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The effects of local variations in conditions on carbon storage and release in the continental mantle

National science Review 2024年第06期 22-36页

作者： stephen f.foley Chunfei Chen Dorrit E.Jacob school of Natural sciences Macquarie University Research school of Earth sciences Australian National University state Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences

Recent advances indicate that the amount of carbon released by gradual degassing from the mantle needs to be revised upwards, whereas the carbon supplied by plumes may have been overestimated in the *** in rock types and oxidation state may be very local and exert strong influences on carbon storage and release mechanisms. Deep subduction may be prevented by diapirism in thick sedimentary packages,whereas carbonates in thinner sequences may be subducted. Carbonates stored in the mantle transition zone will melt when they heat up, recognized by coupled stable isotope systems(e.g. Mg, Zn, Ca). There is no single ‘mantle oxygen fugacity’, particularly in the thermal boundary layer(TBL) and lowermost lithosphere, where very local mixtures of rock types coexist. Carbonate-rich melts from either subduction or melting of the uppermost asthenosphere trap carbon by redox freezing or as carbonate-rich dykes in this zone. Deeply derived, reduced melts may form further diamond reservoirs, recognized as polycrystalline diamonds associated with websteritic silicate minerals. Carbon is released by either edge-driven convection,which tears sections of the TBL and lower lithosphere down so that they melt by a mixture of heating and oxidation, or by lateral advection of solids beneath rifts. Both mechanisms operate at steps in lithosphere thickness and result in carbonate-rich melts, explaining the spatial association of craton edges and carbonate-rich magmatism. High-pressure experiments on individual rock types, and increasingly on reactions between rocks and melts, are fine-tuning our understanding of processes and turning up unexpected results that are not seen in studies of single rocks. future research should concentrate on elucidating local variations and integrating these with the interpretation of geophysical signals. Global concepts such as average sediment compositions and a uniform mantle oxidation state are not appropriate for small-scale processes; an increa

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-Lobato Mariam Masmudi-Martín Manuel f.López-Aranda Juan f.López-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan Laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGs14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGs14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNf).A knockdown of BDNf gene in RGs14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNf-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGs14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGs14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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There is more to the knee joint than just the quadriceps:A systematic review with meta-analysis and evidence gap map of hamstring strength,flexibility,and morphology in individuals with gradual-onset knee disorders

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Journal of sport and Health science 2024年第4期13卷 521-536页

作者： Helder s.Lopes Marina C.Waiteman Liliam B.Priore Neal R.Glaviano David M.Bazett-Jones Ronaldo V.Briani fabio M.Azevedo school of science and Technology Physical Therapy DepartmentSao Paulo State University(UNESP)Presidente Prudente 19060-900Brazil Department of Kinesiology College of AgricultureHealth and Natural ResourcesUniversity of ConnecticutStorrsCT 06269USA school of Exercise and Rehabilitation sciences College of Health and Human ServicesUniversity of ToledoToledoOH 43606USA

Background:Impairments in hamstring strength,flexibility,and morphology have been associated with altered knee biomechanics,pain,and *** the presence of these impairments in individuals with gradual-onset knee disorders is important and may indicate targets for assessment and *** systematic review aimed to synthesize the literature to determine the presence of impairments in hamstring strength,flexibility,and morphology in individuals with gradual-onset knee ***:five databases(MEDLINE,Embase,CINAHL,sPORTDiscus,and Web of science)were searched from inception to september *** studies comparing hamstring outcomes(e.g.,strength,flexibility,and/or morphology)between individuals with gradual-onset knee disorders and their unaffected limbs or pain-free controls were ***-analyses for each knee disorder were ***-level certainty was assessed using the Grading of Recommendations Assessment,Development,and Evaluation,and evidence gap maps were ***:seventy-nine studies across 4 different gradual-onset knee disorders(i.e.,knee osteoarthritis(OA),patellofemoral pain(PfP),chondromalacia patellae,and patellar tendinopathy)were *** with knee OA presented with reduced hamstring strength compared to pain-free controls during isometric(standard mean difference(sMD)=-0.76,95%confidence interval(95%CI):-1.32 to-0.21)and concentric contractions(sMD=-0.97,95%CI:-1.49 to-0.45).Individuals with PfP presented with reduced hamstring strength compared to painfree controls during isometric(sMD=-0.48,95%CI:-0.82 to-0.14),concentric(sMD=-1.07,95%CI:-2.08 to-0.06),and eccentric contractions(sMD=-0.59,95%CI:-0.97 to-0.21).No differences were observed in individuals with patellar *** with PfP presented with reduced hamstring flexibility when compared to pain-free controls(sMD=-0.76,95%CI:-1.15 to-0.36).Evidence gap maps identified insufficient evidence for chondromalacia patel

关键词： Chondromalacia patellae Knee flexors Knee osteoarthritis Patellar tendinopathy Patellofemoral pain

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sTCf conceptual design report (Volume 1): Physics & detector

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frontiers of physics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai L.P.An R.Aliberti Q.An X.Z.Bai Y.Bai O.Bakina A.Barnyakov V.Blinov V.Bobrovnikov D.Bodrov A.Bogomyagkov A.Bondar I.Boyko Z.H.Bu f.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.Y.Chen H.Chen H.X.Chen J.f.Chen K.Chen L.L.Chen P.Chen s.L.Chen s.M.Chen s.Chen s.P.Chen W.Chen X.Chen X.f.Chen X.R.Chen Y.Chen Y.Q.Chen H.Y.Cheng J.Cheng s.Cheng T.G.Cheng J.P.Dai L.Y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding L.Y.Dong W.H.Dong V.Druzhinin D.s.Du Y.J.Du Z.G.Du L.M.Duan D.Epifanov Y.L.fan s.s.fang Z.J.fang G.fedotovich C.Q.feng X.feng Y.T.feng J.L.fu J.Gao Y.N.Gao P.s.Ge C.Q.Geng L.s.Geng A.Gilman L.Gong T.Gong B.Gou W.Gradl J.L.Gu A.Guevara L.C.Gui A.Q.Guo f.K.Guo J.C.Guo J.Guo Y.P.Guo Z.H.Guo A.Guskov K.L.Han L.Han M.Han X.Q.Hao J.B.He s.Q.He X.G.He Y.L.He Z.B.He Z.X.Heng B.L.Hou T.J.Hou Y.R.Hou C.Y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu Y.C.Hu J.Hua G.s.Huang J.s.Huang M.Huang Q.Y.Huang W.Q.Huang X.T.Huang X.J.Huang Y.B.Huang Y.s.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia s.Jia Z.K.Jia H.B.Jiang J.Jiang s.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.L.Kang X.s.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin Y.Lei E.Levichev C.H.Li C.Li D.Y.Li f.Li G.Li G.Li H.B.Li H.Li H.N.Li H.J.Li H.L.Li J.M.Li J.Li L.Li L.Li L.Y.Li N.Li P.R.Li R.H.Li s.Li T.Li W.J.Li X.Li X.H.Li X.Q.Li X.H.Li Y.Li Y.Y.Li Z.J.Li H.Liang J.H.Liang Y.T.Liang G.R.Liao L.Z.Liao Y.Liao C.X.Lin D.X.Lin X.s.Lin B.J.Liu C.W.Liu D.Liu f.Liu G.M.Liu H.B.Liu J.Liu J.J.Liu J.B.Liu K.Liu K.Y.Liu K.Liu L.Liu Q.Liu s.B.Liu T.Liu X.Liu Y.W.Liu Y.Liu Y.L.Liu Z.Q.Liu Z.Y.Liu Z.W.Liu I.Logashenko Y.Long C.G.Lu J.X.Lu N.Lu Q.f.Lü Y.Lu Y.Lu Z.Lu P.Lukin f.J.Luo T.Luo X.f.Luo Y.H.Luo H.J.Lyu X.R.Lyu J.P.Ma P.Ma Y.Ma Y.M.Ma f.Maas s.Malde D.Matvienko Z.X.Meng R.Mitchell A.Nefediev Y.Nefedov s.L.Olsen Q.Ouyang P.Pakhlov G.Pakhlova X.Pan Y.Pan E.Passemar Y.P.Pei H.P.Peng L.Peng X.Y.Peng X.J.Peng K.Peters s.Pivovarov E.Pyata B.B.Qi Y.Q.Qi W.B.Qian Y.Qian C.f.Qiao J.J.Qin J.J.Qin L.Q.Qin X.s.Qin T.L.Qiu J.Rademacker C.f.Redmer H.Y.sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nuclear Physics Novosibirsk 630090Russia CAs Key Laboratory of Theoretical Physics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish Laboratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central China Normal University Wuhan 430079China Central south University Changsha 410083China China University of Geosciences Wuhan 430074China China University of Mining and Technology Xuzhou 221116China École Polytechnique fédérale de Lausanne(EPfL) LausanneSwitzerland fudan University Shanghai 200433China Goethe University frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced study UCASHangzhou 310024China Hebei Normal University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University of Technology Hefei 230601China Helmholtz Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal University Xinxiang 453007China Henan University Kaifeng 475004China High Energy Physics Center Chung-Ang UniversitySeoul 06974Korea Higher school of Economy 11 Pokrovsky Bulvar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University of Automotive Technology Shiyan 442002China Hunan Normal University Changsha 410081China Hunan University of science and Technology Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongolia University Hohhot 010021China Institute of Advanced science facilities Shenzhen 518107China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Institute of Physics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China Jilin University Changch

The superτ-charm facility(sTCf)is an electron–positron collider proposed by the Chinese particle physics *** is designed to operate in a center-of-mass energy range from 2 to 7 GeV with a peak luminosity of 0.5×10^(35) cm^(–2)·s^(–1) or *** sTCf will produce a data sample about a factor of 100 larger than that of the presentτ-charm factory—the BEPCII,providing a unique platform for exploring the asymmetry of matter-antimatter(charge-parity violation),in-depth studies of the internal structure of hadrons and the nature of non-perturbative strong interactions,as well as searching for exotic hadrons and physics beyond the standard *** sTCf project in China is under development with an extensive R&D *** document presents the physics opportunities at the sTCf,describes conceptual designs of the sTCf detector system,and discusses future plans for detector R&D and physics case studies.

关键词： electron–positron collider tau-charm region high luminosity sTCf detector conceptual design

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GliomaCNN: An Effective Lightweight CNN Model in Assessment of Classifying Brain Tumor from Magnetic Resonance Images Using Explainable AI

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Computer Modeling in Engineering & sciences 2024年第9期140卷 2425-2448页

作者： Md.Atiqur Rahman Mustavi Ibne Masum Khan Md Hasib M.f.Mridha sultan Alfarhood Mejdl safran Dunren Che Department of Computer science and Engineering Ahsanullah University of Science and TechnologyDhaka1208Bangladesh Department of Computer science and software Engineering The University of Western AustraliaPerthWA 6009Australia Department of Computer science American International University-BangladeshDhaka1229Bangladesh Department of Computer science College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia school of Computing Southern Illinois UniversityCarbondale62901USA

Brain tumors pose a significant threat to human lives and have gained increasing attention as the tenth leading cause of global *** study addresses the pressing issue of brain tumor classification using Magnetic resonance imaging(MRI).It focuses on distinguishing between Low-Grade Gliomas(LGG)and High-Grade Gliomas(HGG).LGGs are benign and typically manageable with surgical resection,while HGGs are malignant and more *** research introduces an innovative custom convolutional neural network(CNN)model,*** stands out as a lightweight CNN model compared to its *** research utilized the BraTs 2020 dataset for its *** with the gradient-boosting algorithm,GliomaCNN has achieved an impressive accuracy of 99.1569%.The model’s interpretability is ensured through sHapley Additive exPlanations(sHAP)and Gradient-weighted Class Activation Mapping(Grad-CAM++).They provide insights into critical decision-making regions for classification *** challenges in identifying tumors in images without visible signs,the model demonstrates remarkable performance in this critical medical application,offering a promising tool for accurate brain tumor diagnosis which paves the way for enhanced early detection and treatment of brain tumors.

关键词： Deep learning magnetic resonance imaging convolutional neural networks explainable AI boosting algorithm ablation

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Wettability,reactivity,and interface structure in Mg/Ni system

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Journal of Magnesium and Alloys 2024年第2期12卷 659-672页

作者： s.Terlicka N.sobczak Ł.Maj P.Darłak J.J.sobczak Institute of Metallurgy and Materials science Polish Academy of Sciences25 Reymonta Str.KrakowPoland faculty of foundry Engineering AGH University23 Reymonta Str.KrakowPoland

The sessile drop method was applied to the experimental investigation of the wetting and spreading behaviors of liquid Mg drops on pure Ni *** comparison,the experiments were performed in two variants:(1)using the Capillary Purification(CP)procedure,which allows the non-contact heating and squeezing of a pure oxide-free Mg drop;(2)by classical Contact Heating(CH)*** high-temperature tests were performed under isothermal conditions(CP:760℃for 30 s;CH:715℃for 300 s)using Ar+5 wt%H_(2) *** the sessile drop tests,images of the Mg/Ni couples were recorded by CCD cameras(57 fps),which were then applied to calculate the contact angles of metal/substrate *** and transmission electron microscopy analyses,both coupled with energy-dispersive X-ray spectroscopy,were used for detailed structural characterization of the solidified *** was found that an oxide-free Mg drop obtained by the CP procedure showed a wetting phenomenon on the Ni substrate(an average contact angleθs),followed by fast spreading and good wetting over the Ni substrate(θ_((CP))~20°in 5 s)to form a final contact angle ofθ_(f(CP))~18°.In contrast,a different wetting behavior was observed for the CH procedure,where the unavoidable primary oxide film on the Mg surface blocked the spreading of liquid Mg showing apparently non-wetting behavior after 300 s contact at the test ***,in both cases,the deep craters formed in the Ni substrates under the Mg drops and significant change in the structure of initially pure Mg drops to Mg-Ni alloys suggest a strong dissolution of Ni in liquid Mg and apparent values of the final contact angles measured for the Mg/Ni system.

关键词： Magnesium-based alloys sessile drop tests Capillary purification procedure Wettability Reactivity Contact angle

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促进慢性阻塞性肺疾病哮喘患者自我监控空气质量的护理干预措施: 整合性综述

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International Journal of Nursing sciences 2024年第1期11卷 46-56页

作者： Bruna f.sebastiao Raquel M.Hortelao sara s.Granadas Jose M.faria Joana R.Pinto Helga Rafael Henriques Nursing school of Lisbon LisbonPortugal Hospital Center of Central Lisbon Portugal CUf Tejo Hospital LisbonPortugal University Hospital Center of Northern Lisbon LisbonPortugal Nursing Research Innovation and Development Centre of Lisbon(CIDNUR)LisbonPortugal

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通... 详细信息

目的哮喘-慢性阻塞性肺疾病肺重叠症(Asthma-chronie obst ructive pulmonary disease overlap,A-CO)患者的生活质量较低,肺功能较差,病情经常加重。由于暴露于污染环境会加重其症状,增加发病率和病死率,环境管理对其至关重要。旨在通过系统性综述,寻找证据,以指导制订护理干预措施,促进ACO患者对空气质量的自我管理。方法2023年3月 ,系统检索CINAHL、Medline、Academie search Complete .scopus、Webofscience、Cochrane图书馆、乔安娜布里格斯研究所(JoannaBriggsInstitute,JBI)循证实践数据库,以及Googlescholar。对纳人研究进行数据提取和综合,并对护理干预措施进行分类。采用JBI研究质量评估工具进行方法学质量评估。结果共纳入5篇来自不同国家的研究。促进ACO患者自我监控空气质量的干预措施包括:警觉性干预措施(医务人员定期巡诊、进行症状评估),监测干预措施(监测室内外诱发因素) ,教育干预措施(空气质量警报、避免接触过敏原),以及相关政策的影响,如无烟政策和改善空气质量的综合战略。尽管这些研究报告了不同的干预措施,方法质量也存在差异,但这些干预措施显示了预防患者病情恶化、尽量减少急诊就诊和住院治疗的潜力。这些关键点可作为护理干预措施的关键组成部分。结论有必要采取全面措施,让护士参与促进患者自我监控空气质量的多学科团队.提高认识、制订和实施护理干预,从而使ACO患者受益。同时,需要进--步开展研究,以扩大证据基础并完善这些干预措施。

关键词：空气质量哮喘哮喘-慢阻肺重叠慢性病慢性阻塞性肺疾病护理自我管理

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In situ nanoscale mapping of electrical and catalytic properties

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National science Review 2024年第07期 65-66页

作者： Christopher s.Kley Helmholtz Young Investigator Group Nanoscale Operando CO2 Photo-Electrocatalysis Helmholtz-Zentrum Berlin für Materialien und Energie GmbH Department of Interface science Fritz Haber Institute of the Max Planck Society

By enabling the conversion of sustainably-derived electrical energy into chemical energy, electrocatalytic reactions are vital for closing the anthropogenic carbon cycle. A wide array of electrocatalytic reactions have gained extensive attention, including hydrogen evolution（HER）, oxygen evolution（OER）, and CO2electroreduction（CO2RR）.

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BsN:The first Light Curve Analysis of the Total Eclipse Binary system EL Tuc

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Research in Astronomy and Astrophysics 2024年第10期24卷 66-75页

作者： Elham sarvari Eduardo fernández Lajús Atila Poro Independent researcher TehranIran Instituto de Astrofísica de La Plata(CCT La Plata-CONICET-UNLP) La PlataArgentina BsN Project &Astronomy Department of the Raderon AI Lab.BurnabyBCCanada

We conducted the first light curve study of the binary star EL Tuc within the Binary systems of south and North project's *** photometric observations were made using standard multiband BVR_cI_c filters at an observatory in *** presented a new ephemeris for EL Tuc and a linear fit to the O–C diagram,utilizing our extracted times of minima and additional *** employed the PHysics Of Eclipsing BinariEs Python code and the Markov chain Monte Carlo approach for the system's light curve *** target system's light curve solution required a cold starspot on the hotter *** conclude that EL Tuc is a total contact binary system with a low mass ratio of q=0.172±0.002,an orbital inclination of i=83°.74±0°.40,and a fillout factor of f=53.7%±1.6%.We used the P-a relationship and the Gaia Data Release 3 parallax method to determine the absolute parameters of EL Tuc to compare the precision of our *** system was classified as W-type based on the mass and effective temperature of the companion *** positions of the systems were depicted on the M-L,M-R,T-M,and *** relationship between the spectroscopic and photometric mass ratios of binaries was discussed.

关键词： (stars:)binaries:eclipsing stars:individual(EL Tuc) line:identification

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Inhibition of Ehrlich ascites carcinoma growth by melatonin:studies with micro-CT

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Oncology Research 2024年第1期32卷 175-185页

作者： sEHER YILMAZ ZÜLEYHA DOĞANYIĞIT MERT OCAK EVRIM sUNA ARIKAN sÖYLEMEZ AsLI OKAN OfLAMAZ sÜMEYYE UÇAR ŞÜKRÜATEŞ AMMAD AHMAD fAROOQI Department of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOhioUSA Department of Histology and Embriology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Department of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Department of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Department of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Department of Molecular Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a versatile indolamine synthesized and secreted by the pineal gland in response to the photoperiodic information received by the retinohypothalamic signaling *** has many benefits,such as organizing circadian rhythms and acting as a powerful *** aimed to show the antitumor effects of melatonin in both in vivo and in vitro models through the mammalian target of rapamycin(mTOR)signaling pathway and the Argyrophilic Nucleolar Regulatory Region(AgNOR),using the Microcomputed Tomography(Micro CT).Ehrlich ascites carcinoma(EAC)cells were administered into the mice by subcutaneous *** with solid tumors were injected intraperitoneally with 50 and 100 mg/kg melatonin for 14 *** measurements for the taken tumors were made with micro-CT imaging,immunohistochemistry(IHC),real-time polymerase chain reaction(PCR)and ***,the tumor tissue volume in the Tumor+100 mg/kg melatonin group was significantly lower than that in the other groups in the data obtained from micro-CT *** the IHC analysis,the groups treated with Tumor+100 mg/kg melatonin were compared when the mTOR signaling pathway and factor 8(f8)expression were compared with the control *** was determined that there was a significant decrease(psignificant differences were found in the total AgNOR area/nuclear area(TAA/NA)ratio in the treatment groups(pfurthermore,there were significant differences between the amount of mTOR mRNA for the phosphatidylinositol 3-kinase(PI3K),AKT serine/Threonine Kinase(PKB/AKT)genes(psis was evaluated with Annexin V in an in vitro study with different doses of melatonin;It was observed that 100µg/mL melatonin dose caused an increase in the apoptotic cell *** this study,we have reported anti-tumor effects of melatonin in cell culture studies as well as in mice *** characterization of the melatonin-mediated cancer inhibitory effects will be valuable in advanc

关键词： signaling pathway Apoptosis Real-time PCR AgNOR

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