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The pathogenic mechanism of TAR DNA-binding protein 43(TDP-43)in amyotrophic lateral sclerosis

Neural Regeneration Research 2024年第4期19卷 800-806页

作者： Xinxin Wang Yushu hu Renshi Xu Medical College of Nanchang University Department of Neurology Jiangxi Provincial People's HospitalThe First Affiliated Hospital of Nanchang Medical CollegeThe Clinical College of Nanchang Medical College

The onset of amyotrophic lateral sclerosis is usually characterized by focal death of both upper and/or lower motor neurons occurring in the motor cortex,basal ganglia,brainstem,and spinal cord,and commonly involves the muscles of the upper and/or lower extremities,and the muscles of the bulbar and/or respiratory ***,as the disease progresses,it affects the adjacent body regions,leading to generalized muscle weakness,occasionally along with memory,cognitive,behavioral,and language impairments;respiratory dysfunction occurs at the final stage of the *** disease has a complicated pathophysiology and currently,only riluzole,edaravone,and phenylbutyrate/taurursodiol are licensed to treat amyotrophic lateral sclerosis in many industrialized *** TAR DNA-binding protein 43 inclusions are observed in 97%of those diagnosed with amyotrophic lateral *** review provides a preliminary overview of the potential effects of TAR DNAbinding protein 43 in the pathogenesis of amyotrophic lateral sclerosis,including the abnormalities in nucleoplasmic transport,RNA function,post-translational modification,liquid-liquid phase separation,stress granules,mitochondrial dysfunction,oxidative stress,axonal transport,protein quality control system,and non-cellular autonomous functions(e.g.,glial cell functions and prion-like propagation).

关键词： amyotrophic lateral sclerosis axonal transport liquid-liquid phase separation noncellular autonomous functions oxidative stress pathogenesis post-translational modification protein quality control system stress granules TAR DNA-binding protein 43(TDP-43)

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Exploring the correlation between temperature and crime:A case-crossover study of eight cities in America

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Journal of safety science and Resilience 2024年第1期5卷 13-36页

作者： Jinming hu Xiaofeng hu Xin’ge Han Yan Lin huanggang Wu Bing shen school of Information Technology and Cyber security People’s Public Security University of ChinaBeijing 100038China Center for Capital social safety People’s Public Security University of ChinaBeijing 100038China China Association for Public safety Beijing 100084China school of Emergency Management and safety Engineering China University of Mining and TechnologyBeijing 100083China school of International Police studies People’s Public Security University of ChinaBeijing 100038China

Recent years have seen increasing academic interest in exploring the correlation between temperature and ***,it is uncertain whether similar long-term trends or seasonality(rather than causal effect)of temper-ature and crime is the major reason for the observed correlation between *** explore whether there is still a correlation between temperature and crime when long-term trends and seasonal cycles are filtered out,we use the Kalman filter to decompose the time series of temperature and crimes,and then the fast Fourier transform is used to calculate the exact circle of their seasonality *** on that,the box-plot method and linear regression are used to explore the correlation between temperature residuals and crime *** results show that more than half of the crime types have similar seasonal cycles(approximately 1 year)to that of ***,the daily residual analyses show that temperature residuals have a positive correlation with assault and robbery residuals in all cities,whose average slopes are more than *** other four types of crimes vary greatly from case to *** temperature residuals show a weak correlation with the residuals of some crime types.

关键词： Time series decomposition Crime Temperature Kalman filter Fast fourier transform

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Parametric resonance of axially functionally graded pipes conveying pulsating fluid

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 239-260页

作者： Jie JING Xiaoye MAO hu DING Liqun CHEN shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Frontier Science Center of MechanoinformaticsShanghai Institute of Applied Mathematics and MechanicsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200444China shanghai Institute of Aircraft Mechanics and Control Shanghai 200092China

Based on the generalized Hamilton's principle,the nonlinear governing equation of an axially functionally graded(AFG)pipe is *** non-trivial equilibrium configuration is superposed by the modal functions of a simply supported *** the direct multi-scale method,the response and stability boundary to the pulsating fluid velocity are solved analytically and verified by the differential quadrature element method(DQEM).The influence of Young's modulus gradient on the parametric resonance is investigated in the subcritical and supercritical *** general,the pipe in the supercritical region is more sensitive to the pulsating *** nonlinearity changes from hard to soft,and the non-trivial equilibrium configuration introduces more frequency components to the ***,the increasing Young's modulus gradient improves the critical pulsating flow velocity of the parametric resonance,and further enhances the stability of the *** addition,when the temperature increases along the axial direction,reducing the gradient parameter can enhance the response *** work further complements the theoretical analysis of pipes conveying pulsating fluid.

关键词： pipe conveying fluid axially functionally graded supercritical resonance multi-scale method parametric resonance

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The action mechanism of the work done by the electric field force on moving charges to stimulate the emergence of carrier generation/recombination in a PN junction

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1001-1014页

作者： Lingyun GUO Yizhan YANG Wanli YANG Yuantai hu Department of Mechanics School of Aerospace EngineeringHubei Key Laboratory of Engineering Structural Analysis and Safety AssessmentHuazhong University of Science and TechnologyWuhan 430074China

It is discovered that the product of the current and the electric field in a PN junction should be regarded as the rate of work(power)done by the electric field force on moving charges(hole current and electron current),which was previously misinterpreted as solely a Joule heating *** clarify that it is exactly the work done by the electric field force on the moving charges to stimulate the emergence of non-equilibrium carriers,which triggers the novel physical *** regards to Joule heat,we point out that it should be calculated from Ohm’s law,rather than simply from the product of the current and the electric *** on this understanding,we conduct thorough discussion on the role of the electric field force in the process of carrier recombination and carrier *** thermal effects of carrier recombination and carrier generation followed are incorporated into the thermal equation of *** present study shows that the exothermic effect of carrier recombination leads to a temperature rise at the PN interface,while the endothermic effect of carrier generation causes a temperature reduction at the *** two opposite effects cause opposite heat flow directions in the PN junction under forward and backward bias voltages,highlighting the significance of managing device heating phenomena in design ***,this study possesses referential significance for the design and tuning on the performance of piezotronic devices.

关键词： piezoelectric semiconductor(Ps) work done by electric field force thermal effect piezotronic device resistivity conductivity

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self-separation ionic liquid catalyst for the highly effective conversion of H2s by α,β-unsaturated carboxylate esters under mild conditions

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Green Energy & Environment 2024年第9期9卷 1440-1448页

作者： Wenjie Xiong Xiaomin Zhang Xingbang hu Youting Wu Key Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical Engineering Nanjing University The Institute of Green Chemistry and Engineering School of Chemistry and Chemical Engineering Nanjing University

The deep-processing utility of pure hydrogen sulfide （H2s） is a significant direction in natural gas chemical ***,a brand-new strategy of H2s conversion by a,β-unsaturated carboxylate esters into thiols or thioethers using task-specific carboxylate ionic liquids （ILs） as catalyst has been developed,firstly accomplishing the phase separation of product and catalyst without introducing the third *** can be considered as a cascade reaction in which the product selectivity can be controlled by adjusting the molar ratio of H2s to a,β-unsaturated carboxylate ***,the effects of ILs with different anions and cations,intermittent feeding operations,as well as pressure-time kinetic behaviors on cascade reaction were ***,the proposed interaction mechanism of H2s conversion using butyl acrylate catalyzed by[Emim][Ac]was revealed by DFT-based theoretical *** approach enables the self-phase separation promotion of catalyst and product and achieves 99%quantitative conversion under mild conditions in the absence of solvent,making the entire process ecologically ***-efficiency reaction activity can still be maintained after ten cycles of the ***,the good results,combined with its simplicity of operation and the high recyclability of the catalyst,make this green method environmentally friendly and *** is anticipated that this self-separation method mediated by task-specific ILs will provide a feasible strategy for H2s utilization,which will guide its application on an industrial scale.

关键词： Ionic liquid Cascade reaction self-separation H 2 s conversion Catalysis

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Natural vibration and critical velocity of translating Timoshenko beam with non-homogeneous boundaries

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Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1523-1538页

作者： Yanan LI Jieyu DING hu DING Liqun CHEN shanghai Institute of Applied Mathematics and Mechanics Shanghai Key Laboratory of Mechanics in Energy EngineeringShanghai Frontier Science Center of MechanoinformaticsSchool of Mechanics and Engineering ScienceShanghai UniversityShanghai 200072China school of Mathematics and statistics Qingdao UniversityQingdao 266071Shandong ProvinceChina

In most practical engineering applications,the translating belt wraps around two fixed *** boundary conditions of the dynamic model are typically specified as simply supported or fixed *** this paper,non-homogeneous boundaries are introduced by the support *** the translating belt as the mechanical prototype,the vibration characteristics of translating Timoshenko beam models with nonhomogeneous boundaries are investigated for the first *** governing equations of Timoshenko beam are deduced by employing the generalized Hamilton's *** effects of parameters such as the radius of wheel and the length of belt on vibration characteristics including the equilibrium deformations,critical velocities,natural frequencies,and modes,are numerically calculated and *** numerical results indicate that the beam experiences deformation characterized by varying curvatures near the *** radii of the wheels play a pivotal role in determining the change in trend of the relative difference between two beam *** the results unearths that the relative difference in equilibrium deformations between the two beam models is more pronounced with smaller-sized *** the two wheels are of equal size,the critical velocities of both beam models reach their respective *** addition,the relative difference in natural frequencies between the two beam models exhibits nonlinear variation and can easily exceed 50%.Furthermore,as the axial velocities increase,the impact of non-homogeneous boundaries on modal shape of translating beam becomes more *** dealing with non-homogeneous boundaries is challenging,beam models with non-homogeneous boundaries are more sensitive to parameters,and the differences between the two types of beams undergo some interesting variations under the influence of non-homogeneous boundaries.

关键词： translating beam Timoshenko beam non-homogeneous boundary natural frequency critical velocity

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An impact sensitivity assessment method of spacecraft based on virtual exterior wall

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Defence Technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang Chi Yuyan Liu Diqi hu Baojun Pang Hypervelocity Impact Research Center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of s3DE(survivability of spacecraft in space Debris Environment),BUMPER,MDPANTO,EsABAsE2/Debris to verify the feasibility of the *** PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： sensitivity OD/M spacecraft Virtual exterior wall

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Underwater Directional Acoustic source Based on Pentamode Material

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Acta Mechanica solida sinica 2024年第1期37卷 1-9页

作者： Binghao Zhao Peng Wang Dongwei Wang Gengkai hu school of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Wuhan second ship Design and Research Institute Wuhan 430205China

An underwater directional acoustic emitter is conceived with a highly anisotropic lattice material,whose acoustic characteristics manifest strong dependence on the orientation of the lattice material’s principal *** these features,a cylindrical structure made of such anisotropic lattice material is engineered to possess distinct impedance values in different directions,thereby facilitating wave emission along the principal axis while inducing reflection in other ***,through numerical simulations,it is demonstrated that the emission direction can be effectively manipulated by adjusting the principal axis orientation,concurrently enhancing the emitted *** contrast to previous directional acoustic structures,the compact emitter presented in this study can get rid of the size-wavelength constraint,enabling effective control of low-frequency waves.

关键词： Underwater Directional emission Pentamode material Broadband frequency

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pH- and near-infrared light-responsive,biomimetic hydrogels from aqueous dispersions of carbon nanotubes

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Nano Research 2024年第4期17卷 3120-3129页

作者： Lulin hu Xinxin Yu Jingcheng Hao Lu Xu shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 264000China state Key Laboratory of solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Yantai Center for Food and Drug Control Yantai 264000China Key Laboratory of Colloid and Interface Chemistry&Key Laboratory of special Aggregated Materials Shandong UniversityJinan 250100China

Owing to their low flexibility,poor processability and a lack of responsiveness,inorganic materials are usually non-ideal for constructing a living ***,to date,lifelike materials with structural hierarchies and adaptive properties usually rely on light and soft organic molecules,although few exceptions have been acquired using two-dimensional(2D)inorganic ***,with a systematic study on the gelation behavior of carbon-based 0D quantum dots,1D nanotubes,and 3D fullerenes,we find that acidified 1D carbon nanotubes(CNTs)can serve as an alternative building block for fabricating purely inorganic biomimetic soft *** as-prepared CNT gels exhibit not only a pH-or photothermal-triggered mechanical and tribological adaptivity,which allows them to simulate the behavior of sea cucumbers,peacock mantis shrimps,and mammalian muscles or cortical bones,but also a unique damping property that is similar to spider’s cuticular *** high elasticity,effective lubrication,excellent biocompatibility,and controllable friction and wear also allow them to function as a new type of smart lubricants,whose tribological properties can be regulated either by its internal pH changes or spatiotemporally by near-infrared(NIR)light irradiations,free of any toxic and flammable base oils or additives.

关键词： biomimetic hydrogels carbon nanotubes(CNTs) mechanical and tribological adaptivity pH-and near-infrared(NIR)light responsiveness switchable lubrication

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slippery hydrogel with desiccation-tolerant‘skin’for high-precision additive manufacturing

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International Journal of Extreme Manufacturing 2024年第2期6卷 486-500页

作者： Desheng Liu Pan Jiang Yue hu Yaozhong Lu Yixian Wang Jiayu Wu Danli hu Tao Wu Xiaolong Wang state Key Laboratory of solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China CAs Key Laboratory of Chemistry of Northwestern Plant Resources Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai Zhongke Research Institute of Advanced Materials and Green Chemical EngineeringYantai 264006People’s Republic of China Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003People’s Republic of China

Hydrogels inevitably undergo dehydration,structural collapse,and shrinkage deformation due to the uninterrupted evaporation in the atmosphere,thereby losing their flexibility,slipperiness,and manufacturing ***,we propose a novel bioinspired strategy to construct a spontaneously formed‘skin’on the slippery hydrogels by incorporating biological stress metabolites trehalose into the hydrogel network,which can generate robust hydrogen bonding interactions to restrain water *** contents of trehalose in hydrogel matrix can also regulate the desiccation-tolerance,mechanical properties,and lubricating performance of slippery hydrogels in a wide *** vat photopolymerization three-dimensional printing and trehalose-modified slippery hydrogels enables to achieve the structural hydrogels with high resolution,shape fidelity,and sophisticated architectures,instead of structural collapse and shrinkage deformation caused by *** thus,this proposed functional hydrogel adapts to manufacture large-scale hydrogels with sophisticated architectures in a long-term *** a proof-of-concept demonstration,a high-precision and sophisticated slippery hydrogel vascular phantom was easily fabricated to imitate guidewire ***,the proposed protocol is universally applicable to diverse types of hydrogel *** strategy opens up a versatile methodology to fabricate dry-resistant slippery hydrogel for functional structures and devices,expanding their high-precision processing and broad applications in the atmosphere.

关键词： slippery hydrogel trehalose desiccation tolerance vat photopolymerization 3D printing hydrogen bonding

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