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spatial analysis of the.oste.arthritis microe.vironme.t: te.hnique., insights, and applications

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Bone.Re.e.rch 2024年第1期12卷 1-19页

作者： Xiwe. Fan Antonia Rujia sun Re.be. s.e.Young Isaac O.Afara Bre.t R.Hamilton Louis Jun Ye.Ong Ross Crawford Indira Prasadam Ce.tre.for Biome.ical Te.hnologie. Queensland University of TechnologyBrisbaneQLDAustralia school of Me.hanical Medical&Process EngineeringQueensland University of TechnologyBrisbaneQLDAustralia Ce.tral Analytical Re.e.rch Facility Queensland University of TechnologyBrisbaneQLDAustralia Mole.ular Horizons University of WollongongWollongongNSWAustralia De.artme.t of Te.hnical Physics University of Eastern FinlandKuopioFinland school of e.e.trical e.gine.ring and Compute. scie.ce Faculty of EngineeringArchitecture and Information TechnologyUniversity of QueenslandBrisbaneQLDAustralia Ce.tre.for Microscopy and Microanalysis University of QueenslandBrisbaneQLDAustralia The.Prince.Charle. Hospital BrisbaneQLDAustralia

Oste.arthritis(OA)is a de.ilitating de.e.e.ative.dise.se.affe.ting multiple.joint tissue.,including cartilage.bone.synovium,and adipose.*** pre.e.ts dive.se.clinical phe.otype. and distinct mole.ular e.dotype.,including inflammatory,me.abolic,me.hanical,ge.e.ic,and synovial ***,innovative.te.hnologie. are.ne.de. to support the.de.e.opme.t of e.fe.tive.diagnostic and pre.ision the.ape.tic *** analysis of bulk OA tissue.e.tracts has limitations due.to te.hnical constraints,causing challe.ge. in the.diffe.e.tiation be.we.n various physiological and pathological phe.otype. in joint *** issue.has le. to standardization difficultie. and hinde.e. the.succe.s of clinical *** insights into the.spatial variations of the.ce.lular and mole.ular structure. in OA tissue.,e.compassing DNA,RNA,me.abolite.,and prote.ns,as we.l as the.r che.ical prope.tie.,e.e.e.tal composition,and me.hanical attribute.,can contribute.to a more.compre.e.sive.unde.standing of the.dise.se.*** re.olve. biology e.able. biologists to inve.tigate.ce.ls within the.conte.t of the.r tissue.microe.vironme.t,providing a more.holistic vie. of ce.lular *** advance. in innovative.spatial biology te.hnique. now allow intact tissue.se.tions to be.e.amine. using various-omics le.se.,such as ge.omics,transcriptomics,prote.mics,and me.abolomics,with spatial *** fusion of approache. provide. re.e.rche.s with critical insights into the.mole.ular composition and functions of the.ce.ls and tissue. at pre.ise.spatial ***,advance. imaging te.hnique.,including high-re.olution microscopy,hype.spe.tral imaging,and mass spe.trome.ry imaging,e.able.the.visualization and analysis of the.spatial distribution of biomole.ule.,ce.ls,and *** the.e.mole.ular imaging outputs to conve.tional tissue.histology can facilitate.a more.compre.e.sive.characte.ization of dise.se.*** re.ie. summarize. the.re.

关键词： insight spatial e.able

e.fe.t of biochar on the.me.abolome.of soybe.n se.dlings

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Oil Crop scie.ce 2024年第1期9卷 60-68页

作者： Nathalia e.silva Mariana G.Aguilar Osania e.Fe.re.ra Gle.cia M.Paulino Jaque.ine.C.L.Carvalho Lúcia P.s.Pime.ta Alan R.T.Machado Programa de.Pos-graduaçao e. Cie.cias Ambie.tais Universidade do Estado de Minas GeraisFrutalMinas Gerais38202-436Brazil De.artame.to de.Química Universidade Federal de Minas GeraisMinas GeraisBelo Horizonte31270-901Brazil De.artame.to de.e.ge.haria Aplicada e.Te.nologias Ambie.tais Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil De.artame.to de.Cie.cias e.atas Universidade do Estado de Minas GeraisJoao MonlevadeMinas Gerais35930-314Brazil

The.use.of biochar can have.se.e.al e.fe.ts on plant ge.mination,de.e.ding on raw mate.ial,pre.aration me.hod and application ***,the.mole.ular me.hanisms that le.d to those.re.ults have.ye. to be.*** aim of this re.e.rch was to improve.the.unde.standing of the.e.me.hanisms by characte.izing the.me.abolic e.fe.ts of sugarcane.bagasse.biochar on soybe.n *** type. of biochars we.e.pre.are. by pyrolysis at 300℃(sCB300),400℃(sCB400)and 600℃(sCB600).The.,e.ch one.was mixe. into sand at 1%,3%,5%(w/w)dose.*** e.pe.ime.t was pe.forme. in 8 days of incubation,whe. the.numbe. of ge.minate. se.ds and the.ave.age.radicle.le.gth we.e.*** e.aluate.the.me.abolome.the.dry biomass(DB)was subje.te. to e.traction with a mixture.of me.hanol-d4 and D2O(1:1 v/v).The.e.tracts we.e.submitte. to me.abolomics analysis by Proton Nucle.r Magne.ic *** Re.ative.Ge.mination,Re.ative.Ave.age.Radicle.Growth and Ge.mination Inde. incre.se. in all tre.tme.ts compare. to *** the.othe. hand,the.DB incre.se. in all tre.tme.ts,e.ce.t for sCB300,at dose. of 1%and 3%w/*** me.abolite.(alanine.asparagine.ace.ic acid,citric acid,glyce.ol,fatty acids and sucrose.we.e.ide.tifie. and quantifie. in DB e.tracts as the.most influe.tial finding for the.se.aration of *** toge.he.,the.e.re.ults strongly sugge.te. that biochars acce.e.ate. the.catabolism of triacylglyce.ols to sucrose.and induce. a slight osmotic stre.s.

关键词： Ge.mination Me.abolomics 1H NMR Pyrolysis sugarcane.bagasse

A rat mode. of multicompartme.tal traumatic injury and he.orrhagic shock induce. bone.marrow dysfunction and profound ane.ia

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Animal Mode.s and e.pe.ime.tal Me.icine 2024年第3期7卷 367-376页

作者： Laure. s.Ke.ly Je.nife. A.Munle. e.ick e.Pons Kole.kode.B.Kannan e.izabe.h M.Whitle. Le.itia e.Bible.Philip A.e.ron Alicia M.Mohr De.artme.t of surge.y and se.sis and Critical Illne.s Re.e.rch Ce.te. University of Florida College of MedicineGainesvilleFloridaUSA Pathoge.e.is LLCGainesvilleFloridaUSA

Background:se.e.e.trauma is associate. with syste.ic inflammation and organ *** rode.t trauma mode.s are.the.mainstay of postinjury re.e.rch but have.be.n criticize. for not fully re.licating se.e.e.human *** aim of this study was to cre.te.a rat mode. of multicompartme.tal injury which re.re.te. profound traumatic ***:Male.sprague.Dawle. rats we.e.subje.te. to unilate.al lung contusion and he.orrhagic shock(LCHs),multicompartme.tal polytrauma(PT)(unilate.al lung contusion,he.orrhagic shock,ce.e.tomy,bife.oral pse.dofracture.,or na?ve.***,plasma toll-l ike.re.e.tor 4(TLR4),he.oglobin,sple.n to body we.ght ratio,bone.marrow(BM)e.ythroid proge.itor(CFU-Ge.M,BFU-e.and CFU-e.growth,plasma granulocyte.colony-stimulating factor(G-CsF)and right lung histologic injury we.e.asse.se. on day 7,with significance.de.ine. as p value.e.ults:Polytrauma re.ulte. in marke.ly more.profound inhibition of we.ght gain compare. to LCHs(p=0.0002)along with e.e.ate. plasma TLR4(pe. he.oglobin(pe.large. sple.n to body we.ght ratios(p=0.004).Both LCHs and PT de.onstrate. suppre.sion of CFU-e.and BFU-e.growth compare. to naive.psma G-CsF was e.e.ate. in PT compare. to both na?ve.and LCHs(ps and PT de.onstrate. significant histologic right lung injury with poor alve.lar wall inte.rity and inte.stitial ***:Multicompartme.tal injury as de.cribe. he.e.e.tablishe. a re.roducible.mode. of multicompartme.tal injury with worse.e. ane.ia,sple.ic tissue.e.large.e.t,we.ght loss,and incre.se. inflammatory activity compare. to a le.s se.e.e.*** may se.ve.as a more.e.fe.tive.mode. to re.re.te.profound traumatic injury to re.licate.the.human inflammatory re.ponse.postinjury.

关键词： ane.ia i nflammation polytrauma pse.dofracture shock

A hybrid machine.le.rning mode. for solar irradiance.fore.asting

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Cle.n e.e.gy 2024年第1期8卷 100-110页

作者： Ame.ra M.Almarzooqi Mahe. Maalouf Tare. H.M.e.-Fouly Vasile.os e.Katzourakis Mohame. s.e. Moursi Constantinos V.Chrysikopoulos De.artme.t of Industrial and syste.s e.gine.ring Khalifa UniversityAbu DhabiPO Box 127788UAE e.e.trical e.gine.ring and Compute. scie.ce.De.artme.t Khalifa University Abu DhabiUAE De.artme.t of Civil Infrastructure.and e.vironme.tal e.gine.ring Khalifa UniversityAbu DhabiPO Box 127788UAE school of Che.ical and e.vironme.tal e.gine.ring Technical University of CreteChaniaGreece

Nowcasting and fore.asting solar irradiance.are.vital for the.optimal pre.iction of grid-conne.te. solar photovoltaic(PV)powe. *** plants face.ope.ational challe.ge. and sche.uling dispatch difficultie. due.to the.fluctuating nature.of the.r powe. *** the.ge.e.ation capacity within the.e.e.tric grid incre.se.,accurate.y pre.icting this output be.ome. incre.singly e.se.tial,e.pe.ially give. the.random and non-line.r characte.istics of solar irradiance.unde. variable.we.the. *** study pre.e.ts a nove. pre.iction me.hod for solar irradiance.which is dire.tly in corre.ation with PV powe. output,targe.ing both short-te.m and me.ium-te.m fore.ast *** propose. hybrid frame.ork e.ploys a fast trainable.statistical le.rning te.hnique.base. on the.truncate.-re.ularize. ke.ne. ridge.re.re.sion *** propose. me.hod e.ce.s in fore.asting solar irradiance.e.pe.ially during highly inte.mitte.t we.the. pe.iods.A ke. stre.gth of our mode. is the.incorporation of multiple.historical we.the. parame.e.s as inputs to ge.e.ate.accurate.pre.ictions of future.solar irradiance.value. in its scalable.*** e.aluate. the.pe.formance.of our mode. using data se.s from both cloudy and sunny days in se.ttle.and Me.ford,UsA and compare. it against thre. fore.asting mode.s:pe.siste.ce.modifie. 24-hour pe.siste.ce.and le.st *** on thre. wide.y acce.te. statistical pe.formance.me.rics(root me.n square. e.ror,me.n absolute.e.ror and coe.ficie.t of de.e.mination),our hybrid mode. de.onstrate. supe.ior pre.ictive.accuracy in varying we.the. conditions and fore.ast horizons.

关键词： solar powe. ge.e.ation ke.ne. ridge.re.re.sion hybrid mode. fore.asting

Blood Pre.sure.Profile.and Glyce.ic Control of Type.2 Diabe.ics and Hype.te.sive. at the.Yalgado Oue.raogo Unive.sity Hospital: A Re.ie. of 116 Case.

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World Journal of Cardiovascular Dise.se. 2024年第1期14卷 61-76页

作者： G. R. C. Millogo A. Thiam Y. Kambiré e. Nongkouni s. e. Dabiré L. J. Kagambéga J. K. Kologo V. N. Yaméogo P. Zabsonré De.artme.t of Cardiology Yalgado Ouédraogo University Hospital Ouagadougou Burkina Faso De.artme.t of Cardiology Tengandogo University Hospital Ouagadougou Burkina Faso

Obje.tive. The.association hype.te.sion and diabe.e. is important. The.two pathologie. may influe.ce.e.ch othe.. The.aim was to study the.corre.ation be.we.n glyce.ic control and blood pre.sure.control and to de.e.mine.the.factors associate. with blood pre.sure.control. Me.hodology: This was a de.criptive.cross-se.tional study with an analytical focus ove. 7 months. Patie.ts we.e.re.ruite. as outpatie.ts and all unde.we.t ambulatory blood pre.sure.me.sure. glycate. he.oglobin and cre.tinine.me.sure.e.ts, and asse.sme.t of compliance.with tre.tme.t. Re.ults: During this pe.iod 116 patie.ts we.e.colle.te.. The.pre.ominance.was fe.ale.69%. The.me.n age.of the.patie.ts was 62 ± 7 ye.rs with a pe.k be.we.n 60 and 70 ye.rs. The.ave.age.age.of hype.te.sion was 12 ye.rs and that of diabe.e. 6 1/2 ye.rs. The.most fre.ue.tly associate. cardiovascular risk factor was a se.e.tary life.tyle.(71.5%) afte. age. 57.8% of patie.ts we.e.not controlle. at the.office. with a pre.ominance.of systolic hype.te.sion (58.2%). 61.6% of patie.ts we.e.controlle. by ambulatory blood pre.sure.me.sure. a rate.of 47.8% of white.coat hype.te.sion. Glyce.ic control was obse.ve. in 42.2% of case. and 87% of patie.ts had good re.al function (glome.ular filte. rate.≥ 60 ml/mn). The.ape.tic compliance.was good in 53.4% of case. and dual the.apy was the.most use. the.ape.tic modality 44.8% (52 patie.ts) followe. by triple.the.apy. The.factors associate. with poor blood pre.sure.control we.e.glyce.ic imbalance. non-compliance.and monothe.apy. Dual the.apy had a prote.tive.e.fe.t. Conclusion: The.association of hype.te.sion and type.2 diabe.e. is fre.ue.t. The.risk of occurre.ce.incre.se. with age. Ambulatory blood pre.sure.me.sure.is the.be.t me.hod to asse.s blood pre.sure.control. Optimization of blood pre.sure.control should also include.optimization of glyce.ic control.

关键词： Blood Pre.sure.Control Glyce.ic Control Hype.te.sive.and Diabe.ic Patie.ts

Re.ponse. of Annual Variability of Ve.e.ation NPP to Climate.Variable. Using sate.lite.Te.hnique. in Gadarif state. sudan

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Journal of Ge.graphic Information syste. 2024年第2期16卷 136-147页

作者： Anwar Mohame.e.hassan Bo Zhang Abde.rahim e. Jahe.nabi e.an M. e.hassan Faculty of Ge.graphy and e.vironme.tal scie.ce. Northwest Normal University Lanzhou China Faculty of Agriculture University of Khartoum Khartoum Sudan Faculty of Agriculture Omdurman Islamic University Omdurman Sudan

Plants play an e.se.tial role.in matte. and e.e.gy transformations and are.ke. me.se.ge.s in the.carbon and e.e.gy cycle. Ne. primary productivity (NPP) re.le.ts the.capability of plants to transform solar e.e.gy into photosynthe.is. It is ve.y se.sible.for factors affe.ting on ve.e.ation variability such as climate. soils, plant characte.istics and human activitie.. so, it can be.use. as an indicator of actual and pote.tial tre.d of ve.e.ation. In this study we.use. the.actual NPP which was de.ive. from MODIs to asse.s the.re.ponse.of NPP to climate.variable. in Gadarif state. from 2000 to 2010. The.corre.ations be.we.n NPP and climate.variable. (te.pe.ature.and pre.ipitation) are.calculate. using Pe.rson’s Corre.ation Coe.ficie.t and ordinary le.st square. re.re.sion. The.main re.ults show the.following 1) the.corre.ation Coe.ficie.t be.we.n NPP and me.n annual te.pe.ature.is some.hat ne.ative.for Fe.haga, Rahd, Gadarif and Galabat are.s and we.kly ne.ative.in Faw are.;2) the.corre.ation Coe.ficie.t be.we.n NPP and annual total pre.ipitation is we.kly ne.ative.in Faw, Rahd and Galabat are.s and some.hat ne.ative.in Galabat and Rahd are.s. This study de.onstrate. that the.corre.ation analysis be.we.n NPP and climate.variable. (pre.ipitation and te.pe.ature. give. re.iably re.ult of NPP re.ponse. to climate.variable. that is cle.rly in a ve.y large.scale.of study are..

关键词： Climate.Variable. MODIs NPP Climate.Change Corre.ation Coe.ficie.t Gadarif state Re.ote.se.sing GIs Applications

Broad Hormonal Re.ponse. Induce. by Aluminum in Roots of Dwarf Transge.ics of solanum lycope.sicum L. cv “Micro-Tom”

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Ame.ican Journal of Plant scie.ce. 2024年第5期15卷 349-358页

作者： Arthur B. Rate. Danie.a Boanare. Danie.e.s. G. Piane.ti Fe.ipe.De.la-Torre.Joni e. Lima Marce. G. C. França De.artme.t of Botany and Plant Physiology Laboratory Federal University of Minas Gerais Belo Horizonte Brazil

The.spatial patte.n distribution of plant hormone. in re.ponse.to aluminum (Al) toxicity in roots re.ains to be.shown. This study was pe.forme. to asse.s the.root hormonal accumulation and ge.e.e.pre.sion in re.ponse.to Al toxicity in five.transge.ic miniature.dwarf tomatoe. cv. Micro-Tom (MT). MT and MT transge.ics to acid indole.ace.ic, cytokinin, gibbe.e.lin, abscisic acid and e.hyle.e.we.e.cultivate. in nutrie.t solutions containing diffe.e.t Al conce.trations. Root growth e.ongation was me.sure. and ce.lular damage.was visualize. by staining e.ans’s blue. The.GUs re.orte. ge.e.staining te.hnique.was use. to visualize.hormonal change. in MT ape. root tissue.. Data indicate. that the.MT is se.sitive.to Al that induce. significant growth inhibition and ce.lular damage. Al conce.tration of 27 μM was significantly toxic, inducing root ape. darke.ing and inhibition of root de.e.opme.t. The.qualitative.e.aluation of GUs re.orte. ge.e.e.pre.sion showe. inte.se.crosstalk among all hormone. studie., unde.scoring the.comple.ity of signaling induce. by Al in ape. roots. Re.ults point out to a major unde.standing of the.hormonal signaling in re.ponse.to Al toxicity, which may induce.a change.of root growth and archite.ture.with growth inhibition and ce.l constraints modulate. by all diffe.e.t hormone. e.aluate..

关键词： Ge.e.Re.orte. Me.al Plant Hormone. Root staining

Comme.tary on "Association of daily sitting time.and le.sure.time.physical activity with body fat among ***"

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Journal of sport and He.lth scie.ce 2024年第2期13卷 127-129页

作者： Barbara e.Ainsworth school of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China

In the.r study,association of daily sitting time.and le.sure.time.physical activity (LTPA) with body fat among ***,Liao e. al.^(1) analyze. data from the.2011-2018 National He.lth and e.amination surve. to e.amine.associations be.we.n h/day sitting,me.ting (or not me.ting) the.*** Activity Guide.ine. of≥150 min/we.k of mode.ate.and vigorous-inte.sity LTPA,and combinations of sitting time.and LTPA on totaland trunk pe.ce.t body fat (BF%).

关键词： U.s. adult among

De.e.tion and cle.rance.in Alzhe.me.’s dise.se. le.ding with illusive.che.ical, structural and morphological fe.ture. of the.targe.s

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Ne.ral Re.e.e.ation Re.e.rch 2024年第3期19卷 497-498页

作者： Luís Gale. i3s−Instituto de.Inve.tigação e.Inovação e. saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de.Cie.ncias Biome.dicas Abe. salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly spe.ific inte.actions be.we.n biomole.ule.,such as antige.-antibody,prote.n-ligand,or nucle.c acid base.pair comple.e.tary are.on the.basis of the.organization of comple. *** same.principle. may be.te.tative.y use. in mole.ular me.icine.for diagnosis and the.ape.tics.A mole.ule.can be.de.igne. to se.e.tive.y bind a prote.se.and the.e.y inhibit the.production of a pe.tide.that forms toxic aggre.ate. in the.brain or an antibody may be.produce. to bind spe.ifically to that pe.tide.for de.e.tion or cle.rance.***,inte.fe.e.ce.in biological syste.s is not that *** a start the.e.is the.inhibition of the.physiological role.of the.prote.se.more.ve.,se.e.al cle.vage.fragme.ts may be.produce.,which may continue.to dive.ge.due.to putative.post-translational modification and se.f-asse.bly proce.se.,hiding the.toxic targe. in a“soup”of pe.tide.spe.ie. varying in size.structure.and che.ical composition.A pe.spe.tive.of the.curre.t status and challe.ge. in targe.ing pe.tide.spe.ie. for diagnosis and tre.tme.t in the.conte.t of Alzhe.me.’s dise.se.is give..

关键词： Alzhe.me. diagnosis the.e.y