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structural build-up model for three-dimensional concrete printing based on kinetics theory

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Frontiers of structural and Civil Engineering 2024年第7期18卷 998-1014页

作者： prabhat Ranjan pREM p.s.AMBILY shankar kumar Greeshma GIRIDHAR Dengwu JIAO Advanced Materials Laboratory CSIR-Structural Engineering Research CentreChennai 600113India Department of Architecture and Civil Engineering City University of Hong KongHong Kong 999077China

The thixotropic structural build-up is crucial in extrusion-based three-dimensional(3D)concrete *** paper uses a theoretical model to predict the evolution of static and dynamic yield stress for printed *** model employs a structural kinetics framework to create a time-independent constitutive link between shear stress and shear *** model considers flocculation,deflocculation,and chemical hydration to anticipate structural *** reversible and irreversible contributions that occur throughout the build-up,breakdown,and hydration are defined based on the proposed structural ***,detailed parametric studies are conducted to evaluate the impact of model *** is revealed that the proposed model is in good agreement with the experimental results,and it effectively characterizes the structural build-up of 3D printable concrete.

关键词： structural build-up rheology thixotropy 3D printable concrete kinetics theory ultra high performance concrete

Enhancing fatigue performance of AZ31 magnesium alloy components fabricated by cold metal transfer-based wire arc directed energy deposition through LpB

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Journal of Magnesium and Alloys 2024年第4期12卷 1638-1662页

作者： shambhu kumar Manjhi srikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Transfer-Based Wire Arc Directed Energy Deposition(CMT-WA-DED)presents a promising avenue for the rapid fabrication of components crucial to automotive,shipbuilding,and aerospace ***,the susceptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components has impeded their widespread adoption for critical load-bearing *** this study,a comprehensive investigation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has been carried out and compared to commercially available wrought AZ31 *** findings indicate that the as-deposited parts exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor surface finish,tensile residual stress,porosity,and coarse grain microstructure inherent in the WA-DED *** plasticity Burnishing(LpB)treatment is applied to mitigate these issues,which induce significant plastic deformation on the *** treatment resulted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in surface roughness,grain refinement and enhancement of compressive residual stress ***,during cyclic deformation,WA-DED specimens exhibited higher plasticity and dislocation density compared to both wrought and WA-DED+LpB specimens.A higher fraction of Low Angle Grain Boundaries(LAGBs)in WA-DED specimens contributed to multiple crack initiation sites and convoluted crack paths,ultimately leading to premature *** contrast,wrought and WA-DED+LpB specimens displayed a higher percentage of High Angle Grain Boundaries(HAGBs),which hindered dislocation movement and resulted in fewer crack initiation sites and less complex crack paths,thereby extending fatigue *** findings underscore the effectiveness of LpB as a post-processing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** study highlights the importance of LpB surface treatment on AZ31 Mg components produced by CMT-WA-DED to remove surface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plasticity burnishing Low cycle fatigue test strain amplitude

Bile acid metabolism and signaling in health and disease:molecular mechanisms and therapeutic targets

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signal Transduction and Targeted Therapy 2024年第5期9卷 2014-2064页

作者： Joshua s.Fleishman sunil kumar Department of pharmaceutical sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNYUSA

Bile acids,once considered mere dietary surfactants,now emerge as critical modulators of macronutrient(lipid,carbohydrate,protein)metabolism and the systemic pro-inflammatory/anti-inflammatory *** acid metabolism and signaling pathways play a crucial role in protecting against,or if aberrant,inducing cardiometabolic,inflammatory,and neoplastic conditions,strongly influencing health and *** curative treatment exists for any bile acid influenced disease,while the most promising and well-developed bile acid therapeutic was recently rejected by the ***,we provide a bottom-up approach on bile acids,mechanistically explaining their biochemistry,physiology,and pharmacology at canonical and non-canonical *** this mechanistic model of bile acids,we explain how abnormal bile acid physiology drives disease pathogenesis,emphasizing how ceramide synthesis may serve as a unifying pathogenic feature for cardiometabolic *** provide an in-depth summary on pre-existing bile acid receptor modulators,explain their shortcomings,and propose solutions for how they may be ***,we rationalize novel targets for further translational drug discovery and provide future *** than dismissing bile acid therapeutics due to recent setbacks,we believe that there is immense clinical potential and a high likelihood for the future success of bile acid therapeutics.

关键词： metabolism rejected shortcomings

Fuzzy Reliability and Availability of system under a Calendar-based Inspection Involving Multiple Failures and Its Application to Wind Turbine system

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Journal of systems science and systems Engineering 2024年第2期33卷 187-206页

作者： Mintu kumar Himani pant s.B.singh Department of Mathematics statistics and Computer science G.B.Pant University of AgricultureTechnologyPantnagarUttarakhandIndia

Uncertainty is an important factor that needs to be considered while analyzing the performance of any engineering *** order to quantify uncertainty,fuzzy set theory is frequently used by most of researchers,including energy system *** to the classical reliability theory,component lifetimes have crisp parameters,but due to uncertainty and inaccuracy in data,it is sometimes very difficult to determine the exact values of these parameters in real-world *** overcome this difficulty in the current research,failure and repair rates were taken as triangular fuzzy numbers to determine the fuzzy availability of a system undergoing calendar-based periodic inspection subject to multiple failure modes(FMs).It was assumed that each component in the system had an exponential failure rate and repair rate with fuzzy *** FMs were explicitly taken into account when a functional state of the system was *** FM had a random failure *** the occurrence of any failure,a random time was selected for the relevant corrective repair *** proposed research was studied for one of the major sources of green energy,namely a wind turbine system wherein all the derived propositions have been implemented on it.

关键词： Fuzzy reliability fuzzy availability wind turbine system multiple failure modes triangular fuzzy number

Comparison of the Anatomy and Adaptability of Reconstructed Teeth with Natural Teeth:An Innovative Approach in Forensic Dentistry

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Journal of Forensic science and Medicine 2024年第1期10卷 47-54页

作者： supraja s p M Tejaswi Ravikanth Manyam Mohan kumar pasupuleti swetha p Ramesh kumar Budumuru Department of Oral and Maxillofacial pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Vishnu Dental College BhimavaramAndhra PradeshIndia Department of periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Department of Oral Medicine and Radiology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Background:Forensic tooth reconstruction is the technique of reconstructing the morphology of a missing tooth from the intra-alveolar morphology of dental sockets from skeletal *** and Objectives:The aim and objective of the study are to compare and investigate whether the anatomy and adaptability of reconstructed teeth simulate with the natural tooth and to investigate whether the dental materials have potential in reconstruction of *** and Methods:An in vitro experimental study was undertaken on a human *** to the Fédération Dentaire Internationale,charting will be done based on the number of teeth *** entire study will be conducted in three phases using dental *** 1 comprised preparation for negative replica,where an impression will be taken,phase 2 comprised preparation of a positive replica or cast,and phase 3 comprised tooth reconstruction using the flowable ***:The specimen tooth(which had been taken from its socket)and the newly constructed tooth were compared,and when the length of the newly constructed root was measured using digital vernier calipers,there was a disparity of 0.5-1 *** cone-beam computed tomography radiographs demonstrated the necessary ***:The present study demonstrated that dental information can be obtained even when teeth are absent postmortem by making an attempt to recreate the teeth using dental materials while documenting the intra-alveolar anatomy of the dental root socket.

关键词： Adaptability anatomy reconstruction teeth

protected simultaneous quantum remote state preparation scheme by weak and reversal measurements in noisy environments

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Chinese physics B 2024年第2期33卷 169-177页

作者： Mandal Manoj kumar Choudhury Binayak s. samanta soumen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is possible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote state preparation noisy environments weak and reversal measurements

Enhancing Multicriteria-Based Recommendations by Alleviating scalability and sparsity Issues Using Collaborative Denoising Autoencoder

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Computers, Materials & Continua 2024年第2期78卷 2269-2286页

作者： s.Abinaya K.Uttej kumar school of Computer science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender system(Rs)is a crucial part of several firms,particularly those involved in *** conventional Rs,a user may only offer a single rating for an item-that is insufficient to perceive consumer ***,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’*** the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested ***,the cost of these computations increases nonlinearly as the number of items and users *** triumph over the issues,a novel expanded stacked autoencoder(EsAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is proposed with two *** the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the EsAE approach and users are clustered using the KFCM *** the next phase of online,the top-N recommendation prediction is made by the EsAE approach involving only the most similar user from multiple *** the EsAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation *** experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the EsAE_KFCM model constantly outperforms conventional Rs algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder Kernel Fuzzy C-Means Clustering

Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth p.R.Vikram Tegginamath pramod kumar Gunjan kumar Narasimha M.Beeraka Rajashree Deka sheik Mohammed suhail sandeep Jat Namitha Bannimath Gayatiri padmanabhan Ravandur s.Chandan pramod kumar Bannimath Gurupadayya Department of pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare pvt.Ltd. New Delhi110076India Department of pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds,particularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(ApIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Identification of gene classifier and modules associated with sARs-CoV-2 ARI in nasal swab

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Genes & Diseases 2024年第1期11卷 38-41页

作者： pandikannan Krishnamoorthy Athira s.Raj Himanshu kumar Department of Biological sciences Laboratory of Immunology and Infectious Disease BiologyIndian Institute of Science Education and Research(llSER)BhopalBhopalMP 462066India Laboratory of Host Defense WPl ImmunologyFrontier ResearchCentreOsakaUniversityOsaka 5650871Japan

During a sudden viral pandemic,where the pathogenesis and nature of the infection are unclear,early and accurate identification of the patients infected with the pandemiccausing pathogen is crucial to prevent excess *** the coronavirus disease 2019(COvID-19)pandemic,early diagnosis of severe acute respiratory syndrome virus-2(sARs-CoV-2)is limited by the incidence of the symptoms that are shared with acute respiratory illnesses(ARl)caused by other pathogens.

关键词： acute diagnosis respiratory