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study of the CKM angle γ sens.tivity using flavor untagged Bs0→D（*）0φ decays

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Chinese Physics C 2021年第2期45卷 60-96页

作者：敖冬 D.Decamp 钱文斌 s.Ricciardi H.sazak s.t'jampens V.tisserand 王子睿杨振伟张舒楠周晓康 Univers.ty of Chinese Academy of sciences Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRS stFC Rutherford Appleton Laboratory Univers.té Clermont Auvergne CNRS/IN2P3LPC Center for High Energy Physics Tsinghua University school of Physics state Key Laboratory of Nuclear Physics and technology Peking University

A sens.tivity study on the measurement of the CKM angle y from B→Dφ decays is conducted using the D-meson reconstructed in the quasi flavour-specific modes Kπ,K3π,and Kππ,as well as CP-eigenstate modes KK and ππ,where the notation Dcorresponds.to a Dor *** LHCb experiment is presented as a use case.A statistical uncertainty of approximately 8°-19°can be achieved with the pp collision data collected in the LHCb experiment from 2011 to *** sens.tivity to y should be of the order 3°-8° after accumulating 23 fbof pp collision data by 2025,whereas it is expected to improve further by 300 fbby the second half of the 2030 *** accuracy is dependent on the strong parameters rand δ,which together with γdescribe the interference between the leading amplitudes of the B→Dφ decays.

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Measurement of Ξcc++ production in pp collisions at s1/2=13 teV

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Chinese Physics C 2020年第2期44卷 13-23页

作者： R.Aaij C.Abellán Beteta t.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala s.Aiola Z.Ajaltouni s.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr s.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann J.J.Back s.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi V.Batozskaya B.Batsukh A.Battig A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin s.Belin V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim s.Benson s.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom M.s.Bieker s.Bifani P.Billoir A.Bizzeti M.Bjørn M.P.Blago t.Blake F.Blanc s.Blusk D.Bobulska V.Bocci O.Boente Garcia t.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Bors.to J.t.Borsuk t.J.V.Bowcock C.Bozzi M.J.Bradley s.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche A.Butkevich J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese L.Calero Diaz s.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero s.Celani R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen s.Chen A.Chernov s.-G.Chitic V.Chobanova s.Cholak M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins.t.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs s.Coquereau G.Corti C.M.Costa sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz torres R.Currie C.L.Da silva E.Dall'Occo J.Dalseno C.D' Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and technology Peking UniversityBeijingChina Univers.ty of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Univers.téClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3UniversitéParis-SaclayOrsayFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultät Physik Technische Universität DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universität HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN sezione di Genova GenovaItaly INFN sezione di Milano-Bicocca MilanoItaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari MonserratoItaly INFN sezione di Padova PadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma tor Vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU Univers.ty Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakówPoland AGH-Univers.ty of science and technology Faculty of Physics and Applied Computer ScienceKrakówPoland Nationa

the production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 teV is measured in the transverse-momentum range 4t<15GeV/c and the rapidity range2.0ta used in this measuremen... 详细信息

the production of ■baryons in proton-proton collisions at a centre-of-mass energy of √s = 13 teV is measured in the transverse-momentum range 4tthe rapidity range2.0ta used in this measurement correspond to an integrated luminos.ty of 1.7fb^-1,recorded by the LHCb experiment during *** ratio of the ■ production cross-section times.the branching fraction of the■→∧^+cK^-π^+ π^+decay relative to the prompt ∧^+c production cross-section is found to be(2.22±0.27±0.29)×10^-4,assuming the central value of the measured lifetime,where the first uncertainty is statistical and the second systematic.

关键词： doubly charmed baryons hadron production QCD

search for the rare decays W^(+)→D_(s)^(+)γ and Z→D^(0)γ at LHCb

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Chinese Physics C 2023年第9期47卷 14-26页

作者： R.Aaij A.s.W.Abdelmotteleb C.Abellan Beteta F.Abudinén t.Ackernley B.Adeva M.Adinolfi P.Adlarson H.Afsharnia C.Agapopoulou C.A.Aidala Z.Ajaltouni s.Akar K.Akiba J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche P.Alvarez Cartelle R.Amalric s.Amato J.L.Amey Y.Amhis L.An L.Anderlini M.Andersson A.Andreianov M.Andreotti D.Andreou D.Ao F.Archilli A.Artamonov M.Artuso E.Aslanides M.Atzeni B.Audurier s.Bachmann M.Bachmayer J.J.Back A.Bailly-reyre P.Baladron Rodriguez V.Balagura W.Baldini J.Baptista de souza Leite M.Barbetti R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay A.Beck M.Becker F.Bedeschi I.B.Bediaga A.Beiter V.Belavin s.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Benane G.Bencivenni E.Ben-Haim A.Berezhnoy *** *** Andres D.Berninghoff H.C.Bernstein C.Bertella A.Bertolin C.Betancourt F.Betti Ia.Bezshyiko s.Bhasin J.Bhom L.Bian M.s.Bieker N.V.Biesuz s.Bifani P.Billoir A.Biolchini M.Birch F.C.R.Bishop A.Bitadze A.Bizzeti M.P.Blago t.Blake F.Blanc J.E.Blank s.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia t.Boettcher A.Boldyrev C.s.Bolognani R.Bolzonella N.Bondar F.Borgato s.Borghi M.Bors.to J.t.Borsuk s.A.Bouchiba t.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley s.Braun A.Brea Rodriguez J.Brodzicka A.Brossa Gonzalo J.Brown D.Brundu A.Buonaura L.Buonincontri A.t.Burke C.Burr A.Bursche A.Butkevich J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese L.Calefice s.Cali R.Calladine M.Calvi M.Calvo Gomez P.Campana D.H.Campora Perez A.F.Campoverde Quezada s.Capelli L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti L.Carus A.Casais Vidal R.Caspary G.Casse M.Cattaneo G.Cavallero V.Cavallini s.Celani J.Cerasoli D.Cervenkov A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier C.A.Chavez Barajas M.Chefdeville C.Chen s.Chen A.Chernov s.Chernyshenko V.Chobanova s.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek G.Ciullo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cognera Centro Brasileiro de Pesquisas Físicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina Institute Of High Energy Physics(IHEP) BeijingChina school of Physics state Key Laboratory of Nuclear Physics and technology Peking UniversityBeijingChina Univers.ty of Chinese Academy of sciences BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univers.té savoie Mont Blanc CNRSIN2P3-LAPPAnnecyFrance Univers.téClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Univers.téParis-saclay CNRS/IN2P3IJCLabOrsayFrance Laboratoire Leprince-Ringuet CNRS/IN2P3Ecole PolytechniqueInstitut Polytechnique de ParisPalaiseauFrance LPNHE Sorbonne UniversitéParis Diderot Sorbonne Paris CitéCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN sezione di Genova GenovaItaly INFN sezione di Milano MilanoItaly INFN sezione di Milano-Bicocca MilanoItaly INFN sezione di Cagliari MonserratoItaly Univers.tàdegli studi di Padova Universitàe INFNPadovaPadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma La sapienza RomaItaly INFN sezione di Roma tor Vergata RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU Univers.ty Amsterdam AmsterdamNetherlands AGH-Univers.ty of science and technology Faculty of Physics and Applied Computer Scienc

A search for the rare decays W^(+)→D_(s)^(+)γ and Z→D0γis performed using proton-proton collision data collected by the LHCb experiment at a centre-of-mass energy of 13teV,corresponding to an integrated luminos.ty of 2.0fb−*** significant signal is observed for either decay mode and upper limits on their branching fractions are s.t using W^(+)→D_(s)^(+)γ and Z→μ+μ−decays as normalization *** upper limits are 6.5×10^(−4) and 2.1×10^(−3) at 95% confidence level for the W^(+)→D_(s)^(+)γ and Z→D^(0)γ decay modes,*** is.the first reported search for the Z→D^(0)γ decay,while the upper limit on the W+→D+sγbranching fraction improves upon the previous best limit.

关键词： W/Z boson rare decay upper limit of branching fraction

KAI（sO4）2-12H2O （Alum） Catalyzed One-Pot three-Component synthesis of 2-Alkyl and 2-Aryl-4（3H）-quinazolinone under Microwave Irradiation and solvent Free Conditions

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Chinese Journal of Chemistry 2011年第9期29卷 1982-1984页

作者： Mohammadi, Ali A. sadat Hossini, s. s.t Department of Chemistry Sabzevar Branch Islamic Azad University Sabzevar Iran Univers.ty of Applied science and technology Tehran P.. O. Box 14155-1644 Tehran Iran

twenty 2,3-disubstituted-4（3H）-quinazolinones were synthesed by one-pot three-component method with isa- toic anhydride, orthoesters and amines as raw materials in the presence of KAI（sO4）2·12H2O （Alum） under micro- wave irradiation and solvent-free conditions. 6-Bromo-2-propyl-3-p-tolylquinazolin-4（3H）-one （4m）, 6-bromo-2- methyl-3-phenethylquinazolin-4（3H）-one （4n） and 6-bromo-2-ethyl-3-phenethylquinazolin-4（3H）-one （40） were characterized by IR, 1H NMR, 13C NMR and elemental analysis.

关键词： is.toic anhydride orthoesters ammonium acetate 4(3H)-quinazolinone multi component micro-wave-assisted reactions

Revis.ting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is.the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,paras.tes living in the human intestine constitute the human intestinal *** refers.to composi-tional and quantitative changes.that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis.treatment strategies.targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is.the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

search for the doubly charmed baryon ■

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science China(Physics,Mechanics & Astronomy) 2020年第2期63卷 8-22页

作者： R.Aaij C.Abellán Beteta t.Ackernley B.Adeva M.Adinolfi H.Afsharnia C.A.Aidala s.Aiola Z.Ajaltouni s.Akar P.Albicocco J.Albrecht F.Alessio M.Alexander A.Alfonso Albero G.Alkhazov P.Alvarez Cartelle A.A.Alves Jr s.Amato Y.Amhis L.An L.Anderlini G.Andreassi M.Andreotti F.Archilli J.Arnau Romeu A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann J.J.Back s.Baker V.Balagura W.Baldini A.Baranov R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov G.Bassi V.Batozskaya B.Batsukh A.Battig V.Battista A.Bay M.Becker F.Bedeschi I.Bediaga A.Beiter L.J.Bel V.Belavin s.Belin N.Beliy V.Bellee K.Belous I.Belyaev G.Bencivenni E.Ben-Haim s.Benson s.Beranek A.Berezhnoy *** D.Berninghoff H.C.Bernstein E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom M.s.Bieker s.Bifani P.Billoir A.Birnkraut A.Bizzeti M.Bjφrn M.P.Blago t.Blake F.Blanc s.Blusk D.Bobulska V.Bocci O.Boente Garcia t.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Bors.to J.t.Borsuk t.J.V.Bowcock C.Bozzi s.Braun A.Brea Rodriguez M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu E.Buchanan A.Buonaura C.Burr A.Bursche J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese s.Cali R.Calladine M.Calvi M.Calvo Gomez A.Camboni P.Campana D.H.Campora Perez L.Capriotti A.Carbone G.Carboni R.Cardinale A.Cardini P.Carniti K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero R.Cenci J.Cerasoli M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis M.Chefdeville V.Chekalina C.Chen s.Chen A.Chernov s.-G.Chitic V.Chobanova M.Chrzaszcz A.Chubykin P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek F.Cindolo P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins.t.Colombo A.Comerma-Montells A.Contu N.Cooke G.Coombs s.Coquereau G.Corti C.M.Costa sobral B.Couturier D.C.Craik J.Crkovska A.Crocombe M.Cruz torres R.Currie C.L.Da silva E.Dall'Occo J.Dalseno C.D'Ambrosio A.Danilina P.d'Argent A.Davis O.De Aguiar Francisco K.De Bruyn s.De Capua M Centro Brasileiro de Pesquisas Fisicas(CBPF) Rio de JaneiroBrazil Universidade Federal do Rio de Janeiro(UFRJ) Rio de JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and technology Peking UniversityBeijingChina Univers.ty of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BeijingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Univers.te Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance LAL Univ.Paris-SudCNRS/IN2P3Universite Paris-SaclayOrsayFrance LPNHE Sorbonne Universite Paris Diderot Sorbonne Paris Cite CNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut für Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati FrascatiItaly INFN sezione di Genova GenovaItaly INFN sezione di Milano-Bicocca MilanoItaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari MonserratoItaly INFN sezione di Padova PadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma tor Vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU Univers.ty Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakowPoland AGH-Univers.ty of science and technology Faculty of Physics and Applied Computer ScienceKrakowPoland Natio

A search for the doubly charmed baryon ■^+cc is performed through its decay to theΛ^+c K^-π^+ final state,using proton-proton collision data collected with the LHCb detector at centre-of-mass energies of 7,8 and 13 *** data correspond to a total integrated luminos.ty of 9 fb^-*** significant signal is observed in the mass range from 3.4 to 3.8 GeV/c^*** limits are s.t at 95%credibility level on the ratio of the ■^+cc production cross-section times.the branching fraction to that ofΛ^+c and ■^++cc *** limits are determined as functions of the ■^+cc mass for different lifetime hypotheses,in the rapidity range from 2.0 to 4.5 and the transverse momentum range from 4 to 15 GeV/c.

关键词： charmed baryons limits on production of particles charmed quarks experimental tests

search for the rare decay B^(0)→J/ψФ

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Chinese Physics C 2021年第4期45卷 47-60页

作者： R.Aaij C.Abellin Beteta t.Ackernley B.Adeva M.Adinolfi H.Afsharnial C.A.Aidala s.Aiola Z.Ajaltouni s.Akar J.Albrecht F.Alessio M.Alexander A.Alfonso Albero Z.Aliouche G.Alkhazov P.Alvarez Cartelle s.Amato Y.Amhis L.An L.Anderlini A.Andreianov M.Andreotti F.Archilli A.Artamonov M.Artuso K.Arzymatov E.Aslanides M.Atzeni B.Audurier s.Bachmann M.Bachmaver J.J.Back s.Baker P.Baladron Rodriguez V.Balagura W.Baldinit J.Baptista Leite R.J.Barlow s.Barsuk W.Barter M.Bartolini F.Baryshnikov J.M.Basels G.Bassi B.Batsukh A.Battig A.Bay M.Becker F.Bedeschis I.Bediaga A.Beiter V.Belavin s.Belin V.Bellee K.Belous I.Belov I.Belyaev G.Bencivenni E.Ben-Haim A.Berezhnoy *** D.Berninghoff H.C.Bernstein C.Bertella E.Bertholet A.Bertolin C.Betancourt F.Betti M.O.Bettler Ia.Bezshyiko s.Bhasin J.Bhom L.Bian M.s.Bieker s.Bifani P.Billoir M.Birch F.C.R.Bishop A.Bizzeti M.Biorn M.P.Blago t.Blake F.Blanc s.Blusk D.Bobulska J.A.Boelhauve O.Boente Garcia t.Boettcher A.Boldyrev A.Bondar N.Bondar s.Borghi M.Borisyak M.Bors.to J.t.Borsuk s.A.Bouchiba t.J.V.Bowcock A.Boyer C.Bozzi M.J.Bradley s.Braun A.Brea Rodriguezs M.Brodski J.Brodzicka A.Brossa Gonzalo D.Brundu A.Buonaura C.Burr A.Burschee A.Butkevich J.s.Butter J.Buytaert W.Byczynski s.Cadeddu H.Cai R.Calabrese L.Calefice L.Calero Diaz s.Cali R.Calladine M.Calvi M.Calvo Gomez P.Camargo Magalhaes A.Camboni P.Campana D.H.Campora Perez A.F.Campoverde Quezada s.Capelli L.Capriotti A.Carbonel G.Carboni R.Cardinale A.Cardini I.Carli P.Carniti L.Carus K.Carvalho Akiba A.Casais Vidal G.Casse M.Cattaneo G.Cavallero s.Celani J.Cerasoli A.J.Chadwick M.G.Chapman M.Charles Ph.Charpentier G.Chatzikonstantinidis C.A.Chavez Barajas M.Chefdeville C.Chen s.Chen A.Chernov s.-G.Chitic V.Chobanova s.Cholak M.Chrzaszcz A.Chubykin V.Chulikov P.Ciambrone M.F.Cicala X.Cid Vidal G.Ciezarek P.E.L.Clarke M.Clemencic H.V.Cliff J.Closier J.L.Cobbledick V.Coco J.A.B.Coelho J.Cogan E.Cogneras L.Cojocariu P.Collins.t.Colombo L.Congedo A.Contu N.Cooke G.Coombs G.Corti C.M.Costa sobral B.Couturier D.C.Craik J.Crkovska M.Cruz Centro Brasileiro de Pesquisas Fisicas(CBPF) Riode JaneiroBrazil Universidade Federal do Riode Janeiro(UFRJ) Riode JaneiroBrazil Center for High Energy Physics Tsinghua UniversityBeijingChina school of Physics state Key Laboratory of Nuclear Physics and technology Peking UniversityBeijingChina Univers.ty of Chinese Academy of sciences BeijingChina Institute Of High Energy Physics(IHEP) BejingChina Institute of Particle Physics Central China Normal UniversityWuhanHubeiChina Univ.Grenoble Alpes Univ.Savoie Mont BlancCNRSIN2P3-LAPPAnnecyFrance Univers.te Clermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance Aix Marseille Univ CNRS/IN2P3CPPMMarseilleFrance Univers.tq Paris-saclay CNRS/IN2P3IJCLabOrsayFrance LPNHE Sorbonne UniversiteParis Diderot Sorbonne Paris CiteCNRS/IN2P3ParisFrance I.Physikalisches Institut RWTH Aachen UniversityAachenGermany Fakultat Physik Technische Universitat DortmundDortmundGermany Max-Planck-Institut fir Kernphysik(MPIK) HeidelbergGermany Physikalisches Institut Ruprecht-Karls-Universitat HeidelbergHeidelbergGermany school of Physics University College DublinDublinIreland INFN sezione di Bari BariItaly INFN sezione di Bologna BolognaItaly INFN sezione di Ferrara FerraraItaly INFN sezione di Firenze FirenzeItaly INFN Laboratori Nazionali di Frascati Frascatiltaly INFN sezione di Genova GenovaItaly INFN sezione di Milano Bicocca Milanolaly INFN sezione di Milano MilanoItaly INFN sezione di Cagliari Monserratoltaly Univers.ta degli studi di Padova Universita e INFNPadovaPadovaItaly INFN sezione di Pisa PisaItaly INFN sezione di Roma tor Vergata RomaItaly INFN sezione di Roma La sapienza RomaItaly Nikhef National Institute for subatomic Physics AmsterdamNetherlands Nikhef National Institute for subatomic Physics and VU Univers.ty Amsterdam AmsterdamNetherlands Henryk Niewodniczanski Institute of Nuclear Physics Polish Academy of sciences KrakowPoland AGH-Univers.ty of science and technology Faculty of Physics and Applied Computer Science

A search for the rare decay B^(0)→J/ψФis performed using Pp collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7,8 and 13 teV,corresponding to an integrated luminos.ty of9 *** significant signal of the decay is observed and an upper limitof 1.1x 10^(-7)at 90%confidence level is s.t on the branching fraction.

关键词： B physics flavour physics rare decay ω-Фmixing branching fraction

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-ons.t familial Alzheimer’s disease.γ-secretase has.thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-ons.t Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates.the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-trim,”“sliding-Unwinding,”and“tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch