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structural and Functional Annotation of Hypothetical Protein of Fusobacterium nucleatum strain MJR7757B: An in silico Approach

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Computational Molecular Bioscience 2024年第1期14卷 17-33页

作者： md. Isrfil Hossen Fouzia Mostafa Nusrat Jahan Jannatul Ferdaus Amgad Albahi sayed Mashequl Bari College of Food science and Technology Huazhong Agricultural University Wuhan China Department of Crop science and Technology Rajshahi University Rajshahi Bangladesh Abdul Malek Ukil Medical College Noakhali Bangladesh Department of Medicine IBN Sina Medical College Dhaka Bangladesh National Food Research Centre Khartoum Sudan Department of Aquatic Animal Health Management Sher-e-Bangla Agricultural University Dhaka Bangladesh

Fusobacterium nucleatum is an anaerobic, commensal, gram-negative oral bacterium that is carcinogenic and causes a wide range of human diseases. The present study focused on the analysis of the hypothetical protein, HMPREF3221_01179, derived from F. nucleatum strain MJR7757B, employing various computational methods to anticipate both its structure and functional characteristics. NCBI conserved domain analysis, NCBI BLAsTp and MEGA Phylogenetic tree study characterize the target protein as an outer membrane efflux protein (ToIC family) which facilitate the bacterial transmembrane transport. With a molecular weight of 52120.02 Da, an isoelectric point (pI) of 8.33, and an instability index of 29.47, the protein is anticipated to exhibit good solubility in the extracellular space and crucial stability for pharmaceutical applications. The protein’s structure meets quality standards during the construction and refinement of its 3D model. The efflux inhibitor Arginine beta-naphthylamide exhibits a significant binding affinity (-7.1 kcal/mol) to the binding site of the target protein. The in-silico analysis improves the understanding of the protein and facilitates future investigations into therapeutic medication.

关键词： Fusobacterium nucleatum In silico Bacteria Hypothetical Protein Molecular Docking

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surgical or medical treatment of obesity-associated type 2 diabetesan increasing clinical conundrum

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World Journal of Diabetes 2024年第10期15卷 2036-2040页

作者： Ryan J Jalleh Karen L Jones md shahidul Islam Lu Cai Michael Horowitz Adelaide Medical school and Centre of Research Excellence in Translating Nutritional science to Good Health University of Adelaide Endocrine and Metabolic Unit Royal Adelaide HospitalAdelaide 5000South AustraliaAustralia Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalDurban 4000KwaZulu-NatalSouth Africa Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyUniversity of LouisvilleWendy Novak Diabetes InstituteNorton Children’s HospitalLouisvilleKY 40202United States

In this editorial,we comment on the article by He et al,specifically in relation to the efficacy of bariatric surgery vs glucagon-like peptide-1 receptor agonist(GLP-1RA)therapy in the management of type 2 diabetes(T2D)associated with *** surgery has now also been shown to be safe and effective in pre-teens and teenagers with obesity and T2D,but information on newer GLP-1RAs in these groups is predictably *** older individuals(age>65 years),both bariatric surgery and GLP-1RA therapy improve cardiovascular ***-tric surgery is not infrequently associated with post-operative postprandial hypoglycemia,which is not the case with GLP-1RAs and,paradoxically,there is evidence that GLP-1RAs may reduce both the frequency and severity of postprandial *** trials of the long-term efficacy of bariatric surgery and GLP-1RAs are indicated.

关键词： Glucagon-like peptide-1 Glucagon-like peptide-1 receptor agonist Obesity Diabetes Weight loss Bariatric surgery Metabolic surgery Hypoglycemia

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加载速率对密砂应力-应变特性影响的试验研究

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水利水电技术（中英文） 2024年第5期55卷 50-59页

作者： md RAsEL Ahammed 邓刚张延亿胡敏云张茵琪中国水利水电科学研究院流域水循环模拟与调控国家重点实验室北京100038 中国水利水电科学研究院水利部水工程建设与安全重点实验室北京100038 中国水利水电科学研究院水利部白蚁防治重点实验室北京100038

【目的】砂是一种常见的建筑材料,在水利水电工程、交通、海洋和其他土木工程中应用广泛。在不同的工程应用中,砂土经受不同的加载过程和加载速率。因为加载速率效应,砂在相同幅值荷载作用下产生的变形有一定差异。这项研究旨在深入了... 详细信息

【目的】砂是一种常见的建筑材料,在水利水电工程、交通、海洋和其他土木工程中应用广泛。在不同的工程应用中,砂土经受不同的加载过程和加载速率。因为加载速率效应,砂在相同幅值荷载作用下产生的变形有一定差异。这项研究旨在深入了解不同应变速率三轴剪切条件下砂的应力应变特性。【方法】采用相对密度为0.9的密砂,开展了一系列三轴固结排水剪切试验,在两种不同围压(750 kPa和2000 kPa)下对试样进行固结后,分别采用三种不同的常应变速率(0.00625%/min,0.0625%/min和0.625%/min)进行应变控制排水剪切。根据试验数据,绘制了应力-应变关系发展曲线,分析了应变速率对砂土偏应力和体积应变演化的影响。【结果】结果表明,在本试验采用的恒定应变速率和围压条件下,密砂在轴向应变约为2%时将发生屈服。屈服前,相同轴应变增量对应的土样偏应力增量和体积应变增量对剪切速率比较敏感,特别是体积应变,即加载应变速率较小时获得的土样剪应力较低,但体积应变(收缩)发展量较大。【结论】在屈服前,砂土的模量随着加载速率的增加而增大;但是屈服后,当加载达到大应变(ε1=15%)条件时,应变率对砂土应力变形的影响不明显。另外,在相同围压下,以不同应变率加载的砂样在加载过程中的应力比(q/p)-偏应变关系呈现出一致性。该研究可以提高对砂土力学特性的认识,并为砂土地基上的结构设计和安全评价提供参考。

关键词：密砂三轴固结排水试验应变率偏应力体积应变变形力学性能影响因素

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surface settlement induced by horizontal directional drilling

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Underground space 2023年第1期8卷 94-108页

作者： Asif Ahmed md Azijul Islam md Zahangir Alam Hashmi s.Quazi College of Engineering State University of New York Polytechnic Institute(SUNY Poly)UticaNY 13502USA Department of Civil Engineering The University of Texas at ArlingtonArlingtonTX 76019USA Department of Civil Engineering Bangladesh University of Engineering and Technology(BUET)Dhaka 1000Bangladesh Converse Consultants RedlandsCA 92373USA

Horizontal directional drilling(HDD)is a widely used trenchless method for underground utility *** associated ground settlement triggered by HDD depends on the size,types,and surface texture of pipe,diameter of borehole,and soil *** pre-sent study investigates the surface settlement due to the construction of a 1067 mm diameter HDD,which will replace an existing sewer siphon under the sR-60 highway in Chino,California using empirical,and numerical *** on the results obtained from the subsurface investigation,an empirical analysis was conducted *** by numerical modeling of the HDD using PLAXIs 2D soft-ware.A careful comparison between two different methods indicated closer values of surface settlement between the empirical method(7.3 mm)and the numerical modeling(4.6 mm).In addition,the shape of surface settlement and horizontal settlement curves for the empirical and numerical methods was found to be *** minor discrepancy between the two methods resulted as the numerical model can host several soil layers whereas the empirical equation can use only one type of ***,a parametric study was conducted to evaluate the effect of borehole cover depth,size,and soil parameters on surface *** was observed that soil strength param-eters yielded a greater effect on surface movement,whereas modulus of elasticity has a relatively smaller influence with zero contribution from Poisson’s ratio.

关键词： Horizontal directional drilling(HDD) surface settlement Cover depth soil arching Borehole

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New structures for closed-form wave solutions for the dynamical equations model related to the ion sound and Langmuir waves

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Communications in Theoretical Physics 2021年第3期73卷 1-13页

作者： md Nur Alam M s Osman Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt Department of Mathematics Faculty of Applied ScienceUnrni Alqura UniversityMakkah 21955Saudi Arabia

This treatise analyzes the coupled nonlinear system of the model for the ion sound and Langmuir *** modified(G'/G)-expansion procedure is utilized to raise new closed-form wave *** solutions are investigated through hyperbolic,trigonometric and rational *** graphical design makes the dynamics of the equations *** provides the mathematical foundation in diverse sectors of underwater acoustics,electromagnetic wave propagation,design of specific optoelectronic devices and physics quantum ***,we concluded that the studied approach is advanced,meaningful and significant in implementing many solutions of several nonlinear partial differential equations occurring in applied sciences.

关键词： the modified(G'/G)-expansion method ion sound wave Langmuir wave closed-form wave solutions

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微带漏波天线及其波束控制方法

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无线通信技术 2024年第2期33卷 29-32页

作者： Hossain md Yousuf 华昌洲宁波大学信息科学与工程学院宁波315211

漏波天线是一类具有广大应用前景的导波天线,与传统天线相比具有明显的优势,可为各种无线通信和雷达应用提供波束控制功能。本文提出一种使用容性负载实现方向图动态辐射模式控制的漏波天线设计及波束控制方法。波束控制方法作为研究的... 详细信息

漏波天线是一类具有广大应用前景的导波天线,与传统天线相比具有明显的优势,可为各种无线通信和雷达应用提供波束控制功能。本文提出一种使用容性负载实现方向图动态辐射模式控制的漏波天线设计及波束控制方法。波束控制方法作为研究的主要重点,即在天线结构的特定位置引入电容元件来调制导波的有效折射率,通过改变波束的辐射角度来实现波束的控制。此外,研究还通过改变容性负载的参数分析了不同参数的容性负载对漏波天线辐射特性的影响。该技术具有结构简单、低成本、易小型化等特点,可以集成到各种无线通信系统和雷达阵列中。

关键词：漏波天线导波天线波束偏转

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In silico identification of antiviral compounds for the treatment of chikungunya virus infection:qsar modelling and md simulation analysis

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Medicine in Novel Technology and Devices 2024年第2期22卷 102-114页

作者： Hayder M Abdulhamza Muthanna s.Farhan sara.s Hassan Hany Aqeel Al-Hussainy Amjad Ibrahim Oriabi Department of Pharmacy Kut University CollegeAlkutWasit52001Iraq Department of Pharmaceutical Chemistry College of PharmacyUniversity of BaghdadBaghdadIraq Al-Manara College for Medical sciences Department of PharmacyIraq Department of Pharmacy Hilla University CollegeBabylonIraq Dr Hany Akeel Institute Iraqi Medical Research CenterBaghdad10001Iraq

Chikungunya virus(CHIKV),transmitted by arthropods,has gained global recognition for its impact on public *** has expanded globally,including Africa,Asia,and the Indian subcontinent,and has a helicase protein in its genome that is crucial for its ***,the study targeted the helicase protein of CHIKV with 745 antiviral compounds using an ML-based QsAR model and molecular *** binders(5279172,78161839,6474310,and 5330286)were selected for md simulation based on the control(silvestrol).All compounds had the highest binding scores,with 78161839 showing the most consistent RMsD and the least conformational variation,indicating high *** also showed the lowest binding free energy(ΔG¼31.31 kcal/mol),indicating energetically favourable *** and FEL also depicted the stable complex confirmation of the protein and 78161839 complex during the 100 ns ***,this study aimed to identify helicase function antiviral binders that could be experimentally tested for treating CHIKV.

关键词： Chikungunya virus Machine learning based QsAR Molecular dynamic solution Helicase

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聚乙烯醇/透明质酸复合导电水凝胶的制备及其传感和抗菌性能

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现代纺织技术 2024年第8期32卷 23-34页

作者：王艳敏丁新波刘涛仇巧华 HAsAN md Kamrul 朱灵奇周家宝浙江理工大学纺织科学与工程学院(国际丝绸学院) 杭州310018

为制备兼具传感和抗菌功能的导电水凝胶,以聚乙烯醇(PVA)和透明质酸(HA)为原料,通过原位聚合和冻融法制得氧化锌/聚(3,4-乙烯二氧噻吩)/聚乙烯醇/透明质酸(ZnO/PEDOT/PVA/HA,简写ZP)导电水凝胶;并对其形貌、结构组成、力学性能、传感性... 详细信息

为制备兼具传感和抗菌功能的导电水凝胶,以聚乙烯醇(PVA)和透明质酸(HA)为原料,通过原位聚合和冻融法制得氧化锌/聚(3,4-乙烯二氧噻吩)/聚乙烯醇/透明质酸(ZnO/PEDOT/PVA/HA,简写ZP)导电水凝胶;并对其形貌、结构组成、力学性能、传感性能及其抗菌性能进行分析。结果表明:氧化锌的质量分数在0.3%时,ZP导电水凝胶的电导率最高可达2.91 s/m;ZP导电水凝胶具有良好的拉伸应变性能(≥100%)、灵敏的响应速度(s)和较好的稳定性(>1000次),能够对人体不同部位的运动信号进行监测识别;此外,ZP导电水凝胶对金黄色葡萄球菌(***)和大肠杆菌(***)具有良好的抑制效果。该导电水凝胶在柔性可穿戴传感器及医疗健康监测方面具有良好的应用前景。

关键词：导电水凝胶传感性能柔性可穿戴传感器抗菌性能

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Pattern of Eye Diseases among Tea Workers

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Open Journal of Ophthalmology 2024年第2期14卷 117-127页

作者： Rifat Binth Rezayee md. showkat Kabir Mohammed Moinul Hoque Nirupam Chowdhury Mohammad shish Rahman Nawreen Binte Anwar shah-Noor Hassan Department of Community Ophthalmology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh Department of Ophthalmology Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh

Background: Bangladesh’s tea industry is essential to the country’s economic expansion. since tea workers in Bangladesh are marginalized within our community, they have limited access to comprehensive eye care services. Productivity and well-being are cornerstones of comprehensive health care strategy. Ocular disorders are influenced by life expectancy, sociodemographic status, and the epidemiological transition. In this context, the state of ocular health and the many eye illnesses remain to be significantly addressed. Purpose: To evaluate the pattern of eye diseases among tea workers in a tea estate of Bangladesh. Methods: This cross-sectional observational study was carried out in Halda Valley Tea Estate, Nazirhat, Fatickchari, Chattogram, Bangladesh, under the supervision of the Department of Community Ophthalmology, BsMMU, following ethical clearance and approval by the IRB board of BsMMU. With informed written consent and approval from the authority of the tea estate, a total of 110 tea workers were recruited. socio-demographic characteristics, ocular findings, and patterns of eye diseases were determined and recorded. Results: The mean age of the study participants was 39.60 ± 11.63 years. The maximum (58.1%) study participants were 31 - 50 years old, female (64.5%), illiterate (82.7%), and tribal (71.8%) indigenes. Eye diseases were found in 94.5% of workers. Presbyopia (28.2%), cataracts (27.3%), and refractive error (26.4%) were the most common. Tea workers with eye diseases were significantly older than those who did not have any eye diseases (40.20 ± 11.57 vs. 29.17 ± 7.31 years, p Conclusion: A significant number of tea workers had eye diseases, of which presbyopia, cataracts, and refractive error were the most common.

关键词： Tea Workers Eye Diseases Presbyopia Cataract Refractive Errors

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Insights into the physical properties and anisotropic nature of ErPdBi with an appearance of low minimum thermal conductivity

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Chinese Physics B 2021年第1期30卷 398-406页

作者： s K Mitro R Majumder K M Hossain md Zahid Hasan md Emran Hossain M A Hadi Bangamata sheikh Fojilatunnesa Mujib science and Technology University Jamalpur-2012Bangladesh Physics Discipline Khulna UniversityKhulna-9208Bangladesh Department of Materials science and Engineering University of RajshahiRajshahi-6205Bangladesh Department of Electrical and Electronic Engineering International Islamic University ChittagongKumiraChittagong-4318Bangladesh Department of Physics University of RajshahiRajshahi6205Bangladesh

We theoretically study the structural, elastic and optical properties of Er Pd Bi together with its anisotropic behaviors using density functional theory. It is observed that Er Pd Bi satisfies the Born stability criteria nicely and possesses high quality of machinability. The anisotropic behavior of Er Pd Bi is reported with the help of theoretical anisotropy indices incorporating 3 D graphical presentation, which suggests that Er Pd Bi is highly anisotropic in nature. It is noticed that the minimum thermal conductivity is very low for Er Pd Bi compared to the several species. This low value of minimum thermal conductivity introduces the potentiality of Er Pd Bi in high-temperature applications such as thermal barrier *** addition, deep optical insights of Er Pd Bi reveal that our material can be used in different optoelectronic and electronic device applications ranging from organic light-emitting diodes, solar panel efficiency, waveguides etc. to integration of integrated circuits. Therefore, we believe that our results will provide a new insight into high-temperature applications and will benefit for the development of promising optoelectric devices as well.

关键词： Er Pd Bi minimum thermal conductivity anisotropy density functional theory(DFT)

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