检索结果-南通市图书馆

Journal of Pharmaceutical Analysis 2015年第3期5卷 161-168页

作者： B.ramesh N.Manjula s.r.bijargi V.U.M.sarma P.sita Devi Natural Products Chemistry Division Indian Institute of Chemical Technology Medicinal Chemistry & Pharmacology Division Indian Institute of Chemical Technology

Three extraction methods were compared for their efficiency to analyze sitagliptin and simvastatin in rat plasma by LC-Ms/Ms, including （1） liquid-liquid extraction （LLE）, （2） solid phase extraction （sPE） and （3） supported liquid extraction （sLE）. Comparison of recoveries of analytes with different extraction methods revealed that sLE was the best extraction method. The detection was facilitated with ion trap-mass spectrometer by multiple reactions monitoring （MrM） in a positive ion mode with EsI. The transitions monitored were m./z 441.1→325.2 for simvastatin, 408.2→235.1 for sitagliptin and 278.1→260.1 for the Is. The lower limit of quantification （LLOQ） was 0.2 ng/mL for sitagliptin and 0.1 ng/mL for simvastatin. The effective sLE offers enhanced chromatographic selectivity, thus facilitating the potential utility of the method for routine analysis of biological samples along with pharmacokinetic studies.

关键词： rat plasma simvastatin sita#'ptin supported liquid extraction

Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

在线全文

学校读者我要写书评

暂无评论

Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko r.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

FEA-based Geometrical Modification of switched reluctance Motor for radial Force reduction

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electrical Engineering 2024年第1期10卷 124-135页

作者： rani s Jayapragash r school of Electrical Engineering Vellore Institute of TechnologyChennai 600127India

switched reluctance motors(srMs)are becoming increasingly popular in the automotive sector owing to their robust ***,srMs are preferred particularly for EV applications owing to their fault tolerance,magnet-free structure,and high power/torque *** main concerns of srM compared to other machines include torque ripple and *** primary cause of vibration is the radial force created by the srM.A geometry-based modification of the srM to reduce the radial force without significantly changing the average torque produced is *** primary goal is to design a 4-phase,8/6 srM with a lower radial *** possible geometrical alterations are proposed:one with square windows and the other with circular holes on the rotor *** windows are sized and positioned to avoid flux *** criteria are developed for the optimal window size and *** element analysis(FEA)modelling of the srM is used to validate its *** FEA results are compared with the performance parameters obtained using the analytical *** the multiphysics design tool ANsYs to obtain the natural frequencies and associated deformations through modal *** to the conventional geometry,the radial force is significantly reduced by providing windows.

关键词： 8/6 srM radial force modal analysis FEA analysis natural frequencies srM with windows

Kinematic analysis of flexible bipedal robotic systems

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 795-818页

作者： r.FAZEL A.M.sHAFEI s.r.NEKOO Department of Mechanical Engineering Shahid Bahonar University of KermanKerman ***Iran Departamento de Ingenieria de sistemas y Automatica Escuela Técnica Superior de IngenieriaUniversidad de SevillaSeville 41092Spain

In spite of its intrinsic complexities,the passive gait of bipedal robots on a sloping ramp is a subject of interest for numerous *** distinguishes the present research from similar works is the consideration of flexibility in the constituent links of this type of robotic *** is not a far-fetched assumption because in the transient(impact)phase,due to the impulsive forces which are applied to the system,the likelihood of exciting the vibration modes increases ***,the human leg bones that are involved in walking are supported by viscoelastic muscles and ***,for achieving more exact results,it is essential to model the robot links with viscoelastic *** this end,the Gibbs-Appell formulation and Newton's kinematic impact law are used to derive the most general form of the system's dynamic equations in the swing and transient phases of *** most important issue in the passive walking motion of bipedal robots is the determination of the initial robot configuration with which the system could accomplish a periodic and stable gait solely under the effect of gravitational *** extremely unstable nature of the system studied in this paper and the vibrations caused by the impulsive forces induced by the impact of robot feet with the inclined surface are some of the very serious challenges encountered for achieving the above-mentioned *** overcome such challenges,an innovative method that uses a combination of the linearized equations of motion in the swing phase and the algebraic motion equations in the transition phase is presented in this paper to obtain an eigenvalue *** solving this problem,the suitable initial conditions that are necessary for the passive gait of this bipedal robot on a sloping surface are *** effects of the characteristic parameters of elastic links including the modulus of elasticity and the Kelvin-Voigt coefficient on the walking stability of this type of

关键词： bipedal robot flexible link swing phase transient phase eigenvalue problem Kelvin-Voigt coefficient

Parametric investigation on the novel and cost-effective nano fly ash impregnated geopolymer system for sustainable construction

在线全文

学校读者我要写书评

暂无评论

Frontiers of structural and Civil Engineering 2024年第2期18卷 170-183页

作者： r.MOHANA s.M.Leela BHArATHI Department of Civil Engineering Mepco Schlenk Engineering CollegeSivakasi 626123India

The hazardous environmental effects of greenhouse gas emissions and climate change demand alternative sources for cementitious materials in the construction *** development of geopolymer structures provides a way of producing 100%cement-free *** this research work,a novel and simple way of deriving nano particles from waste fly ash particles is *** effect of adding the synthesized nano fly ash particles as a filler medium in geopolymer mortars was investigated by considering strength and durability *** optimization was done by using regression analysis on the geopolymer mortar and the impact of adding nano fly ash particles was studied by varying different percentages of addition ranging from 0 to 7.5%by weight of binder *** the results,it was observed that 1%nano fly ash acted not only as a filler but also as nano-sized precursors of the polymerization process,resulting in denser geopolymer *** can explain the extraordinary gain in strength of 72.11 MPa as well as the denser core with negligible level of chloride ion penetration,making the material suitable for the development of structures susceptible to marine environment.

关键词： geopolymer nano fly ash chloride ion penetration durability polymerization fillers

An Efficient Modelling of Oversampling with Optimal Deep Learning Enabled Anomaly Detection in streaming Data

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Communications 2024年第5期21卷 249-260页

作者： r.rajakumar s.sathiya Devi srinivasa ramanujan Centre SASTRA Deemed UniversityKumbakonamTamil Nadu 612001India University College of Engineering BIT CampusAnna UniversityTiruchirappalli 620024India

recently,anomaly detection(AD)in streaming data gained significant attention among research communities due to its applicability in finance,business,healthcare,education,*** recent developments of deep learning(DL)models find helpful in the detection and classification of *** article designs an oversampling with an optimal deep learning-based streaming data classification(Os-ODLsDC)*** aim of the OsODLsDC model is to recognize and classify the presence of anomalies in the streaming *** proposed Os-ODLsDC model initially undergoes preprocessing *** streaming data is unbalanced,support vector machine(sVM)-synthetic Minority Over-sampling Technique(sVM-sMOTE)is applied for oversampling ***,the Os-ODLsDC model employs bidirectional long short-term memory(Bi LsTM)for AD and ***,the root means square propagation(rMsProp)optimizer is applied for optimal hyperparameter tuning of the Bi LsTM *** ensuring the promising performance of the Os-ODLsDC model,a wide-ranging experimental analysis is performed using three benchmark datasets such as CICIDs 2018,KDD-Cup 1999,and NsL-KDD datasets.

关键词： anomaly detection deep learning hyperparameter optimization oversampling sMOTE streaming data

A bird's-eye overview of molecular mechanisms regulating feed intake in chickens—with mammalian comparisons

在线全文

学校读者我要写书评

暂无评论

Animal Nutrition 2024年第2期17卷 61-74页

作者： Anastasiia r.Volyanskaya Ilya r.Akberdin Mikhail A.Kulyashov Ivan s.Yevshin Michael N.romanov Elena I.shagimardanova Oleg A.Gusev Fedor A.Kolpakov Department of Natural sciences Novosibirsk State University Biosoft.ru Ltd. sirius University of science and Technology school of Biosciences University of Kent L.K.Ernst Federal research Centre for Animal Husbandry regulatory Genomics research Center Institute of Fundamental Medicine and BiologyKazan Federal University Life Improvement By Future Technologies (LIFT) Center Intractable Disease research Center Juntendo University

In recent decades, a lot of research has been conducted to explore poultry feeding behavior. However, up to now, the processes behind poultry feeding behavior remain poorly understood. The review generalizes modern expertise about the hormonal regulation of feeding behavior in chickens, focusing on signaling pathways mediated by insulin, leptin, and ghrelin and regulatory pathways with a cross-reference to mammals. This overview also summarizes state-of-the-art research devoted to hypothalamic neuropeptides that control feed intake and are prime candidates for predictors of feeding *** analysis of the signaling pathways that mediate the feed intake regulation allowed us to conclude that there are major differences in the processes by which hormones influence specific neuropeptides and their contrasting roles in feed intake control between two vertebrate clades.

关键词： Chicken Feed intake Hypothalamus Neuropeptide signaling pathway Hormone

Mathematical modelling of ball and plate system with experimental and correlation function-based model validation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Control Theory and Technology 2024年第2期22卷 326-341页

作者： T.r.Dil Kumar s.J.Mija Department of Electrical Engineering National Institute of Technology CalicutKozhikode673601KeralaIndia

The ball and plate system is an inherently nonlinear under actuated benchmark system used for validating the performance of various control schemes. A mathematical model depicting the dynamics close to that of the system is very much required for such a test bed. In this correspondence, the complete nonlinear model, a simplified nonlinear model, and a linearized model of the ball and plate system are developed. The system comprises a ball and plate mechanism and a rotary servo unit. The ball and plate mechanism is modelled using the Euler–Lagrange method, whereas the rotary servo subsystem is modelled from the first principles. The nonlinear model of the combined system is developed by including the dynamics of the servo motor with gear and rolling resistance between the ball and the plate. The simplified nonlinear model of the system is obtained with suitable assumptions. The model is linearized around the operating point using the Jacobian. The validity of the developed models is investigated through correlation function analysis. The open-loop response of the three models, viz., nonlinear, simplified nonlinear, and linearized models, is analyzed in the MATLAB/simulink platform. since the open-loop system is unstable, the experimental validation of the model is performed with a double-loop PsO (particle swarm optimization) PID control scheme.

关键词： Ball and plate system Correlation function Model validation Particle swarm optimization(PsO) PsO PID controller

Probing the Bardeen-Kiselev black hole with the cosmological constant caused by Einstein equations coupled with nonlinear electrodynamics using quasinormal modes and greybody bounds

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Communications in Theoretical Physics 2024年第6期76卷 102-119页

作者： s r Wu B Q Wang Z W Long College of Physics Guizhou UniversityGuiyang 550025China College Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this work,we investigate a static and spherically symmetric Bardeen-Kiselev black hole(BH)with the cosmological constant,which is a solution of the Einstein-non-linear Maxwell field *** compute the quasinormal frequencies for the Bardeen-Kiselev BH with the cosmological constant due to electromagnetic and gravitational *** varying the BH parameters,we discuss the behavior of both real and imaginary parts of the BH quasinormal frequencies and compare these frequencies with the reissner-Nordström-de sitter BH surrounded by quintessence(rN-dsQ).Interestingly,it is shown that the responses of the Bardeen-Kiselev BH with the cosmological constant and the rN-dsQ under electromagnetic perturbations are different when the charge parameter q,the state parameter w and the normalization factor c are varied;however,for the gravitational perturbations,the responses of the Bardeen-Kiselev BH with the cosmological constant and the rN-dsQ are different only when the charge parameter q is ***,compared with the gravitational perturbations,the electromagnetic perturbations can be used to understand nonlinear and linear electromagnetic fields in curved spacetime *** interesting observation is that,due to the presence of Kiselev quintessence,the electromagnetic perturbations around the Bardeen-Kiselev BH with the cosmological constant damps faster and oscillates slowly;for the gravitational perturbations,the quasinormal mode decays slowly and oscillates *** also study the reflection and transmission coefficients along with the absorption cross section in the Bardeen-Kiselev BH with the cosmological constant;it is shown that the transmission coefficients will increase due to the presence of Kiselev quintessence.

关键词： quasinormal modes greybody factors Bardeen-Kiselev black hole with cosmological constant

MgO-attached graphene nanosheet(MgO@GNs)reinforced magnesium matrix nanocomposite with superior mechanical,corrosion and biological performance

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2062-2076页

作者： s.Abazari A.shamsipur H.r.Bakhsheshi-rad M.s.soheilirad F.Khorashadizade s.s.Mirhosseini Department of Materials and Metallurgical Engineering Amirkabir University of TechnologyTehran ***Iran Iranian National standards Organization of Hormozgan HormozganIran Advanced Materials research Center Department of Materials EngineeringNajafabad BranchIslamic Azad UniversityNajafabadIran Department of Materials and Metallurgical Engineering Iran University of Science and TechnologyTehranIran

Magnesium(Mg)alloys are gaining great consideration as body implant materials due to their high biodegradability and ***,they suffer from low corrosion resistance and antibacterial *** this research,semi-powder metallurgy followed by hot extrusion was utilized to produce the magnesium oxide@graphene nanosheets/magnesium(MgO@GNs/Mg)composite to improve mechanical,corrosion and cytocompatibility *** have revealed that the incorporation of MgO@GNs nanohybrids into Mg-based composite enhanced microhardness and compressive *** vitro,osteoblast cell culture tests show that using MgO@GNs nanohybrid fillers enhances osteoblast adhesion and apatite *** presence of MgO@GNs nanoparticles in the composites decreased the opening defects,micro-cracks and micro-pores of the composites thus preventing the penetration of the corrosive solution into the *** demonstrated that the MgO@GNs/Mg composite possesses excellent antibacterial properties because of the combination of the release of MgO and physical damage to bacterium membranes caused by the sharp edges of graphene nanosheets that can effectively damage the cell wall thereby facilitating penetration into the bacterial lipid ***,the MgO@GNs/Mg composite with high mechanical strength,antibacterial activity and corrosion resistance is considered to be a promising material for load-bearing implant applications.

关键词： metal matrix composites MgO@GNs nanohybrid strengthening mechanisms antibacterial activity biocompatibility