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MicroRNA-502-3p regulates GABAergic synapse function in hippocampal neurons

Neural Regeneration Research 2024年第12期19卷 2698-2707页

作者： Bhupender sharma Melissa MTorres sheryl Rodriguez Laxman Gangwani subodh kumar Center of Emphasis in Neuroscience Department of Molecular and Translational MedicinePaul L.Foster School of MedicineTexas Tech University Health Sciences CenterEl PasoTXUSA Bond Life sciences Center and Department of Veterinary pathobiology University of MissouriColumbiaMOUSA L.Frederick Francis Graduate school of Biomedical sciences Texas Tech University Health Sciences CenterEl PasoTXUSA

Gamma-aminobutyric acid(GABA)ergic neurons,the most abundant inhibitory neurons in the human brain,have been found to be reduced in many neurological disorders,including Alzheimer's disease and Alzheimer's disease-related *** previous study identified the upregulation of microRNA-502-3p(miR-502-3p)and downregulation of GABA type A receptor subunitα-1 in Alzheimer's disease *** study investigated a new molecular relationship between miR-502-3p and GABAergic synapse *** vitro studies were perfo rmed using the mouse hippocampal neuronal cell line HT22 and miR-502-3p agomiRs and *** silico analysis identified multiple binding sites of miR-502-3p at GABA type A receptor subunitα-1 *** assay confirmed that miR-502-3p targets the GABA type A receptor subunitα-1 gene and s.p.resses the luciferase ***,quantitative reve rse transcription-polymerase chain reaction,miRNA in situ hybridization,immunoblotting,and immunostaining analysis confirmed that overexpression of miR-502-3p reduced the GABA type A receptor subunitα-1 level,while s.p.ression of miR-502-3p increased the level of GABA type A receptor subunitα-1 ***,as a result of the overexpression of miR-502-3p,cell viability was found to be reduced,and the population of necrotic cells was found to be *** whole cell patch-clamp analysis of human-GABA receptor A-α1/β3/γ2L human embryonic kidney(HEK)recombinant cell line also showed that overexpression of miR-502-3p reduced the GABA current and overall GABA function,suggesting a negative correlation between miR-502-3p levels and GABAergic synapse ***,the levels of proteins associated with Alzheimer s disease were high with miR-502-3p overexpression and reduced with miR-502-3p *** present study provides insight into the molecular mechanism of regulation of GABAergic synapses by *** propose that micro-RNA,in particular miR-502-3p,could be a potential the

关键词： Alzheimer's disease GABAergic synapse gamma-aminobutyric acid type A receptor subunitα-1(GABRα1) microRNA-502-3p(miR-502-3p) miRNA in situ hybridization patch-clamp

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Entropy generation minimization in the Carreau nanofluid flow over a convectively heated inclined plate with quadratic thermal radiation and chemical reaction:A stefan blowing application

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propulsion and power Research 2024年第2期13卷 233-244页

作者： B.Lavanya J.Girish kumar M.Jayachandra Babu C.s.K.Raju Bander Almutairi Nehad Ali shah Department of Mathematics Manipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India Department of Mathematics S.V.A Government CollegeSrikalahasti 517644India Department of Mathematics GITAM School of Science(GSS)GITAMBangaloreKarnatakaIndia Department of Mathematics College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Mechanical Engineering Sejong UniversitySeoul 05006South Korea

Entropy analysis can help to identify the sources of entropy generation in a heat transfer process more accurately than other methods,such as energy efﬁciency *** is because entropy analysis takes into account the quality of energy as well as its ***-noﬂuids have already been shown to have s.p.rior heat transfer characteristics compared to conventionalﬂ*** blowing can further enhance the heat transfer capabilities of nano-ﬂuids by increasing the massﬂux and turbulence at the *** can be beneﬁcial in a wide range of applications,such as heat exchangers,electronic cooling,and solar energy *** convective boundary condition accounts for heat transfer effects,inﬂuencing temperature distribution and the thermal boundary *** on the direction of heat transfer,the convective boundary condition can induce cooling or heating effects on the inclined *** has.p.actical implications for various engineering applications,such as the cooling of electronic devices or heating in industrial *** nanofluids have a wide range of potential applications in heat transfer,energy storage,drug delivery,and food *** research investigates how the presence of stefan blowing affects the properties of Carreau nanofluid flow across a convectively heated tilted *** and mass transport phenomena are studied using quadratic thermal radiation and chemical reaction *** mathematical model for this work is based on the Buongiorno *** governing equations are converted into a system of ordinary differential equations and then solved using the bvp4c *** parameters such as the mass transfer rate can be visualized using bar *** study’s.p.imary findings are that when the Weissenberg number increases,the velocity rises and the concentration profile declines due to Brownian *** is discovered that,when 0.5≤γ≤3(the inverse porosity parameter),the friction factor declines by 0.34001(

关键词： Thermal radiation BVp4C stefan blowing Biot number Brownian motion Irreversibilit

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scenario of solar energy and policies in India

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Clean Energy 2024年第5期8卷 117-128页

作者： sathish kumar M prity kumari Y.A.Lad sherin Maria Teaching Assistant Symbiosis Institute of Business ManagementSymbiosis International(Deemed)UniversityNagpur440008MaharashtraIndia Assistant professor and Head Department of Basic ScienceCollege of HorticultureAnand Agricultural UniversityAnand388110GujaratIndia Associate professor&Head Department of HRD&PMInternational Agribusiness Management InstituteAnand Agricultural UniversityAnand388110GujaratIndia Research Assistant International Maize and Wheat Improvement Center(CIMMYT)HyderabadTelanganaIndia

solar power is energy from the sun that is converted into thermal or electrical ***,the UsA,and India have the world’s richest solar energy *** receives solar radiation with an average intensity of 200 MW/km^(2) and 250–300 sunny days a *** solar radiation in India varies from 4 to 7 kWh/m^(2)/day,with 2300–3200 sunshine hours yearly,depending on the *** solar park,Jodhpur,India,is the world’s largest solar plant,with 2.25 GW of installed *** energy is the best alternative elec-tricity source used explicitly in the agricultural *** the farming sector,the consumption of solar energy has been *** major issues were the installation costs,low availability of technicians,and poor quality of *** focus on skill development equips the workforce to drive innovation,efficiency,and sustained growth in the renewable-energy *** the s.p.ort of inter-national collaboration and a skilled workforce,India’s.p.ogress in solar energy development is a boon for the industry.

关键词： solar energy benefits policies challenges achievements

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Management of strawberry Grey Mold Disease Using Biocontrol Agents and plant Extracts

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American Journal of plant sciences 2024年第7期15卷 538-551页

作者： p. sakthi priya srushtideep Angidi Uday kumar Thera s. V. Nandeesha Thangaswamy Rajesh Department of plant pathology College of Post Graduate Studies in Agricultural Sciences Central Agricultural University Imphal India Department of plant pathology North Dakota State University Fargo ND USA Department of plant science and Landscape Architecture University of Maryland College Park MD USA

strawberry (Fragaria × ananassa Duch.) is a significant global soft fruit crop, prized for its nutrient content and pleasant flavor. However, diseases, particularly grey mold caused by Botrytis cinerea pers. Fr. poses major constraints to strawberry production and productivity. Grey mold severely impacts fruit quality and quantity, diminishing market value. This study evaluated five B. cinerea isolates from various locations in the Ri-Bhoi district of Meghalaya. All isolates were pathogenic, with isolate sGM 2 identified as highly virulent. Host range studies showed the pathogen-producing symptoms in the fava bean pods, marigold, gerbera, and chrysanthemum flowers and in the fava bean, gerbera, and lettuce leaves. In vitro tests revealed that neem extract (15% w/v) achieved the highest mycelial growth inhibition at 76.66%, while black turmeric extract (5% w/v) had the lowest inhibition at 9.62%. Dual culture methods with bio-control agents indicated that Bacillus subtilis recorded the highest mean inhibition at 77.03%, while pseudomonas fluorescens had the lowest at 20.36% against the two virulent isolates. pot evaluations demonstrated that B. subtilis resulted in the lowest percent disease index at 20.59%, followed by neem extract at 23.31%, with the highest disease index in the control group at 42.51%. Additionally, B. subtilis significantly improved plant growth, yielding an average of 0.32 kg compared to 0.14 kg in the control. The promising results of B. subtilis and neem leaf extract from this study suggest their potential for eco-friendly managing grey mold in strawberries under field conditions.

关键词： strawberry Grey Mold BCA plant Extracts Botrytis cinerea

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U-Net Inspired Deep Neural Network-Based smoke plume Detection in satellite Images

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Computers, Materials & Continua 2024年第4期79卷 779-799页

作者： Ananthakrishnan Balasundaram Ayesha shaik Japmann Kaur Banga Aman kumar singh Centre for Cyber physical systems Vellore Institute of Technology(VIT)ChennaiTamil Nadu600127India school of Computer science and Engineering Vellore Institute of Technology(VIT)ChennaiTamil Nadu600127India

Industrial activities, through the human-induced release of Green House Gas (GHG) emissions, have beenidentified as the primary cause of global warming. Accurate and quantitative monitoring of these emissions isessential for a comprehensive understanding of their impact on the Earth’s climate and for effectively enforcingemission regulations at a large scale. This work examines the feasibility of detecting and quantifying industrialsmoke plumes using freely accessible geo-satellite imagery. The existing systemhas so many lagging factors such aslimitations in accuracy, robustness, and efficiency and these factors hinder the effectiveness in s.p.orting timelyresponse to industrial fires. In this work, the utilization of grayscale images is done instead of traditional colorimages for smoke plume detection. The dataset was trained through a ResNet-50 model for classification and aU-Net model for segmentation. The dataset consists of images gathered by European space Agency’s sentinel-2 satellite constellation from a selection of industrial sites. The acquired images.p.edominantly capture scenesof industrial locations, some of which exhibit active smoke plume emissions. The performance of the abovementionedtechniques and models is represented by their accuracy and IOU (Intersection-over-Union) *** images are first trained on the basic RGB images where their respective classification using the ResNet-50model results in an accuracy of 94.4% and segmentation using the U-Net Model with an IOU metric of 0.5 andaccuracy of 94% which leads to the detection of exact patches where the smoke plume has occurred. This work hastrained the classification model on grayscale images achieving a good increase in accuracy of 96.4%.

关键词： smoke plume ResNet-50 U-Net geo satellite images early warning global monitoring

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Determining the Checkpoint of Transition from Thin to Thick periodontal phenotypes in the Maxillary and Mandibular Anterior Regions of south Indian population

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Journal of Forensic science and Medicine 2024年第1期10卷 55-61页

作者： Mohan kumar pas.p.leti Rasagna Chowdary G Gautami spenmetsa Vivek Bypalli Ramesh s.V.Konathala sruthima N.V.s.Gottumukkala Department of periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia2Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Aim:The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incisors utilizing the probe visibility method and traditional way of measuring gingival thickness(GT)by endodontic ***:In 200 selected patients,the GT was measured at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival *** checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups:Group A:21-30 years;Group B:31-40 years;Group C:41-50 years;and Group D:51-60 ***:GT varied from 0.3 to 1.9 *** translucency was observed up to the thickness of 0.7 *** 0.8 mm of GT,there was no probe ***:According to the present research,the gingiva appears transparent up to a thickness of around 0.7 *** checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.

关键词： Gingiva periodontal phenotype probe visibility

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Unleashing the potential of morphotropic phase boundary based hybrid triboelectric–piezoelectric nanogenerator

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Journal of Materiomics 2024年第4期10卷 792-802页

作者： sugato Hajra Aneeta Manjari padhan Basanta kumar panigrahi phakkhananan pakawanit Zvonko Jagličić Naratip Vittayakorn Yogendra kumar Mishra sanghoon Lee Hoe Joon Kim Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Department of Electrical Engineering Siksha O Anusandhan UniversityBhubaneswar751030India synchrotron Research and Applications Division Synchrotron Light Research InstituteNakhon Ratchasima30000Thailand Institute of Mathematics Physics and Mechanics&Faculty of Civil and Geodetic EngineeringUniversity of LjubljanaJadranska191000LjubljanaSlovenia Advanced Materials Research Unit Department of ChemistrySchool of ScienceKing Mongkut's Institute of Technology LadkrabangBangkok10520Thailand Mads Clausen Institute NanoSYDUniversity of Southern DenmarkAlsion 26400SønderborgDenmark Robotics and Mechatronics Research Center Daegu Gyeongbuk Institute of Science and Technology(DGIST)Daegu42988Republic of Korea

Morphotropic phase boundary(MpB)-based ceramics are excellent for energy harvesting due to their enhanced physical properties at phase boundaries,broad operating temperature range,and ability to customize properties for efficient conversion of mechanical energy into electrical *** this work,Bi_(1–x)Na_(x)Fe_(1–x)Nb_(x)O_(3)(x=0.20,0.30,0.32 and 0.40,BNFNO abbreviation)based ceramics were synthesized using a solid-state route and blended with polydimethylsiloxane(pDMs)to achieve flexible *** material characterization and energy harvesting were performed by designing a hybrid piezoelectric(pENG)-triboelectric(TENG)*** voltage and current of pENG,TENG,and hybrid bearing same device area(2 cm×2 cm)were recorded as 11 V/0.3μA;60 V/0.7μA;110 V/2.2μ*** strategies for enhancing the output performance of the hybrid device were evaluated,such as increased surface area(creating micro-roughness and porous morphology)and increasing electrode size and multi-layer hybrid device *** self-powered acceleration monitoring was demonstrated using the hybrid ***,the low-frequency-based wave energy is converted into electrical energy,confirming the usage of hybrid pENG-TENG devices as a base for battery-free sensors and blue energy harvesting.

关键词： Lead-free Acceleration Wave energy Morphotropic

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Erosion Wear Behaviour of Kenaf/Glass Hybrid polymer Composites

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Journal of Harbin Institute of Technology(New series) 2024年第1期31卷 78-89页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo punyapriya Mishra Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018India

The awareness amongst the researchers to develop an environment friendly sustainable material leads to explore new class of plant-based fiber for making composites. Hybridization of such plant-based fiber with inclusion of engineered fiber is one of the promising methods to not only enhanced the mechanical performance but also s.p.ressed the drawbacks that associate with such plant-based fiber to some extent. A usual hand lay-up method was taken-up in this work to fabricate four layered of hybrid kenaf(K)/glass(G)polyester laminates with different stacking order such as KKKK,KGKG,KGGK,GKKG and GGGG. The erosive character of the laminates was examined under three distinct particle velocities(48m/s, 70m/s,82m/s)and four different impact angles(30°, 45°, 60°, 90°). All fabricated laminates exhibited a semiductile character at lower velocities(48m/s and70m/s)as.p.ak wear rate was observed at45° impact angle. However,they showed a semi-brittle character at high velocity(82m/s)as maximum rate of erosion was noticed at60° impact angle. Again,the influence of stacking order of piles on erosion wear was also clearly noticed. Moreover,the semi-brittle/semi-ductile characterization was also evidenced in accordance to the range of erosion efficiencies. The micro-structures of worn surfaces were inspected thoroughly from the images of scanning electron microscope(sEM)to evident the mechanism of erosion.

关键词： hybrid composites erosion wear void micro⁃hardness

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Artificial Intelligence for Maximizing Agricultural Input Use Efficiency: Exploring Nutrient, Water and Weed Management strategies

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phyton-International Journal of Experimental Botany 2024年第7期93卷 1569-1598页

作者： sumit sow shivani Ranjan Mahmoud F.seleiman Hiba M.Alkharabsheh Mukesh kumar Navnit kumar smruti Ranjan padhan Dhirendra kumar Roy Dibyajyoti Nath Harun Gitari Daniel O.Wasonga Department of Agronomy Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of plant production College of Food and Agriculture SciencesKing Saud UniversityRiyadh11451Saudi Arabia Department of Crop sciences Faculty of AgricultureMenoufia UniversityShibin El-Kom32514Egypt Department of Water Resources and Environmental Management Faculty of Agricultural TechnologyAl Balqa Applied UniversitySalt19117Jordan Division of Agronomy ICAR-Indian Agricultural Research InstitutePusa CampusNew Delhi110012India Department of soil science Dr.Rajendra Prasad Central Agricultural UniversityPusaSamastipurBihar848125India Department of Agricultural science and Technology School of Agriculture and Environmental SciencesKenyatta UniversityNairobi43844Kenya Department of Crop sciences University of Illinois Urbana-ChampaignUrbanaIL 61801USA

Agriculture plays a crucial role in the economy,and there is an increasing global emphasis on automating agri-cultural *** the tremendous increase in population,the demand for food and employment has also increased signiﬁ*** methods traditionally used to meet these requirements are no longer ade-quate,requiring solutions to issues such as excessive herbicide use and the use of chemical *** of technologies such as the Internet of Things,wireless communication,machine learning,artiﬁcial intelligence(AI),and deep learning shows.p.omise in addressing these ***,there is a lack of comprehensive documentation on the application and potential of AI in improving agricultural input efﬁ*** address this gap,a desk research approach was used by utilizing peer-reviewed electronic databases like pubMed,scopus,Goo-gle scholar,Web of science,and science Direct for relevant *** of 327 initially identiﬁed articles,180 were deemed pertinent,focusing primarily on AI’s.p.tential in enhancing yield through better management of nutrients,water,and *** into account researchﬁndings worldwide,we found that AI technologies could assist farmers by providing recommendations on the optimal nutrients to enhance soil quality and deter-mine the best time for irrigation or herbicide *** present status of AI-driven automation in agricul-ture holds signiﬁcant promise for optimizing agricultural input utilization and reducing resource waste,particularly in the context of three pillars of crop management,i.e.,nutrient,irrigation,and weed management.

关键词： Agriculture artiﬁcial intelligence crop management nutrient irrigation weed management resource use efﬁciency

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performance Improvement of Kenaf/Glass.p.lymer Hybrid Composites by Effective Application of Fish scale powder as Filler:A Novel Approach

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Journal of Harbin Institute of Technology(New series) 2024年第3期31卷 80-96页

作者： Chandrakanta Mishra Deepak kumar Mohapatra Chitta Ranjan Deo Chetana Tripathy Kiran kumar Ekka Department of Mechanical Engineering Veer Surendra Sai University of TechnologySambalpur 768018OdishaIndia

Modern technology for developing new items made from renewable resources is becoming more and more popular as a result of rising environmental ***,contemporary polymer composites have included the hybridization of natural fibers with synthetic ones,along with the inclusion of a variety of biowaste filler for developing sustainable *** this work,the kenaf/glass hybrid polyester composites are strengthened by the addition of fish scale(Fs),which is taken from the fish􀆳s outermost layer of *** different stacked-order laminates,such as KKKK,KGKG,GKKG,KGGK,and GGGG,are fabricated by using the hand lay-up method with four different weight concentrations of filler content:0%,5%,10%,and 15%.Mechanical possessions such as tensile,flexural,impact strength and micro-hardness have been evaluated through experimentation in accordance with AsTM *** experimental findings revealed that,the tensile strength and micro-hardness value of KGKG laminates with 15wt% of Fs filler are found to be maximum of 118.72 Mpa and 17.82 HV respectively which are 39.67%and 26.11%greater than that of KGKG laminates without Fs ***,the flexural and impact strength of same laminates with 10 wt% Fs filler exhibited a maximum value of 142.77 Mpa and 62.08 kJ/m^(2).In order to corroborate its applicability for structural and building materials in open environment,the dimensional stability of the composite has been studied through moisture absorption *** influences of Fs filler loading on dimensional stability and resistance to moisture absorption capacity of laminates are also *** experimental results reflected that the addition of Fs-filler has significantly improved the dimensional stability of the laminates in moist environment by reducing the moisture absorption *** further s.p.ort the mode of failures,a fractography investigation of fractured surfaces was conducted.

关键词： fish scale fiber polyester hybrid composites mechanical properties

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