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OIP5 Interacts with NCK2 to Mediate Human spermatogonial stem Cell self-Renewal and Apoptosis through Cell Cyclins and Cycle Progression and Its Abnormality Is Correlated with Male Infertility

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Research 2024年第1期2023卷 455-469页

作者： Yinghong Cui Wei Chen Li Du Zuping he The Key Laboratory of Model Animals and stem Cell Biology in Hunan Province The Research Center of Reproduction and Translational Medicine of Hunan ProvinceHunan Normal University School of MedicineChangsha 410013HunanChina

spermatogonial stem cells(ssCs)have important applications in both reproduction and regenerative ***,specific genes and signaling transduction pathways in mediating fate decisions of human ssCs remain ***,we have demonstrated for the first time that OIP5(Opa interacting protein 5)controlled the self-renewal and apoptosis of human *** sequencing identified that NCK2 was a target for OIP5 in human ssCs,and interestingly,OIP5 could interact with NCK2 as shown by Co-IP(co-immunoprecipitation),IP-Ms(mass spectrometry),and GsT pulldown ***2 silencing decreased human ssC proliferation and DNA synthesis but enhanced their ***,NCK2 knockdown reversed the influence of OIP5 overexpression on human ***,OIP5 inhibition decreased the numbers of human ssCs at s and G2/M phases,while the levels of numerous cell cycle proteins,including cyclins A2,B1,D1,E1 and H,especially cyclin D1,were remarkably ***,whole-exome sequencing of 777 patients with nonobstructive azoospermia(NOA)revealed 54 singlenucleotide polymorphism mutations of the OIP5 gene(6.95%),while the level of OIP5 protein was obviously lower in testes of NOA patients compared to fertile ***,these results implicate that OIP5 interacts with NCK2 to modulate human ssC self-renewal and apoptosis via cell cyclins and cell cycle progression and that its mutation and/or lower expression is correlated with *** such,this study offers novel insights into molecular mechanisms underlying the fate determinations of human ssCs and the pathogenesis of NOA,and it provides new targets for treating male infertility.

关键词： OIP5 Apoptosis reversed

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In-situ powder mixing for laser-based directed energy deposition of functionally graded materials

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Advances in Manufacturing 2024年第1期12卷 150-166页

作者： Ji-Peng Chen shou-Chun Xie he Huang school of Mechanical and Electronic Engineering Nanjing Forestry UniversityNanjing210037People’s Republic of China Nanjing Huirui Photoelectric Technology Co. LtdNanjing211121People’s Republic of China

The mixing of powders is a highly relevant field under additive manufacturing,however,it has attracted limited interest to *** in-situ mixing of various powders remains a significant *** paper proposes a new method utilizing a static mixer for the in-situ mixing of multiple powders through the laser-based directed energy deposition(DED)of functionally graded ***,a powder-mixing experimental platform was established;WC and 316L powders were selected for the mixing ***,scanning electron microscopy,energy dispersive spectroscopy,and image processing were used to visually evaluate the homogeneity and proportion of the in-situ mixed ***,powder-mixing simulations were conducted to determine the powder-mixing *** the simulations,a powder carrier gas flow field and particle mixing were ***,a WC/316L metal matrix composite sample was produced using laser-based DED to verify the application potential of the static *** was found that the static mixer could adjust the powder ratio online,and a response time of 1–2 s should be considered when adjusting the ratio of the mixed powder.A feasible approach for in-situ powder mixing for laser-based DED was demonstrated and investigated,creating the basis for functionally graded materials.

关键词： Laser Deposition static mixer Powder mixing Functionally graded materials

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Enhancing lithium-sulfur battery performance with In_(2)O_(3)-In_(2)s_(3)@NsC heterostructures:synergistic effects of double barrier and catalytic transformation

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Journal of Materials science & Technology 2024年第2期169卷 105-114页

作者： Deqing he Chunyu Zhu Yutao Huo Zhonghao Rao school of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China hebei Key Laboratory of Thermal science and Energy Clean Utilization Hebei University of TechnologyTianjin 300401China school of Low-carbon Energy and Power Engineering China University of Mining and TechnologyXuzhou 221116China

The sluggish redox reaction kinetics of lithium polysulfides(LiPss)are considered the main obstacle to the commercial application of lithium-sulfur(Li-s)*** accelerate the conversion by catalysis and inhibit the shuttling of soluble LiPss in Li-s batteries,a solution is proposed in this *** solution involves fabrication of N,s co-doped carbon coated In_(2)O_(3)/In_(2)s_(3)heterostructure(In_(2)O_(3)-In_(2)s_(3)@NsC)as a multifunctional host material for the *** In_(2)O_(3)-In_(2)s_(3)@NsC composite can reduce the Gibbs free energy for the conversion reactions of LiPss,which results in superior *** synergy between different components in In_(2)O_(3)-In_(2)s_(3)@NsC and the unique 3D structure facilitate ion and electron transport in Li-s *** In_(2)O_(3)-In_(2)s_(3)@NsC/Li 2 s 6 cathode exhibits excellent rate capacity,with a capacity of 599 mAh g−1 at 5.5 C,and good cycle stability,with a capacity of 436 mAh g^(−1)after 1000 cycles at 1 ***,this study proposes a promising solution to improve the energy storage properties of Li-s batteries,which could potentially facilitate the commercialization of Li-s batteries.

关键词： Li-s battery Multifunctional host material synergy heterostructures Energy storage properties

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Global well-posedness for 2D inhomogeneous asymmetric fluids with large initial data

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science China Mathematics 2024年第3期67卷 527-556页

作者： Chenyin Qian Beibei he Ting Zhang school of Mathematical sciences Zhejiang Normal UniversityJinhua 321004China school of Mathematical sciences Zhejiang UniversityHangzhou 310058China

In this paper, by using time-weighted global estimates and the Lagrangian approach, we first investigate the global existence and uniqueness of the solution for the 2D inhomogeneous incompressible asymmetric fluids with the initial(angular) velocity being located in sub-critical sobolev spaces H^(s)(R^(2))(0she initial density being bounded from above and below by some positive constants. The global unique solvability of the 2D incompressible inhomogeneous asymmetric fluids with the initial data in the critical Besov space(u_(0), w_(0))∈˙B^(0)_(2,1)(R^(2))andρ^(−1)−1∈˙B^(ε)_(2/ε),1(R^(2))is established. In particular, the uniqueness of the solution is also obtained without any more regularity assumptions on the initial density which is an improvement on the recent result of Abidi and Gui(2021) for the 2D inhomogeneous incompressible Navierstokes system.

关键词： inhomogeneous asymmetric fluids Littlewood-Paley theory Besov spaces global well-posedness

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A systematic Review and Performance Evaluation of Open-source Tools for smart Contract Vulnerability Detection

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Computers, Materials & Continua 2024年第7期80卷 995-1032页

作者： Yaqiong he Jinlin Fan Huaiguang Wu school of Computer science and Technology Zhengzhou University of Light IndustryZhengzhou450001China

With the rise of blockchain technology,the security issues of smart contracts have become increasingly *** the availability of numerous smart contract vulnerability detection tools,many face challenges such as slow updates,usability issues,and limited installation *** challenges hinder the adoption and practicality of these *** paper examines smart contract vulnerability detection tools from 2016 to 2023,sourced from the Web of science(WOs)and Google *** systematically collecting,screening,and synthesizing relevant research,38 open-source tools that provide installation methods were selected for further *** a developer’s perspective,this paper offers a comprehensive survey of these 38 open-source tools,discussing their operating principles,installation methods,environmental dependencies,update frequencies,and installation *** on this,we propose an Ethereum smart contract vulnerability detection *** framework enables developers to easily utilize various detection tools and accurately analyze contract security *** validate the framework’s stability,over 1700 h of testing were ***,a comprehensive performance test was performed on the mainstream detection tools integrated within the framework,assessing their hardware requirements and vulnerability detection *** results indicate that the slither tool demonstrates satisfactory performance in terms of system resource consumption and vulnerability detection *** study represents the first performance evaluation of testing tools in this domain,providing significant reference value.

关键词： Blockchain security ethereum smart contracts detection tools evaluation

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Image segmentation-P300 selector: A Brain–Computer Interface system for Target selection

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Computers, Materials & Continua 2024年第5期79卷 2505-2522页

作者： Hang sun Changsheng Li he Zhang Mechanical Engineering Nanjing University of Science and TechnologyNanjing210018China

Brain–computer interface (BCI) systems, such as the P300 speller, enable patients to express intentions withoutnecessitating extensive ***, the complexity of operational instructions and the slow pace of characterspelling pose challenges for some patients. In this paper, an image segmentation P300 selector based on YOLOv7-mask and DeepsORT is proposed. The proposed system utilizes a camera to capture real-world objects forclassification and tracking. By applying predefined stimulation rules and object-specificmasks, the proposed systemtriggers stimuli associated with the objects displayed on the screen, inducing the generation of P300 signals in thepatient’s brain. Its video processing mechanism enables the system to identify the target the patient is focusing oneven if the object is partially obscured, overlapped, moving, or changing in number. The system alters the target’scolor display, thereby conveying the patient’s intentions to caregivers. The data analysis revealed that the selfrecognitionaccuracy of the subjects using this method was between 92% and 100%, and the cross-subject P300recognition precision was 81.9%–92.1%. This means that simple instructions such as “Do not worry, just focuson what you desire” effectively discerned the patient’s intentions using the Image segmentation-P300 selector. Thisapproach provides cost-effective support and allows patients with communication difficulties to easily express theirneeds.

关键词： Brain-computer interface deep learning electroencephalogram P300 YOLOv7-mask

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Restoring cosmological concordance with axion-like early dark energy and dark matter characterized by a constant equation of state?

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Communications in Theoretical Physics 2024年第7期76卷 74-82页

作者： Yan-Hong Yao Xin-he Meng school of Physics and Astronomy Sun Yatsen University 2 Daxue RoadTangjiaZhuhaiChina school of Physics Nankai University 94 Weijin RoadNankaiTianjinChina

The Hubble tension persists as a challenge in *** early dark energy(EDE)models,initially considered the most promising for alleviating the Hubble tension,fall short of addressing the issue without exacerbating other tensions,such as the s_(8)*** that a negative dark matter(DM)equation of state(Eos)parameter is conducive to reduce the value of the σ_(8)parameter,we extend the axion-like EDE model in this paper by replacing the cold dark matter(CDM)with DM characterized by a constant Eos w_(dm)(referred to as WDM hereafter).We then impose constraints on this axion-like EDE extension model,along with three other models:the axion-like EDE model,ΛWDM,and Λ*** constraints are derived from a comprehensive analysis incorporating data from the Planck 2018 cosmic microwave background,baryon acoustic oscillations,and the Pantheon compilation,as well as a prior on H_(0)(i.e.H_(0)=73.04±1.04,based on the latest local measurement by Riess et al)and a Gaussianized prior on s_(8)(i.e.s_(8)=0.766±0.017,determined through the joint analysis of KID1000+BOss+2dLens).We find that although the new model maintains the ability to alleviate the Hubble tension to~1.4σ,it still exacerbates the s_(8)tension to a level similar to that of the axion-like EDE model.

关键词： Hubble tension early dark energy noncold dark matter s8 tension

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Quantum search with prior knowledge

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science China(Information sciences) 2024年第9期67卷 321-329页

作者： Xiaoyu he Xiaoming sUN Jialing ZHANG state Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences school of Computer science and Technology University of Chinese Academy of Sciences

The combination of contextual side information and search is a powerful paradigm in the scope of artificial intelligence. The prior knowledge enables the identification of possible solutions but may be imperfect. Contextual information can arise naturally, for example in game AI where prior knowledge is used to bias move decisions. In this work we investigate the problem of taking quantum advantage of contextual information, especially searching with prior knowledge. We propose a new generalization of Grover's search algorithm that achieves the optimal expected success probability of finding the solution if the number of queries is fixed. Experiments on small-scale quantum circuits verify the advantage of our algorithm. since contextual information exists widely, our method has wide applications. We take game tree search as an example.

关键词： quantum computing quantum search quantum query algorithm prior knowledge

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A Time series Intrusion Detection Method Based on ssAE,TCN and Bi-LsTM

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Computers, Materials & Continua 2024年第1期78卷 845-871页

作者： Zhenxiang he Xunxi Wang Chunwei Li school of Cyberspace security Gansu University of Political Science and LawLanzhou730000China

In the fast-evolving landscape of digital networks,the incidence of network intrusions has escalated ***,the crucial role of time series data in intrusion detection remains largely underappreciated,with most systems failing to capture the time-bound nuances of network *** leads to compromised detection accuracy and overlooked temporal *** this gap,we introduce a novel ssAE-TCN-BiLsTM(sTL)model that integrates time series analysis,significantly enhancing detection *** approach reduces feature dimensionalitywith a stacked sparse Autoencoder(ssAE)and extracts temporally relevant features through a Temporal Convolutional Network(TCN)and Bidirectional Long short-term Memory Network(Bi-LsTM).By meticulously adjusting time steps,we underscore the significance of temporal data in bolstering detection *** the UNsW-NB15 dataset,ourmodel achieved an F1-score of 99.49%,Accuracy of 99.43%,Precision of 99.38%,Recall of 99.60%,and an inference time of 4.24 *** the CICDs2017 dataset,we recorded an F1-score of 99.53%,Accuracy of 99.62%,Precision of 99.27%,Recall of 99.79%,and an inference time of 5.72 *** findings not only confirm the sTL model’s superior performance but also its operational efficiency,underpinning its significance in real-world cybersecurity scenarios where rapid response is *** contribution represents a significant advance in cybersecurity,proposing a model that excels in accuracy and adaptability to the dynamic nature of network traffic,setting a new benchmark for intrusion detection systems.

关键词： Network intrusion detection bidirectional long short-term memory network time series stacked sparse autoencoder temporal convolutional network time steps

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Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus

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Neural Regeneration Research 2024年第6期19卷 1177-1178页

作者： Longlong Tu Yanlin he Yong Xu Children’s Nutrition Research Center Department of PediatricsBaylor College of MedicineOne Baylor PlazaHoustonTXUSA Brain Glycemic and Metabolism Control Department Pennington Biomedical Research CenterLouisiana State UniversityBaton RougeLAUSA Department of Molecular and Cellular Biology Section of EndocrinologyDiabetes and MetabolismDepartment of MedicineBaylor College of MedicineHoustonTXUSA

Glucose is the primary fuel source of the brain,and therefore glucose levels need to be tightly regulated and maintained within a small physiological ***,the body necessitates a stable supply of energy mainly provided by glucose for various bodily *** or low blood glucose levels would impair the physiological functions of various organs of the body.

关键词： inhibited medial organs

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