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神童黑客和他的两万名受害人

商业周刊（中文版） 2024年第7期 62-71页

作者： drake BEnnETT JUUsO WEsTERLUnD(摄影) 许诺(译) 不详

亚历山大·基维迈基是一位网络神童他正因一场前所未有的恶性犯罪而受审。巴黎西郊的库尔贝沃区紧邻塞纳河左岸,拉德芳斯商务区就位于这里。在市区可以远远看到拉德芳斯的一簇簇摩天大楼;从卢浮宫沿香榭丽舍大街穿过凯旋门,这条长长的... 详细信息

亚历山大·基维迈基是一位网络神童他正因一场前所未有的恶性犯罪而受审。巴黎西郊的库尔贝沃区紧邻塞纳河左岸,拉德芳斯商务区就位于这里。在市区可以远远看到拉德芳斯的一簇簇摩天大楼;从卢浮宫沿香榭丽舍大街穿过凯旋门,这条长长的中轴线终点就是市容乏善可陈的拉德芳斯。

关键词：香榭丽舍大街库尔贝摩天大楼乏善可陈中轴线商务区塞纳河

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增长放缓科技行业开始习惯裁员

商业周刊（中文版） 2024年第4期 20-21页

作者： Antonia Mufarech drake Bennett 竹西(译) 不详

●今年的大规模裁员表明,一个行业禁忌已经被打破对西德尼·鲁萨科夫(sydney Russakov)来说,这是转型的一年。2023年3月,她失去了在一家名为Universe的初创公司的工作(该公司的产品是“无代码”软件设计工具),当时该公司裁掉了她担任的... 详细信息

●今年的大规模裁员表明,一个行业禁忌已经被打破对西德尼·鲁萨科夫(sydney Russakov)来说,这是转型的一年。2023年3月,她失去了在一家名为Universe的初创公司的工作(该公司的产品是“无代码”软件设计工具),当时该公司裁掉了她担任的产品经理职位。去年6月,她在超本地化社区社交网络服务nextdoor Holdings Inc.找到了一个新职位,但到了去年11月,nextdoor也裁员时,她又被解雇了。

关键词：初创公司社交网络服务产品经理增长放缓西德尼裁员本地化

Climate-change habitat shifts for the vulnerable endemic oak species (Quercus arkansana sarg.)

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Engineering porous organic polymers for carbon dioxide capture

林业研究（英文版） 2024年第1期 121页

作者： suresh Chandra subedi seth drake Binaya Adhikari Mark V. Coggeshall

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science China Chemistry 2017年第8期60卷 1007-1014页

作者： ning Huang Gregory Day Xinyu Yang Hannah drake Hong-Cai Zhou Department of Chemistry Texas A＆M University College Station TX 77843 US

As atmospheric CO_2 levels rise, the development of physical or chemical adsorbents for CO_2 capture and separation is of great importance on the way towards a sustainable low-carbon future. Porous organic polymers are promising candidates for CO_2 capture materials owing to their structural flexibility, high surface area, and high stability. In this review, we highlight high-performance porous organic polymers for CO_2 capture and summarize the strategies to enhance CO_2 uptake and selectivity, such as increasing surface area, increasing interaction between porous organic polymers and CO_2, and pore surface functionalization.

关键词： porous organic polymers C02 capture nanomaterials post-synthesis polymer

The expression and functions of microRnAs in pancreatic adenocarcinoma and hepatocellular carcinoma

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Chinese Journal of Cancer 2011年第8期30卷 540-550页

作者： Wei Li drake G. LeBrun Min Li College of Medicine Shandong University of Traditional Chinese Medicine Jinan Shandong 250355 P. R. China The Vivian L. smith Department of neurosurgery the University of Texas Health Science Center at Houston Medical School Houston Texas 77030 USA.

Pancreatic adenocarcinoma and hepatocellular carcinoma are devastating human malignancies that are characterized by poor prognosis,late onset,and a lack of known *** diagnostic and therapeutic molecular targets are desperately needed to develop novel and effective treatment *** (miRnAs) are an emerging class of molecules with roles in various cellular processes,including growth,survival,and *** importantly,aberrant expression of miRnAs has been implicated in cancer *** expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma indicate selective overexpression of oncogenic miRnAs and down-regulation of tumor suppressive miRnAs in these *** review summarizes results from key studies conducted to characterize the miRnA expression profiles of pancreatic adenocarcinoma and hepatocellular carcinoma and describes the potential mechanisms by which some oncogenic or tumor suppressive miRnAs ***,this review outlines novel therapeutic strategies for targeting miRnAs.

关键词： microRnA 胰腺癌肝癌 miRnAs 小分子RnA 肿瘤抑制生物标志物恶性肿瘤

Bioreactor design and validation for manufacturing strategies in tissue engineering

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Bio-Design and Manufacturing 2022年第1期5卷 43-63页

作者： Diana Lim Eric s.Renteria.drake s.sime Young Min Ju Ji Hyun Kim Tracy Criswell Thomas D.shupe Anthony Atala Frank C.Marini Metin n.Gurcan shay soker Joshua Hunsberger James J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineWinston-SalemNC 27157USA Center for Biomedical Informatics Wake Forest School of MedicineWinston-SalemNC 27157USA RegenMed Development Organization(ReMDO) Winston SalemNC 27106USA

The fields of regenerative medicine and tissue engineering offer new therapeutic options to restore,maintain or improve tissue function following disease or *** maximize the biological function of a tissue-engineered clinical product,specific conditions must be maintained within a bioreactor to allow the maturation of the product in preparation for ***,the bioreactor should be designed to mimic the mechanical,electrochemical and biochemical environment that the product will be exposed to in ***-time monitoring of the functional capacity of tissue-engineered products during manufacturing is a critical component of the quality management *** present review provides a brief overview of bioreactor engineering *** addition,strategies for bioreactor automation,in-line product monitoring and quality assurance are discussed.

关键词： Bioreactor Monitoring sensors and automation Manufacturing Tissue engineering Regenerative medicine

Isotopic niche provides an insight into the ecology of a symbiont during its geographic expansion

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Current Zoology 2022年第2期68卷 185-197页

作者： Enrique GOnZALEZ-ORTEGOn Marta PEREZ-MIGUEL Jose I.nAVAs Pilar drake Jose A.CUEsTA Instituto de Ciencias Marinas de Andalucia(ICMAn-CsIC) Campus Universitario Rio San PedroAvda.Republica Saharaui211519CadizPuerto RealSpain Unidad Asociada Crecimiento Azul CsIC-IFAPA El Puerto de Santa Maria SpainSpain Instituto de Investigacion y Formacion Agraria y Pesquera IFAPA-Centro Agua del PinoCtra.EI Rompido-Punta Umbriakm 3.821459 EI RompidoHuelvaSpain

The study of the recent colonization of a symbiont and its interaction with host communities in new locations is an opportunity to understand how they *** use of isotopic ratios in trophic ecology can provide measurements of a species'isotopic niche,as well as knowledge about how the isotopic niches between symbiont and host species *** isotope measurements were used to assess the sources of carbon assimilated by the host species(the bivalves Mytilus galloprovincialis and scrobicularia plana)and their associated symbiont pea crab Afropinnotheres monodi,which occurs within these bivalves'mantle *** mixing model estimates suggest that all of them assimilate carbon from similar sources,particularly from pseudofaeces and particulate organic matter in this symbiotic system based on filter *** symbiotic species occupy comparable trophic levels and its association seems to be commensal or parasitic depending on the duration of such *** pea crab *** reflects a sex-specific diet,where males are more generalist than the soft females because the latter's habitat is restricted to the host *** high isotopic overlap between soft females and *** may reflect a good commensal relationship with the host.

关键词： bivalves commensal kleptoparasitism parasitism stable isotope trophic position

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Persistence of tumor-infiltrating CD8 T cells is tumor-dependent but antigen-independent

人力资源开发与管理 2024年第08期

作者： Antonia Mufarech drake Bennett

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Cellular & Molecular Immunology 2011年第5期8卷 415-423页

作者： Mobolaji O Olurinde Ching-Hung shen Adam drake Ailin Bai Jianzhu Chen Harvard-MIT Division of Health sciences and Technology CambridgeMAUSA Koch Institute for Integrative Cancer Research Massachusetts Institute of TechnologyCambridgeMAUSA Department of Biological Engineering Massachusetts Institute of TechnologyCambridgeMAUSA Department of Biology Massachusetts Institute of TechnologyCambridgeMAUSA

How tumor-infiltrating lymphocytes(TILs)that are tumor-specific but functionally tolerant persist in the antigen-expressing tumor tissue is largely *** have previously developed a modified TRansgenic Adenocarcinoma of the Mouse Prostate(TRAMP)model where prostate cancer cells express the T-cell epitope sIYRYYGL(sIY)recognized by CD8 T cells expressing the 2C T-cell receptor(TCR)(referred to as TRP-sIY mice).In TRP-sIY mice,activated 2C T cells rapidly become tolerant following infiltration into the prostate *** this study,we show that tolerant 2C T cells persist in the prostate tumor of TRP-sIY mice by proliferating slowly in a tumor-dependent,but antigen-,interleukin(IL)-7-and IL-15-independent *** also show that disappearance of 2C T cells from the lymphoid organs of TRP-sIY mice are due to antigen-induced T-cell contraction rather than altered trafficking or generalized T-cell depletion in the ***,we show that clonal T cells unreactive to sIY are equally capable of persisting in the prostate *** findings suggest that while functional tolerance of TILs is induced by antigen,persistence of tolerant TILs in the tumor tissue is mediated by a novel mechanism:slow proliferation independent of antigen and homeostatic *** results also allow CD8 T-cell survival in the tumor environment to be compared with T-cell survival in chronic infection.

关键词： antigen cytokines tolerance tumor-associated factors tumor-infiltrating lymphocytes