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Perturbations in the earthworm metabolite profile during a two-week exposure to metformin

Emerging Contaminants 2024年第3期10卷 221-229页

作者： J.d.Gillis G.W.Price s.O.Prasher department of Bioresource Engineering McGill UniversityFaculty of Agricultural and Environmental SciencesMacdonald-Stewart Building MS1-02721111 Lakeshore RoadSainte-Anne-de-BellevueQuebecH9X 3V9Canada department of Engineering Dalhousie UniversityFaculty of Agriculture39 Cox RoadPO Box 550TruroNova ScotiaB2N 5E3Canada

Metformin is among the most prescribed pharmaceuticals in many countries,and as a result has shown up in biosolids.d.rived from municipal wastewater treatment that are destined for land *** humans taking metformin,the effects include reduced glucose uptake in the intestine,a reduction in gluconeogenesis,increas.d.oxidation of fatty acids,and reduced fatty acid *** effects of metformin on soil-dwelling organisms are not well *** study tested the effects of metformin exposure(0,10,40,160,640μg g^(-1))on the earthworm(***)at four time points(6 h,2 d,7 d,and 14 d)using GC-Ms to reveal sub-lethal effects and elucidate potential modes of action for *** were no mortalities observed,and earthworms expos.d.to the highest concentrations(160 and 640μg g^(-1))gained weight relative to the control on days 7 and *** reductions on day 7 were observed for glucose and malic acid(consistent with a reduction in gluconeogenesis),and for palmitic and margaric acid(consistent with increas.d.oxidation and reduced synthesis of fatty acids).Lactic acid ranked first and second among canonicals 1 and 2 respectively and led to significant differences in discriminant scores across concentration and *** levels increas.d.to equal or greater than the control on day 14,likely caus.d.by reduced exposure as metformin is reported to be readily transformed by microorganisms under aerobic *** observations were consistent with the known effects of metformin in humans,and suggests that a similar mode of action exists in earthworms.

关键词： Metabolites Toxicity Earthworms Metformin GC-Ms

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基于玄府气液论探讨防己黄芪汤的应用思路

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河北中医 2024年第5期46卷 845-848页

作者：邝振威易亚乔成绍武宋祯彦况瑞旭张炜文张铭驿肖慧湖南中医药大学中医学院湖南长沙410208

玄府气液论认为,玄府是人体物质交换的通道,是精、气、血、津液等基础物质交换的场所。结合玄府气液理论探讨《金匮要略》湿痹和水气病中防己黄芪汤证的病因病机,两病均因玄府开阖失司,津液运行障碍,致使水湿停聚于人体体表部位。在津... 详细信息

玄府气液论认为,玄府是人体物质交换的通道,是精、气、血、津液等基础物质交换的场所。结合玄府气液理论探讨《金匮要略》湿痹和水气病中防己黄芪汤证的病因病机,两病均因玄府开阖失司,津液运行障碍,致使水湿停聚于人体体表部位。在津液始于脾、运于肺、出于肾的代谢过程中,玄府作为遍布于脏腑的微观结构而发挥关键作用。将玄府气液论与藏象学说相结合,解析津液代谢过程,分析防己黄芪汤证所涉及的病变部位,进一步明确该方的适用范围,揭示该方药物配伍对玄府开阖的影响,从而为临床对该方的使用拓展理论依据。

关键词：玄府气液防己黄芪汤津液代谢

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Forecasting of tropical cyclones AsANI(2022)and MOCHA(2023)over the Bay of Bengal-real time challenges to forecasters

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Tropical Cyclone Research and Review 2024年第2期13卷 88-112页

作者： s.d.Kotal T.Arulalan M.Mohapatra India Meteorological department Ministry of Earth ScienceGovernment of IndiaNew DelhiIndia

This study examines the track and intensity forecasts of two typical Bay of Bengal tropical cyclones(TC)AsANI and *** analysis of various Numerical Weather Prediction(NWP)model forecasts[ECMWF(European Centre for Medium range Weather Forecast),NCEP(National Centers for Environmental Prediction),NCUM(National Centre for Medium Range Weather Forecast-Uniﬁed Model),IMd(India Meteorological department),HWRF(Hurricane Weather Research and Forecasting)],MME(Multi-model Ensemble),sCIP(statistical Cyclone Intensity Prediction)model,and OFCL(Ofﬁcial)forecasts shows that intensity forecasts of AsANI and track forecasts of MOCHA were reasonably good,but there were large errors and wide variation in track forecasts of AsANI and in intensity forecasts of *** all model forecasts,the track forecast errors of IMd model and MME were least in general for AsANI and MOCHA ***,the landfall point forecast errors of IMd were least for AsANI,and the MME and OFCL forecast errors were least for *** model is found to be consistently better for landfall time forecast for AsANI,and the errors of ECMWF,IMd and HWRF were least and of same order for *** intensity forecast errors of OFCL and sCIP were least for AsANI,and the forecast errors of HWRF,IMd,NCEP,sCIP and OFCL were comparable and least for MOCHA up to 48 h forecast and HWRF errors were least thereafter in *** ECMWF model forecast errors for intensity were found to be highest for both the *** results also show that although there is signiﬁcant improvement of track forecasts and limited or no improvement of intensity forecast in previous.d.cades but challenges still persists in real time forecasting of both track and intensity due to wide variation and inconsistency of model forecasts for different TC cases.

关键词： Tropical cyclone Track forecast Intensity forecast NWP model Bay of Bengal North Indian Ocean

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Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.sardar M.d.Hossain M.s.sikder M.N.I.Khan M.R.Rahman Physics.d.scipline Khulna UniversityKhulna9208Bangladesh department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh department ofComputer science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh Material science division Atomic Energy CentreDhaka1000Bangladesh

spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRd),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FEsEM),energy dispersive X-ray(EdX),vibrating sample magnetometer(VsM),and an impedance analyzer were us.d.to characterize the structural,magnetic,and dielectric properties of the *** XRd patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increas.d.with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FEsEM images,and it is increas.d.from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EdX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

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Exploring one material for dual applications:A red-emitting Mg_(2)GeO_(4):Eu^(3+)nanophosphor for future generation energy efficient WLEds and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Akshay Arjun G.P.darshan s.C.sharma H.Nagabhushana d.V.sunitha H.B.Premkumar department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India Honorary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India C.N.R.Rao Centre for Advanced Materials Tumkur UniversityTumkur572103India school of Applied sciences(Physics) REVA UniversityBengaluru560064India

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-like structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was estimated and obtained to be~4.12-4.32 *** photoluminescence emission spectra exhibit intense peaks at^(5)79,589,610,661,and 707 nm,which are due to characteristic^(5)d_(0)→^(7)F_(0),^(5)d_(0)→^(7)F_(1),^(5)do→^(7)F_(2),^(5)d_(0)→^(7)F_(3)and^(5)d_(0)→^(7)F_(4)transitions of Eu^(3+)ions,*** Commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peaks showcase excellent super-linear response at low doses ofγ-irradiations,indicating that the prepared phosphor can be us.d.in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results.d.monstrate that the prepared Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors are cons.d.red an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes(WLEds)and personal dosimetric applications.

关键词： Nanophosphors Photoluminescence Thermoluminescence dosimetry Photometric properties Rare earths

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睾酮治疗性腺功能减退症男性患者对骨折风险影响的临床研究

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中国临床药理学杂志 2024年第5期40卷 731-731页

作者： sNYdER P J BAUER d C ELLENBERG s s 孟海峰

男性性腺功能减退症患者的睾酮治疗可以改善骨密度和骨质量,但需要足够大的样本和足够长的持续时间来确定睾酮对骨折发生率的影响。

关键词：骨折发生率性腺功能减退症骨质量骨折风险睾酮治疗骨密度持续时间男性患者

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基于Instant-NGP平台的NeRF复现研究

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现代计算机 2024年第16期30卷 44-50页

作者：邹梓越王永丽殷文艺匡皓瑞成都信息工程大学网络空间安全学院成都610225

基于NVIdIA的Instant-NGP平台,旨在对NeRF方法在三维重建领域的实现进行复现。通过利用Instant-NGP平台的强大计算能力和优化算法,成功复现了NeRF方法,并在多个数据集上进行了实验验证。实验结果表明,在Instant-NGP平台上,该方法能够快... 详细信息

基于NVIdIA的Instant-NGP平台,旨在对NeRF方法在三维重建领域的实现进行复现。通过利用Instant-NGP平台的强大计算能力和优化算法,成功复现了NeRF方法,并在多个数据集上进行了实验验证。实验结果表明,在Instant-NGP平台上,该方法能够快速高效地生成逼真的三维重建结果,并获得与原论文一致的定量和定性评估结果。此研究对NeRF方法的研究验证了其可行性和可重复性,并展示了NeRF方法在Instant-NGP平台上的优越性能,为相关领域的研究和应用提供了实际参考和基础。

关键词： Instant-NGP NeRF 三维重建复现研究

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隐丹参酮调节Rac1/AKT/NF-κB信号通路对脓毒症大鼠肠损伤的影响

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河北医学 2024年第10期30卷 1597-1603页

作者：张树柳刘瑞瑞陈玉刚杜超崔云亮解放军联勤保障部队第九六〇医院重症医学科山东济南250031

目的:探究隐丹参酮(CRY)调节Ras相关C3肉毒素底物1(Racl)/丝氨酸-苏氨酸蛋白酶(AKT)/核转录因子-κB(NF-κB)信号通路对脓毒症大鼠肠损伤的影响。方法:建立脓毒症大鼠模型。大鼠分为Control组、Model组、隐丹参酮高、中、低剂量组(7.0mg... 详细信息

目的:探究隐丹参酮(CRY)调节Ras相关C3肉毒素底物1(Racl)/丝氨酸-苏氨酸蛋白酶(AKT)/核转录因子-κB(NF-κB)信号通路对脓毒症大鼠肠损伤的影响。方法:建立脓毒症大鼠模型。大鼠分为Control组、Model组、隐丹参酮高、中、低剂量组(7.0mg·kg^(-1)·d^(-1)CRY-H组、14.0mg·kg^(-1)·d^(-1)CRY-M组、28.0mg·kg^(-1)·d^(-1)CRY-L组)和隐丹参酮高剂量+NF-κB通路激活剂组(28mg·kg^(-1)·d^(-1)CRY-H+5 mg·kg^(-1)·d^(-1)PMA组),每组12只,Control组与Model组使用同等剂量生理盐水进行处理,每天1次,连续21d。用试剂盒检测脓毒症大鼠血清炎症因子、氧化应激、肠黏膜屏障指标水平;HE染色观察大鼠肠组织病理形态;免疫组化和免疫印迹法分别检测大鼠肠组织中ZO-1、occludin和通路蛋白表达。结果:与Control组比较,Model组黏膜绒毛排列紊乱,部分黏膜脱落、坏死,大量炎细胞浸润,组织病理评分较高,血清TNF-α、IL-1β、MdA、内毒素、d-乳酸水平上升,s.d.平降低,Rac1、p-AKT/AKT、p-NF-κB/NF-κB表达上调,ZO-1、occludin下调表达(Pdel组比较,CRY-L、CRY-M、CRY-H组肠黏膜绒毛相对完整,炎细胞浸润减轻,组织病理评分降低,血清TNF-α、IL-1β、MdA、内毒素、d-乳酸水平降低,s.d.平上升,Rac1、p-AKT/AKT、p-NF-κB/NF-κB表达下调,ZO-1、occludin上调表达(PdA、内毒素、d-乳酸水平升高,s.d.平降低,Rac1、p-AKT/AKT、p-NF-κB/NF-κB表达上调,ZO-1、occludin下调表达(P<0.05)。结论:隐丹参酮抑制Rac1/AKT/NF-κB信号通路改善脓毒症大鼠肠损伤。

关键词：脓毒症隐丹参酮 Ras相关C3肉毒素底物1/丝氨酸-苏氨酸蛋白酶/核转录因子-κB信号通路肠损伤

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Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina díaz del Arco M Jesús Fernández Aceñero Luis Ortega Medina department of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnos.d.at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free dNA Circulating tumor dNA Molecular

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Population dynamics and Key Influencing Factors of Microthrix parvicella Caus.d.sludge Bulking

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Huanjing Kexue/Environmental science 2024年第11期45卷 6766-6774页

作者： su G.-X. Qi R. Xiao s.-M. dou d.-C. Guo Y.-X. Gao J. Tianjin Key Laboratory of Aquatic science and Technology School of Environmental and Municipal Engineering Tianjin Chengjian University Tianjin 300384 China state Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

Given the frequent occurrence of the sludge bulking phenomena caus.d.by Microthrix parvicella（M. parvicella）overgrowth during the low-temperature period in the full-scale municipal wastewater treatment plant，the filamentous bacteria dynamics of the M. parvicella population were systematically investigated during the completed bulking period using the multi-dimensional integrated filamentous monitoring method combined with the molecular quantitative method. A lab-scale reactor was constructed and successfully simulated bulking phenomena under the low-temperature condition. The trend of dominant filamentous bacterial shift and the main influencing parameters were estimated during the bulking period，to verify the key factors for filament growth and extinction of the sludge bulking phenomenon in the full-scale plant. The results showed that the bulking-caus.d.M. parvicella was characterized by significant changes in the diversity of filamentous bacteria，and the dominant filamentous bacterial succession was reflected in the competition between the skeleton filamentous bacteria Type 0092 and Type 0041 and M. parvicella. At lower temperatures，sludge loading was an important controlling factor for the competitive growth advantage of M. parvicella：when the temperature was lower（approximately 15°C），low sludge loading［0.05 kg·（kg·d）−1］could lead to the stabilized elevation of M. parvicella，and with the loading increas.d.to 0.1 kg·（kg·d）−1 or more，M. parvicella populations showed a targeted decline despite the presence of the low temperature factor. © 2024 science Press. All rights reserved.

关键词： filamentous bacteria Microthrix parvicella population dynamics sludge bulking sludge loading

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