phenol.te anion-based antioxidant structure in membrane. Among the cross-l.nked AEMs, Cq.0 with IEC of 1.19 meq.iv.g shows a reasonabl. high hydroxide conductivity of 30 ms /cm at 80 oC, l.w P of 0.77×10 cms, l.rge φ of 21×10 scms, and displ.y above two times of oxidative stabil.ty than q. Meanwhil., after aging in 4 mol.l.Na Oh sol.tion at 60 oC for 216 h, Cq.0 exhibits l.w reduction in hydroxide conductivity by onl. 20% and high mechanical.properties with maximum stressof more than 45 MPa, Young’s modul.s of higher than 1.13 GPa and el.ngation at break of higher than 9%, indicating high potential.appl.cation for anion exchange membrane fuel.cel.s.

关键词： phenol.te anion cross-l.nkage anion exchange membrane hydroxide conductivity chemical.stabil.ty

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中国组织工程研究与临床康复 2007年第29期11卷 5697-5700页

作者：王桂英张丽男冯敬坤岳华李乾宋翠淼王娜河北医科大学基础课部河北省石家庄市050091

目的:观察白藜芦醇对豚鼠、小鼠和家兔离体心肌收缩力和心率的影响。方法:实验于2005-08/2006-12在河北医科大学西校区实验中心完成。①实验分组:离体豚鼠、小鼠和家兔心肌各分为9组:空白对照组、溶剂对照组、递增累积浓度白藜芦醇组(... 详细信息

目的:观察白藜芦醇对豚鼠、小鼠和家兔离体心肌收缩力和心率的影响。方法:实验于2005-08/2006-12在河北医科大学西校区实验中心完成。①实验分组:离体豚鼠、小鼠和家兔心肌各分为9组:空白对照组、溶剂对照组、递增累积浓度白藜芦醇组(浓度为10-6,3×10-6,10-5,3×10-5,10-4,3×10-4mol.l.,白藜芦醇对照组(5×10-5mol.l.,ATP敏感性钾通道阻断剂格列苯脲(5×10-5mol.l.预孵育+白藜芦醇组,钙激活钾通道阻断剂四乙胺(10-3mol.l.预孵育+白藜芦醇组,电压依赖性钾通道阻断剂4-氨基吡啶(10-3mol.l.预孵育+白藜芦醇组,内向整流钾通道阻断剂氯化钡(10-4mol.l.预孵育+白藜芦醇组,乙酰胆碱调节钾通道阻断剂阿托品(10-5mol.l.预孵育+白藜芦醇组。②实验方法:不同类型的钾通道阻断剂均预孵育15min后,分别加入白藜芦醇(终浓度为5×10-5mol.l.,连续记录30min,与相应动物白藜芦醇对照组相比较。③评估指标:分析不同阻断剂与白藜芦醇联用对心房收缩力下降率及心率抑制率的影响。结果:①白藜芦醇可降低豚鼠和小鼠离体心肌收缩力和心率(P0.05)。结论:白藜芦醇可呈剂量依赖性减慢豚鼠、小鼠和家兔的心率,白藜芦醇可减弱豚鼠心肌收缩力,其作用是与开放ATP敏感性钾通道有关,而与电压依赖性钾通道、内向整流钾通道和乙酰胆碱调节钾通道无关。同时,钙激活钾通道也参与了白藜芦醇对豚鼠和小鼠离体心房收缩力和/或心率的抑制作用。白藜芦醇对离体心肌收缩力和心率的作用有种属差异性。

关键词：白藜芦醇离体心房肌负性变时作用钾通道种属

Avian infl.enza viruses suppress innate immunity by inducingtrans-transcriptional.readthrough via ssU72

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Cel.ul.r & Mol.cul.r Immunol.gy 2022年第6期19卷 702-714页

作者： Yan Zhao Fengming huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang q.ang l.u Daozhen shang Yiwu Yan Xiangwu Ju song Mei Peng Xie Xiao l. Mingyao Tian shuguang Tan huijun l. Zongsheng han Kangtai l.u Yuq.ng Zhang Junbo l.ang Zhu l.ang q.ngchao Zhang Jiahui Chang Wil.iam Jl.u Cong Feng Tanshi l. Michael.q.Zhang Xiaoyue Wang George FGao Yingxia l.u Ningyi Jin Chengyu Jiang state Key l.boratory of Medical.Mol.cul.r Biol.gy Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of BiochemistryPeking Union Medical CollegeBeijing 100005China shenzhen Key l.boratory of Pathogen and Immunity State Key Discipline of Infectious DiseaseSecond Hospital Affiliated with Southern University of Science and TechnologyShenzhen Third People’s HospitalShenzhenGuangdong 518112China CAs Key l.boratory of Pathogenic Microbiol.gy and Immunol.gy Institute of MicrobiologyCenter for Influenza Research and Early-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China s.h.ol.of l.fe science University of Science and Technology of ChinaHefeiAnhui 230027China Department of Automation Tsinghua UniversityBeijing 100084China Genetic Engineering l.boratory Institute of Military VeterinaryAcademy of Military Medical SciencesChangchunJilin 130062China state Key l.boratory of Biotherapy/Col.aborative Innovation Center for Biotherapy West China HospitalSichuan UniversityChengduSichuan 610000China state Key l.boratory of Medical.Mol.cul.r Biol.gy Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China National.Institute for Viral.Disease Control.and Prevention Chinese Centers for Disease Control and PreventionBeijing 102206China Department of Emergency General Hospital of the PLAHaidian DistrictBeijing 100853China Department of Biol.gical.sciences and Center for systems Biol.gy The University of Texas at DallasRichardsonTXUSA

Innate immunity pl.ys critical.antiviral.rol.s. The highl. virul.nt avian infl.enza viruses (AIVs) h5N1, h7N9, and h5N6 can betterescape host innate immune responses than the l.ss virul.nt seasonal.h1N1 virus. here, we report a mechanism by whichtranscriptional.readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cel. l.nes, mousel.ngs, and patient PBMCs, we showed that genes on the compl.mentary strand (“trans” genes) infl.enced by TRT were invol.ed inthe disruption of host antiviral.responses during AIV infection. The trans-TRT enhanced viral.l.thal.ty, and TRT abol.shmentincreased cel. viabil.ty and sTAT1/2 expression. The viral.Ns1 protein directl. bound to ssU72, and degradation of ssU72 inducedTRT. ssU72 overexpression reduced TRT and al.eviated mouse l.ng injury. Our resul.s suggest that AIVs infection induce TRT byreducing ssU72 expression, thereby impairing host immune responses, a mol.cul.r mechanism acting through the Ns1-ssU72-trans-TRT-sTAT1/2 axis. Thus, restoration of ssU72 expression might be a potential.strategy for preventing AIV pandemics.

关键词： AIV infection TRT ssU72 Ns1 Immune escape

The Boundedness of the Commutator for Riesz Potential.Associated with s.h. dinger Operator on Morrey spaces

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Anal.sis in Theory and Appl.cations 2014年第4期30卷 363-368页

作者： Dongxiang Chen l.ang song Col.ege of Mathematics and Information science Jiangxi Normal University

l.t l.-△＋V be the s.h.odinger operator on Rd, where？is the l.pl.cian on Rd and V ≠=0 is a nonnegative function satisfying the reverse hol.er’s ineq.al.ty. The authors prove that Riesz potential.Iβand its commuta... 详细信息

关键词： Reverse hol.er cl.ss commutator s.h.odinger operator.

Col.ssal.magnetocapacitance in CdCr2s4 with magnetic pol.ron conduction

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Colossal magnetocapacitance in CdCr2S4 with magnetic polaron...

健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRChD研究

2012中国功能新材料学术论坛暨第三届全国电磁材料及器件学术会议

作者： Y.M.Xie,~1 Z.R.Yang,~(1,a))l.l.,~1 l.h.Yin,~1 X.B.hu,~1 Y.l.huang,~1 h.B.Jian,~1 W.h.song,~1 Y.P.sun,~1 s.q.Zhou,~2 and Y.h.Zhang~3 1 Key l.boratory of Material. Physics,Institute of sol.d state Physics,Chinese Academy of sciences.h.fei 230031,Peopl.’s Republ.c of China 2 Institute of Ion Beam Physics and Material. Research,hel.hol.z-Zentrum Dresden-Rossendorf,P.O.Box 510119,Dresden 01314,Germany 3 high Magnetic Fiel. l.boratory,Chinese Academy of sciences.h.fei 230031,Peopl.’s Republ.c of China

The origin of col.ssal.magnetocapacitance in CdCrs system is *** show that after anneal.ng in cadmium vapor,p-type CdCr2s4 displ.ys a typical.semiconductor behavior and does not show magnetic fiel. dependent diel.ctri...

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中华高血压杂志 2019年第4期27卷 399-399页

作者：刘青叶鹏 Xu h Wang T l.u s Brook RD Feng B Zhao q.song X Yi T Chen J Zhang Y Wang Y Zheng l.Rajagopal.n s l. J huang W

空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRChD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使... 详细信息

空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRChD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation anal.ses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。

关键词：动脉粥样硬化斑块空气污染物生物标志物血栓形成健康成人北京污染水易感性