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Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal surgery 2024年第3期16卷 740-750页

作者： Phillip Gu shishir Dube Norman Gellada so Yung Choi susan Win Yoo Jin Lee shaohong Yang Talin Haritunians Gil Y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav syal Andres J Yarur David Ziring shervin rabizadeh Phillip Fleshner Cindy Kallman suzanne Devkota s.ephan r targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics shared resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGrOUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POr)of Crohn’s disease(CD).However,its prognostic value is INTrODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POr)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POr,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTEs Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube s and Choi sY were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win s,Lee YJ and Yang s were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

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Immunopathogenesis of inflammatory bowel disease

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World Journal of Gastroenterology 2008年第3期14卷 390-400页

作者： David Q shih s.ephan r targan Cedars-sinai Inflammatory Bowel Disease Center Los Angeles CA United States Department of Medicine Division of Digestive Diseases University of California Los Angeles CA United States Cedars-sinai Inflammatory Bowel Disease Center Los Angeles CA United States

Crohn’s disease and ulcerative colitis are chronic relapsing immune mediated disorders that results from an aberrant response to gut luminal antigen in genetically susceptible host. The adaptive immune response that is then triggered was widely considered to be a T-helper-1 mediated condition in Crohn’s disease and T-helper-2 mediated condition in ulcerative colitis. recent studies in animal models, genome wide association, and basic science has provided important insights in in the immunopathogenesis of inflammatory bowel disease, one of which was the characterization of the interleukin-23/Th-17 axis.

关键词：克罗恩氏病溃疡性结肠炎免疫系统症状

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A case of steroid-dependent myeloid granulocytic sarcoma masquerading as Crohn's disease

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World Journal of Gastroenterology 2011年第19期17卷 2446-2449页

作者： Lola Y Kwan s.ephan r targan David Q shih Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States Inflammatory Bowel Disease Center and Immunobiology research Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States Cedars-sinai Inflammatory Bowel and Immunobiology research Institute 8700 Beverly Blvd.Suite 4066Los AngelesCA 90048United States

small bowel tumors and Crohn's disease are common causes of small bowel *** stage neoplasms can easily be mistaken for Crohn's ***,thorough work-ups including imaging studies and endoscopic evaluation with biopsies are critical for accurate *** we report a case of an otherwise healthy female with progressive onset of multiple,recurrent obstructive symptoms secondary to terminal ileal narrowing who was referred for management of steroid-dependent Crohn's *** thorough evaluation,the diagnosis was revised to myeloid granulocytic sarcoma involving the terminal *** this case,a delay in diagnosis can be detrimental for prognosis,as myeloid granulocytic sarcoma is highly predictive of underlying acute myeloid leukemia and needs urgent referral for chemotherapy and/or resection.

关键词：粒细胞依赖型肉瘤激素伪装回肠末端肠梗阻肠肿瘤

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