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Current systems and recent developments of subthreshold laser systems in glaucoma:a narrative review

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Annals of Eye science 2022年第3期7卷 38-54页

作者： Amrish selvam Joshua Ong Rajesh s.Kumar Jay Chhablani Dmitrii s.Maltsev Department of Ophthalmology University of Pittsburgh School of MedicinePittsburghPAUSA Cleveland Clinic Abu DhabiUnited Arab Emirates Cleveland Clinic Lerner school of Medicine Case Western Reserve UniversityClevelandOHUSA Department of Ophthalmology Military Medical AcademySt.PetersburgRussia

Background and Objective:subthreshold laser technologies and their applications in ophthalmology have greatly expanded in the past few *** used for retinal diseases such as central serous chorioretinopathy and diabetic macular edema,subthreshold lasers have recently shown efficacy in the treatment of various types of *** primary objectives are to review the clinical applications of subthreshold laser in the context of glaucoma treatment and discuss the mechanisms of different subthreshold laser techniques,including subthreshold selective laser trabeculoplasty(ssLT),micropulse laser trabeculoplasty(MLT),pattern-scanning laser trabeculoplasty(PsLT),titanium laser trabeculoplasty(TLT),and micropulse transscleral cyclophotocoagulation(MP-TsCPC).Methods:This was a narrative review compiled from literature of PubMed and Google *** review was performed from March 2021 to October 2021 and included publications in *** also included information from web pages to cover details of relevant laser *** discuss the history of subthreshold laser,recent advancements in subthreshold techniques,and commercially available systems that provide subthreshold capabilities for *** highlight basic science and clinical studies that deepen the understanding of treatment mechanisms and treatment effectiveness in the clinical setting *** review commonly used parameters for each technique and provide comparisons to conventional *** Content and Findings:We found five distinct types of subthreshold laser used in the management of *** subthreshold laser systems are commercially available and can provide this ***,understanding the differences between subthreshold techniques and laser systems will be critical in utilizing subthreshold laser in the clinical ***:Traditional laser trabeculoplasty(LT)and cyclophotocoagulation(CPC)have shown effectiveness in the treatment of various type

关键词： subthreshold laser cyclophotocoagulation(CPC) micropulse laser laser trabeculoplasty(LT) glaucoma

New scheme to trigger fusion in a compact magnetic fusion device by combining muon catalysis and alpha heating effects

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High Power Laser science and Engineering 2016年第4期4卷 1-7页

作者： s.D.Moustaizis P.Lalousis H.Hora Z.Henis s.Eliezer I.Ploumistakis Technical University of Crete Lab of Matter Structure and Laser Physics Institute of Electronic structure and Laser FORTH Department of Theoretical Physics University of New South Wales Applied Physics Division Soreq NRC Nuclear Fusion Institute Polytechnique University of MadridETSII

The application of laser pulses with psec or shorter duration enables nonthermal efficient ultrahigh acceleration of plasma blocks with homogeneous high ion energies exceeding ion current densities of 10^(12) A cm^(-2). The effects of ultrahigh acceleration of plasma blocks with high energy proton beams are proposed for muon production in a compact magnetic fusion device. The proposed new scheme consists of an ignition fusion spark by muon catalyzed fusion(μCF) in a small mirror-like configuration where low temperature D–T plasma is trapped for a duration of 1 μs. This initial fusion spark produces sufficient alpha heating in order to initiate the fusion process in the main device. The use of a multi-fluid global particle and energy balance code allows us to follow the temporal evolution of the reaction rate of the fusion process in the device. Recent progress on the ICAN and IZEsT projects for high efficient high power and high repetition rate laser systems allows development of the proposed device for clean energy production. With the proposed approaches,experiments on fusion nuclear reactions and μCF process can be performed in magnetized plasmas in existing kJ/PW laser facilities as the GEKKO-LFEX, the PETAL and the ORION or in the near future laser facilities as the ELI-NP Romanian pillar.

关键词： alpha heating effect high energy density physics laser plasmas interaction laser proton acceleration high energy density physics muon catalyzed fusion ultra-intense ultra-short pulse laser interaction with matters

Gyrokinetic simulation of low-n Alfvénic modes in tokamak HL-2A plasmas

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Chinese Physics B 2023年第2期32卷 358-365页

作者：林文浩李继全 J Garcia s Mazzi southwestern Institute of Physics Chengdu 610041China CEA IRFM13108Saint-Paul-lez-DuranceFrance EPFL Swiss Plasma CenterLausanneSwitzerland

The turbulence characteristics of plasmas with internal transport barriers in the HL-2A tokamak are analyzed by means of linear gyrokinetic simulations. It is found that turbulence is dominated by the ion temperature gradient(ITG)mode together with large-scale modes characterized by high-frequency electromagnetic fluctuation, which are destabilized by the steep ion temperature gradient in the weak magnetic shear regime. Comparison with solutions of analytical dispersion relations shows that their linear features match well with the beta-induced Alfvén eigenmode branch of the shear Alfvénic spectrum. It is further clarified that the large population of fast ions in these plasmas plays a stabilization role through the dilution mechanism in high-n ITG mode regimes.

关键词： low-n Alfvénic modes fast ions gyrokinetic simulation tokamak

ABTL0812 enhances antitumor effect of paclitaxel and reverts chemoresistance in triple-negative breast cancer models

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Cancer Communications 2022年第6期42卷 567-571页

作者： Emma Polonio-Alcala sònia solé-sánchez Pau Munoz-Guardiola Elisabet Megías-Roda Héctor Perez-Montoyo Marc Yeste-Velasco Jose Alfón Jose Miguel Lizcano Carles Domènech santiago Ruiz-Martínez Teresa Puig New Therapeutic Targets Laboratory(TargetsLab)-Oncology Unit Department of Medical SciencesUniversity of GironaGirona 17003Spain Product Process and Production Engineering Research Group(GREP)Department of Mechanical Engineering and Industrial ConstructionUniversity of GironaGirona 17003Spain Ability Pharmaceuticals SLCerdanyola del VallesBarcelona 08290Spain Protein Kinases and signal Transduction Laboratory Department de Bioquimica i Biologia Molecular and Institut de NeurocienciesUniversitat Autonoma de BarcelonaBellaterraBarcelona 08193Spain

Dear Editor,Triple-negative breast cancer(TNBC)accounts for 20%of all breast carcinomas and lacks a validated targeted therapy;thus,currently,cytotoxic chemotherapy is the treatment of choice[1].Compared with other breast cancer types,patientswith TNBCare younger,have larger tumors,a higher risk of metastasis,and a higher rate of recurrence[2].Among all the subtypes described by Lehmann et al.[3],mesenchymal-like and mesenchymal stem-like(MsL)subtypes had the lowest 5-year distant metastasis-free survival rates.

关键词： ABTL0812 TRIB3 Autophagy Breast Cancer Targeted Therapy Chemoresistance

Carbon nanotube-based nanoelectromechanical resonatoras mass biosensor

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Chinese Physics B 2020年第7期29卷 583-587页

作者： Ahmed MElseddawy Adel HPhillips Ahmed s Bayoumi Faculty of Graduate studies University of WindsorWindsorOntarioCanada Faculty of Engineering Ain-Shams UniversityCairoEgypt Faculty of Engineering Kafr-Elsheikh UnversityKafr-ElsheikhEgypt

The use of single walled carbon nanotube-based nanoelectromechanical system(NEMs)resonator to sense the biomolecules'mass is investigated under the influence of an external ac-field.A single walled carbon nanotube(sWCNT)cantilever has been proposed and studied if the mass is attached at the tip or various intermediate *** shift of the resonant frequency and the quality factor have been investigated and show high sensitivity to the attached mass of biomolecule and its *** proposed sWCNT-based NEMs resonator is a good candidate for sensing and tracing biomolecules'mass as concentration of acetone in human exhale,resulting in a painless,correct,and simple diabetics'diagnosis.

关键词： single walled carbon nanotube nanoelectromechanical system resonator ac-field biomolecule

A borehole stability study by newly designed laboratory tests on thick-walled hollow cylinders

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Journal of Rock Mechanics and Geotechnical Engineering 2015年第5期7卷 519-531页

作者： s.s.Hashemi N.Melkoumian A.Taheri Deep Exploration Technologies Cooperative Research Centre School of Civil Environmental and Mining Engineering University of Adelaide

At several mineral exploration drilling sites in Australia, weakly consolidated formations mainly consistof sand particles that are poorly bonded by cementing agents such as clay, iron oxide cement or *** formations are being encountered when drilling boreholes to the depth of up to 2 0 0 m. To studythe behaviour of these materials, thick-walled hollow cylinder （TWHC） and solid cylindrical syntheticspecimens were designed and prepared by adding Portland cement and water to sand grains. The effectsof different parameters such as water and cement contents, grain size distribution and mixture curingtime on the characteristics of the samples were studied to identify the mixture closely resembling theformation at the drilling site. The Hoek triaxia! cell was modified to allow the visual monitoring of graindebonding and borehole breakout processes during the laboratory tests. The results showed the significanceof real-time visual monitoring in determining the initiation of the borehole breakout. The sizescaleeffect study on TWHC specimens revealed that with the increasing borehole size, the ductility ofthe specimen decreases, however, the axial and lateral stiffnesses of the TWHC specimen remain *** different confining pressures the lateral strain at the initiation point of boreholebreakout is considerably lower in a larger size borehole （2 0 mm） compared to that in a smaller one（10 mm）. Also, it was observed that the level of peak strength increment in TWHC specimens decreaseswith the increasing confining pressure.

关键词： Real-time monitoring Experimental investigation Thick-walled hollow cylinder(TWHC) Poorly cemented sand formations

AN APPROACH ON sEVERAL PROBLEMs OF CHINA's URBANIZATION DEVELOPMENT

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Journal of Geographical sciences 1996年第2期6卷 35-41页

作者： Chen Wen(Nanjing Institute of Geography & Limnology, CAs, Nanjing 210008People’s Republic of China) Nanjing Inst of Geogr + Limnology CAS Nanjing 210008 China

China, having urique national conditions, is facing a basic contradiction between large numbers of less educated surplus rural labor forces and limited capacities of urban employment and infrastructure on the urbanization ***, the urbanization model should prevail in comprehensive and several ways: (1)On occupational and spatial shift rural surplus labors, two fashions of 'leaving land bot not countryside' and 'leaving both land and countryside' should be integrated with joint effort of cities and countryside. (2) On urbanization motive, urban construction will be invested by not only the govermment (from the upper), but the locality, personnel and foreigners (from the lower). (3) On urban scales, metropolis,large, medium-sized and small cities and towns should play fully their roles to absorb rural surplus lanors. Thereby, the present urban development policy needs to be rectified, which this paper has discussed particularly. (4) On account of great regional disparities in China, urban development should perform different models in different regions. In addition, this paper has also focused on the problem and its primary countermeasures of 'labor force mass', a hot issue closely related to urbanization and rural labor transfer.

关键词： national conditions urban development model urban development policy,rural labor mass

Housing and Urban Development in the People's Republic of China (A selected Bibliography 1980-1987)

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China City Planning Review 1991年第4期8卷 68-80页

作者： Ellen s Rieser

226.“Modernization and China’s UrbanDevelopment”sen-dou ChangAnnals of the Association of AmericanGeographersVol.71,No.21981,pp.202-219227.“Urbanization and economicReadjustment in China”sen-dou ChangIn Chi-Keung... 详细信息

关键词：少阴刀子

Breast Cancer Detection Using Breastnet-18 Augmentation with Fine Tuned Vgg-16

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Intelligent Automation & soft Computing 2023年第5期36卷 2363-2378页

作者： s.J.K.Jagadeesh Kumar P.Parthasarathi Mofreh A.Hogo Mehedi Masud Jehad F.Al-Amri Mohamed Abouhawwash Department of Computer science and Engineering Kathir College of EngineeringCoimbatore641062India Department of Computer science and Engineering Bannari Amman Institute of TechnologySathyamangalam638401TamilnaduIndia Electrical Engineering Department Faculty of EngineeringBenha UniversityBenha13518Egypt Department of Computer science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Women from middle age to old age are mostly screened positive for Breast cancer which leads to *** over the past decades,the overall sur-vival rate in breast cancer has improved due to advancements in early-stage diag-nosis and tailored *** all hospital brings high awareness and early detection technologies for breast *** increases the survival rate of *** traditional breast cancer treatment takes so long,early cancer techniques require an automation *** research provides a new methodol-ogy for classifying breast cancer using ultrasound pictures that use deep learning and the combination of the best ***,after successful learning of Convolutional Neural Network(CNN)algorithms,data augmentation is used to enhance the representation of the feature *** it uses BreastNet18 withﬁne-tuned VGG-16 model for pre-training the augmented *** feature classiﬁcation,Entropy controlled Whale Optimization Algorithm(EWOA)is *** features that have been optimized using the EWOA were utilized to fuse and optimize the *** identify the breast cancer pictures,training classiﬁers are *** using the novel probability-based serial technique,the best-chosen characteristics are fused and categorized by machine learning *** main objective behind the research is to increase tumor prediction accuracy for saving human *** testing was performed using a dataset of enhanced Breast Ultrasound Images(BUsI).The proposed method improves the accuracy com-pared with the existing methods.

关键词： Deep learning classiﬁcation data augmentation feature extraction the fusion of features breast cancer optimization classiﬁcation