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BIOCELL 2022年第1期46卷 127-136页

作者： AAsTHA MITTAL NEELAM MAHALA KOWTHAVARAPU VENKATA KRIsHNA UMA s.dubey sUNIL KUMAR dubey Department of Biological sciences Birla Institute of Technology and SciencePilani CampusPilani(BITS-PILANI)333031India Department of Pharmacy Birla Institute of Technology and SciencePilani CampusPilani(BITS-PILANI)333031India R&D Healthcare Division Emami Ltd.Kolkata700056India

sorafenib,a multikinase inhibitor used for the treatment of hepatocellular carcinoma,is limited by its low oral *** overcome this drawback,we have developed novel camel milk casein-derived nanoparticles as a drug delivery *** milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical *** is used because of its amphiphilic nature,self-assembling property,ability to show sustained release,and capability of encapsulating both hydrophilic and hydrophobic *** this study,camel milk casein nanoparticles loaded with sorafenib were developed and *** of casein nanoparticles was done by dynamic light scattering(DLs),zeta potential analysis,scanning light microscopy(sEM),and *** drug content in nanoparticle and drug-protein binding studies were conducted by UV *** cytotoxicity and cellular uptake efficiency studies were performed in HepG2 cell *** was observed that the cytotoxic effect of sorafenib loaded camel milk casein nanoparticles was more than free sorafenib in HepG2 *** work suggests camel milk casein as a suitable drug delivery molecule for *** the future,it may also be used in enhancing the efficacy and specific distribution of other water-insoluble anticancer drugs.

关键词： Camel milk derived casein nanoparticles sorafenib UV spectroscopy FTIR HepG2 cells Apoptosis

Comprehensive analysis of uncertainty quantification for the^(58)Ni(n,p)^(58)Co reaction cross section

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Chinese Physics C 2024年第9期48卷 170-175页

作者： Mahesh Choudhary Aman sharma Namrata singh Mahima Upadhyay Punit dubey A.Gandhi Akash Hingu G Mishra sukanya De L.s.Danu Ajay Kumar R.G.Thomas saurav sood sajin Prasad s.Mukherjee I.N.Ruskov Yu.N.Kopatch A.Kumar Department of Physics Banaras Hindu UniversityVaranasi 221005India Horia Hulubei National Institute of Physics and Nuclear Engineering-IFIN-HH Bucharest 077125Romania Department of Physics The Maharaja Sayajirao University of BarodaVadodara 390002India Nuclear Physics Division Bhabha Atomic Research CentreMumbai 400085India Health Physics Division Bhabha Atomic Research CentreMumbai 400085India Department of Electrical Power Engineering Brno University of TechnologyBrno 61600Czech Republic Institute for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofia 1784Bulgaria Joint Institute for Nuclear Research(JINR) Dubna 141980Russia

In this study,we measured the^(58)Ni(n,p)^(58)Co reaction cross section with neutron energies of 1.06,1.86,and 2.85 *** cross section was measured using neutron activation techniques andγ-ray spectroscopy,and it was compared with cross section data available in the ***,we calculated the covariance matrix of the measured cross section for the aforementioned nuclear *** uncertainties of the theoretical calculation for^(58)Ni(n,p)^(58)Co reaction cross section were calculated via Monte Carlo *** this study,we used uncertainties in the optical model and level density parameters to calculate uncertainties in the theoretical cross *** theoretical calculations were performed by using *** this study,we aim to analyze the effect of uncertainties of the nuclear model input as well as different experimental variables used to obtain the values of reaction cross section.

关键词： ^(58)Ni(n p)^(58)Co reaction γ-ray spectroscopy uncertainty quantification of cross section covariance analysis

阿尔茨海默病小鼠模型:MR引导聚焦超声定位到海马并突破血脑屏障,改善病理异常和行为

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国际医学放射学杂志 2015年第1期 74-74页

作者： A.Burgess s.dubey s.Yeung O.Hough N.Eterman I.Aubert Physical sciences Platform Sunnybrook Research Institute

目的旨在利用小鼠模型验证重复MR引导超声聚焦靶向治疗与阿尔茨海默病(AD)相关的大脑结构海马是否可以调节病理异常、可塑性和行为。材料与方法所有动物

关键词：聚焦超声 MR 病理异常海马边缘系统阿尔茨海默病大脑结构小鼠模型定位

On-current modeling of short-channel double-gate(DG) MOsFETs with a vertical Gaussian-like doping profile

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Journal of semiconductors 2013年第5期34卷 46-53页

作者： sarvesh dubey Pramod Kumar Tiwari s.Jit Department of Electronics Engineering Indian Institute of Technology(BHU)Varanasi-221005India Department of Electronics and Communication Engineering National Institute of Technology Rourkela-769008India

An analytic drain current model is presented for doped short-channel double-gate MOsFETs with a Gaussian-like doping profile in the vertical direction of the channel. The present model is valid in linear and satura- tion regions of device operation. The drain current variation with various device parameters has been demonstrated. The model is made more physical by incorporating the channel length modulation effect. Parameters like transcon- ductance and drain conductance that are important in assessing the analog performance of the device have also been formulated. The model results are validated by numerical simulation results obtained by using the commercially available ATLAs^TM, a two dimensional device simulator from sILVACO.

关键词： drain current DG MOsFET transconductance drain conductance

Upconversion nanoparticles:Recent strategies and mechanism based applications

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Journal of Rare Earths 2022年第9期40卷 1343-1359,I0001页

作者： Neha dubey sudeshna Chandra Department of Chemistry Sunandan Divatia School of ScienceSVKM's NMIMS(Deemed to-be)UniversityVile Parle(West)Mumbai400056India

Upconversion nanoparticles(UCNPs)doped with lanthanides can convert near-infrared excitation into UV and visible *** of their relatively high emission efficiency,UCNPs are appealing materials for use in a variety of *** are known for low auto-fluorescence,excellent chemical and thermal photo-stability,deep tissue penetration,exceptional biocompatibility,low toxicity,color purity,and ease of surface *** this review,we explain a few recent strategies to boost the efficiency and luminescence of upconversion nanoparticles and minimize quenching by fabricating them as core/shell,nanofibers,or heavily doped *** of UCNPs in drug delivery,Photodynamic therapy(PDT),biosensors,bioimaging,and optogenetics are also discussed along with their mechanism of *** motivation for this review is to understand the working mechanism of UCNPs and their applications in various fields.

关键词： Luminescence Upconversion nanoparticles Optical imaging Mechanism Applications Rare earths

Effect of temperature on the ML of Au doped(Zn,Cd)s mixed phosphors

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Chinese Chemical Letters 2011年第6期22卷 709-712页

作者： Jagjeet Kaur N.s.suryanarayana Vikas.dubey Department of Physics Govt.Vishwanath Yadav Tamaskar Post Graduate Autonomous College Durg(C.G.)India

In this paper the effect of temperature on the mechanoluminescence of Au doped phosphors of（Zn,Cd）s is *** is found that the ML disappears beyond a particular *** temperature dependence of ML intensity follows the relation I =I_T^O（1-TIT_C）~n,where I_T^O is a constant,n is the slop of log I_T versus log（1- TIT_C） plot which lies between 0.9 and 1.10,T_C is the temperature at which ML *** is found that the ML intensity in（Zn,Cd）s：Au disappear at 600 K.

关键词： Mechanoluminescence Temperature dependence in Ⅱ-Ⅵ semiconductors

Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu s.Baehr s.Bahinipati A.M.Bakich P.Bambade sw.Banerjee s.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner s.Bettarini V.Bhardwaj F.Bianchi T.Bilka s.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano s.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho s.Cho s.-K.Choi s.Choudhury D.Cinabro L.Corona L.M.Cremaldi s.Cunliffe T.Czank F.Dattola E.De La Cruz-Burelo G.De Nardo M.De Nuccio G.De Pietro R.de sangro M.Destefanis s.Dey A.De Yta-Hernandez F.Di Capua s.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort s.dubey s.Duell s.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro s.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou s.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek s.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki s.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon s.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim s.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno s.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara s.Kurz A.Kuzmin Y.-J.Kwon s.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.s.Lange K.Lautenbach I.-s.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics sB RAs Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 Deutsches Elektronen–synchrotron 22607 Hamburg Duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich Department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced studies(sOKENDAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 Department of Physics and Institute of Natural sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN sezione di Napoli I-80126 Napoli INFN sezione di Padova I-35131 Padova INFN sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 s) resonance was collected with the Belle Ⅱ detector at the superKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

stability and Bifurcation of a Prey-Predator system with Additional Food and Two Discrete Delays

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Computer Modeling in Engineering & sciences 2021年第2期126卷 505-547页

作者： Ankit Kumar Balram dubey Department of Mathematics BITS PilaniPilani CampusPilani333031India

In this paper,the impact of additional food and two discrete delays on the dynamics of a prey-predator model is *** interaction between prey and predator is considered as Holling Type-II functional *** additional food is provided to the predator to reduce its dependency on the *** delay is the gestation delay in predator while the other delay is the delay in supplying the additional food to *** positivity,boundedness and persistence of the solutions of the system are studied to show the system as biologically *** existence of steady states,their local and global asymptotic behavior for the non-delayed system are *** is shown that(i)predator’s dependency factor on additional food induces a periodic solution in the system,and(ii)the two delays considered in the system are capable to change the status of the stability behavior of the *** existence of periodic solutions via Hopf-bifurcation is shown with respect to both the *** analysis shows that both delay parameters play an important role in governing the dynamics of the *** direction and stability of Hopf-bifurcation are also investigated through the normal form theory and the center manifold *** experiments are also conducted to validate the theoretical results.

关键词： predator delay system

Protective Effects of Certain Natural and synthetic Complexans on the Toxicity of Chromium and Tin to a N_2-Fixing Cyanobacterium, Anabaena doliolum

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Biomedical and Environmental sciences 1989年第3期2卷 271-281页

作者： LC.RAI s.K.dubey Laboratory of Algal Biology Centre of Advanced Study in Botany Banaras Hindu University Varanasi-221005. India

The effects of chromium and tin on survival, growth, carbon fixation, nitrate reduction, ammonia assimilation, and nitrogenase activity of a N_2-fixing cyanobacterium, Anabaena doliolum, and their amelioration by synthetic and natural complexans, viz., EDTA, nitrilotriacetic acid (NTA), pyridine dicarboxylic acid (PDA), and citrate, have been studied. Chromium proved to be much more toxic than tin, as it inhibited growth yield (49%), carbon fixation (53%), and nitrate reductase (79%), glutamine synthetase (30%), and nitrogenase activities (77%) at its sublethal concentration, whereas tin induced less inhibition of growth yield (42%), carbon fixation (50%). and nitrate reductase (66%), glutamine synthetase (32.4%), and nitrogenase activities (70%). Despite its inhibitory effects at 10μml^(-1), EDTA supplementation in metal-spiked medium counteracted the toxicity of chromium and tin more significantly than NTA, PDA, and citrate. When supplemented with LD_(50) of Cr, EDTA protected growth, carbon fixation, NR, Gs. and Noase, respectively, by 32.6, 50.0, 33.3. 17.7. and 65.4%. However, EDTA-induced restoration of the above parameters at a sublethal concentration of tin was only 30.2, 50.0,28.1, 27.7, and 61.5%, respectively. Although NTA and citrate at 10/μgml^(-1) each were stimulatory to various processes of test cyanobacterium, they were comparatively less effective than EDTA in the amelioration of metal toxicity. On the basis of these observations, a generalized hierarchical sequence of protective efficiency of synthetic and natural cornplexing ligands may be given as EDTA > NTA > citrate > PDA. It seems plausible that the toxicity of various heavy metals may be regulated by a large array of organic complexing agents of the aquatic environment because they possess various metal binding sites. (c) 1989 Academic Press,lnc.

关键词： NTA Anabaena doliolum Protective Effects of Certain Natural and synthetic Complexans on the Toxicity of Chromium and Tin to a N2-Fixing Cyanobacterium PDA EDTA 络合试剂 Cr

sex Determination using Primary and Permanent Teeth under Different Environment Conditions:A Deoxyribonucleic Acid-based study

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Journal of Forensic science and Medicine 2023年第3期9卷 250-256页

作者： Jaya dubey Jigna s.shah Department of Oral Medicine and Radiology Government Dental College and HospitalAhmedabadGujaratIndia

Aims: The purpose of this study was to determine the sex of primary and permanent tooth pulp tissue under different environmental conditions using deoxyribonucleic acid (DNA) analysis and the polymerase chain reaction (PCR) amplification method. Materials and Methods: For this study, 40 permanent and primary teeth (20 males and 20 females) that were scheduled for extraction were used. For 6 months, the teeth were divided into four groups of ten (5 males and 5 females) based on different environmental conditions. The pulp was extracted from each tooth, DNA was isolated using QIAGEN’s DNeasy Blood and Tissue Kit, and sex was determined using a PCR technique. Results: DNA was extracted from all 40 samples subjected to various environmental conditions, but sex was correctly determined in only 90% of the samples. Conclusions: PCR-based sex determination using primary and permanent teeth under different environmental conditions for up to 6 months is a reliable technique with high accuracy.

关键词： Amelogenin gene deoxyribonucleic acid forensic gender determination polymerase chain reaction