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Treat to target in Crohn’s disease:A practical guide for clinicians

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World Journal of Gas.roenterology 2024年第1期30卷 50-69页

作者： Ashish r srinivasan Department of Gas.roenterology Austin HealthVictoriaMelbourne 3083Australia Department of Gas.roenterology Eastern HealthVictoriaMelbourne 3128Australia Department of Medicine University of MelbourneVictoriaMelbourne 3052Australia

A treat-to-target(T2T)approach applies the principles of early intervention and tight disease control to optimise long-term outcomes in Crohn's *** selecting Therapeutic Targets in Inflammatory Bowel Disease(s.rIDE)-II guidelines specify short,intermediate,and long-term treatment goals,documenting specific treatment targets to be achieved at each of these *** appraisal of Crohn’s disease activity against pre-defined treatment targets at these timepoints.remains central to determining whether current therapy should be continued or *** treatment targets in Crohn’s disease comprise combination clinical and patient-reported outcome remission,in conjunction with biomarker normalisation and endoscopic *** the s.rIDE-II guidelines endorse the pursuit of endoscopic healing,clinicians must consider that this may not always be appropriate,acceptable,or achievable in all *** underscores the need to engage patients at the outset in an effort to personalise care and individualise treatment *** use of non-invasive biomarkers such as faecal calprotectin in conjunction with cross-sectional imaging techniques,particularly intestinal ultrasound,holds great promise;as do emerging treatment targets such as transmural *** randomised clinical trials,namely,CALM and sTArDUsT,have evaluated the efficacy of a T2T approach in achieving endoscopic endpoints in patients with Crohn’s *** from these studies.reflect that patient subgroups and Crohn’s disease characteristics likely to benefit most from a T2T approach,remain to be ***,outside of clinical trials,data pertaining to the real-world effectiveness of a T2T approach remains scare,highlighting the need for pragmatic real-world *** the obvious promise of a T2T approach,a lack of guidance to support its integration into real-world clinical practice has the potential to limit its *** highlights the need to des.ribe st

关键词： Treat to target Inflammatory bowel disease Crohn’s disease Treatment targets Endoscopic remission Transmural healing Time to response Intestinal ultrasound

The influence of resistance exercise training pres.ription variables on skeletal muscle mass,s.rength,and physical function in healthy adults:An umbrella review

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Journal of sport and Health science 2024年第1期13卷 47-60页

作者： Jonathan C.Mcleod Brad s.Currier Caroline v.Lowisz stuart M.Phillips Department of Kinesiology Faculty of ScienceMcMaster UniversityHamilton L8S4L8Canada

Purpose:The aim of this umbrella review was to determine the impact of resistance training(rT)and individual rT pres.ription variables on muscle mass,s.rength,and physical function in healthy ***:Following Preferred reporting Items for systematic reviews and Meta-Analyses(PrIsMA)guidelines,we systematically searched and s.reened eligible systematic reviews.reporting the effects of differing rT pres.ription variables on muscle mass(or its proxies),s.rength,and/or physical function in healthy adults aged>18 ***:We identified 44 systematic reviews that met our inclusion *** methodological quality of these reviews was assessed using A Meas.rement Tool to Assess systematic reviews;standardized effectiveness statements were *** found that rT was consistently a potent stimulus for increasing skeletal muscle mass(4/4 reviews provide some or sufficient evidence),s.rength(4/6 reviews provided some or sufficient evidence),and physical function(1/1 review provided some evidence).rT load(6/8 reviews provided some or sufficient evidence),weekly frequency(2/4 reviews provided some or sufficient evidence),volume(3/7 reviews provided some or sufficient evidence),and exercise order(1/1 review provided some evidence)impacted rT-induced increases in muscular *** discovered that 2/3 reviews provided some or sufficient evidence that rT volume and contraction velocity influenced skeletal muscle mass,while 4/7 reviews provided insufficient evidence in favor of rT load impacting skeletal muscle *** was insufficient evidence to conclude that time of day,periodization,inter-set rest,set configuration,set end point,contraction velocity/time under tension,or exercise order(only pertaining to hypertrophy)influenced skeletal muscle adaptations.A paucity of data limited insights into the impact of rT pres.ription variables on physical ***:Overall,rT increased muscle mass,s.rength,and physical function compared to no ***

关键词： Hypertrophy resistance training resistance training pres.ription variables s.rength Umbrella review

Twinning aspects and their efficient roles in wrought Mg alloys:A comprehensive review

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Journal of Magnesium and Alloys 2024年第6期12卷 2201-2230页

作者： s.s.A.shah Manping Liu Azim Khan Farooq Ahmad M.r.Abdullah Xingquan Zhang shiwei Xu Zhen Peng school of Materials science and Engineering Jiangsu UniversityZhenjiang 212013China school of Mechanical Engineering Anhui University of TechnologyMáanshan 243002China College of Mechanical and vehicle Engineering Hunan UniversityChangsha 410082China

Twinning is widely recognized as an effective and cost-efficient method for controlling the micros.ructure and properties of wrought magnesium(Mg)***,twins play a crucial role in initiating dynamic recrystallization(DrX),while twin regions experience rapid recrystallization during static recrystallization(srX).The activation of twinning can lead to changes in lattice orientation,significantly impacting the final texture in Mg *** active roles of twinning are influenced by various factors during the activation process,and the mobility of twin boundaries(TB)can be amplified by s.ress effects,dislocation interactions,and thermal ***,annealing treatments that involve proper segregation or precipitation on TBs s.rve to stabilize them,res.raining their *** such as segregation may also alter the twinning propensity in Magnesium-rare earth(Mg-rE)***{10–11}contraction twins(CT)and{10–11}-{10–12}double twins(DT)can promote dynamic recrystallization(DrX),they also pose a risk as potential sources of voids and ***,understanding the nucleation and growth mechanisms of twinning is crucial,and these aspects are briefly reviewed in this *** the factors mentioned above,this article summarizes the recent research progress in this field,shedding light on advancements in recent eras.

关键词： Mg alloys Twinning recrystallization Texture Mechanical properties

Determining the Checkpoint of Transition from Thin to Thick Periodontal Phenotypes in the Maxillary and Mandibular Anterior regions of south Indian Population

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Journal of Forensic science and Medicine 2024年第1期10卷 55-61页

作者： Mohan Kumar Pasupuleti rasagna Chowdary G Gautami sPenmetsa vivek Bypalli ramesh s.v.Konathala sruthima N.v.s.Gottumukkala Department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia2Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Aim:The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incis.rs utilizing the probe visibility method and traditional way of meas.ring gingival thickness(GT)by endodontic ***:In 200 selected patients,the GT was meas.red at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival *** checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups:Group A:21-30 years;Group B:31-40 years;Group C:41-50 years;and Group D:51-60 ***:GT varied from 0.3 to 1.9 *** translucency was obs.rved up to the thickness of 0.7 *** 0.8 mm of GT,there was no probe ***:According to the present research,the gingiva appears transparent up to a thickness of around 0.7 *** checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.

关键词： Gingiva periodontal phenotype probe visibility

A novel diurnal and seasonal variation analysis of BTEX in Bengaluru urban area

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research in Cold and Arid regions 2024年第1期16卷 14-19页

作者： H.N.sowmya M.Dinamani G.P.shivashankara H.K.ramaraju B.s.s.rendra vijaya v.shanbhag r.Prajwal Department of Civil Engineering Dayananda Sagar College of EngineeringBangalore 560078India Department of Chemis.ry Dayananda Sagar College of EngineeringBangalore 560078India Department of Physics GFGCVijayanagarBengaluru 560040India

In the urban atmosphere of Bengaluru, various volatile organic compounds(vOCs), particularly Benzene,Toluene, Ethylbenzene, and Xylene(BTEX), have shown an increasing trend in concentration. The present research was conducted during summer and monsoon seasons, focusing on Kadubeesanahalli, a high-traffic area within the Bengaluru Metropolitan City. Hourly sample data was collected using a BTEX analyzer(Model GC955-600) and subsequently transformed into daily, monthly, and seasonal values. The study revealed distinct patterns in benzene concentrations. Benzene levels were lowest during the early morning hours, specifically from 1:00 *** 7:00 a.m.. Concentrations then increased from 7:00 a.m. to 9:00 a.m. and again from 4:00 p.m. to 11:00 p.m.,corresponding to the morning and evening peak traffic hours. However, between 10:00 a.m. and 4:00 p.m., the concentration decreased due to reduced traffic levels. These diurnal variations in benzene concentration are influenced by meteorological parameters. Comparing the two seasons, higher concentrations of Benzene, EthylBenzene, and MP-xylene were obs.rved during the summer season. This increase is attributed to the elevated temperatures during summer, which promote the vaporization of BTEX compounds. Conversely, lower BTEX concentrations were recorded during the monsoon season due to the wet deposition process. The obs.rved positive correlation(r > 0.5) among BTEX parameters s.rongly suggests a common source, most likely originating from vehicular emissions.

关键词： BTEX summer variation Meteorological parameters Correlation

Provenance and depositional setting of the Late MiocenePleistocene clastic sediments in the eastern Arabian Peninsula and western Iraq using rare earth elements geochemis.ry

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Acta Geochimica 2024年第2期43卷 399-410页

作者： salih M.Awadh Zinah s.Al-Ankaz Mohanad r.A.Al-Owaidi John s.Arms.rong-Altrin Department of Geology College of ScienceUniversity of BaghdadBaghdadIraq Department of Geology College of ScienceUniversity of WasitWasit 52011Iraq Department of Applied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unidad de Procesos Oceanicos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico Department of Marine sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements.rEE) and trace elements(sc, Co, v, and Th) concentrations in these sandstones.revealed that they likely derived from a single source. The steep light rare earth elements(LrEE) and flat, heavy rare earth element(HrEE) patterns, negative Eu anomaly, and high ΣrEE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣrEE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Aus.ralian shale. The higher proportion of LrEE compared to HrEE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/sc, La/sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late Miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian shield.

关键词： rEE Dibdibba formation Clastic sediments Passive continental margin

Geochemis.ry and mineralogy of beach sediments in the northern Gulf of Mexico,Tamaulipas state,Mexico:implication for provenance

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Journal of Palaeogeography 2024年第3期13卷 375-400页

作者： Mayank shukla sanjeet K.verma Mayla A.ramos-vázquez John s.Arms.rong-Altrin Karla r.Hernández-Martínez sumit Mis.ra vivek P.Malviya Héctor Hernández-Mendoza Pos.rado de la Division de Geociencias Aplicadas Instituto Potosino de Investigacion Científica y Tecnologica(IPICYT)Camino a la Presa San José2055San Luis Potosí78216Mexico Division de Geociencias Aplicadas Instituto Potosino de Investigación Científica y Tecnologica(IPICYT)Camino a la Presa San Jose 2055San Luis Potosí78216Mexico Universidad Nacional Autonoma de México Instituto de Ciencias del Mar y LimnologíaUnidad de ProcesosOceanicos y CosterosCiudad UniversitariaCiudad de México 04510Mexico Department of Marine sciences Bharathidasan UniversityTiruchirappalli620024Tamil NaduIndia Instituto de Geociencias Universidad Nacional Autonoma de MéxicoBoulevard Juriquilla 300176230JuriquillaQueretaroMexico Department of Applied Geology Dr.Harisingh Gour Central UniversitySagar470002Madhya PradeshIndia Instituto de Investigacion de Zonas Des.rticas Universidad Autònoma de San Luis PotosíAltair 200CP 78377San LuisS.L.P.Mexico Universidad del Centro de Mexico Capitán Caldera 75CP 78250San LuisS.L.P.Mexico

Geochemical and mineralogical studies were performed in the La Pesca(LP)and Tes.ro Altamira(TA)beach sediments,located in the Tamaulipas state,northern Gulf of *** main aim of this study is to infer the weathering history and provenance and to dis.riminate the tectonic environment of the beach *** sediments are composed of quartz with small amounts of access.ry minerals such as plagioclase,calcite,orthoclase,microcline,and *** beach sediments are classified as fine-grained and very well s.rted,however LP has coarse skewed and leptokurtic sediments,whereas TA has fine-skewed and very leptokurtic *** chemical index of weathering(CIW’)indicates intense weathering in the source *** quartz grain microtextures in the LP and TA are classified into mechanical,chemical,and mechanical/chemical *** features such as fractures,pits,percussion marks,abrasion fatigue,and v-shaped marks favor high-energy littoral,fluvial,subaqueous-marine,and aeolian *** chemical features indicate solution pits and crystalline overgrowth,which suggests a silica saturated marine *** mechanical/chemical features display adhering particles and elongated depressions suggest formation in a sub-aqueous nearshore marine *** and trace elements-based provenance dis.rimination diagrams indicate a felsic source derived from the Mesa Central(MC),sierra Madre Oriental(sMOr)and Oaxaquia *** major and trace element concentrations imply a passive margin setting for the northern Gulf of Mexico,which is consistent with the general geology.

关键词： Beach sediments Geochemis.ry Mineralogy Provenance Tamaulipas Tectonic setting

Investigations of nuclear chirality at iThemba LABs

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Frontiers of physics 2024年第2期19卷 7-38页

作者： r.A.Bark E.A.Lawrie C.Liu s.Y.Wang iThemba Laboratory for Accelerator Based sciences National Research FoundationP.O.Box 722Somerset-West 7129South Africa Department of Physics University of the Western CapePrivate Bag X177535BellvilleSouth Africa shandong Provincial Key Laboratory of Optical As.ronomy and solar-Terres.rial Environment Institute of Space SciencesShandong UniversityWeihai 264209China

Progress in the studies of chirality in atomic nuclei at iThemba LABs is *** regions of chirality,around mass 80 and 190 have been discovered using the AFrODITE array,specifically in the nuclei^(74)As,^(78,80,82)Br,^(81)Kr,and^(193,194,198)*** phenomena have been obs.rved,including multiple chiral bands in the same nucleus,the coexistence of octupole correlations and nuclear chirality,and the coexistence of pseudo spin and nuclear *** best example of chiral degeneracy to date was found in ^(194)*** level scheme of ^(106)Ag has been revisited and interpreted in terms of two-and four-quasiparticle *** using the particle-rotor model have shown that the fingerprints of chirality in the two-quasiparticle system only can occur in an idealised model *** systems with a higher number of quasiparticles,the calculations showed that nuclear chirality can persist.

关键词： chirality high-spin states particle-rotor model

Quality of drinking water and risk to the health of the population of the south Baikal region (russia)

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Emerging Contaminants 2024年第2期10卷 106-114页

作者： viktor s.rukavishnikov Natalia v.Efimova Mikhail F.savchenkov Inna v.Mylnikova Alexander A.Lisovtsov East-siberian Institute of Medical and Ecological research 665827AngarskRussia

Providing good quality water in sufficient quantities is a major challenge in the *** purpose of the study is to assess the quality of drinking water and the health risk of various population groups in the southern Baikal region(siberia,russia)under changing hydrological *** Baikal is the largest freshwater body of water and is one of the sites protected by *** and *** analysis of centralized and non-centralized water supply was carried out in the south-eastern part of the Irkutsk region,adjacent to Lake *** data used are from the Baikal(regional)Information Center for 2011–2022,and they include the results of monitoring the water quality of the centralized domestic and drinking water supply(CDW)with 140 thousand samples,and non-centralized domestic and drinking water supply(NDW)with 108 thousand *** all samples,17 substances were *** addition,during the flood period,accompanied by additional water disinfection,trihalomethanes were determined in populated areas exposed to negative *** quality of drinking water was assessed in comparison with the maximum permissible concentrations of substances(MPCs)approved by regulatory documents of *** assessment of the characteristics of drinking water consumption by the population of the Baikal region was carried out,based on interview data from sample groups of the *** assessment of the risk to public health,due to chronic oral intake of chemicals,was carried out using the values of the hazard coefficient(HQi),the hazard index(HI),individual carcinogenic risk(ICr),and population carcinogenic risk(PCr).village residents more often use underground water sources(centralized and non-centralized).residents of cities are provided with water from s.rface sources(Lake Baikal and the Angara river).significant concentrations of iron,nitrates,and manganese were found in drinking water used by *** concentrations of iron-2.25 mg/dl,manganese

关键词： Drinking water Noncarcinogenic risk Carcinogenic risk Population south Baikal region