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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： shimaa Abd El-salam El-sayed Mohamed z.sayed-Ahmed shaimaa Ahmed Awad Ali Nourah Alsadaan Nawazish Alam Mahmoud s.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

survival and risk analysis of patients with COVID-19 in Iran

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Journal of Acute Disease 2024年第2期13卷 60-66页

作者： Mottaghipoor F Heidari z sami R Memarzadeh H saghaeiannejad Isfahani s Department of Management and Health Information Technology Isfahan University of Medical SciencesIsfahanIran Department of Biostatistics and Epidemiology Isfahan University of Medical SciencesIsfahanIran Department of Internal Medicine School of MedicineIsfahan University of Medical SciencesIsfahanIran software Engineering Isfahan University of Medical SciencesIsfahanIran Health Information Technology Research Center Isfahan University of Medical SciencesIsfahanIran

Objective:To evaluate the risk factors of death caused by COVID-19 in ***:This study was a retrospective cohort study from February 20,2020,to August 22,2022,in the hospitals in Isfahan,*** data were collected through a researcher-made *** determine the risk factors of the death,logistic regression and Cox regression models were *** each variable,the odds ratio and 95%confidence interval were also ***:1885 Patients were *** age of deceased persons was significantly higher than that of the surviving *** risk of death for the age group above 60 years was about 14 times higher than that of people aged 19-35 years[95%CI:14.41(2.02-102.99),Psion[95%CI:1.92(1.47-2.5),Ps[95%CI:1.62(1.23-2.13),Pstructive pulmonary disease[95%CI:1.92(1.47-2.50),Pso risk factors of ***:This study reveals that the mortality rate due to COVID-19 is associated with old age,longer hospitalization in the ICU,increased length of stay,and comorbidities of high blood pressure,diabetes,and chronic pulmonary disease.

关键词： Cause Death survival COVID-19 Risk factors Iran

High-secured Image LsB steganography Using AVL-Tree with Random RGB Channel substitution

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Computers, Materials and Continua 2024年第1期81卷 183-211页

作者： Njoum M. sulaiman R. shukur z. Qamar F. Center of Cyber security Faculty of Information Science and Technology Universiti Kebangsaan Malaysia Selangor Bangi 43600 Malaysia Computer science and Cyber security Faculty of Engineering and Information Technology BirZeit University Ramallah P.O. Box 14 BirZeit Palestine

Random pixel selection is one of the image steganography methods that has achieved significant success in enhancing the robustness of hidden data. This property makes it difficult for steganalysts’ powerful data extraction tools to detect the hidden data and ensures high-quality stego image generation. However, using a seed key to generate non-repeated sequential numbers takes a long time because it requires specific mathematical equations. In addition, these numbers may cluster in certain ranges. The hidden data in these clustered pixels will reduce the image quality, which steganalysis tools can detect. Therefore, this paper proposes a data structure that safeguards the steganographic model data and maintains the quality of the stego image. This paper employs the Adelson-Velsky and Landis (AVL) tree data structure algorithm to implement the randomization pixel selection technique for data concealment. The AVL tree algorithm provides several advantages for image steganography. Firstly, it ensures balanced tree structures, which leads to efficient data retrieval and insertion operations. secondly, the self-balancing nature of AVL trees minimizes clustering by maintaining an even distribution of pixels, thereby preserving the stego image quality. The data structure employs the pixel indicator technique for Red, Green, and Blue (RGB) channel extraction. The green channel serves as the foundation for building a balanced binary tree. First, the sender identifies the colored cover image and secret data. The sender will use the two least significant bits (2-LsB) of RGB channels to conceal the data’s size and associated information. The next step is to create a balanced binary tree based on the green channel. Utilizing the channel pixel indicator on the LsB of the green channel, we can conceal bits in the 2-LsB of the red or blue channel. The first four levels of the data structure tree will mask the data size, while subsequent levels will conceal the remaining digits of s

关键词： AVL tree capacity Image steganography imperceptibility peak signal-to-noise ratio (PsNR) pixel random selection (PRs)

家禽红螨(鸡皮刺螨)的杀螨剂抗药性及其管理方法

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养禽与禽病防治 2024年第2期 18-28页

作者： R.z.Abbas D.D.Colwell z.Iqbal A.khan 刘红(校对) Department of Parasitology University of AgricultureFaisalabad-38040Pakistan Livestock Parasitology Agriculture and Agri-Food CanadaLethbridge Research Centre54031st Ave.S.LethbridgeAB.T1J 4B1Canada Department of Pathology University of AgricultureFaisalabad-38040Pakistan 默沙东动物保健品(上海)有限公司

家禽红螨(鸡皮刺螨)是一种危害养鸡业的吸血害虫,是世界许多地方家禽生产中的重要问题。尽管免疫学、生物技术和遗传学方法取得了进展,但控制家禽红螨却通常仍依赖于合成杀螨剂。随着这些化合物的反复长期使用导致了家禽螨虫抗药性种群... 详细信息

家禽红螨(鸡皮刺螨)是一种危害养鸡业的吸血害虫,是世界许多地方家禽生产中的重要问题。尽管免疫学、生物技术和遗传学方法取得了进展,但控制家禽红螨却通常仍依赖于合成杀螨剂。随着这些化合物的反复长期使用导致了家禽螨虫抗药性种群的形成,可用的有效杀螨剂正在迅速减少。因此需要不断研制新型的化学杀螨剂来取代旧的杀螨剂,但新型杀螨剂的开发和注册是一个漫长且昂贵的过程,故保持和维持现有杀螨剂的有效性至关重要。本综述分为2部分:第一部分提供了对鸡皮刺螨杀螨剂抗药性的基本认识;第二部分提供了关于保持现有杀螨剂有效性的抗药性管理的详细信息。

关键词：家禽红螨杀螨剂杀螨剂抗药性抗药性管理

Rational molecular design of efficient yellow-red dendrimer TADF for solution-processed OLEDs: a combined effect of substitution position and strength of the donors

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science China Chemistry 2024年第5期67卷 1613-1623页

作者： Changfeng si Dianming sun Tomas Matulaitis David B.Cordes Alexandra M.z.slawin Eli zysman-Colman Organic semiconductor Centre EaStCHEM School of ChemistryUniversity of St AndrewsSt AndrewsKY169STUK

The development of high-performance solution-processed red organic light-emitting diodes(OLEDs) remains a challenge,particularly in terms of maintaining efficiency at high luminance. Here, we designed and synthesized four novel orange-red thermally activated delayed fluorescence(TADF) dendrimers that are solution-processable: 2GCz BP, 2DPACz BP, 2FBP2GCz and 2FBP2DPACz. We systematically investigated the effect of substitution position and strength of donors on the optoelectronic properties. The reverse intersystem crossing rate constant(kRIsC) of the emitters having donors substituted at positions 11and 12 of the dibenzo[a,c]phenazine(BP) is more than 10-times faster than that of compounds substituted having donors substituted at positions 3 and 6. Compound 2DPACz BP, containing stronger donors than 2GCz BP, exhibits a red-shifted emission and smaller singlet-triplet energy splitting, ΔE_(sT), of 0.01 e V. The solution-processed OLED with 10 wt% 2DPACz BP doped in m CP emitted at 640 nm and showed a maximum external quantum efficiency(EQE_(max)) of 7.8%, which was effectively maintained out to a luminance of 1,000 cd m-2. such a device's performance at relevant display luminance is among the highest for solution-processed red TADF OLEDs. The efficiency of the devices was improved significantly by using 4Cz IPN as an assistant dopant in a hyperfluorescence(HF) configuration, where the 2DPACz BP HF device shows an EQEmaxof 20.0% at λEL of 605 nm and remains high at 11.8% at a luminance of 1,000 cd m-2, which makes this device one of the highest efficiency orange-to-red HF sP-OLEDs to date.

关键词： thermally activated delayed fluorescence solution-processing red OLEDs dibenzo[a,c]phenazine dendrimers

Microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with different prestrain levels

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Journal of Materials science & Technology 2024年第4期171卷 80-93页

作者： Y.H.zhang H.Li z.W.Yang X.Liu Q.F.Gu state Key Laboratory of solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi’an 710072China

Ni_(47)Ti_(44)Nb_(9)shape memory alloy(sMA)is a promising material in the aerospace field due to its wide transformation *** application of shape memory effect depends on multistep thermomechan-ical loading,viz.,low-temperature deformation and subsequent heating to ***-temperature deformation prestrain plays a pivotal role in shape memory properties tailoring of sMA ***,microstructure evolution and deformation mechanisms of Ni_(47)Ti_(44)Nb_(9)sMA subjected to vari-ous prestrain levels are still *** this end,microstructure evolution and shape memory behaviors of Ni_(47)Ti_(44)Nb_(9)alloy subjected to multistep thermomechanical loading with prestrain levels of 8%-16%at-28℃(M_(s)+30℃)were *** results demonstrate that the stress-strain curve of the specimen exhibits four distinct stages at a maximal prestrain of 16%.Whereas stageⅡand stageⅢend at prestrains of∼8%and∼12%,*** stageⅡ,the stress-induced martensitic transformation is accompanied by the dislocation slip of the NiTi matrix andβ-Nb *** stageⅢ,in addition to the higher density of dislocations and further growth of stress-induced martensite variants(sIMVs),(001)compound twins are introduced as a result of the(001)deformation twinning in stress-induced ***{20-1}martensite twins are gradually introduced in stageⅣ.Correspondingly,after subsequent unloading and heating,a higher density of{114}austenite twins form in the specimen with a larger prestrain of 16%.With increasing prestrain from 8%to 16%,the recoverable strainε_(re)^(T)upon heating increases first and then ***ε_(re)^(T)obtains a maximum of 7.03%at 10%prestrain and de-creases to 6.17%at 16%*** increase ofε_(re)^(T)can be attributed to the formation of new sIMVs,the further growth of existing sIMVs,and the recoverable(001)compound *** the decrease ofε_(re)^(T)is mainly associated with the irrecoverable strain by{20−1}martensite *** effe

关键词： Ni_(47)Ti_(44)Nb_(9)shape memory alloy Wide transformation hysteresis Thermomechanical loading Microstructure evolution shape memory behaviors stress-induced martensitic transformation Deformation twinning

Electromagnetic Performance Analysis of Variable Flux Memory Machines with series-magnetic-circuit and Different Rotor Topologies

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CEs Transactions on Electrical Machines and systems 2024年第1期8卷 3-11页

作者： Qiang Wei z.Q.zhu Yan Jia Jianghua Feng shuying Guo Yifeng Li shouzhi Feng Department of Electronic and Electrical Engineering The University of SheffieldSheffield S13JDU.K. IEEE the CRRC zhuzhou Institute Company Ltd. Zhuzhou 412001China

In this paper,the electromagnetic performance of variable flux memory(VFM)machines with series-magnetic-circuit is investigated and compared for different rotor *** on a V-type VFM machine,five topologies with different interior permanent magnet(IPM)arrangements are evolved and optimized under same *** on two-dimensional(2-D)finite element(FE)method,their electromagnetic performance at magnetization and demagnetization states is *** reveals that the iron bridge and rotor lamination region between constant PM(CPM)and variable PM(VPM)play an important role in torque density and flux regulation(FR)***,the global efficiency can be improved in VFM machines by adjusting magnetization state(Ms)under different operating conditions.

关键词： Memory machine Permanent magnet Rotor topologies series magnetic circuit Variable flux

sTCF conceptual design report (Volume 1): Physics & detector

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Frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.F.Chen K.Chen L.L.Chen P.Chen s.L.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng s.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.s.Du Y.J.Du z.G.Du L.M.Duan D.Epifanov Y.L.Fan s.s.Fang z.J.Fang G.Fedotovich C.Q.Feng X.Feng Y.T.Feng J.L.Fu J.Gao Y.N.Gao P.s.Ge C.Q.Geng L.s.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo Y.P.Guo z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He s.Q.He X.G.He Y.L.He z.B.He z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.s.Huang J.s.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.s.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia s.Jia z.K.Jia H.B.Jiang J.Jiang s.z.Jiang J.B.Jiao z.Jiao H.J.Jing X.L.Kang X.s.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li F.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li s.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.z.Liao Y.Liao C.X.Lin D.X.Lin X.s.Lin B.J.Liu C.W.Liu D.Liu F.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu s.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu z.Q.Liu z.Y.Liu z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.F.Lü Y.Lu Y.Lu z.Lu P.Lukin F.J.Luo T.Luo X.F.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma F.Maas s.Malde D.Matvienko z.X.Meng R.Mitchell A.Nefediev Y.Nefedov s.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters s.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.F.Qiao J.J.Qin J.J.Qin L.Q.Qin X.s.Qin T.L.Qiu J.Rademacker C.F.Redmer H.Y.sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAs Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique Fédérale de Lausanne(EPFL) LausanneSwitzerland Fudan University Shanghai 200433China Goethe University Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher school of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science Facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(sTCF)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** sTCF will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the standard *** sTCF project in China is under development with an extensive R&D *** document presents the physics opportunities at the sTCF,describes conceptual designs of the sTCF detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity sTCF detector conceptual design

Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.Li Nagendran Ramalingam shaomin Li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity