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豆粕替代鱼粉对生长期梭子蟹的影响

饲料博览 2017年第2期27卷 54-54页

作者： Taher s Romano N Arshad A Ebrahimi M Teh J C Ng W K kumar V

试验旨在研究梭子蟹饲料中豆粕(sBM)替代鱼粉的可行性。试验选取远海生长期梭子蟹,经过>6个蜕皮周期后测量其生长、发育情况,检测血液中高胆固醇、甘油三酯、磷酸盐含量以及全身粗蛋白质、胆固醇、肝胰腺的胰蛋白酶活性、组织病理和糖... 详细信息

试验旨在研究梭子蟹饲料中豆粕(sBM)替代鱼粉的可行性。试验选取远海生长期梭子蟹,经过>6个蜕皮周期后测量其生长、发育情况,检测血液中高胆固醇、甘油三酯、磷酸盐含量以及全身粗蛋白质、胆固醇、肝胰腺的胰蛋白酶活性、组织病理和糖原储备情况。6组等量氮、等脂肪和等能量的饲料,其中sBM替代鱼粉量分别为0(对照组)、20%、40%、60%、80%和100%。每组30个重复,从梭子蟹幼年期持续饲喂到蜕皮的第7阶段,蜕皮后期取样共3 d。试验结果表明,20%组梭子蟹生长状况最好,显著优于对照组。sBM替代量≥60%时,生长速度显著降低,而血液中胆固醇、甘油三酯、磷酸盐含量随之显著下降。全身水分、粗蛋白质和胆固醇含量无显著改变。同时,20%组到60%组梭子蟹的肝胰腺的胰蛋白酶活性显著下降,而80%组和100%进一步显著降低。sBM替代量≥60%时,肝胰腺损伤,上皮细胞糖原储备显著减少。试验结果表明,饲料中sBM替代量达40%时会影响生长期梭子蟹的生长及肝胰腺发育。

关键词：胰蛋白酶肝组织病理糖原替代鱼粉远海梭子蟹

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从比较的观点看印度伦理

宜宾学院学报 2012年第3期12卷 1-5页

作者：凯塞.库玛.查克拉巴提邵明戴维斯.埃尔金斯学院哲学与宗教学系美国西弗吉尼亚州26241

古印度梵文史诗《摩诃婆罗多》所表述的伦理思想可以启示我们从一个包容、多元的角度看待西方伦理学中的三种主要理论:康德的道义论、功利主义的后果论和亚里士多德的德性伦理学。它们分别涉及到人的认知性、感受性和德性。这三种理论... 详细信息

古印度梵文史诗《摩诃婆罗多》所表述的伦理思想可以启示我们从一个包容、多元的角度看待西方伦理学中的三种主要理论:康德的道义论、功利主义的后果论和亚里士多德的德性伦理学。它们分别涉及到人的认知性、感受性和德性。这三种理论各有其支持的理由,也存在各自不同的困难。但它们之间不会完全相互排斥,而是和而不同。其中的每一个都不能充分地解释道德行为。只有基于责任、共同善的追求和美德这三者,才能做出一个完整的道德评价。

关键词：《摩诃婆罗多》伦理多元主义道义论后果论德性伦理学

Correction:Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology

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Translational Neurodegeneration 2023年第1期12卷 889-889页

作者： Ankit Verma Anna shteinfer-Kuzmine Nikita Kamenetsky srinivas.p.ttala Avijit paul Edna Nahon Crystal Alberto Ouro Vered Chalifa-Caspi swaroop kumar pandey Alon Monsonego Noga Vardi shira Knafo Varda shoshan-Barmatz Department of Life sciences Ben-Gurion University of the Negev84105 Beer-ShevaIsrael National Institute for Biotechnology in the Negev Ben-Gurion University of the Negev84105 Beer-ShevaIsrael Achva Academic College 79804 ShikmimIsrael Department of physiology Faculty of Health SciencesBen-Gurion University of the Negev84105 Beer-ShevaIsrael Ilse Katz Institute for Nanoscale science and Technology Ben-Gurion University of the Negev84105 Beer-ShevaIsrael The shraga segal Department of Microbiology Immunologyand GeneticsFaculty of Health SciencesBen-Gurion University of the Negev84105 Beer-ShevaIsrael present Address:NeuroAging Group(NEURAL) Clinical Neurosciences Research Laboratory(LINC)Health Research Institute of Santiago de Compostela(IDIS)15706 Santiago de CompostelaSpain

Correction:Translational Neurodegeneration(2022)11:58 https://***/10.1186/s40035-022-00329-7 Following publication of this article[1],the authors iden-tified an error in the family name of Alon *** incorrect author name is:Alon *** correct author name is:Alon *** author group has been updated above and the orig-inal article[1]has been corrected.

关键词： correct degeneration VDAC1

设备及热参数对肝脏热消融术局部组织反应及远处肿瘤生长的影响

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国际医学放射学杂志 2017年第1期 93-93页

作者： E.Velez s.N.Goldberg G.kumar Y.G.Wang s.Gourevitch J.sosna 华蓓 Laboratory for Minimally Invasive Tumor Therapies Department of Radiology Beth Israel Deaconess Medical Center/Harvard Medical School

摘要目的与动物模型肝脏射频消融(RFA)术相比,确定肝脏可变微波消融(MWA)能否引起局部炎症反应及远处前致癌效应。材料与方法本研究经动物保护与使用委员会

关键词：肝脏 RFA 肿瘤生长消融术

A controlled, efficient and robust process for the synthesis of an epidermal growth factor receptor inhibitor: Afatinib Dimaleate

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Chemical Reports 2019年第1期1卷 3-12页

作者： pawan kumar premnath Dhande Muhammad Taufiq F. Mazlee suhaila M. Yaman Nurul syazwani Nadirah Binti Muhammad syafiq Chandran Mohd Zulfadli Bin Makhtar Dhramveer singh shekhawat sunil Vasudeorao Lanke Ramesh kumar sandeep Mhetre Oncogen pharma sdn Bhd No.3 Jalan Jururancang U1/21 Hicom Glenmarie Industrial Park 40150 Shah Alam Selangor Malaysia.

A simple, controlled, robust and scalable three-stage manufacturing process of Afatinib Dimaleate was assessed and optimized leading to improved yield and quality. The synthetic process involves sequence of reactions as nitro-reduction, amidation and salification. The developed and optimized route was demonstrated on 300 g scale with over all isolated yield of 84% for Afatinib free base. The developed process has the capability to control not only the process related impurities but also the degradation impurities. One new impurity was identified during the process development studies and characterized as acetamide impunity, chemically known as (s)-N-(4-((3-chloro-4-fluorophenyl) amino)-7-((tetrahydrofuran-3-yl) oxy) quinazolin-6-yl) acetamide. Other impurities were identified as degradation impurities, process impurities and were labeled as 1-(4-((3-chloro-4-fluorophenyl) amino)-7-(((s)-tetrahydrofuran-3-yl) oxy) quinazoline-6-yl)-5-Hydroxypyrrolidin- 2-one (hydroxy impurity), Afatinib N-Oxide impurity and N4-(3-chloro-4-fluorophenyl)-7-[[(3s)-tetrahydro- 3-furanyl] oxy]-4,6-quinazolinediamine (Intermediate-1).

关键词： Afatinib Dimaleate HpLC degradation impurities NMR LC-Ms new process impurity improved process

Non-random tissue distribution of human na ve umbilical cord matrix stem cells

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World Journal of stem Cells 2011年第4期3卷 34-42页

作者： Dharmendra kumar Maurya Chiyo Doi Marla pyle Raja shekar Rachakatla Duane Davis Masaaki Tamura Deryl Troyer Department of Anatomy and physiology College of Veterinary Medicine Kansas State University Department of Animal sciences and Industry Kansas State University

AIM: To determine the tissue and temporal distribution of human umbilical cord matrix stem (hUCMs) cells in severe combined immunodeficiency (sCID) mice. METHODs: For studying the localization of hUCMs cells, tritiated thymidine-labeled hUCMs cells were injected in sCID mice and tissue distribution was quantitatively determined using a liquid scintillation counter at days 1, 3, 7 and 14. Furthermore, an immunofluorescence detection technique was employed in which anti-human mitochondrial antibody was used to identify hUCMs cells in mouse tissues. In order to visualize the distribution of transplanted hUCMs cells in H&E stained tissue sections, India Black ink 4415 was used to label the hUCMs cells. REsULTs: When tritiated thymidine-labeled hUCMs cells were injected systemically (iv) in female sCID mice, the lung was the major site of accumulation at 24 h after transplantation. With time, the cells migrated to other tissues, and on day three, the spleen, stomach, and small and large intestines were the major accumulation sites. On day seven, a relatively large amount of radioactivity was detected in the adrenal gland, uterus, spleen, lung, and digestive tract. In addition, labeled cells had crossed the blood brain barrier by day 1. CONCLUsION: These results indicate that peripherally injected hUCMs cells distribute quantitatively in a tissue-specific manner throughout the body.

关键词： Human umbilical cord matrix stem cells Immunohistochemistry India black ink loaded cells Radio-labeled transplanted cells Tissue distribution

血清HBV RNA-拉米夫定治疗患者YMDD变异早期出现的预测因子

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药品评价 2007年第3期4卷 162-162页

作者： M. kumar s. satapathy R. Monga 钟艳丹（译）杨永峰（校）

拉米夫定（LAM）是一种核苷类似物，广泛用于治疗慢性乙型肝炎病毒（HBV）感染。逆转录酶区酪氨酸一蛋氨酸一天冬氨酸一天冬氨酸（YMDD）基因序列由于氨基酸置换而导致耐药株的出现．是IAM治疗患者一个严重的问题。与未出现YMDD变异患... 详细信息

拉米夫定（LAM）是一种核苷类似物，广泛用于治疗慢性乙型肝炎病毒（HBV）感染。逆转录酶区酪氨酸一蛋氨酸一天冬氨酸一天冬氨酸（YMDD）基因序列由于氨基酸置换而导致耐药株的出现．是IAM治疗患者一个严重的问题。与未出现YMDD变异患者相比．YMDD变异患者血清共价闭合环状DNA数量更高。然而．在拉米夫定治疗期间．对于早期变异的出现缺乏有利的血清标志物。

关键词：拉米夫定治疗 YMDD变异血清HBV 预测因子乙型肝炎病毒(HBV) 早期共价闭合环状DNA 天冬氨酸

进行性核上性麻痹所致视动性眼球震颤的异常表现

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世界核心医学期刊文摘(眼科学分册) 2005年第2期 2-2页

作者： Garbutt s. Riley D.E. kumar A.N. R.J. Leigh 杨建刚 University Hospitals Cleveland United states Dr. OH 44106-5040 Department of Neurolo gy 11100 Euclid Avenue

Objectives: To measure vertical and horizontal responses to optokinetic (OK) s timulation and investigate directional abnormalities of quick phases in progress ive s.p.anuclear palsy (psp). Methods: saccades and OK nystagmus were studied in six psp patients, five with parkinson’s disease (pD), and 10 controls. The OK stimulus subtended 72°horizontally, 60°vertically, consisted of black and whit e stripes, and moved at 10-50°/s. Results: All psp patients showed slowed volu ntary vertical saccades and nystagmus quick phases compared with pD or controls. small, paired, horizontal saccadic intrusions (sWJ) were more frequent and larg er in psp during fixation. Vertical saccades were transiently faster at the time of sWJ and horizontal saccades in psp. During vertical OK nystagmus, small quic k phases were often combined with horizontal sWJ in all subjects; in psp the vec tor was closer to horizontal. Vertical OK slow phase gain was reduced in psp but , in most pD patients, was similar to normals. The average position of gaze shif ted in the direction of vertical OK stimulus in psp patients with preserved slow phase responses but impaired quick phases. Conclusions: Vertical OK responses i n psp show impaired slow phase responses, and quick phases that are slowed and c ombined with sWJ to produce an oblique vector. sWJ facilitate vertical saccades and quick phases in psp, but it is unclear whether this is an adaptive process o r a result of the disease. A large OK stimulus is useful to induce responses tha t can be quantitatively analysed in patients with limited voluntary range of ver tical gaze.

关键词：进行性核上性麻痹患者 OK psp 眼球震颤眼肌疾病

potential value of pOssUM scoring system in assessment of surgical outcome

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国际外科学杂志 2007年第9期34卷 644-648,F0003页

作者： Birendra kumar sah ZHU Zheng-Gang General surgery Department. Rui Jin Hospital Affiliated to shanghai Jiao- tong University school of Medicine Shanghai 200025 China

The outcome of surgical intervention is not solely dependent on the abilities of the surgeon in isolation. The patient's.p.ysiological status, the disease that requires surgical correction, the nature of the operation... 详细信息

关键词：外科手术手术结局 pOssUM评分系统意义