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High-quality assembled and annotated genomes of Nicotiana tabacum and Nicotiana benthamiana reveal chromosome evolution and changes in defense arsenals

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Molecular plant 2024年第3期17卷 423-437页

作者： Jubin Wang Qingling Zhang Jeffrey Tung Xi Zhang Dan Liu Yingtian Deng Zhendong Tian Huilan Chen Taotao Wang Weixiao Yin Bo Lij Zhibing Lai savithramma p.dinesh-kumar Barbara Baker Feng Li National Key Laboratory for Germplasm Innovation and Utilization for Fruit and Vegetable Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhanHubei 430070China plant Gene Expression Center Department of Plant and Microbial BiologyUniversity of CaliforniaBerkeleyBerkeleyCA 94706USA College of plant science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China College of Life science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Department of plant Biology and The Genome Center College of Biological SciencesUniversity of CalforniaDavisDavisCA 95616USA The Key Laboratory of Horticultural plant Genetic and Improvement of Jiangxi province Institute of Biological ResourcesJiangxi Academy of SciencesNanchang 330299China institute of Vegetables and Flowers Jiangxi Academy of Agricultural SciencesNanchang 330200Chin Hubei Hongshan Laboratory WuhanHubei 430070China

Nicotiana tabacum and Nicotiana benthamiana are widely used models in plant biology ***,genomic studies of these species have *** we report the chromosome-level reference genome assemblies for *** and *** with an estimated 99.5%and 99.8%completeness,*** transcription start and termination site sequencing methods were developed and used for accurate gene annotation in *** analyses revealed evidence for the parental origins and chromosome structural changes,leading to hybrid genome formation of each ***,theantiviral silencinggenesRDR1,RDR6,DCL2,DCL3,andAGO2were lost from one or both subgenomes in ***,while both homeologs were kept in ***,the *** genome encodes fewer immune receptors and signaling components than that of *** find-ings uncover possible reasons underlying the hypersusceptible nature of *** developed the user-friendly Nicomics(http:/***/Nicomics/)web server to facilitate better use of Nicotiana genomic resources as well as gene structure and expression analyses.

关键词： Nicotiana tabacum Nicotiana benthamiana genomics evolution disease resistance NLR

protected simultaneous quantum remote state preparation scheme by weak and reversal measurements in noisy environments

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Chinese physics B 2024年第2期33卷 169-177页

作者： Mandal Manoj kumar Choudhury Binayak s. samanta soumen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We discuss a quantum remote state preparation protocol by which two parties, Alice and Candy, prepare a single-qubit and a two-qubit state, respectively, at the site of the receiver Bob. The single-qubit state is known to Alice while the two-qubit state which is a non-maximally entangled Bell state is known to Candy. The three parties are connected through a single entangled state which acts as a quantum channel. We first describe the protocol in the ideal case when the entangled channel under use is in a pure state. After that, we consider the effect of amplitude damping(AD) noise on the quantum channel and describe the protocol executed through the noisy channel. The decrement of the fidelity is shown to occur with the increment in the noise parameter. This is shown by numerical computation in specific examples of the states to be created. Finally, we show that it is.p.ssible to maintain the label of fidelity to some extent and hence to decrease the effect of noise by the application of weak and reversal measurements. We also present a scheme for the generation of the five-qubit entangled resource which we require as a quantum channel. The generation scheme is run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote state preparation noisy environments weak and reversal measurements

Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra priyanka Gola Jiten singh pooja Gond swarnabha Ghosh Mahesh Rachamalla Abhijit Dey Danish Iqbal Mehnaz Kamal punya sachdeva saurabh kumar Jha shreesh Ojha dinesh kumar Niraj kumar Jha Hitesh Chopra shing Cheng Tan Department of pharmaceutical sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates school of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/s.p.lements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various.p.ssible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

Enhancing Multicriteria-Based Recommendations by Alleviating scalability and sparsity Issues Using Collaborative Denoising Autoencoder

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Computers, Materials & Continua 2024年第2期78卷 2269-2286页

作者： s.Abinaya K.Uttej kumar school of Computer science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender system(Rs)is a crucial part of several firms.p.rticularly those involved in *** conventional Rs,a user may only offer a single rating for an item-that is insufficient to perceive consumer ***,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’*** the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested ***,the cost of these computations increases nonlinearly as the number of items and users *** triumph over the issues,a novel expanded stacked autoencoder(EsAE)with Kernel Fuzzy C-Means Clustering(KFCM)technique is.p.oposed with two *** the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the EsAE approach and users are clustered using the KFCM *** the next phase of online,the top-N recommendation prediction is made by the EsAE approach involving only the most similar user from multiple *** the EsAE_KFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation *** experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the EsAE_KFCM model constantly outperforms conventional Rs algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder Kernel Fuzzy C-Means Clustering

proxitome profiling reveals a conserved sGT1- NsL1 signaling module that activates NLRmediated immunity

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Molecular plant 2024年第9期17卷 1369-1391页

作者： Dingliang Zhang Xinxin Yang Zhiyan Wen Zhen Li Xinyu Zhang Chenchen Zhong Jiajie she Qianshen Zhang He Zhang Wenli Li Xiaoyun Zhao Mingliang Xu Zhen su Dawei Li savithramma p.dinesh-kumar Yongliang Zhang state Key Laboratory of plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBejing 100193China Department of plant Biology and The Genome Center College of Biological SciencesUniversity of CaliforniaDavisDavisCA 95616USA state Key Laboratory of plant Environmental Resilience College of Agronomy and BiotechnologyChina Agricultural UniversityBejing 100193China

s.p.ressor of G2 allele of s.p.(sGT1)is a highly conserved eukaryotic protein that plays a vital role in growth,development,and immunity in both animals and *** some sGT1 interactors have been identified,the molecular regulatory network of sGT1 remains ***1 serves as a co-chaperone to stabilize protein complexes such as the nucleotide-binding leucine-rich repeat(NLR)class of immune receptors,thereby positively regulating plant ***1 has also been found to be asso-ciated with the s.p.-Cullin-F-box(sCF)E3 ubiquitin ligase ***,whether sGT1 targets im-mune repressors to coordinate plant immune activation remains *** this study,we constructed a toolbox for TurbolD-and split-TurbolD-based proximity labeling(pL)assays in Nicotiana benthamiana and used the pL toolbox to explore the sGT1 interactome during pre-and post-immune *** comprehensive sGT1 interactome network we identified highlights a dynamic shift from proteins associ-ated with plant development to those linked with plant immune *** found that sGT1 interacts with Necrotic spotted Lesion1(NsL1),which negatively regulates salicylic acid-mediated defenseby inter-fering with the nucleocytoplasmic trafficking of non-expressor of pathogenesis-related genes 1(NpR1)during N NLR-mediated response to tobacco mosaic ***1 promotes the sCF-dependent degrada-tion of NsL1 to facilitate immune activation,while salicylate-induced protein kinase-mediated phosphory-lation of sGT1further potentiates this *** NNLR,NsL1also functions in several other NLR-mediated ***,our study unveils the regulatory landscape of sGT1 and reveals a novel sGT1-NsL1 signaling module that orchestrates.p.ant innate immunity.

关键词： s.p.ressor of G2 allele of s.p. sGT1 proximity labeling N NLR immune receptor Necrotic spotted Lesion 1 NsL1 salicylic acid ubiquitination

Nitrosamines crisis in pharmaceuticals-Insights on toxicological implications,root causes and risk assessment:A systematic review

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Journal of pharmaceutical Analysis 2024年第5期14卷 639-652页

作者： Hemanth p.R.Vikram Tegginamath pramod kumar Gunjan kumar Narasimha M.Beeraka Rajashree Deka sheik Mohammed suhail sandeep Jat Namitha Bannimath Gayatiri padmanabhan Ravandur s.Chandan pramod kumar Bannimath Gurupadayya Department of pharmaceutical Chemistry JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Xenone Healthcare pvt.Ltd. New Delhi110076India Department of pharmaceutics JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow119991Russian Federation Department of pharmacology Raghavendra Institute of Pharmaceutical Education and Research(RIPER)Ananthapuramu515721India Herman B.Wells Center for pediatric Research Department of PediatricsIndiana University School of MedicineIndianapolisIN46202USA Animal physiology and Biochemistry Laboratory Department of ZoologyGauhati UniversityGuwahati781014India Department of pharmacology JSS College of Pharmacy MysuruJSS Academy of Higher Education and Research(JSSAHER)Mysuru570015India Department of pharmaceutical Analysis National Institute of Pharmaceutical Education and Research(NIPER)-GuwahatiChangsari781101India Department of pharmacology University of GalwayGalwayH91 TK33Ireland

The presence of N-nitroso compounds.p.rticularly N-nitrosamines,in pharmaceutical products has raised global safety concerns due to their significant genotoxic and mutagenic *** systematic review investigates their toxicity in active pharmaceutical ingredients(ApIs),drug products,and pharmaceutical excipients,along with novel analytical strategies for detection,root cause analysis,reformulation strategies,and regulatory guidelines for *** review emphasizes the molecular toxicity of N-nitroso compounds,focusing on genotoxic,mutagenic,carcinogenic,and other physiological ***,it addresses the ongoing nitrosamine crisis,the development of nitrosamine-free products,and the importance of sensitive detection methods and precise risk *** comprehensive overview will aid molecular biologists,analytical scientists,formulation scientists in research and development sector,and researchers involved in management of nitrosamine-induced toxicity and promoting safer pharmaceutical products.

关键词： Carcinogenicity Genotoxicity Mutagenicity Molecular toxicity Nitrosamine impurities Nitrosamine drug substance-related impurities

Identification of gene classifier and modules associated with sARs-CoV-2 ARI in nasal swab

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Genes & Diseases 2024年第1期11卷 38-41页

作者： pandikannan Krishnamoorthy Athira s.Raj Himanshu kumar Department of Biological sciences Laboratory of Immunology and Infectious Disease BiologyIndian Institute of Science Education and Research(llSER)BhopalBhopalMP 462066India Laboratory of Host Defense WPl ImmunologyFrontier ResearchCentreOsakaUniversityOsaka 5650871Japan

During a sudden viral pandemic,where the pathogenesis and nature of the infection are unclear,early and accurate identification of the patients infected with the pandemiccausing pathogen is crucial to prevent excess *** the coronavirus disease 2019(COvID-19)pandemic,early diagnosis of severe acute respiratory syndrome virus-2(sARs-CoV-2)is limited by the incidence of the symptoms that are shared with acute respiratory illnesses(ARl)caused by other pathogens.

关键词： acute diagnosis respiratory

Mathematical modelling of ball and plate system with experimental and correlation function-based model validation

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Control Theory and Technology 2024年第2期22卷 326-341页

作者： T.R.Dil kumar s.J.Mija Department of Electrical Engineering National Institute of Technology CalicutKozhikode673601KeralaIndia

The ball and plate system is an inherently nonlinear under actuated benchmark system used for validating the performance of various control schemes. A mathematical model depicting the dynamics close to that of the system is very much required for such a test bed. In this correspondence, the complete nonlinear model, a simplified nonlinear model, and a linearized model of the ball and plate system are developed. The system comprises a ball and plate mechanism and a rotary servo unit. The ball and plate mechanism is modelled using the Euler–Lagrange method, whereas the rotary servo subsystem is modelled from the first principles. The nonlinear model of the combined system is developed by including the dynamics of the servo motor with gear and rolling resistance between the ball and the plate. The simplified nonlinear model of the system is obtained with suitable assumptions. The model is linearized around the operating point using the Jacobian. The validity of the developed models is investigated through correlation function analysis. The open-loop response of the three models, viz., nonlinear, simplified nonlinear, and linearized models, is analyzed in the MATLAB/simulink platform. since the open-loop system is unstable, the experimental validation of the model is.p.rformed with a double-loop psO (particle swarm optimization) pID control scheme.

关键词： Ball and plate system Correlation function Model validation particle swarm optimization(psO) psO pID controller

Multi-omics.p.werful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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Molecular plant 2024年第1期17卷 13-15页

作者： priyanka Gupta Anuj sharma dinesh A.Nagegowda Molecular plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of scientific and Innovative Research Ghaziabad 201002India

As sessile organisms.p.ants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites.p.Ms)or natural ***,psMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids.p.enylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds.p.enolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur