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Optimal sequential therapy using tyrosine kinase inhibitors as the first-line treatment in patients with metastatic renal cell carcinoma: A nationwide multicenter study

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Asian Journal of Urology 2024年第3期11卷 450-459页

作者： Jung Ki Jo seong Il seo MinYong Kang Jinsoo Chung Cheol Kwak sung-hoo Hong Cheryn song Jae Young Park Chang Wook Jeong seok Hwan Choi sung Han Kim Eu Chang Hwang Chan Ho Lee Hakmin Lee Department of Urology Medical and Digital EngineeringCollege of MedicineHanyang UniversitySeoulRepublic of Korea Department of Urology Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Urology National Cancer CenterGoyangRepublic of Korea Department of Urology Seoul National University HospitalSeoulRepublic of Korea Department of Urology Kangnam St Mary’s HospitalSeoulRepublic of Korea Department of Urology Asan Medical CenterSeoulRepublic of Korea Department of Urology Korea University Ansan HospitalAnsanRepublic of Korea Department of Urology Kyungpook National University HospitalDaeguRepublic of Korea Department of Urology Chonnam National University Hwasun HospitalHwasunRepublic of Korea Department of Urology Inje University Busan Paik HospitalBusanRepublic of Korea Department of Urology Seoul National University Bundang HospitalSeongnamRepublic of Korea

Objective:The purpose of the study was to identify the best sequence of therapy beginning with a tyrosine kinase inhibitor(TKI)as the first-line therapy for patients with metastatic renal cell carcinoma(mRCC)in terms of overall survival(Os),progression-free survival(PFs),and rates of discontinuation and adverse effects during the treatment ***:This is a retrospective,nationwide multicenter study of patients with mRCC after diagnosis at 10 different tertiary medical centers in Korea from January 1992 to December *** focused on patients at either“favorable”or“intermediate”risk according to the International mRCC Database Consortium criteria,and they were followed up(median 335 days).Finally,a total of 1409 patients were selected as the study *** generated a Cox proportional hazard model adjusted for covariates,and the different therapy schemes were statistically tested in terms of Os as well as *** addition,frequencies of discontinuation and adverse events were compared among the therapy ***:Of the primary patterns of treatment sequences(24 sequences),“sunitinib epazopanib”and“sunitinibeeverolimuseimmunotherapy”showed the most beneficial results in both Os and PFs with significantly lower hazards than“sunitinib”,which is the most commonly treated agent in *** that the“TKIeTKI”structure showed relatively higher discontinuation rates with higher adverse effects,the overall beneficial sequence would be“sunitinibeeverolimuseimmunotherapy”.Conclusion:Among several sequential therapy starting with TKIs,“sunitinibeeverolimuse immunotherapy”was found to be the best scheme for mRCC patients with“favorable”or“intermediate”risks.

关键词： Tyrosinekinase inhibitor Metastaticrenalcell carcinoma Overall survival Progression-free survival

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A Regional Economy's Resistance to the COVID-19 shock: sales Revenues of Micro-, small-, and Medium-sized Enterprises in south Korea

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International Journal of Disaster Risk science 2022年第2期13卷 190-198页

作者： seong-Jin Lee Joong-hoo Park seung-Min Cha Donghyun Kim Department of Public Policy and Management.Pusan National University Busan 46241South Korea Department of Urban Planning and Engineering Pusan National UniversityBusan 46241South Korea

The coronavirus disease 2019(COVID-19) is a global pandemic that has heavily impacted not only the health sector, but also the economic sector in *** countries have projected a negative economic impact, and the effect on micro-, small-, and medium-sized enterprises(MsMEs) is predicted to be significantly *** study estimated the regional resistance of MsME sales revenues and identified the regional economic factors that affect resistance by analyzing south Korea, a country with one of the lowest economic impact projections from COVID-19. Resistance was estimated by comparing sales revenues and changes in resistance observed during the early COVID-19 period to those recorded in the same weeks(weeks 6 to 9) of 2019. The factors that affect regional resistance were determined by conducting robust regression and spatial regression analyses. The results show that the number of confirmed COVID-19 cases, a direct risk factor, is negatively related to regional resilience, while diversity is positively related to regional resistance. To improve the regional resistance against uncertain events, this study recommends increased diversity among regional industrial structures to reduce the duration of the early shock of an unexpected adverse event.

关键词： COVID-19 Economic resistance MsMEs south Korea

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二维半导体材料中激子对介电屏蔽效应的探测及其应用

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物理学报 2022年第12期71卷 118-132页

作者：胡倩颖许杨中国科学院物理研究所北京100190 南开大学物理科学学院天津300191

二维过渡金属硫族化合物作为二维半导体材料领域研究的重要分支,凭借较强的光-物质相互作用和独特的自旋-谷锁定等特性,吸引了广泛而持久的关注.单层的二维过渡金属硫族化合物半导体具有直接带隙,在二维的极限下,由于介电屏蔽效应的减弱... 详细信息

二维过渡金属硫族化合物作为二维半导体材料领域研究的重要分支,凭借较强的光-物质相互作用和独特的自旋-谷锁定等特性,吸引了广泛而持久的关注.单层的二维过渡金属硫族化合物半导体具有直接带隙,在二维的极限下,由于介电屏蔽效应的减弱,电荷间的库仑相互作用得到了显著的增强,其光学性质主要由紧密束缚的电子-空穴对—激子主导.本文简单回顾了近年来二维过渡金属硫族化合物光谱学的研究历程,阐述了栅压和介电环境对激子的调制作用,之后重点介绍了一种新颖的激子探测方法.由于激发态激子(里德伯态)的玻尔半径远大于单原子层本身的厚度,电子-空穴对之间的电场线得以延伸到自身之外的其他材料中.这使得二维半导体材料的激子可以作为一种高效的量子探测器,感知周围材料中与介电函数相关的物理性质的变化.本文列举了单层Wse_(2)激子在探测石墨烯-氮化硼莫尔(moiré)超晶格势场引发的石墨烯二阶狄拉克点,以及Ws_(2)/Wse_(2)莫尔超晶格中分数填充的关联绝缘态中的应用.最后,本文展望了这种无损便捷、高空间分辨率、宽适用范围的激子探测方法在其他领域的潜在应用场景.

关键词：过渡金属硫族化合物激子介电屏蔽激子探测

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Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black soybean on Chronic Bacterial Prostatitis Rat Model

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Chinese Journal of Integrative Medicine 2018年第8期24卷 621-626页

作者： Byung Il Yoon Woong Jin Bae Yong sun Choi su Jin Kim U syn Ha sung-hoo Hong Dong Wan sohn sae Woong Kim Department of Urology International St Mary's HospitalThe Catholic Kwandong University of Korea Department of Urology College of MedicineThe Catholic University of Korea

Objective： To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis（CBP） rat ***： The spragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups（n=8 in each group）.Then,drip infusion of bacterial suspension（Escherichia coli Z17O2：K1：H^-） into sprague-Dawley rats was conducted to induce *** 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each ***： The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group（P〈0.05）.The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group（P〈0.05）.Conclusions： These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ***,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.

关键词： prostatitis anti-bacterial agents anthocyanins

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Traditional Chinese Medicine in Malaysia:A Brief Historical Overview of the Interactions between China and Malay Peninsula

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Chinese Medicine and Culture 2018年第2期1卷 60-63页

作者： Wen Tien Tan Hon Foong Wong shih Chau Ng si Woei Goh Jun Liu Bao Ling hoo Chyong En Chai Xun Lin Department of Golden Cabinet International Education CollegeShanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Chinese Medicine was introduced to the Malay Peninsula during the colonial era circa 18th to 19th *** British imported Chinese immigrants mainly for tin *** early Chinese settlers had brought with them the knowledge of Traditional Chinese Medicine(TCM)to *** time goes by,TCM becomes one of the popular traditional medicines that are accepted by other *** has thus contributed to the welfare of *** 2016,a Traditional and Complementary Medicine(T and CM)Act was passed by the Malaysia *** is one of the T and CM practices that fall under the *** services are now offered in Malaysia’s public hospitals in addition to private *** article aims to provide a brief overview on the development of TCM in the precolonial and postindependent Malaysia.

关键词： Development history Malaysia Traditional Chinese Medicine

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香港的刑法体系

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中国法律 1997年第S1期 59-60页

作者：胡漢清

1.引言香港的刑法体系是以英国法系为基础的。香港的根本刑法由法规和普通法构成。这些法规主要根据英国的法规修订而成。普通法只要适应于香港当地的情况,就应该在香港使用。就刑事诉讼程序而论,《刑事诉讼程序条例》(第221章)明文规... 详细信息

1.引言香港的刑法体系是以英国法系为基础的。香港的根本刑法由法规和普通法构成。这些法规主要根据英国的法规修订而成。普通法只要适应于香港当地的情况,就应该在香港使用。就刑事诉讼程序而论,《刑事诉讼程序条例》(第221章)明文规定:'所有刑事案件的诉讼程序应尽可能地同英国类似案例所使用的诉讼程序保持一致'(第9节第3款)。

关键词：高等法院刑法普通法香港刑事案件被告

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Photonic crystal fibers, devices, and applications

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Frontiers of Optoelectronics 2013年第1期6卷 3-24页

作者： Wei JIN Jian JU Hoi Lut HO Yeuk Lai hoo Ailing ZHANG Department of Electrical Engineering The Hong Kong Polytechnic University Hong Kong China

This paper reviews different types of air-silica photonic crystal fibers (PCFs), discusses their novel properties, and reports recent advances in PCF components and sensors as well as techniques for splicing PCFs to s... 详细信息

关键词： photonic crystal fibers (PCFs) microstructured optical fibers hollow-core photonic bandgap fibers(HC PBFs) optical fiber devices optical fiber sensors Photonic crystal fibers Optical fiber devices Fiber optic sensors

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Traditional Chinese Medicine in Malaysia: A Brief Historical Overview of Laws and Regulations

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Chinese Medicine and Culture 2019年第3期2卷 162-165页

作者： Hon Foong Wong shih Chau Ng Wen Tien Tan Huiying Wang Xun Lin si Woei Goh Bao Ling hoo Chyong En Chai Jun Liu International Education College Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Chinese Medicine Centre for Complementary and Alternative MedicineInternational Medical UniversityKuala LumpurMalaysia

Although traditional Chinese medicine(TCM)has been a part of the Malaya and the Malaysia people’s method of maintaining health and well-being for many centuries,it was never been enrolled in the public health-care ***,the rising cost of Western drugs and the increasing number of people frequenting TCM has driven the government to search for cheaper options and to look into its safe *** 1992,the government mandated all TCM herbal products to be registered with the National Pharmaceutical Control *** TCM products sold in Malaysia are now Good Manufacturing Practice *** government has also established a Traditional and Complementary Medicine Division within the Ministry of *** 2008 and 2014,a traditional and complementary medicine unit was set up in major hospitals in all *** is one of the main services offered by the *** 2016,the government enacted the Traditional and Complementary Medicine Act to regulate the TCM ***,a 10-vear blueprint has been drawn to support the development of all traditional and complementary medicines in *** article aims to provide a brief overview on the regulatory development of TCM in Malaysia.

关键词： Development of traditional Chinese medicine historical overview laws and regulations Malaysia Traditional Chinese medicine

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