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Anticonvulsant potential of r.s.vastatin in combination with carbamazepine and valproate in animal models of epilepsy

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World Journal of Methodology 2025年第2期15卷 137-144页

作者： Vandana Tayal Akash Mandal Ijasul Haque M Akhilesh Mishra Bhupinder.s.Kalra Vandana roy Department of Pharmacology Maulana Azad Medical CollegeNew Delhi 110002India Department of Pharmacology MES Medical CollegePerintalmanna 679338KeralaIndia Department of Central Animal Facility Maulana Azad Medical CollegeNew Delhi 110002India

BACKGrOUND Epilepsy impacts millions of people,with many not r.s.onding to existing *** evidence links neuroinflammatory processes to *** exhibit anti-inflammatory and neuroprotective properties,potentially offering antiepileptic *** To evaluate the anticonvulsant effects of r.s.vastatin in animal models of *** Ninety-six albino mice were divided into 16 *** the maximal electr.s.ock seizure(MEs)model,eight groups received intraperitoneal vehicle,carbama-zepine,r.s.vastatin,or a *** measured included seizure protection[tonic hind limb extension(THLE)],duration of THLE,seizure duration,and *** the pentylenetetrazol(PTZ)model,eight groups were pretreated with vehicle,valproate,r.s.vastatin,or a combination,with outcomes measured as seizure latency,seizure duration,and *** In the MEs model,r.s.vastatin exhibited protection against THLE in a small percentage of *** shortens the duration of THLE in a dose-dependent ***,none of these were statistically significant com-pared to the control *** combination of r.s.vastatin 10 mg/kg with carbamazepine 4 mg/kg r.s.lted in a significant reduction in seizure duration compared to the control group,better than carbamazepine alone at 4 mg/kg and 6 mg/*** the PTZ model,r.s.vastatin alone showed no significant effects on latency,duration of seizure,or ***,r.s.vastatin 10 mg/kg combined with valproate 100 mg/kg significantly delayed the onset of seizur.s.seizure duration and mortality percentage,better than valproate alone at 100 mg/*** r.s.vastatin enhanced the anticonvulsant effects of carbamazepine and *** studies are required to explore the antiepileptic potential of r.s.vastatin at various doses,durations,dosage for.s.routes and models.

关键词： Antiepileptic Anticonvulsant statins r.s.vastatin Maximal electr.s.ock seizure Pentylenetetrazol

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Zero-Absorption Isolines in a 2-Photon 2-Level Atom Model

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Communications in Theoretical Physics 2017年第7期67卷 83-90页

作者： s.s.Hassan r.A.Alharbey King Abdulaziz University Faculty of Science Mathematics Department P.O. Box 42696 Jeddah 21551 Kingdom of Saudi Arabia

The c-number atomic Bloch equations modelling the coupling of a 2-photon 2-1evel single atom with a non-r.s.nant （A # O） squeezed vacuum （sV） radiation r.s.rvoir.s.ow that：（i） The quantum interference （QI） process, of parameter f O, between the 2-photon transition channels causes coupling of the atomic variables （inversion and polar.s.tion）, and, （ii） The sV r.s.rvoir parameters （N, M） induce periodic coefficients and hence inhibited oscillatory behaviour in the atomic variables. Perturbative analytical solutions of these non-autonomous B1och equations are derived and used to calculate the absorption spectrum of a weak field probing the system. Of particular, the zero-absorption isolines in the relevant （N, f）- and （A, f ）-planes of the the largest set of points, where absorption is zero, in parameter （M） of the sV r.s.rvoir. system parameters are identified computationally. It is found that, the （A, f）-plane depends on the choice of the degree of squeezing

关键词： non-autonomous Bloch equations 2-photon transition quantum interference squeezed vacuumr.s.rvoir absorption spectrum

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Oblique collisional effects of dust acoustic waves in unmagnetized dusty plasma

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Chinese Physics B 2020年第6期29卷 304-313页

作者： M s Alam M r Talukder Department of Mathematics Chittagong University of Engineering and TechnologyChittagong-4349Bangladesh Plasma science and Technology Laboratory Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi-6205Bangladesh

Effects of oblique collisions of the dust acoustic(DA)waves in dusty plasma are studied by considering unmagnetized fully ionized *** plasma consists of inertial warm negatively charged massive dusts,positively charged dusts,superthermal kappa distributed electrons,and isothermal *** extended Poincaré–Lighthill–Kuo(e PLK)method is employed for the drivation of two-sided Korteweg–de Vries(KdV)equations(KdVEs).The Kd V soliton solutions are derived by using the hyperbolic secant *** effects of superthermality index of electrons,temperature ratio of isothermal ion to electron,and the density ratio of isothermal ions to negatively charged massive dusts on nonlinear coefficients are *** effects of oblique collision on amplitude,phase shift,and potential profile of right traveling solitons of DA waves are also *** study reveals that the new nonlinear wave structur.s.are produced in the colliding region due to head-on collision of the two counter propagating DA *** nonlinearity is found to decrease with the increasing density ratio of ion to negative dust in the critical *** phase shifts decrease(increase)with increasing the temperature ratio of ion to electron(κe).The hump(compr.s.ive,κeshaped(rarefactive,κe>κec)solitons are produced depending on the angle(θ)of oblique collision between the two waves.

关键词： ion acoustic wave dusty plasma kappa distribution ePLK method hyperbolic secant method

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Effect of friction stir processing on mechanical properties and heat transfer of TIG welded joint of AA6061 and AA7075

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Defence Technology（防务技术） 2021年第3期17卷 715-727页

作者： Husain Mehdi r.s.Mishra Department of Mechanical Engineering Delhi Technological UniversityDelhiIndia

Tungsten inert gas(TIG) welding is the most commonly used joining process for aluminum alloy for AA6061 and AA7075 which are highly demanded in the aer.s.ace engineering and the automobile sector, but there are some defects occur during TIG welding like micro-crack, coarse grain structure, and por.s.ty. To improve these defects, the TIG welded joint is processed using friction stir processing(FsP).This paper pr.s.nts the effect of friction stir processing on TIG welding with filler Er4043 and Er 5356 for dissimilar aluminum alloy AA6061 and AA7075. The mechanical characterization, finite element formulation and mathematical equations of heat transfer of TIG + FsP welded joints are investigated using ANsYs Fluent software by adjusting process parameters of FsP. The r.s.lts show that the maximum compr.s.ive r.s.dual str.s. 73 MPa was obtained at the fusion zone(FZ) of the TIG weldment with filler Er4043, whereas minimum compr.s.ive r.s.dual str.s. 37 MPa was obtained at stir zone(sZ) of the TIG+ FsP with filler 5356. The maximum heat flux 5.33 × 106 W/m2 and temperature 515C have observed at tool rotation 1600 rpm with a feed rate of 63 mm/min. These r.s.lts give a satisfactory measure of confidence in the fidelity of the simulation。

关键词： r.s.dual str.s. TIG+FsW Heat transfer Micro-hardness Tensile strength

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People’s participation in watershed management programmes:Evaluation study of Vidarbha region of Mahar.s.tra in India

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International soil and Water Conservation r.s.arch 2014年第3期2卷 57-66页

作者： G.L.Bagdi r.s.Kurothe Central soil&Water Conservation r.s.arch&Training Institute Research CentreVasad-388306District-AnandGujaratIndia

People’s participation in watershed management programmes is an important strategy of government of India for making watershed programmes *** of local beneficiary farmers is mandatory in planning,implementation and maintenance of watershed development projects as per common guidelines issued by Ministry of Agriculture,Government of *** Bank for Agriculture and rural Development(NABArD)has launched holistic watershed development programmes on 2nd October,2006 to help farmers in the six distr.s.ed districts of Vidarbha region of Mahar.s.tra in ***,there is a need to know the level of participation by the local people in government sponsored watershed management *** study was conducted during 2011-2012 in this Vidarbha region of Mahar.s.tra to measure the extent of people’s participation in NABArD supported Holistic Watershed Development Programme(NsHWDP).In this paper a detailed structured three-point-continuum schedule was developed by the investigators regarding various aspects of participation by local people in soil and water conservation for watershed management ***’s Participation Index(PPI)was also designed to compute the extent of people’s *** for this study was gathered through personal interviews from farmers of six selected districts in Vidarbha region of *** of this study indicated that the extent of people’s participation in planning was 63.7 per cent,in implementation was 57.7 per cent and in maintenance was 75.1 per *** shows that the extent of people’s participation in NsHWDP in the six distr.s.ed districts of Vidarbha region of Mahar.s.tra was moderate during watershed programme planning and implementation phases,whereas,high level of participation was exhibited during maintenance phase.

关键词： People’s Participation soil&water conservation Watershed development programme

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sYNTHEsEs AND CHArACTErIZATIONs OF OLIGO(AZOMETHINE ETHEr.s.DErIVED FrOM 2,2'-[1,4-ENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE AND 2,2'-[1,2-PHENYLENEBIs(METHYLENEOXY)]DIBENZALDEHYDE

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Chinese Journal of Polymer.s.ience 2012年第5期30卷 682-693页

作者： Ismet Kaya süleyman Culhaoglu Canakkale Onsekiz Mart University Faculty of Science and ArtsDepartment of ChemistryCanakkale 17020Turkey

The oligo（azomethine ether.s.were synthesized via polycondensation of alkyl diamines with aromatic dialdehydes. Two series of dialdehydes, namely 2,2＇-[1,2-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-1,2-（PBMODB）] and 2,2＇- [1,4-phenylenebis（methyleneoxy）]dibenzaldehyde [2,2＇-I,4-（PBMODB）] were prepared from the condensation reactions of salicylaldehyde with o-xylenedibromide and p-xylenedibromide, r.s.ectively. The structur.s.of dialdehydes and oligomers were determined by FT-Ir, 1H-NMr and 13C-NMr. The thermal analyses of oligomers were conducted by DsC and TG/DTA techniques, r.s.ectively. size exclusion chromatography （sEC） technique was also used to determine molecular weights and molecular weight distributions of oligomers. Electrochemical properties of the synthesized products were investigated.

关键词： Polyazomethine Thermal analysis Dialdehyde Oligoazomethine.

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Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental r.s.lts of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their.s. predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatur.s.of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental r.s.lts of branching fractions for.s.mileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** r.s.lts of branching fractions in scalar leptoquark model are found very close to the experimental r.s.lts and exist around the range of 1σ *** pr.s.nted a comparative study of the NP models to check their.s.nsitivity on these *** anticipate that further r.s.arch on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

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Neumann＇s method for boundary problems of thin elastic shells

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Applied Mathematics and Mechanics(English Edition) 2017年第4期38卷 543-556页

作者： Y. s. NEUsTADT Department of Civil Engineering Samara State Architectural and Building University Samara 443001 Russia

The possibility of using Neumann＇s method to solve the boundary problems for thin elastic shells is studied. The variational statement of the static problems for the shells allows for a problem examination within the distribution space. The convergence of Neumann＇s method is proven for the shells with holes when the boundary of the domain is not completely fixed. The numerical implementation of Neumann＇s method normally requir.s.significant time before any reliable r.s.lts can be achieved. This paper.s.ggests a way to improve the convergence of the process, and allows for parallel computing and evaluation during the calculations.

关键词： boundary problem thin elastic shell theory Neumann's method variational principle Korn's inequality distribution embedding theorem Green tensor

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高分子复合材料加工工程

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2004年

作者： (美)r.s.戴夫

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Effect of adrenalectomy and hydrocortisone on ventral pr.s.ate of rats

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Asian Journal of Andrology 2001年第4期3卷 289-300页

作者： Neena Nair r.s.Bedwal r.s.Mathur Cell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 IndiaCell Biology Laboratory Department of Zoology University of Rajasthan Jaipur 302004 India

Aim: To study the effects of adrenalectomy and hydrocortisone on the ventral pr.s.ate of sD rats. Methods: Inadrenalectomised (ADX) and ADX + hydrocortisone (1, 2, or 4 mg) treated rats, the pr.s.atic histology and thecholesterol, protein, zinc, and copper levels and the enzymic profile (acid phosphatase, alkaline phosphatase, aryl sul-phatase, lactic dehydrogenase, and leucine aminopeptidase) in the pr.s.atic tissue were determined; the serum hormon-al profile (testosterone, FsH and LH) was also assayed. r.s.lts; Adrenalectomy caused a progr.s.ive degenerationin pr.s.atic structure that was not reversed by hydrocortisone treatment. The serum testosterone were significantly lowerin ADX than in sham operated rats and lower in ADX + hydrocortisone than in ADX-C rats (P serumFsH and LH were below the detection limit of 1 mIU/mL. The enzymatic activity was higher in ADX than in sham op-erated rats and higher in ADX + hydrocortisone than in ADX-C rats (Pr.s.atic zinc levels wer.s.gnificantly higher in sham operated than in ADX, and higher in ADX-C than in ADX + hydrocortisone rats (P r.s.atic copper level was significantly lower in sham operated than in ADX, and lower in ADX-C thanin the ADX + hydrocortisone rats (P sion; In rats, adrenalectomy leads to pathological and func-tional changes of the pr.s.ate. Hydrocortisone treatment at the doses employed did not reverse these changes. (Asian JAndrol 2001 Dec; 3: 289 - 300)

关键词： adrenalectomy ventral pr.s.ate hydrocortisone testosterone FsH LH cholesterol zinc copper acid phosphatase alkaline phosphatase aryl sulphatase lactic dehydrogenase leucine aminopeptidase

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