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propulsion and power Research 2018年第1期7卷 91-101页

作者： C.sulochana s.p.samrat N.sandeep Department of Mathematics Gulbarga UniversityGulbarga 585106India Department of Mathematics Central University of KarnatakaGulbarga 585367India

present study is a numerical investigation of the flow,heat and mass transfer behaviour of magnetohydrodynamic flow over a vertical rotating cone through porous medium in the presence of thermal radiation,chemical reaction and soret ***,the numerical solutions are elucidated by using Runge-Kutta based shooting *** results are validated with open literature and found an excellent *** influence of non-dimensional governing parameters on velocity,temperature and concentration profiles along with the friction factor,local Nusselt and sherwood numbers are determined and discussed with the help of graphs and *** proved that the variable porosity parameter have tendency to enhance the heat and mass transfer *** increase in the buoyancy parameter depreciates the thermal and concentration boundary layer thicknesses.

关键词： Magnetohydrodynamic(MHD) Rotating cone Radiation soret Chemical reaction

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.p.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

On designing an unaided authentication service with threat detection and leakage control for defeating opportunistic adversaries

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Frontiers of Computer science 2021年第2期15卷 161-179页

作者： Nilesh CHAKRABORTY samrat MONDAL College of Computer science and software Engineering Shenzhen UniversityShenzhen518060China Department of Computer science Indian Institute of Technology PatnaBihar801106India

Unaided authentication services provide the flexibility to login without being dependent on any additional *** power of recording attack resilient unaided authentication services(RARUAs)is undeniable as,in some aspects,they are even capable of offering better security than the biometric based authentication ***,high login complexity of these RARUAs makes them far from usable in *** adopted information leakage control strategies have often been identified as the primary cause behind such high login *** recent proposals have made some significant efforts in designing a usable RARUAs by reducing its login complexity,most of them have failed to achieve the desired usability *** this paper,we have introduced a new notion of controlling the information leakage *** maintaining a good security standard,the introduced idea helps to reduce the login complexity of our proposed mechanism—named as Textual-Graphical password-based Mechanism or TGpM,by a significant *** with resisting the recording attack,TGpM also achieves a remarkable property of threat *** the best of our knowledge,TGpM is the first RARUAs,which can both prevent and detect the activities of the opportunistic recording attackers who can record the complete login activity of a genuine user for a few login *** study reveals that TGpM assures much higher session resiliency compared to the existing authentication services,having the same or even higher login ***,TGpM stores the password information in a distributed way and thus restricts the adversaries to learn the complete secret from a single compromised server.A thorough theoretical analysis has been performed to prove the strength of our proposal from both the security and usability *** have also conducted an experimental study to support the theoretical argument made on the usability standard of TGpM.

关键词： authentication recording attack premature attack opportunistic adversary leakage control threat prevention threat detection

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of parkinson’s disease(pD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes pD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Recent advances in semimetallic pnictogen (As, sb, Bi) based anodes for sodium-ion batteries: structural design, charge storage mechanisms, key challenges and perspectives

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Nano Research 2021年第11期14卷 3690-3723页

作者： samrat sarkar swagata Roy Yufeng Zhao Jiujun Zhang Institute for sustainable Energy & College of sciences Shanghai University Shanghai 200444 China

In the recent times sodium ion batteries(sIBs)have come to the forefront as an economic and resourceful alternative to lithium-ion batteries(LIBs)for powering portable electronic devices and large-scale grid *** the specific capacity,energy density and long cycle life of batteries depend upon the performance of anode materials;their quest is the ultimate need of the *** the anode materials,the semimetallic pnictogens(As,sb,Bi)and their compounds offer high gravimetric/volumetric capacities,but suffer from undesired volume expansion and inferior electrical ***,this paper reviews the recent progress in semimetallic pnictogens as alloying anodes and their compounds mainly as conversion-alloying *** debatable sodiation mechanisms(intercalation or alloying)have been presented with emphasis on in situ/ex situ advanced characterization methods well supported by theoretical modeling and *** reviewed electrochemical reaction mechanisms,coherent structural designs and engineering provide a vital understanding of the electrochemical processes of Na^(+) ion *** existing challenges and perspectives are also presented,and several research directions are proposed from the aspects of special morphological design,employing conductive substrates,electrolyte additives and reducing particle size for technical and commercial success of sIBs.

关键词： sodium-ion battery anode pnictogen arsenic antimony bismuth

Multi-Headed Deep Learning Models to Detect Abnormality of Alzheimer’s patients

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Computer systems science & Engineering 2023年第1期44卷 367-390页

作者： s.Meenakshi Ammal p.s.Manoharan Department of Electrical and Electronics Engineering Thiagarajar College of EngineeringMadurai625015Tamil NaduIndia

Worldwide,many elders are suffering from Alzheimer’s disease(AD).The elders with AD exhibit various abnormalities in their activities,such as sleep disturbances,wandering aimlessly,forgetting activities,etc.,which are the strong signs and symptoms of AD *** these symptoms in advance could assist to a quicker diagnosis and treatment and to prevent the progression of Disease to the next *** proposed method aims to detect the behavioral abnormalities found in Daily activities of AD patients(ADp)using *** the proposed work,a publicly available dataset collected using wearables is ***,no real-world data is available to illustrate the daily activities of ***,the proposed method has synthesized the wearables data according to the abnormal activities of *** the proposed work,multi-headed(MH)architectures such as MH Convolutional Neural Network-Long short-Term Mem-ory Network(CNN-LsTM),MH one-dimensional Convolutional Neural Network(1D-CNN)and MH two dimensional Convolutional Neural Network(2D-CNN)as well as conventional methods,namely CNN-LsTM,1D-CNN,2D-CNN have been implemented to model activity pattern.A multi-label prediction technique is applied to detect abnormal *** results obtained show that the proposed MH architectures achieve improved performance than the conventional ***,the MH models for activity recognition perform better than the abnormality detection.

关键词： Alzheimer’s disease abnormal activity detection classifier chain multi-headed CNN-LsTM wearable sensor

Experimental Investigation on Friction Welding of UNs s32205 Duplex stainless steel

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Acta Metallurgica sinica(English Letters) 2014年第6期27卷 995-1007页

作者： p. M. Ajith p. sathiya s. Aravindan Department of production Engineering National Institute of Technology Department of Mechanical Engineering Indian Institute of Technology Delhi

UNs s 32205 duplex stainless steel specimens were joined by continuous drive friction welding process. The experiments were conducted as per the Taguchi（L16 orthogonal array） method. The friction welding process parameters such as heating pressure, heating time, upsetting pressure, upsetting time, and speed of rotation were fixed with low,medium, and high levels of range based on the machine capacity, and the required knowledge was acquired from the preliminary experiments. The joint characterization studies included micro structural examination and evaluation of mechanical properties of the joints. Microhardness variation, impact toughness, and tensile strength of the joints were evaluated. Neither a crack nor an incomplete bonding zone was observed. The tensile strength of the joints was higher than the strength of the base material, and the friction and upsetting pressures were found to influence the joint strength. The tensile strength of all the welds was observed to be increasing with an increase in the rotational speed. The toughness of the friction welds was evaluated at room temperature and also at subzero（cryo） temperature conditions. The toughness for friction welds was found to be superior to the fusion welds of duplex stainless steel at room temperature and cryo conditions. Weldments exhibited better corrosion resistance than the parent material.

关键词： Duplex stainless steel Hardness Tensile strength Toughness Microstructure Corrosion

On the Optimization of performance of Hg_xCd_(1-x)s Based Electrochemical photosensing Cell

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稀有金属材料与工程 2012年第S1期41卷 43-46页

作者： Lendave s AL p pingale p CL p Deshmukh L p Thin Film and solar studies Research Laboratory Department of Physics(Appli.Elect.)Solapur UniversitySolapur-413255M.S.India

Chemical growth process that favours deposition of semiconductor materials from a liquid phase was used to obtain Cds and HgxCd1-xs(0≤x≤0.25)photosensitive thin film electrodes on the stainless steel *** deposition of these series of thin films was carried out under the optimized conditions of temperature(60℃),time(90 min)and pH(10.8±0.2).These films were then employed as photosensitive electrode in an electrochemical photosensing cell consisting of sulphide/polysulphide redox electrolyte and a graphite counter *** cells were illuminated by an input illumination intensity of 13 mW/cm 2 and the cell characteristic parameters namely photocurrent(Iph),photo voltage(Vph),the quantum conversion efficiency(η%)and fill factor(ff %)have been *** Vph and Iph have been found to be boosted as the electrode composition is *** conversion efficiency and fill factor enhanced from 0.52%to 1.30%and 31.8%to 37.8%,respectively for the change of electrode composition from 0 to *** of junction ideality factor(nd)showed recombination mechanism at the electrode-electrolyte *** height measurements gave pool-Frenkel type conduction *** flat band potentials(Vfb)were determined for all the cells and found to be enhanced with x up to 0.08 and then decreased for further increase in *** lighted junction quality factor(nL)is increased from 1.49 to 2.94 as the photoelectrode composition(x)was varied from 0 to *** barrier heights(B)at the electrode/electrolyte interfaces were also *** is found that B is higher for a cell of electrode composition equal to *** spectral studies on these cells showed the cut off wavelength(λc)shifted from 530 nm to 800 *** transient response studies showed presence of surface states at the interface that causes Fermi-level ***,performance of the electrochemical photosensing cell is found to be improved after Hg-corboration in Cds and is optimum at x= 0.0

关键词： electrochemical cell photosensing fill factor interface states photovoltage photocurrent