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MR神经成像在肌萎缩侧索硬化症与多灶性运动神经病中的应用

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国际医学放射学杂志 2019年第5期 610-610页

作者： M.Kronlage K.C.Knop D.schwarz T.Godel s.heiland M.Bendszus 王子建 Department of Neuroradiology Heidelberg University Hospital

摘要肌萎缩侧索硬化症(ALs)与多灶性运动神经病(MMN)之间的鉴别诊断依赖于临床检查和电生理标准。周围神经成像可能有助于鉴别诊断。目的评估MR神经成像技

关键词：肌萎缩侧索硬化症多灶性运动神经病 MR 神经成像

Detection and clearance in Alzheimer’s disease: leading with illusive chemical, structural and morphological features of the targets

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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： Luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs−Instituto de Ciências Biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

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MR灌注成像的血流动力学参数反应:贝伐单抗在复发性胶质瘤疗效方面的拓展研究

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国际医学放射学杂志 2016年第4期 432-432页

作者： P.Kickingereder A.Radbruch s.Burth A.Wick s.heiland H.P.schlemmer 宋玉坤 Department of Neuroradiology University of Heidelberg Medical Center

摘要目的为了更好地了解贝伐单抗疗法对复发性胶质瘤的血流和氧合状态的影响。材料与方法回顾性数据的评估由海德堡大学的当地伦理委员会批准支持(伦理批准文号:s-320/2012),未签订知情同意书。71例被诊断为复发性胶质瘤的病人治疗前的... 详细信息

摘要目的为了更好地了解贝伐单抗疗法对复发性胶质瘤的血流和氧合状态的影响。材料与方法回顾性数据的评估由海德堡大学的当地伦理委员会批准支持(伦理批准文号:s-320/2012),未签订知情同意书。71例被诊断为复发性胶质瘤的病人治疗前的检查和开始接受贝伐单抗治疗后的第一次随访检查中均是接受常规MRI扫描和动态磁敏感增

关键词：贝伐单抗复发性 MR 胶质瘤力学参数反应

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采用扩散张量成像技术检测周围神经病变

国际医学放射学杂志 2014年第6期 587-587页

作者： P.Bumer M.Pham M.Ruetters s.heiland A.Heckel A.Radbruch 禹智波 Department of Neuroradiology Heidelberg University HospitalIm Neuenheimer Feld 40069120 HeidelbergGermany

摘要目的探讨扩散张量成像(DTI)和T2加权成像来帮助检测轻度神经病变的可能性,如亚临床型肘部尺神经病变。材料与方法本前瞻性研究经伦理委员会的批准,所有受

关键词：神经传导速度 DTI 肘部加权成像神经病变外周神经受试者

牙齿和牙周结构的MR成像:高分辨率MRI、MDCT和锥束CT的对比研究

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国际医学放射学杂志 2012年第1期 100-100页

作者： C.Gaudino R.Cosgarea s.heiland R.Csernus B.B.Zobel M.Pham 李琼 Department of Neuroradiology University Hospital Heidelberg69120 HeidelbergGermany

目的探讨利用MRI观察牙齿和牙周结构的可行性,并将其影像与MDCT、锥束CT进行对比。材料与方法对4头猪的下颌骨分别行3T-MRI、MDCT和锥束CT(CBCT)检

关键词： MRI 牙颌面牙周韧带图像质量解剖标志

Model dependent analysis of D^(+)_(s)→η^(′)l+v_(l) decays in beyond standard model

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Chinese Physics C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Biswas s.sahoo Department of Physics National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental results of branching fractions for D^(+)_(s)→η^(′)l+v_(l) decays,which deviate from their sM predictions,we hve investigated these decays in W' model and scalar leptoquark model to determine potential signatures of new physics(NP) in semileptonic charm decays induced by c→(s,d)l+v_(l) *** recent experimental results of branching fractions for semileptonic D meson decays,new coupling parameters are predicted for the aforementioned NP *** fraction,forward-backward asymmetry,and lepton polarization asymmetry are examined by considering the predicted NP coupling *** results of branching fractions in scalar leptoquark model are found very close to the experimental results and exist around the range of 1σ *** presented a comparative study of the NP models to check their sensitivity on these *** anticipate that further research on these decays will significantly support our findings.

关键词： charm decay new physics W′boson scalar leptoquark flavour changing charged current

采用MR扩散成像、灌注成像、磁敏感成像多参数鉴别原发性中枢神经系统淋巴瘤和不典型性胶质母细胞瘤

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国际医学放射学杂志 2014年第6期 579-579页

作者： P.Kickingereder B.Wiestler F.sahm s.heiland M.Roethke H.P.schlemmer 石彦姝 Departments of Neuroradiology University of Heidelberg Medical CenterHeidelbergGermany

摘要目的对比MR扩散成像、动态磁敏感对比剂增强灌注成像、磁敏感成像多参数在鉴别原发性中枢神经系统淋巴瘤(PCNsL)和不典型性胶质母细胞瘤中的诊断效能。材料

关键词：胶质母细胞瘤诊断效能原发性中枢神经系统淋巴瘤 PCNsL 不典型性扩散成像多参数灌注成像磁敏感成像 MR

肘关节尺神经病:MR神经成像——神经T2信号增高与直径测量

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国际医学放射学杂志 2011年第5期 478-478页

作者： P.Bumer T.Dombert F.staub T.Kaestel A.J.Bartsch s.heiland 蔡兆诚 Department of Neuroradiology and Division of Experimental Radiology University of HeidelbergIm Neuenheimer Feld 40069120 HeidelbergGermany

目的评价尺神经的T2信号及直径大小在肘关节尺神经疾病(UNE)MR神经成像中的诊断效能。材料与方法本研究为前瞻性研究,经机构审查委员会批准,所有参与者

关键词：肘关节神经成像 T2 尺神经臂丛 MR 直径测量

Astrophysical s-factor and reaction rate for 15N(p,γ)16O within the modified potential cluster model

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Chinese Physics C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezerashvili N.A.Burkova B.M.Yeleusheva Fesenkov Astrophysical Institute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate school and University Center City University of New York10016 New YorkUSA al-Farabi Kazakh National University 050040 AlmatyKazakhstan

We study radiative p^(15)N capture on the ground state of ^(16)O at stellar energies within the framework of a modified potential cluster model(MPCM)with forbidden states,including low-lying *** investigation of the ^(15)N(p,γ0)^(16)O reaction includes the consideration of ^(3)s_(1) resonances due to E1 transitions and the contribution of the ^(3)P_(1) scattering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the astrophysical low-energy s-factor,and the extrapolated s(0)turned out to be within 34.7−40.4 keV·*** important role of the asymptotic constant(AC)for the ^(15)N(p,γ0)16O process with interfering ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances is elucidated.A comparison of our calculation for the s-factor with existing experimental and theoretical data is addressed,and a reasonable agreement is *** reaction rate is calculated and compared with the existing *** has negligible dependence on the variation of AC but shows a strong impact of the interference of ^(3)s_(1)(312)and ^(3)s_(1)(962)resonances in reference to the CNO Gamow windows,especially at low *** estimate the contribution of cascade transitions to the reaction rate based on the exclusive experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cascade transitions is observed from T_(9)>0.3 and reaches the maximum factor~1.3 at T_(9)=*** present the Gamow energy window and a comparison of rates for radiative proton capture reactions ^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows,prevalence,and significance of each process.

关键词： low and astrophysical energies p^(15)N system thermonuclear reaction rate potential cluster model CNO-cycle

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