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Ras相关基因在非小细胞肺癌中的异常甲基化研究

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中华结核和呼吸杂志 2010年第1期33卷 32-32页

作者：陈虹 suzuki M Nakamura Y Ohira M ando s Iida T Nakajima T Nakagawara A Kimura H 重庆医科大学附属第一医院呼吸内科 400016

基因启动子中CpG岛的异常甲基化常导致抑癌基因表达沉默，已被证实在众多肿瘤的发生中扮演重要角色。Ras相关区域家族1A基因（RAssF1A）作为新型抑癌基因，已被发现在肺癌和多种恶性肿瘤中具有较高的甲基化率和表达缺失。然而Ras蛋白特... 详细信息

基因启动子中CpG岛的异常甲基化常导致抑癌基因表达沉默，已被证实在众多肿瘤的发生中扮演重要角色。Ras相关区域家族1A基因（RAssF1A）作为新型抑癌基因，已被发现在肺癌和多种恶性肿瘤中具有较高的甲基化率和表达缺失。然而Ras蛋白特异性的鸟苷酸释放因子2（RAsGRF2）仅有报道在胰腺癌细胞株中存在高频率甲基化和表达缺失。

关键词：异常甲基化非小细胞肺癌 Ras蛋白相关基因抑癌基因表达胰腺癌细胞株表达缺失恶性肿瘤

Progress in Physics and Technology Developments for the Modification of JT-60

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Plasma science and Technology 2004年第1期6卷 2141-2150页

作者： H.Tamai M.Matsukawa G.Kurita N.Hayashi K.Urata Y.M.Miura K.Kizu K.Tsuchiya A.Morioka Y.Kudo s.sakurai K.Masaki T.suzuki M.Takechi Y.Kamada A.sakasai s.Ishida K.Abe A.ando T.Cho T.Fujii T.Fujita s.Goto K.Hananda A.Hatayama T.Hino H.Horiike N.Hosogane M.Ichimura Tsuji-Iio s.Itoh M.Katsurai M.Kikuchi A.Kohyama H.Kubo M.Kuriyama M.Matsuoka Y.Miura N.Miya T.Mizuuchi K.Nagasaki H.Ninomiya N.Nishino Y.Ogawa K.Okano T.Ozeki M.saigusa M.sakamoto M.satoh M.shimada R.shimada M.shimizu T.Takagi Y.Takase T.Tanabe K.Toi Y.Ueda Y.Uesugi K.Ushigusa Y.Yagi T.Yamamoto K.Yatsu K.Yoshikawa Japan Atomic Energy Research Institute Naka Ibarahi 311-0193 Japan Tohoku University University of Tsukuba Osaka University Kyushu University Keio University Hokkaido University Tokyo Institute of Technology the University of Tokyo Kyoto University Mie University Hiroshima University Central research Institute of Electric Power Industry Ibaraki University ITER JCT Nagoya University National Institute for Fusion science Kanazawa University National Institute of Advanced Industrial science and Technology

Recent progress in the physics and engineering design study for themodification programme of JT-60 is presented. In order to achieve a steady state high-βplasmaoperation, which is the dominant issue of this programme, physics design for the MHD control and thestability analysis is investigated. Engineering design and the R & D for the superconducting coils,irradiation shield are performed well towards the mission of programme.

关键词： modification of JT-60 physics design technology developments

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建筑与艺术的双重力量

建筑实践 2021年第2期4卷 80-83页

作者：安藤忠雄东京大学

和美术馆的建筑设计理念是从何萌发的?其展出的“超越:安藤忠雄的艺术人生”的展览内涵是什么,如何与在地环境、艺术作品以及观众产生共鸣?在我20岁出头的时候,曾搭乘火车经西伯利亚铁路横穿欧洲,后经非洲返回日本。在那次旅行中我最大... 详细信息

和美术馆的建筑设计理念是从何萌发的?其展出的“超越:安藤忠雄的艺术人生”的展览内涵是什么,如何与在地环境、艺术作品以及观众产生共鸣?在我20岁出头的时候,曾搭乘火车经西伯利亚铁路横穿欧洲,后经非洲返回日本。在那次旅行中我最大的收获就是“世界无国界,地球是一个整体”的认知,和打破一切分界线、朝事物的本质发起挑战的勇气。

关键词：西伯利亚铁路安藤忠雄艺术人生建筑设计理念艺术作品美术馆建筑与艺术双重力量

Azathioprine is essential following cyclosporine for patients with steroid-refractory ulcerative colitis

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World Journal of Gastroenterology 2015年第1期21卷 254-261页

作者： Nobuyuki Miyake Takafumi ando Kazuhiro Ishiguro Osamu Maeda Osamu Watanabe Yutaka Hirayama Keiko Maeda Kazuhiro Morise Masanobu Matsushita Kazuhiro Furukawa Kohei Funasaka Masanao Nakamura Ryoji Miyahara Naoki Ohmiya Hidemi Goto Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya CityAichi 466-8550Japan Department of Gastroenterology Fujita Health University School of MedicineToyoakeAichi 470-1192Japan

AIM: To evaluate long-term prognosis following cyclosporine treatment by examining the rate of surgery avoidance among cyclosporine ***: We retrospectively reviewed clinical records for 29 patients diagnosed with severe steroid-refractory ulcerative colitis in our hospital from August 1997 to August 2008 and treated with cyclosporine by continuous intravenous *** patients were treated with intravenous corticosteroids for more than 5 d prior to cyclosporine *** was continued for up to 21 d under serum monitoring to maintain cyclosporine levels between 400 and 600 ng/*** activity was assessed before and after cyclosporine therapy using the clinical activity index score,with a reduction of ≥ 5 considered to indicate a *** responders,we defined cases not requiring surgery for more than 5 years as exhibiting long-term efficacy of *** considered to be possibly predictive of long-term efficacy of cyclosporine were sex,age,disease duration,clinical activity index score,C-reactive protein level,hemoglobin level,disease extent,endoscopic findings,and clinical ***: Cyclosporine was not discontinued due to side effects in any ***(65.5%) of 29 patients were considered responders.A statistically significant(P = 0.004) inverseas sociation wa s observed between an endoscopic finding of "mucosal bleeding" and responsive ***(9 males,6 females) of these 19 patients were followed for 5 years or more,of whom 9(60%) exhibited long-termefficacy of *** the 10 non-responders,9(90%) underwent surgery within 6 mo of cyclosporine *** of the following factors had a significant impact on the long-term efficacy of cyclosporine: sex,age,duration of disease,clinical activity index score,C-reactive protein level,hemoglobin level,extent of disease,endoscopic findings,or clinical *** contrast,a significant association was observed for maintenance therapy with azat

关键词： Ulcerative colitis Cyclosporine Maintenance therap

日本传统“诗吟”中单个反射声优选时延与自相关函数的关系(英文)

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华南理工大学学报（自然科学版） 2007年第B10期35卷 92-95页

作者：加藤浩介田中慎一郎川井敬二矢野隆安藤四一 Center for Advanced science and Innovation Osaka University. 2-1 Yamada-oka Suita Osaka 565-0871 Japan Faculty of Engineering Kumamoto University Japan Graduate school of science and Technology Kumamoto University Japan Professor Emeritus Kobe University Japan

研究在日本传统"诗吟"表演中,在干信号中加上适当时延的单个反射声是否更为有利.专业"诗吟"表演者嗓音中对典型的"节"的吟唱是该种表演艺术的一种独特的吟咏方式.对此及对"节"外内容的吟唱都在消音室中加以录音.文中通过成对比较法试验... 详细信息

研究在日本传统"诗吟"表演中,在干信号中加上适当时延的单个反射声是否更为有利.专业"诗吟"表演者嗓音中对典型的"节"的吟唱是该种表演艺术的一种独特的吟咏方式.对此及对"节"外内容的吟唱都在消音室中加以录音.文中通过成对比较法试验得出了主观优选的标度值.结果表明,在聆听对"节"的吟唱时,听者更喜欢在干信号中加上延时为10～30ms的单个反射声,而在聆听对"节"外内容的吟唱时,加上单个反射声与否对听者而言并无显著的差别.文中对此项发现从吟唱"节"的声源信号的自相关函数的包络特征上加以讨论.

关键词：诗吟节吟唱自相关主观优选

患弥漫性糖尿病性黄斑水肿患者行吲哚青绿辅助性内界膜剥离的玻璃体切割术后视神经萎缩

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 38-39页

作者： ando F. Yasui O. Hirose H. Ohba N. 秦雪娇 EyeCare Nagoya Meieki 3-13-15 Nakamura-ku 450-0002 Nagoya Japan

Purpose: To report anatomic and visual outcomes of vitrectomy and indocyanine green (ICG)-assisted peeling of the retinal internal limiting membrane (ILM) in the treatment of diffuse diabetic macular edema. Methods: In a retrospective in terventional case series, 15 eyes of 11 patients with refractory diffuse diabeti c macular edema underwent pars plana vitrectomy with removal of the ILM, which w as stained by intravitreal injection of ICG (0.1-0.2 ml of 0.5%ICG), performed by a single surgeon. The patients were followed up for 14-28 months (mean 20.5 months). The main outcome measures were assessment of macular edema by optical coherence tomography and determination of visual acuity and visual field. Result s: Intravitreal ICG visualized the ILM to facilitate complete removal of the str ucture. Qualitative assessment of optical coherence tomography images at the end of follow-up revealed that retinal thickness in the macula appeared nearly nor mal with or without reappearance of foveal pit in 11 of the 15 eyes (73.3%), de creased in 3 eyes (20.0%), and did not change in 1 eye (6.6%). Best-corrected visual acuity at the end of follow-up improved by 2 lines or more in 4 eyes (2 6.7%), virtually unchanged in 6 eyes (40.0%), and deteriorated by 2 lines or m ore in 5 eyes (26.7%). The mean logMAR visual acuity was 0.680 (approximately 1 2/60) preoperatively and 0.812 (approximately 9/60) postoperatively, the differe nce being not statistically significant (paired t-test, P=0.445). seven (46.7% ) of the 15 eyes developed optic nerve atrophy that occurred gradually within 6 months after surgery and caused irreversible peripheral visual field defect pred ominantly affecting the nasal field. Conclusion: Intravitreal application of ICG is beneficial in uneventful ILM peeling to help resolution of diffuse diabetic macular edema, but it may potentially damage the optic nerve fibers and lead to unfavorable visual outcomes.

关键词：内界膜剥离玻璃体切割术视神经萎缩吲哚青绿玻璃体腔弥漫性黄斑水肿睫状体平坦部黄斑中心凹视功能

转甲状腺素蛋白ser50Ile和Tyr114Cys型淀粉样变性患者的肌肉淀粉样血管病

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 24-24页

作者： Yamashita T. ando Y. Katsuragi s. 江山 Department of Diagnostic Medicine Graduate School of Medical Sciences Kumamoto University 1- 1- 1 Honjo Kumamoto 860- 0811 Japan Dr.

Among patients with familial amyloid polyneuropathy (FAP), those with transth yretin Val30Met mainly show distally predominant weakness and atrophy, whereas s ome FAP patients, including those with transthyretin ser50Ile and Tyr114Cys, sho w muscle weakness and atrophy that is dominant proximally, simulating myopathy. To clarify the cause of proximally dominant muscular atrophy in patients with FA P transthyretin ser50Ile and Tyr114Cys, we investigated the distinctive features of muscle specimens of patients with FAP, 3 of who had Val30Met, 2 ser50Ile, an d 2 Tyr114Cys transthyretin. All specimens showed transthyretin amyloid around b lood vessels and perimysium, and neurogenic denervation patterns. The amount of amyloid around the vessels was much greater in patients with FAP ser50Ile and Ty r114Cys than in Val30Met patients. Muscular amyloid angiopathy may contribute to motor nerve injury that, in turn, may lead to amyotropic changes in patients wi th FAP ser50Ile and Tyr114Cys.

关键词：淀粉样血管病 ser50Ile Tyr114Cys 转甲状腺素蛋白淀粉样变性肌萎缩近端肌无力远端肌淀粉状蛋白神经源性

日本苦苣菜sonchus oleraceus L.的化学成分研究

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齐齐哈尔大学学报（自然科学版） 2007年第1期23卷 1-3页

作者：白玉华安政张维冰齐齐哈尔大学化学与化学工程学院黑龙江齐齐哈尔161006 日本新潟大学工学部

将新采摘的日本苦苣菜(sonchus oleraceus L.)粉碎后用甲醇浸泡,浸出液依次用正己烷、乙酸乙酯和氯仿萃取,制得相应的提取物。乙酸乙酯提取物被进一步采用柱层析及高效液相色谱分离,得到三种化合物。利用红外光谱、1H-NMR、13C-NMR方法... 详细信息

将新采摘的日本苦苣菜(sonchus oleraceus L.)粉碎后用甲醇浸泡,浸出液依次用正己烷、乙酸乙酯和氯仿萃取,制得相应的提取物。乙酸乙酯提取物被进一步采用柱层析及高效液相色谱分离,得到三种化合物。利用红外光谱、1H-NMR、13C-NMR方法对得到的化合物进行结构表征,证实其分别为β-谷甾醇、脱镁叶绿酸甲酯(Phaeophorbide-a methyl ester),和10-羟基脱镁叶绿酸甲酯Methyl(10s)-hydroxypheophorbide;其含量分别占乙酸乙酯提取物的0.0234%,0.115%和0.030%。

关键词：苦苣菜化学成分结果表征

应用卵泡刺激素试验预测体外受精的低反应状态

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世界核心医学期刊文摘（妇产科学分册） 2005年第8期1卷 62-62页

作者： Iwase A. ando H. Kuno K. Mizutani s. 王伟华 Dr.Department of Obstetrics Nagoya Univ. Grad. Sch. of Medicine 65 Tsurumai-cho Showa-ku Nagoya 466-8550Japan

OBJECTIVE: Optimized ovarian stimulation protocols are required for the success of in vitro fertilization (IVF). The purpose of this study was to estimate whether the ovarian reserve test using exogenous follicle-stimulating hormone (FsH) could predict ovarian response in ***: This was a prospective observational study of 110 patients who underwent their first IVF cycle. The FsH test was administered as 150 IU of urinary FsH daily from day 3 to day 6 of the menstrual cycle preceding the IVF cycle for evaluation of the plasma estradiol level. Outcomes of IVF, including ovarian response, were analyzed. REsULTs: A negative correlation was observed between the duration of stimulation and the result of the FsH test (r = -.238, P = .014) and between the dose of FsH per retrieved mature oocyte (metaphase II oocyte) and the result of the FsH test (r = -.308, P sults showed that the result of the FsH test was significantly lower in poor responders defined by FsH of 400 IU/metaphase II oocyte or greater (207 ±149 compared with 293 ±174 pg/mL, P =.007). CONCLUsION: The FsH test can be a useful tool for determining the conditions of individualized clinical management plans and optimizing stimulation protocols in IVF.

关键词：体外受精卵泡刺激素反应状态成熟卵母细胞卵巢储备功能促排卵方案血浆雌二醇刺激时间分裂中期评估应用