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Autologous hematopoietic stem cell transplantation conditioning regimens and chimeric antigen receptor T cell therapy in various diseases

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World Journal of Transplantation 2024年第1期14卷 32-41页

作者： shahzaib Maqbool Maryam Farhan Baloch Muhammad Abdul Khaliq khan Azeem Khalid Kiran Naimat Department of Medicine Holy Family HospitalRawalpindi 46000Pakistan Department of Community Medicine Allama Iqbal Medical CollegeLahore 45000Pakistan Department of Community Dentistry Baqai Medical UniversityKarachi 43000Pakistan Department of Medicine Allama lqbal Medical CollegeLahore 45000Pakistan Department of MedicineLiaquat University of Medical and Health sciences Karachi 43000Pakistan

Conditioning regimens employed in autologous stem cell transplantation have been proven useful in various hematological disorders and underlying malignancies;however,despite being efficacious in various instances,negative consequences have also been *** conditioning regimens were extracted from various literature searches from databases like PubMed,Google scholar,EMBAsE,and *** regimens for each disease were compared by using various end points such as overall survival(Os),progression free survival(PFs),and leukemia free survival(LFs).Variables were presented on graphs and analyzed to conclude a more efficacious conditioning *** multiple myeloma,the most effective regimen was high dose melphalan(MEL)given at a dose of 200/mg/*** comparative results of acute myeloid leukemia were presented and the regimens that proved to be at an admirable position were busulfan(BU)+MEL regarding Os and BU+VP16 regarding *** case of acute lymphoblastic leukemia(ALL),BU,fludarabine,and etoposide(BuFluVP)conferred good disease control not only with a paramount improvement in survival rate but also low risk of ***,for ALL,chimeric antigen receptor(CAR)T cell therapy was preferred in the context of better Os and *** respect to Hodgkin’s lymphoma,mitoxantrone(MITO)/MEL overtook carmustine,VP16,cytarabine,and MEL in view of PFs and vice versa regarding ***-Hodgkin’s lymphoma patients were administered MITO(60 mg/m2)and MEL(180 mg/m2)which showed promising ***,amyloidosis was considered,and the regimen that proved to be competent was MEL 200(200 mg/m2).This review article demonstrates a comparison between various conditioning regimens employed in different diseases.

关键词： Conditioning regimens Multiple myeloma Lymphoma Hodgkin Non-Hodgkin Acute leukemia

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Identification of galectin-3 as a novel potential prognostic/predictive biomarker and therapeutic target for cerebral cavernous malformation disease

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Genes & Diseases 2024年第1期11卷 67-71页

作者： souvik Kar Andrea Perrelli Kiran Kumar Bali Raffaella Mastrocola Arpita Kar Bushra khan Luis Gand Arnab Nayak Christian Hartmann Wolfram sKunz Amir samii Helmut Bertalanffy saverio Francesco Retta International Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Department of Clinical and Biological sciences University of TorinoOrbassano(TO)10043Italy CCM Italia Research Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Department of Experimental Pain Research Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Department of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Ricarda-Huch-street-10B Hannover 30880Germany Institute of Molecular and Cell Physiology Hannover Medical SchoolHannover 30625Germany Department of Neuropathology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimental Epileptology and Cognition Research and Department of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epartment of Pharmacology and Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrovascular disease of genetic origin characterized by abnormally dilated capillaries and a wide spectrum of symptoms,including headaches,seizures,neurological deficits,and intracerebral *** unpredictable clinical course and the current lack of therapies make the identification of prognostic and predictive biomarkers an imperative research challenge.1 Herein,we provide evidence that galectin-3(Gal-3),a major tissue and circulating biomarker of oxidative stress and inflammation,is significantly up-regulated both in CCM patients and ***,wholetranscriptome sequencing,qRT-PCR,and Western blotting studies demonstrated a significant up-regulation of Gal-3 expression levels both in surgical CCM specimens and in blood samples of CCM patients.

关键词： inflammation cerebral dilated

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Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha subpopulation to Aid Forensic Profiling:Pilot study

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Journal of Forensic science and Medicine 2024年第1期10卷 11-19页

作者： Vaishali Amarlal sadhwani Nilima Prakash GLPradeep Rekha Patil shubhechha Anand Khivsara sabiha Mokashi khan MGV’s KBH Dental College NashikMaharashtraIndia Oral Cancer screening and Awareness in Cancer screening Vertical Indian Cancer SocietyMumbaiMaharashtraIndia

Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial *** studies have demonstrated the differences in the expression and frequency of dental traits between various ethnic groups for ancestry determination in the context of forensic dental *** present study is an attempt to assess the frequency and variation in nonmetric traits for establishing ethnicity in the Vidarbha ***:The aim of the study was to assess the frequency and variation of nonmetric traits in permanent teeth for establishing ethnicity in the Vidarbha *** and Methods:Participants of the Vidarbha subpopulation were selected by random sampling ***,premolars,and incisors were evaluated for frequency of nonmetric traits,and variations were graded according to Dentoanthropological system of state University of Arizona *** statistics,Chi-square test,and student’s t-test were used for analysis of ***:The most common occlusal morphology in mandibular first and second molar was 5 cusp and 4 cusp,respectively,with the“+”groove *** 3 and cusp 4 were observed frequently in the maxillary *** lingual cusp was most commonly seen in mandibular premolars show while incisors showed faint ***:Our study concludes that nonmetric traits were present and showed variation in permanent maxillary and mandibular teeth among the Vidarbha *** 5 and Cusp 4 in first and second mandibular molars,respectively,groove pattern“+”and grade 1 protostylid were the most frequent grades observed in permanent mandibular *** lingual cusp was most commonly seen in mandibular premolars and faint shoveling was a notable feature in incisors of this population.

关键词： Cusp number ethnicity forensic anthropology molar protostylid

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Privacy-Preserving Information Fusion Technique for Device to server-Enabled Communication in the Internet of Things:A Hybrid Approach

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Computers, Materials & Continua 2024年第7期80卷 1305-1323页

作者： Amal Al-Rasheed Rahim khan Tahani Alsaed Mahwish Kundi Mohamad Hanif Md.saad Mahidur R.sarker Department of Information systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer science AbdulWali Khan University MardanMardan23200Pakistan Faculty of Computing and Informatics University Malaysia SabahKota KinabaluSabah88400Malaysia Applied College Taibah UniversityMadinah41477Saudi Arabia Maynooth International Engineering College Maynooth UniversityCo KildareW23 X021Irland Department of Mechanical Engineering Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia Institute of Visual Informatics Universiti Kebangsaan MalaysiaBangiSelangor43600Malaysia University of Design Innovation and Technology(UDIT)Av.Alfonso XIII97Madrid28016Spain

Due to the overwhelming characteristics of the Internet of Things(IoT)and its adoption in approximately every aspect of our lives,the concept of individual devices’privacy has gained prominent attention from both customers,i.e.,people,and industries as wearable devices collect sensitive information about patients(both admitted and outdoor)in smart healthcare *** addition to privacy,outliers or noise are among the crucial issues,which are directly correlated with IoT infrastructures,as most member devices are resource-limited and could generate or transmit false data that is required to be refined before processing,i.e.,***,the development of privacy-preserving information fusion techniques is highly encouraged,especially those designed for smart IoT-enabled *** this paper,we are going to present an effective hybrid approach that can refine raw data values captured by the respectivemember device before transmission while preserving its privacy through the utilization of the differential privacy technique in IoT *** window,i.e.,δi based dynamic programming methodology,is implemented at the device level to ensure precise and accurate detection of outliers or noisy data,and refine it prior to activation of the respective transmission ***,an appropriate privacy budget has been selected,which is enough to ensure the privacy of every individualmodule,i.e.,a wearable device such as a smartwatch attached to the patient’s *** contrast,the end module,i.e.,the server in this case,can extract important information with approximately the maximum level of ***,refined data has been processed by adding an appropriate nose through the Laplace mechanism to make it useless or meaningless for the adversary modules in the *** proposed hybrid approach is trusted from both the device’s privacy and the integrity of the transmitted information *** and analytical results ha

关键词： Internet of things information fusion differential privacy dynamic programming Laplace function

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Malaysia-China Relations:Exemplary Model for AsEAN

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China Report AsEAN 2024年第6期9卷 48-51页

作者： Dato'Abdul Majid Ahmad khan Malaysia-China Friendship Association

Five Decades(1974-2024)of Harmonious and Mutually Beneficial Partnership Fifty years ago in May 1974,the second Prime Minister of Malaysia,Tun Abdul Razak,journeyed to Beijing,China,to start a new and strategic chapter in Malaysia-China *** was a visionary and courageous initiative by Malaysia that commenced resetting Malaysia's foreign policy towards non-alignment and building mutual trust with China.

关键词： Malaysia mutual policy

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GeoChip-based microbial functions in biogeochemical cycles and their responses to environmental factors in Tengchong hot springs

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Journal of Earth science 2024年

作者： Muhammad Inayat Ullah khan Liuqin Huang Geng Wu Jian Yang Xiangyu Guan Hongchen Jiang school of Environmental studies China University of Geosciences school of Ocean sciences China University of Geosciences Beijing state Key Laboratory of Biogeology and Environmental Geology China University of Geosciences

Microorganisms actively participate in biogeochemical cycling processes and play a crucial role in maintaining the dynamic balance of hot spring ecosystems. However， the distribution of microbial functional genes and their influencing factors in hot springs remain largely unclear. Therefore， this study investigated the microbial functional genes and their potential for controlling biogeochemical cycles (C， N， s， and P) in the hot springs of Tengchong， China， using the Geochip method， a functional gene microarray technology. The examined hot springs have very different microbial functional genes. A total of 22736 gene probe signals were identified， belonging to 567 functional genes and associated with 15 ecological functions， mainly involving stress response， carbon cycle， nitrogen cycle， sulfur cycle， phosphorus cycle and energy processes. The amyA， narG， dsrA and ppx genes were most abundant in carbon， nitrogen， sulfur and phosphorus cycles， respectively， and were significantly correlated with pH， temperature and sO42-. The diversity and abundance of detected gene probes were negatively correlated with temperature. The α-diversity (i.e.， shannon index) was high at low temperature and low pH. Molecular functional interactions revealed by the gene connectivity levels were negatively correlated with temperature， pH and sO42-. These results suggested that the abundance， diversity and interactions of microbial functional genes were significantly influenced by geochemical parameters?. In addition， some genera possessed functional genes related to carbon， nitrogen， sulfur， and phosphorus cycles and can synergistically control the biogeochemical cycles of carbon， nitrogen， sulfur and phosphorus. These findings provide new insights into the functional potentials of microorganisms to participate in biogeochemical cycles and their responses to environmental factors in hot springs.

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M_(4)X_(3) MXenes:Application in Energy storage Devices

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Nano-Micro Letters 2024年第10期16卷 522-542页

作者： Iftikhar Hussain Waqas Ul Arifeen shahid Ali khan sikandar Aftab Muhammad sufyan Javed sajjad Hussain Muhammad Ahmad Xi Chen Jiyun Zhao PRosaiah Khaled Fahmi Fawy Adnan Younis sumanta sahoo Kaili Zhang Department of Mechanical Engineering City University of Hong Kong83 Tat Chee AvenueKowloon TongHong KongPeople's Republic of China school of Mechanical Engineering Yeungnam UniversityDaehak-roGyeongsan-siGyeongbuk-do 38541South Korea Department of semiconductor systems Engineering and Clean Energy Sejong UniversitySeoul 05006Republic of Korea school of Physical science and Technology Lanzhou UniversityLanzhou 730000People's Republic of China Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea Department of Physics Saveetha School of EngineeringSaveetha Institute of Medical and Technical Sciences(SIMATS)ThandalamChennai 602105India Department of Chemistry Faculty of ScienceKing Khalid UniversityP.O.Box 900461413 AbhaSaudi Arabia Department of Physics College of ScienceUnited Arab Emirates UniversityP.O.Box 15551Al-AinUnited Arab Emirates school of Chemical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541South Korea

MXene has garnered widespread recognition in the scientific com-munity due to its remarkable properties,including excellent thermal stability,high conductivity,good hydrophilicity and dispersibility,easy processability,tunable surface properties,and admirable *** have been categorized into different families based on the number of M and X layers in M_(n+1)X_(n),such as M_(2)X,M_(3)X_(2),M_(4)X_(3),and,recently,M_(5)X_(4).Among these families,M_(2)X and M_(3)X_(2),par-ticularly Ti_(3)C_(2),have been greatly explored while limited studies have been given to M_(5)X_(4)MXene ***,studies on the M_(4)X_(3)MXene family have developed recently,hence,demanding a compilation of evaluated ***,this review provides a systematic overview of the latest advancements in M_(4)X_(3)MXenes,focusing on their properties and applications in energy storage *** objective of this review is to provide guidance to researchers on fostering M_(4)X_(3)MXene-based nanomaterials,not only for energy storage devices but also for broader applications.

关键词： MXene M_(4)X_(3)MXenes 2D materials Energy storage Properties

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Effect of Eu3+,Bi3+,and Li+ doping on luminescent property of GdNbO4

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Journal of Rare Earths 2024年第1期42卷 66-75页

作者： s.W.Wi Y.s.Lee Department of Physics and Integrative Institute of Basic sciences Soongsil University

We investigated the emission properties of Eu3+-doped GdNbO4-based oxide phosphors,aiming at improving the Eu3+emission by codoping of Bi3+and Li+.Eu3+singly doped,Eu3+and Bi3+doubly doped,and Eu3+,Bi3+,and Li+triply doped GdNbO4were prepared using a high-temperature solid-state reaction *** red-orange emissions from Eu3+in the singly doped samples are significantly improved by the codoping of Bi3+,mainly due to the energy transfer from Bi3+to Eu3+.The additional codoping of Li+is found to increase the Eu3+emission *** improvement might be attributed to the increase in the photoluminescent quantum yield originating from larger grain sizes and better crystallinity.A detailed analysis of the X-ray diffraction pattern and the asymmetric ratio estimated from the photoluminescence spectra show that the local lattice environment around Eu3+in GdNbO4does not change significantly with the codoping of Bi3+and Li+.Our results indicate that Li+doping is a promising way to improve the emission properties of rare-earth ion-doped GdNbO4phosphors.

关键词： Eu 3+ GdNbO 4 Codoping of Li + Photoluminescence sensitizer Rare earths

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A Game-Theoretic Approach to safe Crowd Evacuation in Emergencies

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Computers, Materials & Continua 2024年第4期79卷 1631-1657页

作者： Maria Gul Imran Ali khan Gohar Zaman Atta Rahman Jamaluddin Mir sardar Asad Ali Biabani May IssaAldossary Mustafa Youldash Ashraf saadeldeen Maqsood Mahmud Asiya Abdus salam Dania Alkhulaifi Abdullah AlTurkey31Department of Computer science COMSATS University IslamabadAbbottabad CampusAbbottabad22010Pakistan Department of Computer science Abbottabad University of Science and TechnologyAbbottabad22010Pakistan Department of Computer science College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia science and Technology Unit Umm Al-Qura UniversityMakkah21955Saudi Arabia Deanship of scientific Research Umm Al-Qura UniversityMakkah21955Saudi Arabia Department of Computer Information systems College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Computer Engineering College of Computer Science and Information TechnologyImam Abdulrahman Bin Faisal UniversityP.O.Box 1982Dammam31441Saudi Arabia Department of Computer science Faculty of Computer Science and Information TechnologyOmdurman Islamic UniversityOmdurman14415Sudan Business Analytic Program Department of Management and MarketingCollege of Business AdministrationUniversity of BahrainSakhir32038Bahrain

Obstacle removal in crowd evacuation is critical to safety and the evacuation system efficiency. Recently, manyresearchers proposed game theoreticmodels to avoid and remove obstacles for crowd evacuation. Game theoreticalmodels aim to study and analyze the strategic behaviors of individuals within a crowd and their interactionsduring the evacuation. Game theoretical models have some limitations in the context of crowd evacuation. Thesemodels consider a group of individuals as homogeneous objects with the same goals, involve complex mathematicalformulation, and cannot model real-world scenarios such as panic, environmental information, crowds that movedynamically, etc. The proposed work presents a game theoretic model integrating an agent-based model to removethe obstacles from exits. The proposed model considered the parameters named: (1) obstacle size, length, andwidth, (2) removal time, (3) evacuation time, (4) crowd density, (5) obstacle identification, and (6) route *** proposed work conducts various experiments considering different conditions, such as obstacle types, obstacleremoval, and several obstacles. Evaluation results show the proposed model’s effectiveness compared with existingliterature in reducing the overall evacuation time, cell selection, and obstacle removal. The study is potentially usefulfor public safety situations such as emergency evacuations during disasters and calamities.

关键词： safe crowd evacuation public safety emergency transition probability cooperation

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First evidence for chiral wobbling of triaxial nuclei

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Nuclear science and Techniques 2024年第7期35卷 4-7页

作者： s.Frauendorf Department of Physics and Astronomy University of Notre DameNotre DameIN 46556USA

Chirality(Greek“handiness”)is a property of many com-plex *** molecules exist in two forms,one being the mirror image of the *** for our hands,it is impossible to make the images identical by a suitable *** two forms are called left-handed and *** have the same binding energy,because the electro-magnetic interaction,which holds the molecule together,does not change under a *** properties that are insensitive to the geometry are also the *** different geometry is the reason why the left-handed form turns the polarization plane of transmitted light in one direction by some angle while the right-handed form turns it in the oppo-site direction by the same ***,the geometrical differences between the two species may have other *** two species of the carvon molecule shown in Fig.1 taste quite differently.

关键词： turns Chiral mirror

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