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Fibroscan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis

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World Journal of gastroenterology 2024年第18期30卷 2440-2453页

作者： Jing-ya Yin Tian-Yuan yang Bing-Qing yang Chen-Xue Hou Jun-Nan Li Yue Li Qi Wang Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing institute of infectious disease Beijing 100015China Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China

BACKgROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NAsH).Based on an international consensus,NAFLD and NAsH were renamed as metabolic dysfunction-associated steatotic liver disease(MAsLD)and metabolic dysfunction-associated steatohepatitis(MAsH),respectively;hence,we introduced the term“high-risk MAsH”.Diagnostic values of seven non-invasive models,including Fibroscan-aspartate transaminase(FAsT),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),*** high-risk MAsH have rarely been studied and compared in *** To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk *** A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December *** screening for MAsLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MAsH *** threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were *** operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).REsULTs MAsLD diagnostic criteria were met by 99.4%patients with *** MAsLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(Fibroscan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and ***,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas s index and gamma-glutamyl transpeptidase to platelet ratio(gPR)were relatively *** the sub

关键词： Metabolic dysfunction-associated steatotic liver disease High-risk metabolic dysfunction-associated steatohepatitis Non-invasive models Liver biopsy Diagnostic value

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synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

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signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： Zhan-Li Chen Chen Xie Wei Zeng Rui-Qi Huang Jin-E yang Jin-Yu Liu ya-Jing Chen shi-Mei Zhuang MOE Key Laboratory of gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China Key Laboratory of Liver Disease of guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTZ),which inhibits the 20s catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not solid tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTZ treatment,or silencing of PsMC5,a subunit of 19s regulatory particle of proteasome,causes g2-and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/gsDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1/PKMYT1(PD0166285),but not inhibitor of ATR,CHK1 or CHK2,abrogates the BTZ-induced g2-phase arrest,thus exacerbates the BTZ-induced mitotic arrest and *** BTZ and PD0166285 treatment(named BP-Combo)selectively kills various types of solid tumor cells,and significantly lessens the IC50 of both BTZ and PD0166285 compared to BTZ or PD0166285 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD0166285 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill solid tumor cells.

关键词： proteasome inhibiting catastrophe

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Metal-organic nanosheet assembly ions sieving membrane for precise lithium ion and anion/solvent separation toward robust lithium metal battery

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science China Chemistry 2024年第10期67卷 3320-3327页

作者： Jian-Qiang shen Tian-Tian Zhao Ying-Li song Lingjuan Zhang ya-Nan gao Xiao-Nan Cui Peng Zhao Xian-Ming Zhang Key Laboratory of Magnetic Molecules&Magnetic Information Materials Ministry of EducationSchool of Chemistry&Material ScienceShanxi Normal UniversityTaiyuan 030031China College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Metal-organic nanosheets(MONs)as a novel material with tunable pore structures and low mass transfer resistance,have emerged as molecular sieves for the separation of gases and *** theory,they can also serve as ion sieves for lithium metal batteries(LMBs),realizing the high-energy and dendritic free ***,there are rarely relevant reports,because it is difficult to simultaneously balance efficient ion sieving ability,high ion passing rate and high electrochemical ***,we synthesized a stable ultrathin MON[Zn_(2)(Bim)_(4)]([Zn_(2)(Bim)_(4)]Nanosheet,HBim=benzimidazolate),which can achieve both efficient lithium ion sieving ability,high lithium ion passing rate and high electrochemical stability at the same *** separator assembled by this MON exhibits high Li^(+)transfer number of 0.81 due to the accurate lithium ion and anion/solvent *** battery containing such separator shows high lithium ionic conductivity of 0.74 m s cm^(-1)and low activation energy of 0.099 eV,which can be attributed to the nanometer level thickness and the ion sieving *** is more,we realized the application of MONs-based ion sieves in LMBs with intercalation cathodes for the first *** the LiFePO_(4)|Li battery with as-assembled separator demonstrates improved Coulombic efficiency(>99%)and significantly extended cycling life(>1600 cycles)with 80%capacity retention.

关键词： lithium sieving membrane metal-organic nanosheets lithium metal battery lithium ion and anion separation lithium ion and solvent separation

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Intermediate-mass black holes in green pea galaxies(IMBH-gP)I:A candidate sample from LAMOsT and sDss

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science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 147-161页

作者： Ruqiu Lin Zhen-ya Zheng Fang-Ting Yuan Jun-Xian Wang Chunyan Jiang Ning Jiang Lingzhi Wang Linhua Jiang Xiang Ji shuairu Zhu Xiaodan Fu Key Laboratory for Research in galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China school of Astronomy and space sciences University of Chinese Academy of SciencesBeijing 100049China CAs Key Laboratory for Research in galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of sciences south America Center for Astronomy(CAssACA) National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China CAs Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

The scaling relation of central massive black holes(M_(BH)s)and their host galaxies is well-studied for supermassive BHs(sM_(BH)s,M_(BH)≥10^(6)M_(⊙)).However,this relation has large uncertainties in the mass range of the intermediate-mass BHs(IM_(BH)s,M_(BH)~10^(3)-10^(6)M_(⊙)).since green pea(gP)galaxies are luminous compact dwarf galaxies,which may be likely to host less massive sM_(BH)s or even IM_(BH)s,we systematically search for M_(BH)s in a large sample of 2190 gP galaxies at zselected from LAMOsT and sDss spectroscopic ***,we report a newly discovered sample of 59 M_(BH) candidates with broad Hα*** sample has a median stellar mass of 108.83±0.11M_(⊙)and hosts M_(BH)s with single-epoch virial masses ranging from M_(BH)~10^(4.7)to 10^(8.5)M_(⊙)(median 105.85±0.64M_(⊙)).Among the 59 M_(BH) candidates,36 have black hole masses M_(BH)≤10^(6)M_(⊙)(IM_(BH) candidates),one of which even has M_(BH)■10^(5)M_(⊙).We find that the M_(BH)-M_(*)relation of our M_(BH) sample is consistent with the M_(BH)-M_(bulge)relation for sM_(BH)s,while is above the M_(BH)-M_(*)relation for M_(BH)s in dwarf galaxies in the same mass ***,we show that 25 M_(BH) candidates,including 4 IM_(BH) candidates,have additional evidence of black hole activities,assessed through various methods such as the broad-line width,BPT diagram,mid-infrared color,X-ray luminosity,and radio *** studies show that it is very promising to find IM_(BH)s in gP galaxies,and the BH sample so obtained enables us to probe the connection between the M_(BH)s and compact dwarf galaxies in the low-redshift Universe.

关键词： sMBHs IMBHs green pea galaxies compact dwarf galaxies

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Investigation of granite failure precursor under axial load using modified LsTM framework

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Journal of Central south University 2024年第8期31卷 2930-2943页

作者： WANg ya-lei XU Jin-ming Department of Civil Engineering Shanghai UniversityShanghai 200444China

granite is usually composed of quartz,biotite,feldspar,and cracks,and the variation characteristics of these components could reflect the deformation and failure process of rock *** granite as an example,the video camera was used to record the deformation and failure process of *** distribution of meso-components in video images was then *** meso-components of rock failure precursors were also ***,a modified LsTM(long short-term memory method)based on ssA(sparrow search algorithm)was proposed to estimate the change of meso-components of rock failure *** shows that the initiation and expansion of cracks are mainly caused by feldspar and quartz fracture,and when the quartz and feldspar exit the stress framework,rock failure occurs;the second large increase of crack area and the second large decrease of quartz or feldspar area may be used as a precursor of rock failure;the precursor time of rock failure based on meso-scopic components is about 4 s earlier than that observed by the naked eye;the modified LsTM network has the strongest estimation ability for quartz area change,followed by feldspar and biotite,and has the worst estimation ability for cracks;when using the modified LsTM network to predict the precursors of rock instability and failure,quartz and feldspar could be given *** results presented herein may provide reference in the investigation of rock failure mechanism.

关键词： granite failure precursor axial load modified long short-term memory method

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Developing and validating a predictive model of delivering large-forgestational-age infants among women with gestational diabetes mellitus

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World Journal of Diabetes 2024年第6期15卷 1242-1253页

作者： Yi-Tian Zhu Lan-Lan Xiang ya-Jun Chen Tian-Ying Zhong Jun-Jun Wang Yu Zeng Department of Clinical Laboratory Jinling Clinical Medical College of Nanjing Medical UniversityNanjing 210002Jiangsu ProvinceChina Department of Clinical Laboratory Women’s Hospital of Nanjing Medical UniversityNanjing Women and Children’s Healthcare HospitalNanjing 210003Jiangsu ProvinceChina

BACKgROUND The birth of large-for-gestational-age(LgA)infants is associated with many shortterm adverse pregnancy *** has been observed that the proportion of LgA infants born to pregnant women with gestational diabetes mellitus(gDM)is significantly higher than that born to healthy pregnant ***,traditional methods for the diagnosis of LgA have ***,this study aims to establish a predictive model that can effectively identify women with gDM who are at risk of delivering LgA *** To develop and validate a nomogram prediction model of delivering LgA infants among pregnant women with gDM,and provide strategies for the effective prevention and timely intervention of *** The multivariable prediction model was developed by carrying out the following ***,the variables that were associated with LgA risk in pregnant women with gDM were screened by univariate analyses,for which the P value wasst Absolute shrinkage and selection Operator regression was fit using ten cross-validations,and the optimal combination factors were se-lected by choosing lambda 1se as the *** final predictors were deter-mined by multiple backward stepwise logistic regression analysis,in which only the independent variables were associated with LgA risk,with a P valuesk prediction model was established and subsequently evaluated by using area under the receiver operating characteristic curve,calibration curve and decision curve *** After using a multistep screening method,we establish a predictive *** risk factors for delivering an LgA infant were identified(Pg weight gain during pregnancy,parity,triglyceride-glucose index,free tetraiodothyronine level,abdominal circumference,alanine transaminase-aspartate aminotransferase ratio and weight at 24 gestational *** nomogram’s prediction ability was supported by the area under the curve(0.703,0.709,and 0.699 f

关键词： Large-for-gestational-age gestational diabetes mellitus Predictive model Nomogram Triglyceride-glucose index

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Basilic vein variation encountered during surgery for arm vein port:A case report

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World Journal of Clinical Cases 2024年第12期12卷 2086-2091页

作者： Cheng-Da Hu Rui Lv ya-Xin Zhao Ming-Hao Zhang Hong-Dou Zeng Yi-Wen Mao Department of Breast surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKgROUND Venous variations are uncommon and usually hard to identify,and basilic vein variation is particularly *** vein variation usually presents without any clinical symptoms and is often regarded as a benign *** case was a patient with congenital basilic vein variation encountered during surgery for an infusion *** sUMMARY We documented and analyzed an uncommon anatomical variation in the basilic vein encountered during arm port *** peculiarity has hitherto remained undescribed in the *** offer remedial strategies for addressing this anomaly in the future and precautionary measures to circumvent its *** conducted a comprehensive review of analogous cases in the literature,offering pertinent therapeutic recommendations and solutions,with the aim of enhancing the efficacy and safety of future arm port *** Venous variation is rare and requires detailed intraoperative and postoperative examination to ensure accuracy,so as not to affect subsequent treatment.

关键词： Totally implantable venous access ports Arm ports Venous variation Postoperative breast cancer systematic review Case report

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survey and clinical considerations of gender identity in lower primary school children

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World Journal of Psychiatry 2024年第1期14卷 36-43页

作者： ya-Lin Zhang Hong-Mei Zhang Jing-Xia Xu Qi-Ying Zhou He Wang Xiao-Cheng Pan Department of Pediatrics Hangzhou Ninth People’s HospitalHangzhou 311225Zhejiang ProvinceChina Department of Nursing Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Pediatric Intensive Care Unit Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Out-patient infection Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina Traditional Chinese Medicine Ward Hangzhou Children’s HospitalHangzhou 310014Zhejiang ProvinceChina

BACKgROUND gender consciousness directly affects the development of gender identity,which is a continuous and lifelong ***,hospitalization is a part of many children's lives and has an impact on their gender *** To investigate the current situation of gender identity in lower primary school children by conducting a survey of 202 hospitalized children in the lower grades and to provide a theoretical basis and foundation for the cultivation of gender identity and medical treatment of children based on the *** study aims to inspire clinical medical staff to scientifically and reasonably arrange hospital wards for lower primary school children and pay attention to gender protection during the medical treatment process and to help children shape a unified and clear gender identity,which will enable them to better integrate into society and promote their personality *** The gender consciousness scale for elementary and middle school students was REsULTs gender identity was already present in lower primary school *** children's gender roles and gender equality consciousness were strong,exceeding the critical value,but their gender characteristics,gender identity,and gender ideal consciousness were *** aged 6 had the weakest gender identity,and girls had significantly stronger gender identity than *** gender identity is already present in lower primary school children,providing a basis and inspiration for the cultivation of gender identity and medical treatment of lower primary school *** medical staff should be aware of and understand these results and should scientifically and reasonably arrange hospital wards for lower primary school children.

关键词： school-age children gender consciousness gender identity Hospitalization gender weakening

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NOX4 promotes tumor progression through the MAPK-MEK1/2-ERK1/2 axis in colorectal cancer

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World Journal of gastrointestinal Oncology 2024年第4期16卷 1421-1436页

作者： Yu-Jie Xu ya-Chang Huo Qi-Tai Zhao Jin-yan Liu Yi-Jun Tian Lei-Lei yang Yi Zhang Biotherapy Center and Cancer Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Oncology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKgROUND Metabolic reprogramming plays a key role in cancer progression and clinical outcomes;however,the patterns and primary regulators of metabolic reprogramming in colorectal cancer(CRC)are not well *** To explore the role of nicotinamide adenine dinucleotide phosphate oxidase 4(NOX4)in promoting progression of *** We evaluated the expression and function of dysregulated and survival-related metabolic genes using gene Ontology and Kyoto Encyclopedia of genes and *** clustering was used to cluster CRC based on dysregulated metabolic genes.A prediction model was constructed based on survival-related metabolic *** formation,migration,invasion,proliferation,apoptosis and clone formation was used to evaluate the biological function of NOX4 in *** sequencing was utilized to explore the alterations of gene expression NOX4 over-expression tumor *** vivo subcutaneous and lung metastasis mouse tumor model was used to explore the effect of NOX4 on tumor *** We comprehensively analyzed 3341 metabolic genes in CRC and identified three clusters based on dysregulated metabolic *** these genes,NOX4 was highly expressed in tumor tissues and correlated with worse *** vitro,NOX4 overexpression induced clone formation,migration,invasion,and stemness in CRC ***,RNA-sequencing analysis revealed that NOX4 overexpression activated the mitogen-activated protein kinase-MEK1/2-ERK1/2 signaling ***,a MEK1/2 inhibitor,abolished the NOX4-mediated tumor *** vivo,NOX4 overexpression promoted subcutaneous tumor growth and lung metastasis,whereas trametinib treatment can reversed the *** Our study comprehensively analyzed metabolic gene expression and highlighted the importance of NOX4 in promoting CRC metastasis,suggesting that trametinib could be a potential therapeutic drugs of CRC clinical therapy targeting NOX4.

关键词： Colorectal cancer Metabolic reprogramming Metastasis Nicotinamide adenine dinucleotide phosphate oxidase 4 Mitogen-activated protein kinase signaling

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青藏高原地表土壤重金属元素组成分布特征及其影响因素研究

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中国环境科学 2024年第4期44卷 2198-2207页

作者：刘小莉高文华魏婷董志文 shao ya-ping 河南大学地理与环境学院国家级实验教学示范中心河南开封475000 中国地质大学地理与信息工程学院湖北武汉430074 中国科学院西北生态环境资源研究院甘肃兰州730000 德国科隆大学地球物理与气象研究所德国科隆50923

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr... 详细信息

由于青藏高原生态系统的脆弱性和对人类活动的敏感性,近年来高原环境中与人类活动相关的重金属污染研究受到越来越多的关注.本文通过2021~2022年间采集的青藏高原表土样品,结合同时期采集的周边高海拔冰川区雪冰样品,分析测定了As、Cr、Co、Ni、Cu、Mo、Cd、Pb和sb共9种重金属元素的含量和组成特征.结果表明,青藏高原表土中重金属的含量(均值为256.5μg/g)远高于雪冰中重金属(均值为14.6μg/L)的含量.其中As的I geo平均值为1.32,总体处于中度污染水平,而土壤中其他重金属以无污染特征为主.表土中重金属的组成和空间分布与周边冰川区雪冰中表现出明显不同特征,而且不同区域表土重金属的空间分布、组成和富集系数(EFs)没有明显差别.结合相关性、主成分分析和APCs-MLR等方法,发现表土中重金属有3个主要来源,分别为居民生活和工业用煤有关的煤燃烧源(42.3%)、局地地表自生土壤来源(20.6%)和交通排放源(14.2%).高海拔雪冰和表土中重金属的组成、分布存在差异,可能是由于地表样品中重金属受到自然风化、和人类活动影响导致远距离输入源的贡献被掩盖,而雪冰中重金属则更多受到大气环流远距离输入污染源的影响.本研究较为全面的展示了目前青藏高原大范围区域表土中重金属组成状况,反映出部分元素的明显富集(例如As)和整体上重金属元素含量仍然表现为清洁的自然状况.

关键词：重金属元素地表土壤青藏高原组成特征源解析

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