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Independent and complementary bio-functional effects of CuO andGa_(2)O_(3) incorporated as therapeutic agents in silica-and phosphate-based bioactive glasses

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Journal of Materiomics 2022年第4期8卷 893-905页

作者： T.Tite A.C.Popa B.W.stuart H.R.Fernandes I.M.Chirica G.A.Lungu D.Macovei C.Bartha L.Albulescu C.Tanase s.nita N.Rusu D.M.Grant J.M.F.Ferreira G.E.stan National Institute of Materials Physics MagureleRO-077125Romania Advanced Materials Research Group Faculty of EngineeringUniversity of NottinghamNG72RDUK CICECOdAveiro Institute of Materials Department of Materials and Ceramics EngineeringUniversity of Aveiro3810-193AveiroPortugal “Victor Babes”National Institute of Research and Development in Pathology and Biomedical sciences BucharestRO-050096Romania National Institute for Chemical Pharmaceutical Research and Development BucharestRO-031299Romania

The incorporation of therapeutic-capable ions into bioactive glasses(BGs),either based on silica(sBGs)or phosphate(PBGs),is currently envisaged as a proficient path for facilitating bone *** with this view,the single and complementary structural and bio-functional roles of CuO andGa_(2)O_(3)(in the 2e5 mol%range)were assessed,by deriving a series of sBG and PBG formulations startingfrom the parent glass systems,FastOs®BG e 38.5siO2d36.1CaOd5.6P2O5d19.2MgOd0.6CaF2,and50.0P2O5d35.0CaOd10.0Na_(2)Od5.0 Fe2O_(3)(mol%),respectively,using the process of *** inter-linked physico-chemistry e biological response of BGs was assessed in search of bio-functional *** light was shed on the structural role e as network former or modifier e ofCu and Ga,immersed in sBG and PBG *** preliminary biological performance was surveyedin vitro by quantification of Cu and Ga ion release under homeostatic conditions,cytocompatibility assays(in fibroblast cell cultures)and antibacterial tests(against staphylococcus aureus).The similar(Cu)anddissimilar(Ga)structural roles in the sBG and PBG vitreous networks governed their ***,Cuions were leached in similar concentrations(ranging from 10e35 ppm and 50e110 ppm at BG doses of 5and 50 mg/mL,respectively)for both type of BGs,while the release of Ga ions was 1e2 orders ofmagnitude lower in the case of sBGs(i.e.,0.2e6 ppm)compared to PBGs(i.e.,9e135 ppm).This wasattributed to the network modifier role of Cu in both types of BGs,and conversely,to the network former(sBGs)and network modifier(PBGs)roles of *** glasses were cytocompatible at a dose of 5 mg/mL,while at the same concentration the antimicrobial efficiency was found to be accentuated by the coupledrelease of Cu and Ga ions from *** collective assessment,the most prominent candidate material forthe further development of implant coatings and bone graft substitutes was delineated as the38.5siO2d34.1CaOd5.6P2O5d16.2MgOd

关键词： Bioactive glass Copper Gallium structure Ion release Antibacterial

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Linking leaf elemental traits to biomass across forest biomes in the Himalayas

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science China Earth sciences 2024年第5期67卷 1518-1528页

作者： nita DYOLA Eryuan LIANG Josep PEÑUELAs J.Julio CAMARERO shalik Ram sIGDEL sugam ARYAL Wentao LIN Xiang LIU Yongwen LIU Xingliang XU sergio ROssI state Key Laboratory of Tibetan Plateau Earth system Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of sciences Beijing 100049China Laboratoire sur lesécosystèmes terrestres boréaux Département des Sciences FondamentalesUniversitédu QuébecàChicoutimi555Boulevard de l′UniversitéChicoutimi(QC)G7H2B1Canada CsIC Global Ecology Unit CREAF-CSIC-UABBellaterraE-08193 CataloniaSpain CREAF Cerdanyola del VallèsE-08193 CataloniaSpain Instituto Pirenaico de Ecología(IPE-CsIC) Avenida Montañana 1005Zaragoza 50059Spain Friedrich-Alexander-Universität Erlangen-Nürnberg Institut für GeographieErlangen 91058Germany state Key Laboratory of Grassland Agro-Ecosystems College of EcologyLanzhou UniversityLanzhou 730000China Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Plants require a number of essential elements in different proportions for ensuring their growth and *** elemental concentrations in leaves reflect the functions and adaptations of plants under specific environmental ***,less is known about how the spectrum of leaf elements associated with resource acquisition,photosynthesis and growth regulates forest biomass along broad elevational *** examined the influence of leaf element distribution and diversity on forest biomass by analyzing ten elements(C,N,P,K,Ca,Mg,Zn,Fe,Cu,and Mn)in tree communities situated every 100 meters along an extensive elevation gradient,ranging from the tropical forest(80 meters above sea level)to the alpine treeline(4200 meters above sea level)in the Kangchenjunga Landscape in eastern Nepal *** calculated communityweighted averages(reflecting dominant traits governing biomass,i.e.,mass-ratio effect)and functional divergence(reflecting increased trait variety,i.e.,complementarity effect)for leaf elements in a total of 1,859 trees representing 116 *** increasing mass-ratio effect and decreasing complementarity in leaf elements enhance forest biomass accumulation.A combination of elements together with elevation explains biomass(52.2%of the variance)better than individual elemental trait diversity(0.05%to 21%of the variance).Elevation modulates trait diversity among plant species in biomass *** promotes biomass at lower elevations,but reduces biomass at higher elevations,demonstrating an interaction between elevation and *** interaction between elevation and mass-ratio effect produces heterogeneous effects on biomass along the elevation *** research indicates that biomass accumulation can be disproportionately affected by elevation due to interactions among trait diversities across vegetation *** higher trait variation enhances the adaptation of species to environmental changes,it reduces

关键词： Ecosystem function Elevational gradient Functional diversity Functional traits Leaf elements Niche complementarity

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喜马拉雅山不同森林群落主要树种叶片元素性状与生物量之间的关系

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中国科学：地球科学 2024年第5期54卷 1544-1555页

作者： nita DYOLA 梁尔源 Josep PEÑUELAs JJulio CAMARERO shalik Ram sIGDEL sugam ARYAL 林文涛刘向刘永稳徐兴良 sergio ROssI 中国科学院青藏高原研究所青藏高原地球系统与资源环境全国重点实验室北京100101 中国科学院大学北京100049 Laboratoire sur lesécosystèmes terrestres boréaux Département des Sciences FondamentalesUniversitédu QuébecàChicoutimi555Boulevard de l′UniversitéChicoutimi(QC)G7H2B1Canada CsIC Global Ecology Unit CREAF-CSIC-UABBellaterraE-08193 CataloniaSpain CREAF Cerdanyola del VallèsE-08193 CataloniaSpain Instituto Pirenaico de Ecología(IPE-CsIC) Avenida Montañana 1005Zaragoza 50059Spain Friedrich-Alexander-Universität Erlangen-Nürnberg Institut für GeographieErlangen 91058Germany 兰州大学生态学院草种创新与草地农业生态系统全国重点实验室兰州730000 中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室北京100101

植物需要多种基本元素调节并保持其特定比例以维持生长发育,叶片元素含量反映了植物的功能及其对环境的适应性.然而,在森林海拔梯度上,我们对于资源获取、光合作用和生长相关的叶片元素如何调节森林生物量仍知之甚少.本研究在喜马拉雅... 详细信息

植物需要多种基本元素调节并保持其特定比例以维持生长发育,叶片元素含量反映了植物的功能及其对环境的适应性.然而,在森林海拔梯度上,我们对于资源获取、光合作用和生长相关的叶片元素如何调节森林生物量仍知之甚少.本研究在喜马拉雅山干城章嘉峰地区沿热带森林(海拔80m)至高山树线(海拔4200m)设置海拔梯度样带,每间隔海拔100m设置一个样点,对116个树种的1859个个体测定了叶片中10种元素(C、N、P、K、Ca、Mg、Zn、Fe、Cu和Mn)的含量,通过计算叶片元素含量的群落加权平均值(反映优势物种的性状优势度,表征质量比效应)和功能离散度(反映物种在生态位空间内的聚集或者离散程度,表征互补效应),探究叶片元素含量及其离散程度沿海拔梯度分异特征,解析其对森林群落生物量的影响.研究结果表明,较强的叶片元素质量比效应和较弱的互补效应有利于森林群落生物量的积累.叶片元素性状多样性与海拔的共同作用对生物量的解释量(解释方差:52.2%)高于元素性状多样性的解释量(解释方差:0.05%~21%).海拔调节了树种性状多样性在生物量积累中的作用,互补效应在低海拔和高海拔地区对生物量的影响分别体现为积极和消极作用,这表明海拔和互补效应之间也存在交互作用.此外,海拔和质量比效应的交互作用对海拔梯度上生物量的影响也存在异质性.本研究表明,不同森林群落生物量的积累可能受到由海拔调控的性状多样性的影响.尽管较高的性状分异不利于生物量的积累,但能增强高海拔地区树种对胁迫环境的适应性.

关键词：生态系统功能海拔梯度功能多样性功能性状叶片元素生态位互补

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subcutaneous and breast metastasis from asymptomatic gallbladder carcinoma

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Hepatobiliary & Pancreatic Diseases International 2009年第2期8卷 209-211页

作者： Pankaj Kumar Garg nita Khurana Niladhar s Hadke Department of surgery Maulana Azad Medical College and Lok Nayak Hospital Department of Pathology Maulana Azad Medical College and Lok Nayak Hospital

BACKGROUND:Though gallbladder carcinoma is asso- ciated with early lymphatic and hematogenous spread, the only common extra-abdominal site of metastasis is *** carcinoma metastasizing to breast and subcutaneous tissue is not known. METHOD:This report describes an interesting and unusual case of asymptomatic gallbladder carcinoma presenting with subcutaneous and breast metastasis. REsULTs:A 42-year-old woman presented with multiple subcutaneous nodules over the abdominal wall,anterior chest wall,back and in bilateral *** needle aspiration cytology(FNAC)of these nodules revealed metastatic *** patient was investigated for a primary *** ultrasound of the abdomen followed by a contrast-enhanced CT scan showed a growth in gallbladder,infiltrating the liver with multiple hepatic ***-guided FNAC from the growth in the gallbladder revealed *** was diagnosed as a case of metastatic adenocarcinoma of the gallbladder and palliative combination chemotherapy with gemcitabine and carboplatin was *** she developed jaundice and deteriorated dramatically in a short span of *** specific therapy could be started and she was given supportive *** died within three weeks of diagnosis due to hepatic encephalopathy. CONCLUsIONs:This report highlights an unusual metastasis of gallbladder carcinoma to the breast and subcutaneous tissue presenting as multiple lesions,which has never been reported in the English *** were unknown sites of metastasis for carcinoma of the ***,bilateral multiple metastatic lesions to breast are also very rare.

关键词： gallbladder carcinoma breast metastasis subcutaneous metastasis

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Prognostic factors for progression of liver structural lesions in chronic hepatitis C patients

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World Journal of Gastroenterology 2008年第16期14卷 2522-2528页

作者： Liliana sC Mendes Marcelo E nita suzane K Ono-nita Evandro s Mello Luiz Caetano da silva Venancio AF Alves Flair J Carrilho Department of Gastroenterology-Hepatology Branch University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil Department of Pathology University of So Paulo School of Medicine So Paulo 04537-040 So Paulo-SP Brazil

AIM: To evaluate the epidemiological, clinical, laboratory and histological variables capable of predicting the progression of hepatic structural disturbances in chronic hepatitis C patients during the time interval between two liver biopsies. METHODs: Clinical charts of 112 chronic hepatitis C patients were retrospectively analyzed, whereas liver biopsies were revised. Immunohistochemical detection of interferon receptor was based on the Envision-Peroxidase system. REsULTs: In the multivariate analysis, the variables in the age at first biopsy, ALT levels, presence of lymphoid aggregates and siderosis were the determinants of the best model for predicting the severity of the disease. The direct progression rate of hepatic structural lesions was significantly higher in untreated patients, intermediate in treated non-responders and lower in treated responders to antiviral therapy (non-treated vs responders, 0.22 ± 0.50 vs -0.15 ± 0.46, P = 0.0053). Immuno-expression of interferon receptor is not a relevant factor. CONCLUsION: The best predictors of the progression of fibrosis are age at the first liver biopsy, extent of ALT elevation, inflammation at liver histology and hepatic siderosis. Antiviral treatment is effective in preventing the progression of liver structural lesions in chronic hepatitis C patients.

关键词： Hepatitis C Histology Fibrosis Interfemns Disease progression

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Hard carbon derived from coconut shells,walnut shells,and corn silk biomass waste exhibiting high capacity for Na-ion batteries

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Journal of Energy Chemistry 2021年第7期30卷 207-218页

作者： Cristina nita Biao Zhang Joseph Dentzer Camélia Matei Ghimbeu Universitéde Haute-Alsace Institut de Science des Matériaux de Mulhouse(IS2M)CNRS UMR 7361F-68100 MulhouseFrance Universitéde strasbourg F-67081 StrasbourgFrance Center for Advanced Laser Technologies(CETAL) National Institute for LasersPlasma and Radiation PhysicsAtomistilor 409 bisRO-77125 MagureleRomania Department of Applied Physics The Hong Kong Polytechnic UniversityKowloonHong KongChina Réseau sur le stockage Electrochimique de l’Energie(Rs2E) CNRS FR345933 Rue Saint Leu80039 Amiens CedexFrance

In recent years,hard carbon materials have gained significant interest as anode materials for Na-ion *** waste is considered one of the most interesting,renewable,available,and cost-effective precursor to obtain hard carbon(HC);however,HC properties must be finely tuned to achieve performance comparable to those provided by Li-ion *** this work,three biomass wastes(coconut shells,walnut shells,and corn silk) were evaluated as potential precursors for HC preparation involving a pyrolysis process and subsequent acid washing to remove the inorganic *** obtained materials exhibited low and similar specific surface areas(sented different structures and surface *** walnut shell HC possessed a lower amount of inorganic impurities and oxygen-based functional groups compared to the coconut shell and corn silk HCs,leading to higher initial coulombic efficiency(iCE).The structural organization was higher in the case of the walnut shell HC,while the corn silk HC revealed a heterogeneous structure combining both highly disordered carbon and localized graphitized *** HCs delivered high initial reversible capacities between 293 and 315 mAh g^(-1) at 50 mA g^(-1) current rate,which remained rather stable during long-term *** best capacity(293 mAh g^(-1) after 100 charge/discharge cycles) and highest capacity retention(93%) was achieved in walnut HCs in half-cells,which could be associated with its higher sp2 C content,better organized structure,and fewer *** "adsorption-insertion" Na storage mechanism is suggested based on several *** walnut HCs exhibited an attractive energy density of 279 Wh/kg when tested in full cells.

关键词： Biomass Pyrolysis Hard carbon Anode Na-ion batteries Energy storage

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Cue hierarchy in the foraging behaviour of the brackish cladoceran Daphniopsis australis

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Journal of Oceanology and Limnology 2018年第6期36卷 2050-2060页

作者： MCCLOUD Clayton Leigh IsMAIL Hasnun nita sEURONT Laurent Australian Fisheries Management Authority CanberraAustralia school of Biology Universiti Teknologi MARASelangorMalaysia CNRs Univ.LilleUniv.Littoral Coe d'OpaleUMR 8187LOGLaboratoire d'Océnologie et de GésciencesF 62930 WimereuxFrance

Zooplankton communities are an essential component of marine and freshwater food webs. However, there is still a relative lack of information on how these organisms behaviourally respond to a range of abiotic and biotic stressors. specifically, the behaviour of the cladoceran D aphniopsis australis, a species endemic to south-eastern Australian saline lakes and ponds, is still unknown despite its potential role in the structure and function of inland water ecosystems. The swimming behaviour of males, parthenogenetic females and epiphial females was investigated under various conditions and combinations of food and conspecific cues. In the absence of cues, males displayed the most extensive swimming behaviour, exploring all areas of the container, and swimming in a series of relatively straight trajectories. In contrast, females typically exhibited a hop-and-sink motion characterised by the alternation between short bursts of swimming and sinking phases. Both females spent long periods near the bottom of the container, but epiphial females appeared to be more active than parthenogenetic ones that rarely made an excursion in the water column. In the presence of cues, males and females showed abilities to detect infochemicals from food and conspecifics, but exhibited specific behavioural strategies. Males essentially increased their swimming speed in the presence of food and/or conspecific infochemicals, and this increase was independent on the source of the cues, i.e. food, conspecific or a mixture of food and conspecifics. In contrast, females exhibited cue hierarchies that were related to their sexual status. Parthenogenetic females swam faster in the presence of food and a mixture of food and conspecific infochemicals than in the presence of cue from the opposite sex, which did not significantly differ from control observations conducted in the absence of cues. Epiphial females decreased their swimming speed in the presence of cues, with the most significant behavi

关键词： zooplankton chemical cues sex-specific behaviour

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Does the laparoscopic approach for liver resections for colorectal liver metastasis truly confer improved survival outcomes?

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Hepatobiliary surgery and Nutrition 2020年第6期9卷 805-808页

作者： nita Thiruchelvam David Cavallucci Adrian Kah Heng Chiow Hepatopancreatobiliary Unit Department of SurgeryChangi General HospitalSingaporeSingapore Royal Brisbane and Women’s Hospital University of QueenslandQueenslandAustralia

As an increasing proportion of surgeons mount their learning curves in laparoscopic liver resections,a larger percentage of liver surgery is being performed laparoscopically(1).syn et al.(2)published an impressive statistical analysis of existing randomized controlled trials(RCT)and propensity-score matched(PsM)studies that model a long-term survival benefit in favor of laparoscopic over open resection for colorectal liver metastases(CRLM).Whilst this is an encouraging outcome,it is critical to analyze the studies included that led to these improved survival outcomes.

关键词： laparoscopic colorectal resection

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India Plans World's First Tiger Move after Debacle

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科技英语学习 2007年第6期 26-28页

作者： nita Bhalla 源泉

百兽之王在印度某保护地的日子并不好过。由于近年来濒繁的偷猎行为,导致当地的老虎濒临绝迹。无奈之下,当局只能向外地征集老虎以恢复保护地的老虎数量。

关键词： India Plans World’s First Tiger Move after Debacle World

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膳食脂肪和心脏代谢健康:证据、争议和指导共识

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英国医学杂志中文版 2021年第3期24卷 144-150页

作者： nita G Forouhi Ronald M Krauss Gary Taubes Walter Willett 仲琳(译) 王春筱(译) 杨军(校) MRC Epidemiology Unit School of Clinical MedicineUniversity of CambridgeCambridgeUK Children′s Hospital Oakland Research Institute and University of California San FranciscoUSA Nutrition science Initiative San DiegoCaliforniaUSA Departments of Nutrition and Epidemiology Harvard T H Chan School of Public HealthHarvard UniversityBostonUSA 烟台毓璜项医院心内科

nita G Forouhi及其同事认为,尽管在营养研究和制定指南方面存在困难,但公众越来越能理解膳食脂肪和整体饮食的复杂性。

关键词：膳食脂肪心脏代谢复杂性

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