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world Journal of Pediatrics 2024年第2期20卷 189-200页

作者： shu-Na sun Yan Zhou Xing Fu Yuan-Zheng Zheng Cao Xie Guo-You Qin Fang Liu chen Chu Feng wang cheng-Long Liu Qing-Tong Zhou De-Hua Yang Di Zhu Ming-wei wang Yong-Hao Gui Children's Hospital of Fudan University National Children's Medical CenterShanghai 201102China The National Center for Drug screening Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Accuramed Technology(shanghai)Ltd. Shanghai 200233China school of Pharmacy Fudan UniversityShanghai 201203China school of Public Health Fudan UniversityShanghai 200032China Department of Pharmacology School of Basic Medical SciencesFudan UniversityShanghai 200032China Research Center for Deepsea Bioresources Sanya 572025China Department of Chemistry School of ScienceThe University of TokyoTokyo 113-0033Japan school of Pharmacy Hainan Medical UniversityHaikou 570288China

Kawasaki disease(KD)is a disorder of immune *** prevalence of KD among 100,000 children aged 0-4 years was 71.9-110.0 in China,170.9-194.9 in Korea,and 18.1-21.3 in the UsA[1].The most severe complication of KD is coronary artery lesions(CALs),including coronary dilatation and coronary aneurysms,which may even lead to myocardial ischemia,myocardial infarction,and sudden death.

关键词： coronary ischemia differentiated

Interface engineering via temperature-dependent self-transformation on sns2/sns for enhanced piezocatalysis

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Chinese Journal of Catalysis 2024年第9期64卷 166-179页

作者： wenrou Tian Jun Han Najun Li Dongyun chen Qingfeng Xu Hua Li Jianmei Lu College of Chemistry Chemical Engineering and Materials ScienceCollaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhou 215123JiangsuChina

Heterojunction has been widely used in vibration-driven piezocatalysis for enhanced charges separation,while the weak interfaces seriously affect the efficiency during mechanical deformations due to prepared by traditional step-by-step ***,the intimate contact interfaces with shared s atoms are ingeniously constructed in sns_(2)/sns anchored on porous carbon by effective interface engineering,which is in-situ derived from temperature-dependent self-transformation of sns_(2).Benefiting from intimate contact interfaces,the piezoelectricity is remarkably improved due to the larger interfacial dipole moment caused by uneven distribution of ***,vibration-induced piezoelectric polarization field strengthens the interfacial electric field to further promote the separation and migration of *** dynamic charges then transfer in porous carbon with high conductivity and adsorption for significantly improved piezocatalytic *** degradation efficiency of bisphenol A(BPA)is 6.3 times higher than sns_(2) and H2 evolution rate is increased by 3.8 *** with sns_(2)/sns prepared by two-step solvothermal method,the degradation efficiency of BPA and H2 evolution activity are increased by 3 and 2 times,*** provides a theoretical guidance for developing various multiphase structural piezocatalyst with strong interface interactions to improve the piezocatalytic efficiency.

关键词： Piezocatalysis self-transformation Phase junction Interfacial field Polarized field

ADAM8 inactivation retards intervertebral disc degeneration in mice

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Genes & Diseases 2024年第3期11卷 91-94页

作者： Zuozhen Tian Frances s.shofer Mingyue Fan Alec Z.sandroni Lutian Yao Lin Han Ling Qin Motomi Enomoto-lwamoto Yejia Zhang Department of Physical Medicine&Rehabilitation Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA19146USA Department of Emergency Medicine Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA Department of Orthopedic surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPA 19104USA school of Biomedical Engineering Science&Health SystemsDrexel UniversityPhiladelphiaPA 19104USA Department of Orthopedics/sports Medicine and Joint surgery the First Hospital of China Medical UniversityShenyangLiaoning 110001China Department of Orthopedics University of Maryland School ofMedicineBaltimoreMD21201USA section of Rehabilitation Medicine Corporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA 19104USA

ADAM8 has been identified as the fibronectin-cleaving enzyme in human degenerative intervertebral disc(IVD)tissues.^(1)Increase of the active form of ADAM8 and its cleavage product,fibronectin fragment,correlated with an increased degree of IVD degeneration.1 Furthermore,fibronectin fragments have been shown to accelerate the progression of IVD degeneration.^(2)These findings suggest that ADAM8 may play a role in degenerative disc disease,a clinical problem with tremendous socioeconomic burdens in the United states.

关键词： ADAM8 degeneration intervertebral

架起政府与市场的桥梁:地方国企的“经纪”行为

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甘肃行政学院学报 2024年第3期 57-69,126页

作者：刘伟陈春润武汉大学政治与公共管理学院武汉430072

地方国企在国民经济体系中占据着举足轻重的地位,其在中国经济发展中的行为备受瞩目。在国家级开发区的发展案例中发现,地方国企展现出桥接地方政府和市场主体的“经纪”行为。地方国企代理着地方政府和市场主体的双重利益,桥接了地方... 详细信息

地方国企在国民经济体系中占据着举足轻重的地位,其在中国经济发展中的行为备受瞩目。在国家级开发区的发展案例中发现,地方国企展现出桥接地方政府和市场主体的“经纪”行为。地方国企代理着地方政府和市场主体的双重利益,桥接了地方政府和市场主体。在这之中,地方国企表现出举荐可靠项目、激发致富渴望、监督履行承诺、增进政商沟通等“经纪”行为,为地方政府和市场主体架起了一座桥梁,促进了双方利益整合。地方国企的“经纪”行为之所以奏效,归功于地方国企在地方政府和市场主体之间建立起信任,赋予双方对彼此的主观确定性,从而改变了限制和机会。地方国企也从中谋求到更多的发展机遇。归根结底,地方国企所呈现的“经纪”行为填补了既有制度下连接地方政府与市场主体的真空。地方国企的“经纪”行为为理解其在中国经济发展中的作用提供了新的解释。这一非正式的桥接机制在一定程度上帮助地方政府和市场主体克服了不确定性难题。

关键词：地方国企地方政府市场主体双重利益代理 “经纪”行为

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天津电力行业CO_(2)影子价格影响因素

华南师范大学学报（自然科学版） 2024年第4期56卷 39-46页

作者：魏琦陈俊瑜兰州理工大学经济管理学院兰州730050

根据线性规划对偶理论建立了电力行业发电成本最小化模型,并以天津市为例,对其2014~2020年的电力行业二氧化碳影子价格进行了测算与分析,并对其影响因素进行了相关研究。研究表明:天津电力行业光伏发电成本的降低将带动其CO_(2)影子价... 详细信息

根据线性规划对偶理论建立了电力行业发电成本最小化模型,并以天津市为例,对其2014~2020年的电力行业二氧化碳影子价格进行了测算与分析,并对其影响因素进行了相关研究。研究表明:天津电力行业光伏发电成本的降低将带动其CO_(2)影子价格的降低:光伏发电成本每降低0.1元/kwh,CO_(2)影子价格平均降低13.66元/t,且平均发电成本也有所降低。在碳排放约束不断收紧的条件下,天津市电力行业CO_(2)影子价格未表现出明显变化,但其发电结构不断优化,说明天津可以通过调整发电结构来满足碳配额要求并使得边际减排成本保持不变。高碳排放强度的火力发电方式可以通过实施CCs技术来降低电力行业CO_(2)影子价格,但平均发电成本会有所上升。

关键词：碳市场二氧化碳影子价格边际减排成本电力行业天津市

The global regulation of c-di-GMP and cAMP in bacteria

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mLife 2024年第1期3卷 42-56页

作者： Cong Liu Rui shi Marcus s.Jensen Jingrong Zhu Jiawen Liu Xiaobo Liu Di sun weijie Liu Jiangsu Key Laboratory of Phylogenomics&Comparative Genomics School of Life SciencesJiangsu Normal UniversityXuzhouChina Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologyNanjing University of Science and TechnologyNanjingChina

Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in *** best-studied examples are cyclic AMP(cAMP)and bis-(3'-5')-cyclic dimeric guanosine monophosphate(c-di-GMP),which both act as global *** regulatory frameworks of c-di-GMP and cAMP in bacteria show several parallels but also significant *** this review,we llustrate the global regulatory models of the two nucleotide second messengers,compare the different regulatory frameworks between c-di-GMP and cAMP,and discuss the mechanisms and physiological significance of cross-regulation between c-di-GMP and cAMP.c-di-GMP responds to numerous signals de-pendent on a great number of metabolic enzymes,and it regulates various signal transduction pathways through its huge number of effectors with varying *** contrast,due to the limited quantity,the cAMP metabolic enzymes and its major effector are regulated at different levels by diverse *** performs its global regulatory function primarily by controlling the transcription of a large number of genes via cAMP receptor protein(CRP)in most *** review can help us understand how bacteria use the two typical nucleotide second messengers to effectively coordinate and integrate various physiological processes,providing theoretical guidelines for future research.

关键词： bacteria cAMP c-di-GMP cross-regulation CRP

全球价值链参与度对产业链韧性的影响——基于台湾地区制造业的实证研究

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台湾研究 2024年第4期 53-67页

作者：曹小衡陈子充南开大学经济学院台湾经济研究所南开大学经济学院

提升产业链韧性是维护产业安全与经济安全迫切的现实需求。如何在嵌入全球价值链体系的同时降低产业链供应链风险具有重要研究意义。基于产业链韧性内涵,构建测度体系,对1997—2021年间中国台湾制造业产业链韧性进行测算,并实证检验全... 详细信息

提升产业链韧性是维护产业安全与经济安全迫切的现实需求。如何在嵌入全球价值链体系的同时降低产业链供应链风险具有重要研究意义。基于产业链韧性内涵,构建测度体系,对1997—2021年间中国台湾制造业产业链韧性进行测算,并实证检验全球价值链参与度对其影响,研究发现:近年来多重风险交织的国际经贸环境使中国台湾制造业产业链韧性程度有所下降。对于制造业整体而言,提升全球价值链前向参与度能够显著提升产业链韧性,而后向参与度升高则会降低产业链韧性。此外,高技术行业中GVC前、后向参与度对产业链韧性的影响更明显。以上研究结论有助于把握中国台湾产业链韧性提升的正确方向,并对内地优化国际分工参与方式、推进高水平对外开放具有重要参考意义。

关键词：台湾地区经济全球价值链参与度产业链韧性中国台湾制造业

Identifying genetic susceptibility to Aspergillus fumigatus infection using collaborative cross mice and RNA-seq approach

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Animal Models and Experimental Medicine 2024年第1期7卷 36-47页

作者： Roa'a H.s.Yosief Iqbal M.Lone Aharon Nachshon Heinz Himmelbauer Irit Gat-Viks Fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael school of Molecular Cell Biology and Biotechnology George S.Wise Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael Institute of Computational Biology Department of BiotechnologyUniversity of Natural Resources and Life SciencesMuthgasse 181190 ViennaAustria

Background:Aspergillus fumigatus(Af)is one of the most ubiquitous fungi and its infection potency is suggested to be strongly controlled by the host genetic *** aim of this study was to search for candidate genes associated with host susceptibility to Aspergillus fumigatus(Af)using an RNAseq approach in CC lines and hepatic gene ***:we studied 31 male mice from 25 CC lines at 8 weeks old;the mice were infected with *** tissues were extracted from these mice 5 days post-infection,and next-generation RNA-sequencing(RNAseq)was *** GENE-E analysis platform was used to generate a clustered heat map ***:significant variation in body weight changes between CC lines was *** gene expression revealed 12 top prioritized candidate genes differ-entially expressed in resistant versus susceptible mice based on body weight ***,three candidate genes are located within genomic intervals of the previ-ously mapped quantitative trait loci(QTL),including Gm16270 and stox1 on chromo-some 10 and Gm11033 on chromosome ***:Our findings emphasize the CC mouse model's power in fine mapping the genetic components underlying susceptibility towards *** a next step,eQTL analysis will be performed for our RNA-seq *** candidate genes from our study will be further assessed with a human cohort with aspergillosis.

关键词： aspergillus fumigatus infection collaborative cross(CC)mice gene expression profile gene-network host susceptibility quantitative trait loci(QTL)mapping RNA-seq

多间隔信息融合的母线保护电流互感器断线再开放策略

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电力自动化设备 2024年第5期44卷 151-157页

作者：陈琦陈福锋唐治国薛明军刘凯祥王胜孙震宇国电南京自动化股份有限公司江苏南京210003 南京国电南自电网自动化有限公司江苏南京211153

对于电流互感器(CT)断线后发生金属性故障的情景,现有母线保护采取的闭锁差动保护动作方式将会引发多个变电站停电。此外,当母线区内发生高阻接地故障时,现有母线保护判据可能会将其误判为CT断线故障,不利于电力系统的安全稳定运行。针... 详细信息

对于电流互感器(CT)断线后发生金属性故障的情景,现有母线保护采取的闭锁差动保护动作方式将会引发多个变电站停电。此外,当母线区内发生高阻接地故障时,现有母线保护判据可能会将其误判为CT断线故障,不利于电力系统的安全稳定运行。针对这一问题,提出了一种母线保护CT断线再开放策略,该策略基于断线间隔与非断线间隔的零序电流变化量对负荷波动和故障进行区分,并基于非断线间隔的差流有效值和间隔失灵保护信息对区内外故障进行判别。实时数字仿真系统仿真结果验证了所提CT断线识别判据和再开放策略的正确性。

关键词：电流互感器断线多间隔信息融合短路故障电流互感器闭锁策略母线保护

The Determination of Heritability in palatal Rugae Pattern among Parents and their Off-springs in western India-A Cross-sectional study

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Journal of Forensic science and Medicine 2024年第1期10卷 42-46页

作者： Aishwarya Bhatnagar sugandha Arya Jyothi s Kumar Aishwarya Arya Kailash Chandra Morya sudhir Baroopal Department of Oral Medicine and Radiology Vyas Dental College and HospitalJodhpurRajasthanIndia Department of Conservative and Endodontics Vyas Dental College and HospitalJodhpurRajasthanIndia

Background:Palatal rugae are asymmetrical elevations present on hard palate and are significant due to their uniqueness,stability and thus,aid in forensic ***:The objective is to determine palatal rugae morphology between parents and their offsprings and to determine their genetic *** and Methods:This randomized controlled cross-sectional single-blinded study was conducted on 50 families(randomly selected)who visited Vyas Dental College and Hospital.A total of 150 maxillary study models were examined and rugae were delineated and shape,size,and pattern of rugae were ***:weak but significant correlation was seen in the nonspecific and angular type of palatal rugae between child and mother and child and father as Pwith either or both of their parent was seen for curved,wavy,divergent,straight,horseshoe,angular,and nonspecific type of rugae with the higher%of wavy pattern matching(52%with mother and 54%with father).A considerable number of samples showed high heritability of primary and secondary rugae from both parents,but more predominantly to their mothers(branched,nonspecific,and straight).Conclusion:Both environmental and genetic factors can influence the rugae ***,studies should be conducted on a larger sample size to get more significant results.

关键词： Forensic identification heredity palatal rugae uniqueness