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Decadal change of East Asian summer tropospheric temperature meridional gradient around the early 1990s

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science China Earth sciences 2015年第9期58卷 1609-1622页

作者： ZHANG LiXia zhou TianJun LAsG Institute of Atmospheric Physics Chinese Academy of Sciences Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science and Technology Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science & Technology Joint Center for Global Change studies

During 1979–2004, the East Asian summer precipitation has experienced another significant decadal shift around the early 1990 s. Based on three radiosonde temperature datasets and four reanalysis datasets, this paper examines the decadal change of the East Asian summer tropospheric temperature around the early 1990 s. The results show that the meridional gradient of layer mean upper tropospheric temperature for 200–500 h pa(here after UTT, UTT is upper tropospheric temperature) also underwent an obvious decadal decrease around 1992. The tropospheric temperature south to 35°N becomes decadal cooling, centered along the Yangtze River Valley, while the tropospheric temperature north to 35°N shows a decadal warming, centered in Northwest China-Mongolia. JRA-25 reanalysis is better than the other reanalysis datasets in revealing this decadal change. This decadal shift of East Asian summer UTT may be ascribed to the decadal change of the ENsO period from low-frequency oscillation(4–6 yr) to quasi-biennial oscillation since 1992. It behaves as an increase of ENsO developing events and a reduction of ENsO decaying events. It leads to stronger forcing of ENsO developing summer and weaker forcing of ENsO decaying summer, leading to the dominant role of monopole cooling mode of East Asian UTT after 1992, in contrast to the dominant role of dipole mode of East Asia UTT before 1992. The summer UTT difference between 1993–2004 and 1979–1992 shows a "south cooling-North Warming" pattern, and thereby contributes to the interdecadal decrease of East Asian summer UTT meridional gradient around 1992.

关键词： decadal variation around the early 1990s East Asian summer monsoon change of ENsO period

GluN2B-NMDA receptors in Alzheimer's disease:beyond synapse loss and cell death

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Neural Regeneration Research 2014年第21期9卷 1878-1879页

作者： Qiang zhou school of Chemical Biology and Biotechnology peking University shenzhen Graduate school

Alzheimer＇s disease （AD） is one of the most devastating dis- eases affecting the life and health of aging population. Two hallmarks of AD are senile plaques and neurofibrillary tan- gles, and AD is well known for the massive loss of neurons and impaired cognitive functions especially memory loss. Despite extensive search for effective treatment, available drugs have limited efficacy without affecting the course of AD. significant efforts have been devoted to curb the pro- duction of amyloid [3 （A[3; the major component of plaques） or enhance the clearance of it, with the aim to reduce the accumulation of plaque in the brain. Antibodies that can bind A[3 to increase their removal have received a lot of at- tention although recent clinical trial results have been largely negative and disappointing （panza et al., 2014）. Targets that are not directly related to A[3 have also been pursued. One such target is N-methyl-D-aspartate （NMDA） receptors （NMDARs）, a subclass of glutamate receptors. The antago- nist of NMDAR memantine has been approved for treating moderate to severe AD, although the exact mechanism un- derlying its action is still in debate （Kotermanski and John- son, 2009）.

关键词： GluN2B-NMDA receptors in Alzheimer’s disease NMDA NMDAR

A Flexible smart Healthcare platform Conjugated with Artificial Epidermis Assembled by Three‑Dimensionally Conductive MOF Network for Gas and pressure sensing

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Nano-Micro Letters 2025年第2期17卷 601-620页

作者： Qingqing zhou Qihang Ding Zixun Geng Chencheng Hu Long Yang Zitong Kan Biao Dong Miae Won Hongwei song Lin Xu Jong seung Kim state Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry Korea UniversitySeoul 02841Republic of Korea TheranoChem Incorporation Seoul 02856Republic of Korea

The rising flexible and intelligent electronics greatly facilitate the noninvasive and timely tracking of physiological information in telemedicine *** building bionic-sensitive moieties is vital for designing efficient electronic skin with advanced cognitive functionalities to pluralistically capture external ***,realistic mimesis,both in the skin’s three-dimensional interlocked hierarchical structures and synchronous encoding multistimuli information capacities,remains a challenging yet vital need for simplifying the design of flexible logic ***,we construct an artificial epidermal device by in situ growing Cu_(3)(HHTp)_(2) particles onto the hollow spherical Ti_(3)C_(2)T_(x) surface,aiming to concurrently emulate the spinous and granular layers of the skin’s *** bionic Ti_(3)C_(2)T_(x)@Cu_(3)(HHTp)_(2) exhibits independent NO_(2) and pressure response,as well as novel functionalities such as acoustic signature perception and Morse code-encrypted message ***,a wearable alarming system with a mobile application terminal is self-developed by integrating the bimodular senor into flexible printed *** system can assess risk factors related with asthmatic,such as stimulation of external NO_(2) gas,abnormal expiratory behavior and exertion degrees of fingers,achieving a recognition accuracy of 97.6%as assisted by a machine learning *** work provides a feasible routine to develop intelligent multifunctional healthcare equipment for burgeoning transformative telemedicine diagnosis.

关键词： Ti_(3)C_(2)T_(x)@Cu_(3)(HHTp)_(2)composites NO_(2)/pressure flexible sensors Health-monitoring Machine learning

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论监察从宽处罚建议制度的适用及其完善

海南大学学报（人文社会科学版） 2025年第1期43卷 217-226页

作者：周建成海南大学法学院海南海口570228

监察从宽处罚建议是监察机关在职务犯罪案件调查过程中享有的一项职权,该项制度对于落实宽严相济的刑事政策以及提高职务犯罪案件调查效果具有重要意义。《中华人民共和国监察法》《中华人民共和国监察法实施条例》对监察从宽处罚建议... 详细信息

监察从宽处罚建议是监察机关在职务犯罪案件调查过程中享有的一项职权,该项制度对于落实宽严相济的刑事政策以及提高职务犯罪案件调查效果具有重要意义。《中华人民共和国监察法》《中华人民共和国监察法实施条例》对监察从宽处罚建议制度的适用条件和程序进行了明确规定,监察实践中该项制度的适用也取得了较好的效果。但是结合规范与实践分析,监察从宽处罚建议适用制度仍然存在着适用条件模糊、适用效力不清以及适用比例不均衡等现象,为此应当在厘清监察从宽处罚建议性质的基础上,有针对性地对该项制度进行完善,以发挥其在职务犯罪案件处理中的作用。

关键词：监察从宽处罚建议制度认罪认罚从宽制度适用条件适用效力

维普期刊数据库博看期刊

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美丽中国建设的制度体系研究

生态经济 2025年第1期41卷 13-18页

作者：董战峰周佳生态环境部环境规划院北京100041

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中... 详细信息

制度体系是美丽中国建设的根本保障。改革开放四十多年以来,我国基本建立了一套行之有效的生态文明制度体系,但与全面推进美丽中国建设的要求相比还存在较大差距。论文分析了美丽中国建设的制度基础和面临的关键挑战,明确了促进美丽中国建设的制度体系思路,提出了健全生态环境空间管控、责任体系、市场体系等十大重点任务,为全面推进美丽中国建设提供坚实支撑。

关键词：美丽中国生态文明制度环境治理现代化重点任务

promoting the Na^(+)-storage of NiCo_(2)s_(4) hollow nanospheres by surfacing Ni-B nanoflakes

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Journal of Materials science & Technology 2021年第23期82卷 114-121页

作者： Jingfa Li Jian zhou Qihao zhou Xin Wang Cong Guo Min Li school of Chemistry and Materials science Nanjing University of Information Science and TechnologyNanjing210044JiangsuChina Jiangsu Key Laboratory for Optoelectronic Detection of Atmosphere and Ocean School of Physics and Optoelectronic EngineeringNanjing University of Information Science and TechnologyNanjing210044JiangsuChina

sodium ion battery(sIB)is considered as the potential alternative for next generation energy system to succeed the lithium ion battery(LIB)due to the low price and vast abundance of Na *** metal sulfide is identified as an impo rtant redox conversion type of negative electrode for *** this study,amorphous nickel boride(Ni-B)nanoflakes are introduced into the hollow Ni-Co sulfide nanospheres by a facile in situ solution growth route to promote the electrochemical performance of Na^(+)-*** measurements demonstrate that the Ni-B component could effectively improve the redox kinetics of the conversion reaction and structural stability during long-term Na^(+)insertion/*** example,the NiCo_(2)s_(4)@Ni-B composites display a high reversible capacity of 251.9 mA h g^(-1)at the current density of 1.0 A g^(-1)after 200 cycles,much higher than that of bare NiCo_(2)s_(4)(37.4 mA h g^(-1)at 1.0 A g^(-1)after 200 cycles).As a consequence,these results demonstrate a new sight to explore heterostructures of mixed metal-sulfides electrode materials with superior Na^(+)-storage performances.

关键词： surface growth Ternary metal sulfides Redox kinetics sodium ion battery

small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching

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Neural Regeneration Research 2025年第9期20卷 2624-2632页

作者： Jangampalli Adi pradeepkiran priyanka Rawat Arubala p.Reddy Erika Orlov pHemachandra Reddy Department of Internal Medicine Texas Tech University Health Sciences CenterLubbockTXUSA Department of Nutritional sciences College of Human SciencesTexas Tech UniversityLubbockTXUSA Department of pharmacology&Neuroscience Texas Tech University Health Sciences CenterLubbockTXUSA Department of Neurology Texas Tech University Health Sciences CenterLubbockTXUSA Department of speech Language and Hearing SciencesTexas Tech University Health Sciences CenterLubbockTXUSA Department of public Health Texas Tech University Health Sciences CenterLubbockTXUSA

The process of neurite outgrowth and branching is a crucial aspect of neuronal development and *** and dendrites,sometimes referred to as neurites,are extensions of a neuron's cellular body that are used to start *** we explored the effects of diethyl(3,4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ)on neurite developmental features in HT22 neuronal *** this work,we examined the protective effects of DDQ on neuronal processes and synaptic outgrowth in differentiated HT22cells expressing mutant Tau(mTau)*** investigate DDQ chara cteristics,cell viability,biochemical,molecular,western blotting,and immunocytochemistry were *** outgrowth is evaluated through the segmentation and measurement of neural *** neural processes can be seen and measured with a fluorescence microscope by manually tracing and measuring the length of the neurite *** neuronal processes can be observed and quantified with a fluorescent microscope by manually tracing and measuring the length of the neuronal ***-treated mTau-HT22 cells(HT22 cells transfected with cDNA mutant Tau)were seen to display increased levels of synaptophysin,MAp-2,andβ-***,we confirmed and noted reduced levels of both total and p-Tau,as well as elevated levels of microtubule-associated protein 2,β-tubulin,synaptophysin,vesicular acetylcholine transporter,and the mitochondrial biogenesis protein-pe roxisome prolife rator-activated receptor-gamma coactivator-1α.In mTa u-expressed HT22 neurons,we observed DDQ enhanced the neurite characteristics and improved neurite development through increased synaptic *** findings conclude that mTa u-HT22(Alzheimer's disease)cells treated with DDQ have functional neurite developmental chara *** key finding is that,in mTa u-HT22 cells,DDQ preserves neuronal structure and may even enhance nerve development function with mTa u inhibition.

关键词： diethyl(3 4-dihydroxyphenethylamino)(quinolin-4-yl)methylphosphonate(DDQ) hippocampal neuronal cells HT22 neurite outgrowth neuronal development small molecule

Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

Microglial dysfunction and genetic risk for neurodegenerative disease

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Neural Regeneration Research 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay penney Department of Biomedical sciences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative disorders such as Alzheimer's and parkinson's diseases a re increasing in prevalence as world populations *** tremendous progress has been made,our understanding of the mechanisms that underlie the development of these diseases remains far from com *** troubling,despite the growing emotional and financial toll being to ken by neurodegenerative disorders,existing treatment options are limited almost exclusively to those that help manage symptoms but that lack the ability to alter the progression of the disease(Liu et al.,2022).

关键词： degenerative diseases