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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 23-24页

作者： Dujardin K. defebvre L. Duhamel A. 江山 Neurol. et Pathologie du Mouvement Neurologie A Centre Hospitalier Universitaire 59037 Lille Cedex France

Objective: To identify features in cognitive functioning and regional cerebral blood flow (rCBF) in newly diagnosed Parkinson’ s disease (PD) patients and to determine whether these factors are able to predict the progression of the disease in general and the development of cognitive decline in particular. Methods: 50 previously treatment- naive PD patients participated in the study. Cognitive assessment and sPECT were performed twice: at the time of diagnosis and then 3 years later. six patients died or refused to continue. The Mattis dementia rating scale, the WAIs- R digit span test, a word list learning/recall test, a word fluency task and the stroop word- colour test were used to assess cognitive function. rCBF was measured in 10 pairs of regions of interest. Principal component analysis of the data from the final examination was used to determine which variables allowed the formation of patient subgroups. Thereafter, factorial discriminant analysis (FDA) was performed in order to obtain a predictive model of these final classes. Results: A stepwise procedure enabled the identification of 3 clusters (26, 16 and 2 patients). As the patients in the smallest cluster met the criteria for dementia at the final examination, they were discarded from further analyses. All the cognitive variables contributed to the constitution of the two other clusters. Age, educational level and all the rCBF parameters also contributed but to a lesser extent. Comparison of these groups showed reduced overall cognitive efficiency and an exacerbated subcorticofrontal syndrome in the 16- patient cluster. FDA showed that the best predictive model for the final classes was based on 7 variables: educational level, semantic and alternating word fluency, stroop interference index and the right medial frontal, left parietal and left lenticular nucleus rCBF findings. Conclusion: Even though both cognitive and rCBF parameters help predict the progression of newly diagnosed PD patients and bearin

关键词：帕金森病 sPECT检查认知功能 rCBF 数字广度预测模型主成分分析局部脑血流量等级量表豆状核

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帕金森病的初级治疗:2000年3月达成共识的治疗原则在北部加莱地区的应用(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 51-52页

作者： simonin C. defebvre L. Destée A. 李一明 serv. Neurol. Pathol. du Mou vement H pital R. Salengro CHRU 59037 Lille Cedex France

Introduction. For Parkinson’s disease, the choice of the initial treatment is essentially between L-Dopa and dopaminergic agonists. selegilin, anticholin ergic and amantadine can be used for subjects with moderate symptoms. The first French consensus conference, held in 2000, elaborated decision-making rules wh ich take into account both the age and disease severity. The aim of our study wa s to evaluate the impact of these recommendations on treatments prescribed for de novo parkinsonian patients in the Nord-Pas de Calais area, comparing initial prescriptions before and after the conference. Methods. Three groups of 50 patients whose diagnosis of Parkinson’s diseaseha d been establish in three periods (1985- 1992, 1993- 1999, and after July 2000 , date of the national publication of the consensus) were constituted. Results. For these 3 groups, the initial treatment complied with the 2000 recommendations for 58, 84 and 82 percent of the patients respectively. The prescriptions of ag onists increased progressively while the prescriptions of L-Dopa decreased for younger patients, in concordance with the consensus, but also for older patient s, in opposition with the recommendations, though without any increase in the incidence of side effects. The non dopaminergic treatments were almost discar ded as initial treatment. Conclusion. Prescription habits have gradually changed over the past 10 years. Changes were linked to the elaboration of the national consensus conference guidelines and to the apparent desire to decrease L-Dopa prescriptions.

关键词：帕金森病左旋多巴多巴胺能药物金刚烷胺抗胆碱能药物疾病严重程度副作用发生率

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small P values may not yield robust findings:an example using REsT-meta-PD

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science Bulletin 2021年第21期66卷 2148-2152,M0003页

作者： Xi-Ze Jia Na Zhao Hao-Ming Dong Jia-Wei sun Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa Bo-Yu Chen Jun Chen s.ephen coombes.luc defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito Guo-Guang Fan Federica Di Nardo Yi-Xuan Feng Brett W.Fling saurabh Garg Moran Gilat Martin Gorges shu-Leong Ho Fay BHorak Xiao Hu Xiao-Fei Hu Biao Huang Pei-Yu Huang Ze-Juan Jia Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani Jing Li Qing Li Ai-Ping Liu Bo Liu Hu Liu Wei-Guo Liu Renaud Lopes Yu-Ting Lou Wei Luo Tara Madhyastha Ni-Ni Mao Grainne McAlonan Martin J.McKeown shirley Pang Andrea Quattrone Irena Rektorova Alessia sarica Hui-Fang shang James M.shine Priyank shukla Tomas slavicek Xiao-Peng song Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt Jian Wang Jue Wang Z.Jane Wang Lu-Qing Wei Xia Wu Xiao-Jun Xu Lei Yan Jing Yang Wan-Qun Yang Nai-Lin Yao De-Long Zhang Jiu-Quan Zhang Min-Ming Zhang Yan-Ling Zhang Cai-Hong Zhou Chao-Gan Yan Xi-Nian Zuo Mark Hallett Tao Wu Yu-Feng Zang Center for Cognition and Brain Disorders the Affiliated HospitalHangzhou Normal UniversityHangzhou 310015China Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Hangzhou 311121China National Basic science Data Center Beijing 100190China state Key Laboratory of Cognitive Neuroscience and Learning&McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China school of Information and Electronics Technology Jiamusi UniversityJiamusi 154007China Neuroscience Program Central European Institute of TechnologyCEITECMasaryk UniversityBrno 62500Czech Republic Department of Applied Physiology and Kinesiology University of FloridaGainesville FL 32611USA Univ.Lille InsermCHU LilleU1172-LilNCog-Lille Neuroscience&CognitionLille F-59000France The Institute for Biomedical Research and Innovation National Research CouncilMangone CS 87050Italy Department of Radiology The First Affiliated Hospital of China Medical UniversityShenyang 110001China Department of Radiology Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Medicine Surgery and DentistryScuola Medica SalernitanaUniversity of SalernoFiscianoSA 132-84084Italy Department of Advanced Medical and surgery sciences University of Campania“Luigi Vanvitelli”Caserta 81100Italy Eye Center of the 2nd Affiliated Hospital Medical College of Zhejiang UniversityHangzhou 310020China Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310020China Department of Health and Exercise science Colorado State UniversityFort Collins CO 80523USA Pacific Parkinson’s Research Centre University of British ColumbiaVancouver BC V6E 2M6Canada Department of Medicine(Neurology)University of British Columbia Vancouver BC V6T 1B7Canada Brain and Mind Center The University of SydneySydney NSW 2006Australia Department of Neurology Ulm UniversityUlm 89081Germany Division of Neurology Department of MedicineQueen Mary HospitalUniversity of Hong KongHong Kong 999077China Department of

Thousands of resting state functional magnetic resonance imaging(Rs-f MRI)articles have been published on brain *** precise localization of abnormal brain activity,a voxel-level comparison is *** of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1].

关键词：帕金森病 precise correction

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运动功能减退和运动徐缓在亨廷顿病患者步态障碍中的作用:一项生物力学研究

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 27-27页

作者： Delval A. Krystkowiak P. Blatt J.-L. L. defebvre 张殿增 Department of Neurology and Movement Disorders Hospital R. Salengro Regional University Hospital 59037 Lille Cedex France

Objective: To evaluate specific patterns of locomotion in Huntington’s disease (HD) and notably the respective roles of hypokinesia (i. e. a decrease in the amplitude of movement) and bradykinesia (i. e. difficulty in executing a movement, slowness) in gait disturbance. Methods: Kinematic, spatial (stride length, speed), temporal (cadence, speed, and stride time) and angular gait parameters (jo int ankle range) were recorded in 15 early-stage HD patients by means of a video motion analysis system and then compared with 15 controls and 15 Parkinson’s disease (PD) patients. Hypokinesia was studied in terms of both spatial (decrease in stride length) and angular gait parameters (decrease in joint ankle range), whereas hyperkinesia was characterized by an increase in joint ankle range. Bradykinesia (defined by a decrease in gait velocity) was also assessed in terms of temporal parameters (cadence, stride time). We studied the influence of clinical symptoms (motor dysfunction, chorea, overall disability and cognitive impairment) and the CAG repeat number on gait abnormalities. Results: we observed a clear decrease in gait speed, a decrease in cadence and an increase in stride time (i. e. bradykinesia) for HD, with significant intra-individual variability. Cadence remained normal in PD. In HD, there was no evidence for a clear decrease in stride length, although the latter is a characteristic feature of hypokinetic gait (such as that observed in PD). Angle analysis revealed the coexistence of hyperkinesia and hypokinesia in HD, which thus participate in gait abnormalities. Gait speed in HD was correlated to the motor part of the UHDRs. Conclusion: Gait in HD is mainly characterized by a timing disorder: bradykinesia was present, with severe intra-individual variability in temporal gait parameters.

关键词：运动功能减退步态障碍亨廷顿病生物力学研究关节活动范围时间参数步行速度运动功能障碍认知功能障碍

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