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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 22-23页

作者： Khairy P. Ouyang d.W. Fernandes s.M. 郭俊 Electrophysiology and Adult Congenital Heart disease Montreal Heart Institute 5000 Bélanger St Montreal Que. H1T 1C8 Canada Dr.

Background -Pregnant women with congenital heart disease are at increas.d.risk for cardiac and neonatal complications, yet risk factors for adverse outcomes are not fully defined. Methods and Results -Between January 1998 and september 2004, 90 pregnancies at age 27.7±6.1 years were followed in 53 women with congenital heart disease. spontaneous abortions occurred in 11 pregnancies at 10.8±3.7 weeks, and 7 underwent elective pregnancy termination. There were no maternal deaths. Primary maternal cardiac events complicated 19.4%of ongoing pregnancies, with pulmonary edema in 16.7%and sustained arrhythmias in 2.8%. Univariate risk factors included prior history of heart failure(odds ratio[OR], 15.5), NYHA functional class ≥2(OR, 5.4), and decreas.d.subpulmonary ventricular ejection fraction(OR, 7.7). Independent predictors were decreas.d.subpulmonary ventricular ejection fraction and/or severe pulmonary regurgitation(OR, 9.0) and smoking history(OR, 27.2). Adverse neonatal outcomes occurred in 27.8%of ongoing pregnancies and included preterm delivery(20.8%), small for gestational age(8.3%), respiratory distress syndrome(8.3%), intraventricular hemorrhage(1.4%), intrauterine fetal demise(2.8%), and neonatal death(1.4%). A subaortic ventricular outflow tract gradient >30 mm Hg independently predicted an adverse neonatal outcome(OR, 7.5). Cardiac risk assessment was improved by including decreas.d.subpulmonary ventricular systolic function and/or severe pulmonary regurgitation(OR, 10.3) in a previously propos.d.risk index developed in pregnant women with acquired and congenital heart disease. Conclusions -Maternal cardiac and neonatal complication rates are cons.d.rable in pregnant women with congenital heart disease. Patients with impaired subpulmonary ventricular systolic function and/or severe pulmonary regurgitation are at increas.d.risk for adverse cardiac outcomes.

关键词：妊娠结局心室射血分数肺动脉瓣新生儿结局胎儿宫内死亡心脏事件心室流出道心室收缩功能自然

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玉米—小麦耕作制不同生产水平施肥对栗钙土有效磷素的影响

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园艺与种苗 1993年第2期 40-42页

作者： C.C.s.Rao K.d.singh 杨建设

人口压力的增加迫切需要提高单位面积的产量,这就有必要在未来的持续增产过程中保持良好的地力。通过前人在印度不同农业气候区对不同作物的跟踪试验,已证实计划产量方程的正确性。然而,仍缺乏玉米一小麦种植制中不同产量水平施肥对土... 详细信息

人口压力的增加迫切需要提高单位面积的产量,这就有必要在未来的持续增产过程中保持良好的地力。通过前人在印度不同农业气候区对不同作物的跟踪试验,已证实计划产量方程的正确性。然而,仍缺乏玉米一小麦种植制中不同产量水平施肥对土壤有效磷影响的资

关键词：玉米小麦麦类作物栗钙土白干土地带性土壤有效磷速效磷磷素

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比较有或无左心室功能紊乱的冠状动脉疾病患者心理应激导致心肌缺血的区别

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世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 36-37页

作者： Akinboboye O. Krantz d.s. Kop W.J. 丁倩 dr.saint Francis Hospital Roslyn State Univ. New York at Stony Brook Stony Brook NY United States

To examine the susceptibility tomyocardial ischemia withmental stress in patients who have coronary artery disease and normal left ventricular(LV) function versus those who have impaired LV function, we examined 58 patients who had coronary artery disease, including 22 who had normal LV function(ejection fractiond mild to moderate LV dysfunction(ejection fraction 30%to 50%), and 20 who had severe LV dysfunction(ejection fraction ≤30%) and underwent bicycle and mental stress testing with myocardial perfusion scintigraphy on consecutive days in random order. Ischemia was assess.d.bas.d.on summed difference scores in regional rest versus stress myocardial perfusion and defined as a summed difference score >3. At comparable double products across the 3 groups, ischemia was induced with mental stress more frequently in patients who had severe LV dysfunction(50%) than in those who had normal LV function(9%; pse-induced ischemia was.d.fferent only between those who had mild/moderate LV dysfunction and those who had normal LV function(56%vs 18%, respectively, pstress versus exercise ischemia differed between groups(ps a higher prevalence of mental stress ischemia versus exercise ischemia in patients who had severe LV dysfunction(p=0.06), a marginally higher prevalence of exercise versus mental stress ischemia in those who had moderate LV dysfunction(p=0.07), and no difference in mental stress versus exercise ischemia in those who had normal LV function. Thus, at comparable double products.d.ring mental stress and similar extent of coronary artery disease, ischemia with mental stress was induced more frequently in patients who had severe LV dysfunction than in those who had normal LV function. These data suggest that mental stress ischemia may be of particular clinical importance in patients who have coronary artery disease and LV dysfunction.

关键词：左心室功能心理应激射血分数左室功能障碍闪烁照相术踏车试验试验调查率更随机顺序数据显示

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对存在治疗选择偏倚的观察性研究的分析:采用倾向评分和工具变量法评价有创性心脏治疗对AMI患者生存率的影响

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世界核心医学期刊文摘（心脏病学分册） 2007年第7期3卷 5-6页

作者： stukel T.A. Fisher E.s. Wennberg d.E. 黄浙勇 Institute for Clinical Evaluative sciences G106 2075 Bayview Ave Toronto Ont. M4N 3M5 Canada Dr.

背景：在观察性研究中，对治疗组和非治疗组间结果的比较可能会因组间患者预后的差异而产生偏倚，常见的原因是未发现的治疗选择偏倚。目的：比较4种分析方法排除观察性研究中选择偏倚的效果：多因素模型风险校正、倾向评分风险校正、... 详细信息

背景：在观察性研究中，对治疗组和非治疗组间结果的比较可能会因组间患者预后的差异而产生偏倚，常见的原因是未发现的治疗选择偏倚。目的：比较4种分析方法排除观察性研究中选择偏倚的效果：多因素模型风险校正、倾向评分风险校正、倾向评分匹配法和工具变量法。设计、地点和患者：此项全国性队列研究纳入1994—1995年间122124例享有医疗保险的老年急性心肌梗死（AMI）住院患者（65～84岁），所有病例均适合行心导管术。基线资料来自心血管合作项目，并与医疗保险管理数据连接，以确保足够充分的预后参数。

关键词：心脏治疗倾向评分 AMI患者偏倚工具生存率有创性老年急性心肌梗死

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一个抗黄瓜枯萎病的显性基因

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农业新技术 1981年第1期 33-36页

作者： d. Netzer s. Niego E. Galun 陈文良北京市农科院植保所

世界上许多地方已描述了黄瓜枯萎病和根腐病。在一些国家中,如日本、荷兰、美国、英国和以色列,黄瓜枯萎病已造成了严重的经济损失。黄瓜枯萎病病菌——黄瓜尖孢镰刀菌Fusarium oxysporum f. sp cucumerinum对黄瓜寄主是专化寄生的。从... 详细信息

世界上许多地方已描述了黄瓜枯萎病和根腐病。在一些国家中,如日本、荷兰、美国、英国和以色列,黄瓜枯萎病已造成了严重的经济损失。黄瓜枯萎病病菌——黄瓜尖孢镰刀菌Fusarium oxysporum f. sp cucumerinum对黄瓜寄主是专化寄生的。从以色列几个发病地块采集到的甜瓜,西瓜和黄瓜的枯萎病株中,只从黄瓜寄主上分离出的这种病菌是黄瓜尖孢镰刀菌。在严重发病的地块,除非采用抗病的栽培品种,否则黄瓜丰收是不可能的。在选育这样的栽培品种过程中,我们研究了黄瓜对枯萎病的有关抗病遗传性问题。现把主要研究结果报告如下。

关键词：黄瓜枯萎病以色列杂种二代自花授粉杂交后代显性基因黄瓜品种栽培品种

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Fontolizumab,一种人源化的抗干扰素γ抗体:临床治疗中重度克罗恩病的安全性与有效性

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 41-42页

作者： Hommes.d.W. Mikhajlova T.L. stoinov s. 王铮 department Gastroenterology and Hepatology Academic Medical CentreMeibergdreef 9 1105 AZAmsterdamNetherlands Dr.

Introduction:Interferon γ is a potent proinflammatory cytokine implicated in the inflammation of Crohn’s.d.sease(Cd) .We evaluated the safety and efficacy of fontolizumab,a humanis.d.anti-interferon γ antibody,in patients with moderate to severe ***:A total of 133 patients with Crohn’s.d.sease activity index(CdAI) scores between 250 and 450,inclusive,were randomis.d.to receive placebo or fontolizumab 4 or 10 mg/*** two patients received one dose and 91 patients received two doses on days 0 and *** and patients were unaware of *** end points were safety,clinical response(decrease in CdAI of 100 points or more) ,and remission(CdAI ≤ 150) .Results:There was no statistically significant difference in the primary end point of the study(clinical response) between the fontolizumab and placebo groups after a single dose at day ***,patients receiving two doses of fontolizumab demonstrated doubling in response rate at day 56 compared with placebo:32%(9/28) versus 69%(22/32,p = 0.02) and 67%(21/31,p = 0.03) for the placebo,and 4 and 10mg/kg fontolizumab groups,*** according to elevated baseline C reactive protein levels resulted in a decreas.d.placebo response and pronounced differences in clinical *** grade 3 adverse events were reported and were cons.d.red to be related to *** death(during sleep) and one serious adverse event(an elective hospitalisation) occurred,both cons.d.red ***-lusion:Treating active Cd with fontolizumab was well tolerated and resulted in increas.d.rates of clinical response and remission compared with placebo.

关键词：克罗恩病 Fontolizumab 干扰素γ 人源化炎性细胞因子终点指标安慰剂单次剂量临床

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匈牙利的商用生物技术

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中外科技信息 1990年第3期 20-24页

作者： M.d.迪布纳 G.s.伯里尔韩星

尽管有众多的不利条件,但匈牙利正在发展生产技术工业。本文考察了对这种发展可能有影响的文化、基础结构、科学和技术的诸因素。当前匈牙利政治领导层的变化可能会加速这个国家生物技术的发展。

关键词：匈牙利企业企业管理布达佩斯生物技术私人投资

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卵巢癌肉瘤系列报道

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 49-50页

作者： Rutledge T.L Gold M.A McMeekin d.s 李奎 University of Oklahoma Health Sciences Center Oklahoma City OK 73104 United States

To evaluate our experience with ovarian carcinosarcoma and identify prognostic factors. Methods. Thirty-one cases of ovarian carcinosarcoma were identified over a 6- year time period through tumor registry and pathology records. Fisher exact test and log rank using Kaplan-Meier method (P s.d.to compare variables with outcome. Results. All 31 patients underwent initial surgical treatment with an appropriate staging procedure. stage distribution: 1 stage I, 6 stage II, 23 stage III, and 1 stage IV. The median followup was 28 months. The median survival for the entire group was 21 months. Early vs. advanced stage significantly influenced progression-free interval, P = 0.05. Nineteen patients were found to have stage IIIC disease and required debulking procedures. In patients with stage IIIC disease, presence of res.d.al disease was associated with decreas.d.overall survival, P = 0.03. 29 patients received adjuvant chemotherapy with 11 patients receiving ifosfamide/cisplatin and 16 patients receiving carboplatin/taxol. Progression-free interval was improved with the use of ifosfamide/cisplatin vs. carboplatin/taxol. The median PFI was 12 months in the carbo/taxol group and has not been reached in the ifos/cisplatin group (P = 0.005). The overall survival was also significantly improved with the use of ifosfamide/cisplatin, P = 0.03. In advanced stage patients, overall survival was not significantly influenced by type of adjuvant chemotherapy administered, P = 0.13. Conclusions. Ovarian carcinosarcoma has a poor overall prognosis with median survival rates reported in the literature ranging from 7- 10 months. Our series, although limited by a small number of patients, exhibits a more encouraging median survival of 21 months for the overall group. Aggressive debulking to eliminate res.d.al disease and the use of ifosfamide/cisplatin chemotherapy seem to be factors in this improved outcome.

关键词：卵巢癌肉瘤中位生存时间进展时间残留灶肿瘤早期肿瘤登记异环磷酰胺手术分期辅助化疗泰素

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新蝶呤的长期预后价值:急性冠状动脉综合征患者单核细胞激活的一种新标记物

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世界核心医学期刊文摘（心脏病学分册） 2007年第10期3卷 40-41页

作者： Ray K.K. Morrow d.A. sabatine M.s. 杜媛 department of Public Health and Primary Care Strangeways Research LaboratoryUniversity of CambridgeWorts CausewayCambridgeCB1 8RNUnited Kingdom Dr.

背景:单核细胞激活被认为在急性冠状动脉综合征(ACs)的发病过程中起着重要作用。新蝶呤是单核细胞激活的一种可溶性标记物,其水平升高对稳定性冠状动脉疾病具有预后预测价值。

关键词：急性冠状动脉综合征新蝶呤冠状动脉事件单核细胞白细胞患者标记物

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呼吸困难对接受心脏负荷试验患者的预后意义

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 28-29页

作者： Abidov A. Rozanski A. Hachamovitch R. d.s. Berman 黄浙勇 department of Imaging Cedars-Sinai Medical Center 8700 Beverly Blvd. Los Angeles CA 90048 United States Dr.

BACKGROUNd: Although dyspnea is a common symptom, there has been only limited investigation of its prognostic significance among patients referred for cardiac evaluation. METHOds: We studied 17,991 patients undergoing myocardial-perfusion single-photon-emission computed tomography during stress and at rest. Patients were divided into five categories on the basis of symptoms at presentation(none, nonanginal chest pain, atypical angina, typical angina, and dyspnea). Multivariable analysis was us.d.to assess the incremental prognostic value of symptom categories in predicting the risk of death from cardiac causes and from any cause. In addition, the prognosis associated with various symptoms at presentation was compared in subgroups selected on the basis of propensity ***: After a mean(±sd)follow-up of 2.7±1.7 years, the rate of death from cardiac causes and from any cause was significantly higher among patients with dyspnea(both those previously known to have coronary artery disease and those with no known history of coronary artery disease)than among patients with other or no symptoms at presentation. Among patients with no known history of coronary artery disease, those with dyspnea had four times the risk of s.d.en death from cardiac causes of asymptomatic patients and more than twice the risk of patients with typical angina. dyspnea was associated with a significant increase in the risk of death among each clinically relevant subgroup and remained an independent predictor of the risk of death from cardiac causes(Pd from any cause(Pdjustment for other significant factors by multivariable and propensity analysis. CONCLUsIONs: In a large series of patients, self-reported dyspnea identified a subgroup of otherwise asymptomatic patients at increas.d.risk for death from cardiac causes and from any cause. Our results suggest that an assessment of dyspnea should be incorporated into the clinical evaluation of patients referred for car

关键词：呼吸困难心脏负荷试验心脏性全因死亡预后意义患者

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