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Optimized Cognitive Learning Model for Energy Efficient Fog-BAN-IoT Networks

Computer systems science & Engineering 2022年第12期43卷 1027-1040页

作者： s.kalpana C.Annadurai sRM Institute of science and Technology Chennai600089India sri sivasubramaniya Nadar College of Engineering Chennai603110India

In Internet of Things (IoT), large amount of data are processed andcommunicated through different network technologies. Wireless Body Area Networks (WBAN) plays pivotal role in the health care domain with an integration ofIoT and Artificial Intelligence (AI). The amalgamation of above mentioned toolshas taken the new peak in terms of diagnosis and treatment process especially inthe pandemic period. But the real challenges such as low latency, energy consumption high throughput still remains in the dark side of the research. This paperproposes a novel optimized cognitive learning based BAN model based on FogIoT technology as a real-time health monitoring systems with the increased network-life time. Energy and latency aware features of BAN have been extractedand used to train the proposed fog based learning algorithm to achieve low energyconsumption and low-latency scheduling algorithm. To test the proposed network,Fog-IoT-BAN test bed has been developed with the battery driven MICOTTboards interfaced with the health care sensors using Micro Python *** extensive experimentation is carried out using the above test beds and variousparameters such as accuracy, precision, recall, F1score and specificity has beencalculated along with Qos (quality of service) parameters such as latency, energyand throughput. To prove the superiority of the proposed framework, the performance of the proposed learning based framework has been compared with theother state-of-art classical learning frameworks and other existing Fog-BAN networks such as WORN, DARE, L-No-DEAF networks. Results proves the proposed framework has outperformed the other classical learning models in termsof accuracy and high False Alarm Rate (FAR), energy efficiency and latency.

关键词： Fog-IoT-BAN optimized learning model internet of things micott worn dare l-deaf networks quality of service

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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China's transition to a low-carbon economy and climate resilience:The impact of sustainable modernization indicators

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Journal of Geographical sciences 2024年第11期34卷 2145-2165页

作者： BEN AMARA Dhekra ZHU Qiankun QIAO Jiajun sAFRO Isaac REGMI kalpana The College of Geography and Environmental science Henan UniversityKaifeng475004HenanChina Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions(Henan University) Ministry of EducationKaifeng475004HenanChina National Demonstration Center for Environment and Planning(Henan University) Kaifeng475004HenanChina

While sustainability is widely recognized as a necessary path for development and climate change mitigation,there is no consensus on this concept’s goals and future *** of a green economy believe that economic growth is a prerequisite for long-term progress and the modernization of *** entails gradually transitioning to a more sustainable economy and addressing carbon ***,there is a need for the scientific community to investigate how different forms of modernization affect carbon *** study examines the impact of modernization on carbon emissions in China,the world’s largest developing economy,focusing on five indicators of sustainable modernization:ecological modernization,agricultural modernization,digitalization,industrialization,and *** study analyzes data from 31 Chinese provincial-level regions between 2005 and 2020,using the GeoDetector technique to explore the effects of these indicators on carbon *** spatial analysis reveals a distinct“core-periphery”structure of carbon *** findings demonstrate that ecological modernization and digitalization contribute to reducing *** the other hand,industrialization and urbanization have a positive influence on carbon ***,agricultural modernization initially increases carbon emissions in the short term but has a diminishing effect in the long term.

关键词： sustainable modernization indicators carbon emissions climate change geographic indicators technique

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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A Review on Efficient Routing Mechanisms in Urban scenario of Vehicular Ad⁃Hoc Networks

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Journal of Harbin Institute of Technology(New series) 2023年第6期30卷 83-94页

作者： kalpana Devi s Thenmozhi R Department of Computing Technologies SRM Institute of Science and TechnologyKattankulathurChennai 603203India

Efficient routing protocols are crucial for enabling secure communication among the highly mobile and self-configurable nodes in Vehicular Ad-Hoc Networks(VANETs). In this work, we present a performance evaluation of different routing protocols in VANETs based on the currently available research. Our study focuses on analyzing the strength and weaknesses of the routing protocols, namely, Ad-Hoc On-demand Distance Vector(AODV), Dynamic source Routing(DsR), and Destination-sequenced Distance-Vector(DsDV), under varying network conditions. We examine the protocols’ performance based on key metrics such as throughput, delay, and energy consumption. We also highlight the advantages and limitations of each protocol in different scenarios, such as varying vehicular densities and mobility patterns. Our results show that AODV outperforms DsR and DsDV in terms of throughput and delay, while DsR consumes the least energy. We also observe that the performance of the routing protocols varies with the density of vehicles and the mobility patterns of the nodes. Our study highlights the importance of conducting real-world experiments to evaluate the performance of routing protocols in VANETs, as they provide more realistic and accurate results than simulation-based studies. Our findings can help in the selection and design of efficient and secure routing protocols for VANETs.

关键词： Routing metrics VANET mobile nodes simulation

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δ-Opioid receptor as a potential therapeutic target for ischemic stroke

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Neural Regeneration Research 2020年第1期15卷 20-24页

作者： kalpana subedi Hongmin Wang Division of Basic Biomedical sciences and Center for Brain and Behavior Research Sanford School of Medicine University of South Dakota

Ischemic stroke is a global epidemic condition due to an inadequate supply of blood and oxygen to a specific area of brain either by arterial blockage or by narrowing of blood *** having advancement in the use of thrombolytic and clot removal medicine,significant numbers of stroke patients are still left out without option for *** this review,we summarize recent research work on the activation ofδ-opioid receptor as a strategy for treating ischemic stroke-caused neuronal ***,as activation ofδ-opioid receptor by a non-peptidicδ-opioid receptor agonist also modulates the expression,maturation and processing of amyloid precursor protein andβ-secretase activity,the potential role of these effects on ischemic stroke caused dementia or Alzheimer’s disease are also discussed.

关键词： agonist AKT amyloid precursor protein BDNF ischemic stroke neuroprotection δ-opioid receptor p38 MAPK PI3K TrkB

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Understanding activity of butyrate at a cellular level

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Neural Regeneration Research 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie University Motor Neuron Disease Research Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is a short-chain fatty acid of four carbons in length that is a by-product produced by the microbial fermentation of dietary fiber and undigested carbohydrates within the *** the years,butyrate has attracted ... 详细信息

关键词： carbons butyrate fiber

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