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The Combined Effect of Lumenato and Ceramide in the Protection of Collagen Damage Induced by Neutrophils in Normal Human Dermal Fibroblasts

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Advances in Bioscience and Biotechnology 2024年第2期15卷 140-159页

作者： Yulia solomonov Rachel levy Immunology and Infectious Diseases Laboratory Department of Clinical Biochemistry and Pharmacology Faculty of Health Sciences Ben-Gurion University of The Negev Beer-Sheva Israel

Introduction: Collagen is the primary structural protein fibroblasts produce in the skin’s extracellular matrix. Infiltration of neutrophils into the epidermis and dermis by exposure to UV causes collagen damage and contributes to photoaging. Methods: To study the combined effect of Lumenato and ceramide in preventing collagen-1 damage induced by phagocytes, we used co-cultures of normal human dermal fibroblasts (fibroblasts) and activated human neutrophils. The present study aimed to determine the protective effect of the combination of Lumenato and ceramide on fibroblast collagen-1 damage induced by neutrophils. Results: Lumenato (in the range of 6.5 - 208 μg/ml) or ceramide (in the range of 0.1 - 50 μM) inhibited the production of superoxides and MPO by TNFα-stimulated neutrophils, as well as the production of NO by LPs-stimulated macrophages in a dose-dependent manner. The combinations of Lumenato and ceramide, in low concentrations, caused synergistic prevention of fibroblasts’ collagen-1 damage induced by TNFα-activated neutrophils, detected by fluorescence immunostaining and WB analysis. MPO activity in the supernatants of the co-cultures was also synergistically inhibited. Adding Lumenato or ceramide singly or in combinations in these low concentrations to the fibroblast cultures did not affect the expression of collagen-1. The combinations of Lumenato or ceramide in these concentrations also caused a synergistic inhibition of NO production by activated macrophages. Conclusions: The results suggest that combining low concentrations of Lumenato and ceramide results in synergistic protection against fibroblasts’ collagen-1 damage induced by neutrophils, thus indicating their possible potential for enhanced skin health.

关键词： Dermal Fibroblasts Neutrophils Collagen-1 Lumenato Ceramide

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severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael levy Anais R.Briant Etienne Javouhey sophie Breinig Julia Dina Marion Caseris Francois Angoulvant stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical school Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU sainte Justine Research Center MontréalCanada

Background severe acute respiratory syndrome coronavirus-2(sARs-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of sARs-CoV-2 on the mortality rate associated with sARs-CoV-2-related illnesses in the pediatric intensive care unit(PICU).secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive sARs-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental sARs-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMs)recorded in the French PICU registry(PICURe)between september 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of sARs-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to sARs-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to sARs-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMs).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** sARs-CoV-2 mortality in the French pediatric population was *** though the imputability of sARs-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit sARs-CoV-2

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Enhancing Renewable Energy Integration:A Gaussian-Bare-Bones levy Cheetah Optimization Approach to Optimal Power Flow in Electrical Networks

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Computer Modeling in Engineering & sciences 2024年第8期140卷 1339-1370页

作者： Ali s.Alghamdi Mohamed A.Zohdy saad Aldoihi Department of Electrical Engineering College of EngineeringMajmaah UniversityAl-Majmaah11952Saudi Arabia Electrical and Computer Engineering Department Oakland UniversityRochesterMI48309USA Institute of Earth and space science King Abdulaziz City for Science and Technology(KACST)Riyadh11442Saudi Arabia Computer science and systems Engineering Institute Polytechnique de ParisPalaiseau CedexFrance

In the contemporary era,the global expansion of electrical grids is propelled by various renewable energy sources(REss).Efficient integration of stochastic REss and optimal power flow(OPF)management are critical for network *** study introduces an innovative solution,the Gaussian Bare-Bones levy Cheetah Optimizer(GBBLCO),addressing OPF challenges in power generation systems with stochastic *** primary objective is to minimize the total operating costs of REss,considering four functions:overall operating costs,voltage deviation management,emissions reduction,voltage stability index(VsI)and power loss ***,a carbon tax is included in the objective function to reduce carbon *** scrutiny,using modified IEEE 30-bus and IEEE 118-bus systems,validates GBBLCO’s superior performance in achieving optimal *** results demonstrate GBBLCO’s efficacy in six optimization scenarios:total cost with valve point effects,total cost with emission and carbon tax,total cost with prohibited operating zones,active power loss optimization,voltage deviation optimization and enhancing voltage stability index(VsI).GBBLCO outperforms conventional techniques in each scenario,showcasing rapid convergence and superior solution ***,GBBLCO navigates complexities introduced by valve point effects,adapts to environmental constraints,optimizes costs while considering prohibited operating zones,minimizes active power losses,and optimizes voltage deviation by enhancing the voltage stability index(VsI)*** research significantly contributes to advancing OPF,emphasizing GBBLCO’s improved global search capabilities and ability to address challenges related to local *** emerges as a versatile and robust optimization tool for diverse challenges in power systems,offering a promising solution for the evolving needs of renewable energy-integrated power grids.

关键词： Renewable energy integration optimal power flow stochastic renewable energy sources gaussian-bare-bones levy cheetah optimizer electrical network optimization carbon tax optimization

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Mose_(2)/Ws_(2) heterojunction photodiode integrated with a silicon nitride waveguide for near infrared light detection with high responsivity

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Light(science & Applications) 2023年第3期12卷 456-464页

作者： Rivka Gherabli s.R.K.C.Indukuri Roy Zektzer Christian Frydendahl Uriel levy Department of Applied Physics The Faculty of ScienceThe Center for Nanoscience and NanotechnologyThe Hebrew University of JerusalemJerusalem91904Israel

We demonstrate experimentally the realization and the characterization of a chip-scale integrated photodetector for the near-infrared spectral regime based on the integration of a Mose_(2)/Ws_(2) heterojunction on top of a silicon nitride *** configuration achieves high responsivity of~1 A W−1 at the wavelength of 780 nm(indicating an internal gain mechanism)while suppressing the dark current to the level of~50 pA,much lower as compared to a reference sample of just Mose_(2) without Ws_(2).We have measured the power spectral density of the dark current to be as low as~1×10^(−12) A Hz−0.5,from which we extract the noise equivalent power(NEP)to be~1×10^(−12) W Hz^(−0.5).To demonstrate the usefulness of the device,we use it for the characterization of the transfer function of a microring resonator that is integrated on the same chip as the *** ability to integrate local photodetectors on a chip and to operate such devices with high performance at the near-infrared regime is expected to play a critical role in future integrated devices in the field of optical communications,quantum photonics,biochemical sensing,and more.

关键词： heterojunction waveguide resonator

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A genome-wide association analysis implicates sOX6 as a candidate gene for wrist bone mass

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science China(Life sciences) 2010年第9期53卷 1065-1072页

作者： s.awn levy Vanderbilt Microarray shared Resource Vanderbilt University

Osteoporosis is a highly heritable common bone disease leading to fractures that severely impair the life quality of *** fractures caused by osteoporosis are largely due to the scarcity of wrist bone *** we report the results of a genome-wide association study (GWAs) of wrist bone mineral density (BMD).We examined ～500000 sNP markers in 1000 unrelated homogeneous Caucasian subjects and found a novel allelic association with wrist BMD at rs11023787 in the sOX6 (sRY (sex determining region Y)-box 6) gene (P=9.00×10-5).subjects carrying the C allele of rs11023787 in sOX6 had significantly higher mean wrist BMD values than those with the T allele (0.485:0.462 g cm-2 for C allele vs.T allele carriers).For validation,we performed sOX6 association for BMD in an independent Chinese sample and found that sNP rs11023787 was significantly associated with wrist BMD in the Chinese sample (P=6.41×10-3).Meta-analyses of the GWAs scan and the replication studies yielded P-values of 5.20×10-6 for *** of this study,together with the functional relevance of sOX6 in cartilage formation,support the sOX6 gene as an important gene for BMD variation.

关键词： osteoporosis GWAs sOX6 sNPs wrist BMD

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Quantum corrections for Boltzmann equation

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science China(Physics,Mechanics & Astronomy) 2008年第9期51卷 1229-1239页

作者： M. levy PETER Department of Physics New York University

We present the lowest order quantum correction to the semiclassical Boltzmann distribution function,and the equation satisfied by this correction is given. Our equation for the quantum correction is obtained from the conventional quantum Boltzmann equation by explicitly expressing the Planck constant in the gradient approximation,and the quantum Wigner distribution function is expanded in pow-ers of Planck constant,too. The negative quantum correlation in the Wigner dis-tribution function which is just the quantum correction terms is naturally singled out,thus obviating the need for the Husimi’s coarse grain averaging that is usually done to remove the negative quantum part of the Wigner distribution function. We also discuss the classical limit of quantum thermodynamic entropy in the above framework.

关键词： quantum Boltzmann equation Wigner distribution function quantum correction

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levy Constrained search in Fock space：An Alternative Approach to Noninteger Electron Number

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物理化学学报 2018年第6期34卷 625-630页

作者： AYERs Paul W. levy Mel Department of Chemistry and Chemical Biology McMaster University Hamilton Ontario L8S 4M1 Canada. Department of Physics North Carolina A&T State University Greensboro NC 27411 USA. Department of Chemistry Duke University Durham NC 2770

By extending the levy wavefunction constrained search to Fock space,one can define a wavefunction constrained search for electron densities in systems having noninteger number of *** pure-state v-representable densities,the results are equivalent to what one would obtain with the zero-temperature grand canonical *** other cases,the wavefunction constrained search in Fock space presents an upper bound to the grand canonical ensemble *** advantage of the Fock-space wavefunction constrained search functional over the zero-temperature grand-canonical ensemble constrained search functional is that certain specific excited states(i.e.,those that are not ground-statev-representable) are the stationary points of the Fock-space ***,a potential disadvantage of the Fock-space constrained search functional is that it is not convex.

关键词： Density functional theory levy constrained search functional Fock space Fractional electron number Excited-state density functional theory Universal density functional Zero temperature grand canonicalensemble Convexity

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The Influence of Land surface Changes on Regional Climate in Northwest China

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Advances in Atmospheric sciences 2007年第3期24卷 527-537页

作者：徐兴奎张凤 Jason K.levy International Center for Climate and Environment sciences Institute of Atmospheric Physics Chinese Academy of Sciences Western Washington University Department of Environmental studies Huxley College of the Environment516 High StreetBellinghamWA98225

Land surface changes effect the regional climate due to the complex coupling of land-atmosphere interactions. From 1995 to 2000, a decrease in the vegetation density and an increase in ground-level thermodynamic activity has been documented by multiple data sources in Northwest China, including meteorological, reanalysis from European Centre for Medium-Range Weather Forecasts （ECMWF）, National Oceanic and Atmospheric Administration＇s （NOAA） Advanced Very High Resolution Radiometer （AVHRR） and TIROs Operational Vertical sounder （TOVs） satellite remote sensing data. As the ground-level thermodynamic activity increases, humid air from the surrounding regions converge toward desert （and semi-desert） regions, causing areas with high vegetation cover to become gradually more arid. Furthermore, land surface changes in Northwest China are responsible for a decrease in total cloud cover, a decline in the fraction of low and middle clouds, an increase in high cloud cover （due to thermodynamic activity） and other regional climatic adaptations. It is proposed that, beginning in 1995, these cloud cover changes contributed to a ＂green- house＂ effect, leading to the rapid air temperature increases and other regional climate impacts that have been observed over Northwest China.

关键词： land surface features climatic effect Northwest China TOVs NOAA-AVHRR

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IL-10 and TNF-α promoter haplotypes are associated with childhood Crohn’s disease location

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World Journal of Gastroenterology 2009年第30期15卷 3776-3782页

作者： Rocio sanchez Emile levy Florin Costea Daniel sinnett Research Center Sainte-Justine University health centerMontreal H3T 1C5Canada Research Center Sainte-Justine University health centerDepartment of NutritionUniversity of MontrealMontreal H3T 1C5Canada Research Center Sainte-Justine University health centerDepartment of PediatricsUniversity of MontrealMontreal H3T 1C5Canada

AIM： To determine the distribution and frequencies of the genotypes and haplotypes of the genes encoding for the glucocorticoid receptor （GR）, the tumor necrosis factor （TNF）-α and the interleukin （IL）-10 in childhood Crohn＇s disease （CD） and to assess the impact of the corresponding DNA variants on clinical and disease phenotypes.METHODs： Ten variants in GR, TNF-a and IL-10 were genotyped in 113 childhood CD cases and 95 healthy subjects, both of French-Canadian origin.REsULTs： For the GR polymorphisms （R23K and N363s） and IL-10 variants in the 5＇flanking region （-1082 G 〉 A, -819 T 〉 C and -592 A 〉 C）, no difference was observed in allele and genotype frequencies between CD patients and controls. At the haplotype level, we found three IL-10 haplotypes previously described in Caucasians （GCC, ACC and ATA） and three novel haplotypes only present in IBD patients. When we analyzed the haplotype distribution with the anatomical location of the disease, the GCC haplotype was associated with the colonic and the ACC haplotype with the terminal ileum location, respectively. The genotyping of five polymorphisms in the promoter region of the TNF-α gene （-1031 T 〉 C, -863 A 〉 C, -857 T 〉 C, -308 A 〉 G and -238 A 〉 G） revealed a significant overrepresentation of homozygous -1031 CC among CD patients （OR = 9.9） and an association with the colonic location. For TNF-α, eleven haplotypes were inferred, including two frequent ones, TCCGG and CACGG, which were significantly observed more frequently in controls and cases, respectively.CONCLUsION： This is one of the first studies investigating the association between haplotype structure and disease location in a CD pediatric cohort. Our results will help to increase our understanding of the genetic determinants of childhood CD.

关键词： Haplotype Polymorphism Crohn’s disease Glucocorticoid receptor Interleukin-10 Tumor necrosis factor-α

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High-Q ring resonators directly written in As2s3 chalcogenide glass films

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Photonics Research 2015年第3期3卷 63-67页

作者： shahar levy Matvei Klebanov Avi Zadok Faculty of Engineering Bar-Ilan UniversityRamat-Gan 5290002Israel Department of Physics Ben-Gurion University of the NegevBeer-Sheva 8410501Israel

Planar ring resonator waveguides are fabricated in thin films of As2s3 chalcogenide glass,deposited on silicaon-silicon *** cores are directly written by scanning the focused illumination of a femtosecond Ti:sapphire laser at a central wavelength of 810 nm,through a two-photon photo-darkening process.A large photoinduced index change of 0.3–0.4 refractive index units is *** radius of the ring resonator is 1.9 mm,corresponding to a transmission free spectral range of 9.1 GHz.A high loaded（intrinsic） Q value of 110,000（180,000） is *** thermal dependence of the resonator transfer function is *** results provide the first report,to the best of our knowledge,of directly written high-Q ring resonators in chalcogenide glass films,and demonstrate the potential of this simple technique towards the fabrication of planar lightguide circuits in these materials.

关键词： ring As High-Q ring resonators directly written in As2s3 chalcogenide glass films

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